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| 1 | Anti-inflammatory activity of curcumin-loaded tetrahedral framework nucleic acids on acute gouty arthritis显示文摘Gouty arthritis is a very familiar inflammatory arthritis.Controlling inflammation is the key to preventing gouty arthritis.However,colchicine,the most highly represented drug used in clinical practice,has strict contraindications owing to some severe side effects.Curcumin(Cur),a natural anti-inflammatory drug,has demonstrated good safety and efficacy.However,the rapid degradation,poor aqueous solubility,and low bioavailability of Cur limit its therapeutic effect.To strengthen the effectiveness and bioavailability of Cur.Cur loaded tetrahedral framework nucleic acids(Cur-TFNAs)were synthesized to deliver Cur.Compared with free Cur,Cur-TFNAs exhibit a preferable drug stability,good biocompatibility(CCK-8 assay),ease of uptake(immunofluorescence),and higher tissue utilization(in vivo biodistribution).Most importantly,Cur-TFNAs present better anti-inflammatory effect than free Cur both in vivo and in vitro experiments through the determination of inflammation-related cytokines expression.Therefore,we believe that Cur-TFNAs have great prospects for the prevention of gout and similar inflammatory diseases. | Mei Zhang Xiaolin Zhang Taoran Tian Qi Zhang Yuting Wen Junyao Zhu Dexuan Xiao Weitong Cui Yunfeng Lin | 2022 | Bioactive Materials2022，7，2： | 10 |
| 2 | Integrated Energy System Planning at Modular Regional-user Level Based on a Two-layer Bus Structure显示文摘An integrated energy system(IES)planning method with modular simulation and optimization models is proposed in this paper.A two-layer bus structure is adopted in the simulation model,where the external bus structure is used for power balance while the internal bus structure simulates the fast dynamics of electricity and slow dynamics of heat network in detail.In addition,an improved self-adaptive genetic algorithm(GA)is adopted in the optimization model to solve the multi-dimension and multi-time-scales optimization problem for the regional-user level IEPS.The proposed method can improve the extension flexibility of the system optimal planning model with expected accuracy.A case study is used to verify the effectiveness of the proposed planning method. | Bowen Hong Jian Chen Weitong Zhang Zhiyong Shi Junjie Li Weiwei Miao | 2018 | CSEE Journal of Power and Energy Systems2018，4，2： | 8 |
| 3 | A Genome Sequence of Novel SARS-CoV Isolates: the Genotype, GD-Ins29, Leads to a Hypothesis of Viral Transmission in South China显示文摘We report a complete genomic sequence of rare isolates (minor genotype) of theSARS-CoV from SARS patients in Guangdong, China, where the first few casesemerged. The most striking discovery from the isolate is an extra 29-nucleotidesequence located at the nucleotide positions between 27,863 and 27,864 (referredto the complete sequence of B J01) within an overlapped region composed of BGI-PUP5 (BGI-postulated uncharacterized protein 5) and BGI-PUP6 upstream ofthe N (nucleocapsid) protein. The discovery of this minor genotype, GD-Ins29,suggests a significant genetic event and differentiates it from the previously re-ported genotype, the dominant form among all sequenced SARS-CoV isolates. A17-nt segment of this extra sequence is identical to a segment of the same size intwo human mRNA sequences that may interfere with viral genome replication andtranscription in the cytosol of the infected cells. It provides a new avenue for theexploration of the virus-host interaction in viral evolution, host pathogenesis, andvaccine development. | E‘deQin XiongleiHe WeiTian YongLiu WeiLi JieWen BingyinSi YongwuHu WenmingPeng LinTaug TaoJiang JianpingShi JiaJia YuZhang JiaYe Cui’eWang YujunHan JingqiangWang BaochangFan QingfaWu GuohuiChang WuchunCao ZuyuanXu RuifuYang JmgWang ManYu YanLi JingXu JunZhou YajumDeng XiaoyuLi JianfeiHu CaipingWang ChunxiaYan QingrunZhang JingyueBao GuoqingLi HaiqingZhang YilinZhang HuiZhao XiaoweiZhang ShuangliLi XiaoJieCheng XiuqingZhang BinLiu ChangqingZeng HuanmingYang WeijunChen LinFang ChangfengLi MengLei DaweiLi WeiTong XiangjunTian JianWang BoZhang SonggangLi XuehaiTan SiqiLiu WeiDong JunWang GaneKa-ShuWong JunYu QingyuZhu | 2003 | Genomics, Proteomics & Bioinformatics2003，1，2： | 6 |
| 4 | A Simulation System and Speed Guidance Algorithms for Intersection Traffic Control Using Connected Vehicle Technology显示文摘In the connected vehicle environment, real-time vehicle-state data can be obtained through vehicle-toinfrastructure communication, and the prediction accuracy of urban traffic conditions can significantly increase.This study uses the C++/Qt programming language and framework to build a simulation platform. A two-way six-lane intersection is set up on the simulation platform. In addition, two speed guidance algorithms based on optimizing the travel time of a single vehicle or multiple vehicles are proposed. The goal of optimization is to minimize the travel time, with common indicators such as average delay of vehicles, average number of stops, and average stop time chosen as indexes of traffic efficiency. When the traffic flow is not saturated, compared with the case of no speed guidance, single-vehicle speed guidance can improve the traffic efficiency by 20%, whereas multi-vehicle speed guidance can improve the traffic efficiency by 50%. When the traffic flow is saturated, the speed guidance algorithms show outstanding performance. The effect of speed guidance gradually enhances with increasing penetration rate, and the most obvious gains are obtained when the penetration rate increases from 10% to 40%. Thus, this study has shown that speed guidance in the connected vehicle environment can significantly improve the traffic efficiency of intersections, and the multi-vehicle speed guidance strategy is more effective than the single-vehicle speed guidance strategy. | Shuai Liu Weitong Zhang Xiaojun Wu Shuo Feng Xin Pei Danya Yao | 2019 | Tsinghua Science and Technology2019，24，2： | 6 |
| 5 | The Structural Characterization and Antigenicity of the S Protein of SARS-CoV显示文摘The corona-like spikes or peplomers on the surface of the virion under electronicmicroscope are the most striking features of coronaviruses. The S (spike) proteinis the largest structural protein, with 1,255 amino acids, in the viral genome. Itsstructure can be divided into three regions: a long N-terminal region in the exte-rior, a characteristic transmembrane (TM) region, and a short C-terminus in theinterior of a virion. We detected fifteen substitutions of nucleotides by comparisonswith the seventeen published SARS-CoV genome sequences, eight (53.3%) of whichare non-synonymous mutations leading to amino acid alternations with predictedphysiochemical changes. The possible antigenic determinants of the S protein arepredicted, and the result is confirmed by ELISA (enzyme-linked immunosorbentassay) with synthesized peptides. Another profound finding is that three disulfidebonds are defined at the C-terminus with the N-terminus of the E (envelope) pro-tein, based on the typical sequence and positions, thus establishing the structuralconnection with these two important structural proteins, if confirmed. Phyloge-netic analysis reveals several conserved regions that might be potent drug targets. | JingxiangLi ChunqingLuo YajunDeng YujunHan LingTang JingWang JiaJi JiaYe FanboJiang ZhaoXu WeiTong WeiWei QingrunZhang ShengbinLi WeiLi HongyanLi YudongLi WeiDong JianWang ShengliBi HuanmingYaug | 2003 | Genomics, Proteomics & Bioinformatics2003，1，2： | 5 |
| 6 | Study on the application of reinforcement learning in the operation optimization of HVAC system显示文摘Supervisory control can be used to optimize the HVAC system operation and achieve building energy conservation,while reinforcement learning(RL)is considered as a promising model-free supervisory control method.In this paper,we apply RL algorithm to the operation optimization of air-conditioning(AC)system and propose an innovative RL-based model-free control strategy combining rule-based and RL-based control algorithm as well as complete application process.We use a variable air volume(VAV)air-conditioning system for a single-storey office building as a case study to validate the optimization performance of the RL-based controller.We select control strategies with the rule-based control controller(RBC)and proportional-integral-derivative(PID)controller respectively as the reference cases.The results show that,for the air supply of single zone,the RL controller performs the best in terms of both non-comfortable time and energy costs of AC system after one-year exploration learning.The total energy consumption of AC system reduced by 7.7%and 4.7%,respectively compared with RBC and PID strategies.For the air supply of multi-zone,the performance of RL controller begins to outperform the reference strategies after two-year exploration learning and two-year buffer stage.From the seventh year on,RL controller performs much better in terms of both non-comfortable time and operating costs of AC system,while the operating cost of AC system is reduced by 2.7%to 4.6%compared with the reference strategies.In addition,RL controller is more suitable for small-scale operation optimization problems. | Xiaolei Yuan Yiqun Pan Jianrong Yang Weitong Wang Zhizhong Huang | 2021 | Building Simulation2021，14，1： | 5 |
| 7 | MII:A Novel Text Classification Model Combining Deep Active Learning with BERT显示文摘Active learning has been widely utilized to reduce the labeling cost of supervised learning.By selecting specific instances to train the model,the performance of the model was improved within limited steps.However,rare work paid attention to the effectiveness of active learning on it.In this paper,we proposed a deep active learning model with bidirectional encoder representations from transformers(BERT)for text classification.BERT takes advantage of the self-attention mechanism to integrate contextual information,which is beneficial to accelerate the convergence of training.As for the process of active learning,we design an instance selection strategy based on posterior probabilities Margin,Intra-correlation and Inter-correlation(MII).Selected instances are characterized by small margin,low intra-cohesion and high inter-cohesion.We conduct extensive experiments and analytics with our methods.The effect of learner is compared while the effect of sampling strategy and text classification is assessed from three real datasets.The results show that our method outperforms the baselines in terms of accuracy. | Anman Zhang Bohan Li Wenhuan Wang Shuo Wan Weitong Chen | 2020 | Computers, Materials & Continua2020，，6： | 4 |
| 8 | 3D printing biomimeticmaterials and structures for biomedical applications显示文摘Over millions of years of evolution,nature has created organisms with overwhelming performances due to their unique materials and structures,providing us with valuable inspirations for the development of next-generation biomedical devices.As a promising new technology,3D printing enables the fabrication of multiscale,multi-material,and multi-functional threedimensional(3D)biomimetic materials and structures with high precision and great flexibility.The manufacturing challenges of biomedical devices with advanced biomimetic materials and structures for various applications were overcome with the flourishing development of 3D printing technologies.In this paper,the state-of-the-art additive manufacturing of biomimetic materials and structures in the field of biomedical engineering were overviewed.Various kinds of biomedical applications,including implants,lab-on-chip,medicine,microvascular network,and artificial organs and tissues,were respectively discussed.The technical challenges and limitations of biomimetic additive manufacturing in biomedical applications were further investigated,and the potential solutions and intriguing future technological developments of biomimetic 3D printing of biomedical devices were highlighted. | Yizhen Zhu Dylan Joralmon Weitong Shan Yiyu Chen Jiahui Rong Hanyu Zhao Siqi Xiao Xiangjia Li | 2021 | Bio-Design and Manufacturing2021，4，2： | 3 |
| 9 | A potential stratotype for the regional lowermost stage of the continental Paleocene in China显示文摘Phanerozoic chronostratigraphic units can only be defined through their lower boundary stratotypes.The lowermost stage of the Paleocene of China,which mainly consists of terrestrial deposits,can only be defined through its lower boundary stratotype,i.e.the continental Cretaceous/Paleogene boundary stratotype.There is no section yet found which contains continuous terrestrial deposits and biostratigraphic records of the Cretaceous-Paleogene transition in Nanxiong,Guangdong and Jiayin,Heilongjiang,there is no evidence for establishing the continental stratotype of the Cretaceous/Paleogene boundary in either area.Therefore,both the'Shanghuan stage'and'Furaoan stage'are not good candidates for the lowermost stage of the Paleocene of China.From the viewpoint of charophytes,the outcrop section of the Dangyang,Hubei Province(Central China)contains the most continuous,abundant and diverse terrestrial biostratigraphic records of the Cretaceous-Paleogene transition,in particular the early Paleocene,known so far in the world.The biostratigraphic records of ostracods in the transition are also continuous,rich,and diverse.The Dangyang outcrop section is the only section known so far in China that is a possible candidate for a continental stratotype of the Cretaceous/Paleogene boundary in China and the section is the only potential section identified to date for establishing the regional lowermost stage of the Paleocene,Paleogene and Cenozoic in China or stratotype section for the stage. | LI WeiTong LIU GengWu Dennis R.BRAMAN LI YiBin CAO WeiSheng Don BRINKMAN SHEN Jiao CHEN QingBao | 2014 | Science China Earth Sciences2014，57，5： | 3 |
| 10 | Unbalanced development, public services and government responsibility: an analysis based on government preference and government efficiency显示文摘发展失衡是当前中国经济社会运行中的突出问题,一般认为其直接原因是公共服务的提供不足,症结在于政府责任的缺失。通过区分“发展阶段型”和“政府责任型”两种失衡形态,可以发现,公共服务供求双方的因素共同导致了中国经济发展失衡问题的集中爆发,发展阶段型失衡和政府责任型失衡的混合形态是中国当前发展失衡的本质属性。中国经济转轨时期的体制制约了政府的效率,并导致了政府行为的偏差,是当前发展失衡的根本症结所在。因此,改变中国发展失衡现状的途径,不应仅仅要求政府在公共服务领域承担更多责任,更应立足体制转轨背景,加快解决引致政府行为偏差的体制性问题。 | Lv Weia Wang Weitong | 2008 | Social Sciences in China2008，29，4： | 3 |
| 11 | Autophagy,ferroptosis,pyroptosis,and necroptosis in tumor immunotherapy显示文摘In recent years,immunotherapy represented by immune checkpoint inhibitors(ICIs)has led to unprecedented breakthroughs in cancer treatment.However,the fact that many tumors respond poorly or even not to ICIs,partly caused by the absence of tumorinfiltrating lymphocytes(TILs),significantly limits the application of ICIs.Converting these immune“cold”tumors into“hot”tumors that may respond to ICIs is an unsolved question in cancer immunotherapy.Since it is a general characteristic of cancers to resist apoptosis,induction of non-apoptotic regulated cell death(RCD)is emerging as a new cancer treatment strategy.Recently,several studies have revealed the interaction between non-apoptotic RCD and antitumor immunity.Specifically,autophagy,ferroptosis,pyroptosis,and necroptosis exhibit synergistic antitumor immune responses while possibly exerting inhibitory effects on antitumor immune responses.Thus,targeted therapies(inducers or inhibitors)against autophagy,ferroptosis,pyroptosis,and necroptosis in combination with immunotherapy may exert potent antitumor activity,even in tumors resistant to ICIs.This review summarizes the multilevel relationship between antitumor immunity and non-apoptotic RCD,including autophagy,ferroptosis,pyroptosis,and necroptosis,and the potential targeting application of non-apoptotic RCD to improve the efficacy of immunotherapy in malignancy. | Weitong Gao Xueying Wang Yang Zhou Xueqian Wang Yan Yu | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 3 |
| 12 | Influences of the Paddy Rices with Different Moistures on the Head Rice Recovery显示文摘A major component rice varietv of Xiangwanxian 9 (a late Indica variety) with 13.1%, 15.6% and 18.3% of the moisture was respectively mixed with three ad-ditive varieties in 13% of moisture at ration of 7:3 for processing assorted rices. Head rice recovery of the treatments was determined 24 hours later. Analysis indicated sig-nificant differences exist in the effects produced by the component varieties, their moistures and the component variety moisture. | Liu Zemin Li Yongzhao Huang Weitong (Hunan Rice Research Institute, Changsha 410125) | 2000 | Hunan Agricultural Science & Technology Newsletter2000，1，2： | 2 |
| 13 | Prosody con- version of Chinese northwest mandarin dialect based on five degree tone model显示文摘 | Guo Weitong Yang Hongwu Pei Dong | 2012 | Intemational Journal of Digital Content Technology and its Applications2012，6，17： | 1 |
| 14 | Endpoint detection of noisy speech using empirical mode decomposition显示文摘 | Li Manman Yang Hongwu Guo Weitong | 2012 | International Journal of Digital Content Technology and Its Application2012，6，10： | 1 |
| 15 | LM-5 Integrated Modal Test Completed显示文摘The LM-5 integrated modal test was completed at the CALT next-generation launch vehicle industrial base in Tianjin.After 640 days’effort,the LM-5 rocket successively accomplished tests totalling23 technical states such as second-stage flight,first-stage flight,and rocket flight.The data obtained from the tests provided an important basis for rocket dynamic modal correction and the attitude control system.To fully test whether all performance indexes of the LM-5 rocket meet the requirement,the LM-5 rocket | WANG Weitong | 2015 | Aerospace China2015，16，3： | 1 |
| 16 | LM-7 Modal Test Completed in the 'Asian Highest Tower'显示文摘Recently,the full scale rocket modal test of LM-7 has been completed in Tianjin,which was the last large test before its maiden flight.Lasting 121 days,the LM-7 modal test including 16 testing states has been conducted in Beijing and Tianjin by the Beijing Institute of Structural and Environmental Engineering(BISEE).The data acquired from the modal test and the theoretically calculated data is consistent. | WANG Juan WANG Weitong | 2015 | Aerospace China2015，16，4： | 1 |
| 17 | A- nalysis of the user behavior and opinion classification based on the BBS显示文摘 | Weitong Huang Yu Zhao Shiqiang Yang Yuchang Lu | 2008 | Applied mathematics and computation2008，18，205： | 1 |
| 18 | Ex Vivo and In Situ Evaluation of ‘Dispelling‐Wind’ Chinese Medicine Herb–Drugs on Intestinal Absorption of Chlorogenic Acid显示文摘 | Lixiang Zhai Jun Shi Weitong Xu Michael Heinrich Jianying Wang Wenji Deng | 2015 | Phytother. Res2015，，12： | 1 |
| 19 | A novel approach for the field calibration of line structured - light sensors 显示文摘 | XIE Zexiao ZI-IU Weitong Zhang Zhiwei | 2010 | Measurement2010，43，2： | 1 |
| 20 | construction partnering in Critical Success factors for Taiwan 显示文摘 | Chen Weitong Chen T T | 2007 | International Journal of Project Management2007，25，47： | 1 |
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