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| 1 | HuoguⅠformula prevents steroid-induced osteonecrosis in rats by down-regulating PPARγ expression and activating Wnt/LRP5/β-catenin signaling显示文摘OBJECTIVE: To investigate the effects of HuoguⅠformula on regulation of lipid metabolism in steroid-induced osteonecrosis of the femoral head(SONFH) rats and verify our hypothesis that HuoguⅠ formula regulates lipid metabolism by down-regulating peroxisome proliferator-activated receptor gamma(PPARγ) expression and activating Wnt signaling pathways.METHODS: Eighty-five rats were divided into four groups: control, model, Huogu 15 g/kg and Huogu30 g/kg. Six weeks later, animals were anaesthetized, femora were dissected for histopathological examination of the osteonecrotic changes and repair processes, micro computed tomography(Micro-CT)-based micro-angiography was performed to assess vascularization. Serum lipid levels were detected by haematological examination. The expressions of PPARγ, Wnt3a, low density lipoprotein receptor-related protein 5(LRP5) and β-catenin were evaluated by immunohistochemistry,Western blot and quantitative real-time polymerase chain reaction analyses.RESULTS: The incidence of osteonecrosis, ratio of empty lacuna, adipose tissue area and adipocyte perimeter in the bone marrow were dramatically lower in the Huogu Ⅰ formula treatment groups.Bymicro-CTquantification,HuoguⅠformulatreatment dose-dependently increased vessel volume,vessel surface, percentage of vessel volume and vessel thickness of the femoral heads of SONFH rats. Levels of serum lipid in Huogu 15 g/kg and Huogu 30 g/kg groups reduced significantly.HuoguⅠformula treatment could suppress the expression of PPARγ and increase the expressions of Wnt3a, LRP5 and β-catenin at both protein and mRNA levels.CONCLUSION: The results of our present study highlight the lipid-lowering potential of Huogu Ⅰformula, and provide further evidence of the involvement of the PPARγ inhibition and Wnt/LRP5/β-catenin signaling activation in the effects of HuoguⅠformula. | Yini Jiang Daobing Liu Xiangying Kong Ying Xu Weiheng Chen Na Lin | 2014 | Journal of Traditional Chinese Medicine2014，34，3： | 18 |
| 2 | A detail preserving neural network model for Monte Carlo denoising显示文摘Monte Carlo based methods such as path tracing are widely used in movie production. To achieve low noise, they require many samples per pixel,resulting in long rendering time. To reduce the cost,one solution is Monte Carlo denoising, which renders the image with fewer samples per pixel(as little as128) and then denoises the resulting image. Many Monte Carlo denoising methods rely on deep learning:they use convolutional neural networks to learn the relationship between noisy images and reference images,using auxiliary features such as position and normal together with image color as inputs. The network predicts kernels which are then applied to the noisy input. These methods show powerful denoising ability,but tend to lose geometric or lighting details and to blur sharp features during denoising.In this paper, we solve this issue by proposing a novel network structure, a new input feature—light transport covariance from path space—and an improved loss function. Our network separates feature buffers from the color buffer to enhance detail effects. The features are extracted separately and then integrated into a shallow kernel predictor. Our loss function considers perceptual loss, which also improves detail preservation.In addition, we use a light transport covariance feature in path space as one of the features, which helps to preserve illumination details. Our method denoises Monte Carlo path traced images while preserving details much better than previous methods. | Weiheng Lin Beibei Wang Lu Wang Nicolas Holzschuch | 2020 | Computational Visual Media2020，6，2： | 4 |
| 3 | The Spatial Distribution and Attribute Parameter Statistics of Landslides Triggered by the May 12th,2008,MW7.9 Wenchuan Earthquake显示文摘A complete landslide inventory and attribute database is the importantly fundamental for the study of the earthquake-induced landslide.Substantial landslides were triggered by the MW7.9 Wenchuan earthquake on May 12th,2008.Google Earth images of preand post-earthquakes show that 52194 co-seismic landslides were recognized and mapped,with a total landslides area of 1021 km2.Based on the statistics,we assigned all landslide parameters and established the co-seismic landslides database,which includes area,length,and width of landslides,elevation of the scarp top and foot edge,and the top and bottom elevations of each located slope.Finally,the spatial distribution and the above attribute parameters of landslides were analyzed.The results show that the spatial distribution of the co-seismic landslides is extremely uneven.The landslides that mainly occur in a rectangular area(a width of 30 km of the hanging wall of the Yingxiu-Beichuan fault and a length of 120 km between Yingxiu and Beichuan)are obviously controlled by surface rupture,terrain,and peak ground acceleration.Meanwhile,a large number of small landslides(individual landslide area less than 10000 m2)contribute less to the total landslides area.The number of landslides larger than 10000 m2 accounts for 38.7%of the total number of co-seismic landslides,while the area of those landslides account for 88%of the total landslides area.The 52194 co-seismic landslides are caused by bedrock collapse that usually consists of three parts:source area,transport area,and accumulation area.However,based on the area-volume power-law relationship,the resulting regional landslide volume may be much larger than the true landslide volume if the landslide volume is calculated using the influenced area from each landslide. | DU Peng XU Yueren TIAN Qinjian ZHANG Weiheng LIU Shuang | 2020 | Earthquake Research in China2020，34，1： | 3 |
| 4 | Exosomes Released from Rabies Virus-Infected Cells May be Involved in the Infection Process显示文摘Exosomes are cell-derived vesicles that are secreted by many eukaryotic cells. It has recently attracted attention as vehicles of intercellular communication. Virus-infected cells release exosomes, which contain viral proteins, RNA, and pathogenic molecules. However, the role of exosomes in virus infection process remains unclear and needs to be further investigated.In this study, we aimed to evaluate the effects of exosomes on rabies virus infection. OptiPrep^(TM) density gradient centrifugation was used to isolate exosomes from rabies virus-infected cell culture supernatants. A rabies virus G protein enzyme-linked immunosorbent assay and acetylcholinesterase activity assays were performed to verify the centrifugation fractions. Exosomes were then characterized using transmission electron microscopy and Western blotting. Our results showed that rabies virus infection increased the release of exosomes. Treatment with GW4869 and si-Rab27 a, two exosomal secretion inhibitors, inhibited exosome release. Furthermore, the inhibitors reduced the levels of extracellular and intracellular viral RNA. These data indicated that exosomes may participate in the viral infection process. Moreover, our results establish a basis for future research into the roles of exosomes in rabies virus infection and as potential targets for developing new antiviral strategies. | Jingyu Wang Fan Wu Chuntian Liu Wenwen Dai Yawei Teng Weiheng Su Wei Kong Feng Gao Linjun Cai Ali Hou Chunlai Jiang | 2019 | Virologica Sinica2019，34，1： | 3 |
| 5 | A strategy of screening and binding analysis of bioactive components from traditional Chinese medicine based on surface plasmon resonance biosensor显示文摘Elucidating the active components of traditional Chinese medicine(TCM)is essential for understanding the mechanisms of TCM and promote its rational use as well as TCM-derived drug development.Recent studies have shown that surface plasmon resonance(SPR)technology is promising in this field.In the present study,we propose an SPR-based integrated strategy to screen and analyze the major active components of TCM.We used Radix Paeoniae Alba(RPA)as an example to identify the compounds that can account for its anti-inflammatory mechanism via tumor necrosis factor receptor type 1(TNF-R1).First,RPA extraction was analyzed using an SPR-based screening system,and the potential active ingredients were collected,enriched,and identified as paeoniflorin and paeonol.Next,the affinity constants of paeoniflorin and paeonol were determined as 4.9 and 11.8 mM,respectively.Then,SPR-based competition assays and molecular docking were performed to show that the two compounds could compete with tumor necrosis factor-a(TNF-a)while binding to the subdomain 1 site of TNF-R1.Finally,in biological assays,the two compounds suppressed cytotoxicity and apoptosis induced by TNF-a in the L929 cell line.These findings prove that SPR technology is a useful tool for determining the active ingredients of TCM at the molecular level and can be used in various aspects of drug development.The SPR-based integrated strategy is reliable and feasible in TCM studies and will shed light on the elucidation of the pharmacological mechanism of TCM and facilitate its modernization. | Diya Lv Jin Xu Minyu Qi DongyaoWang Weiheng Xu Lei Qiu Yinghua Li Yan Cao | 2022 | Journal of Pharmaceutical Analysis2022，12，3： | 3 |
| 6 | Effect of Ermiao Fang with Xixin(Herba Asari Mandshurici) on bone marrow stem cell directional homing to a focal zone in an osteoarthritis rat model显示文摘OBJECTIVE: To investigate the effects of Ermiao Fang(EM) with medical guide Xixin(Herba Asari Mandshurici)(HAM) on bone marrow stem cell migration to a focal zone in osteoarthritis(OA) rats.METHODS: OA rats were induced by arthrectomy and assigned to sham-operated, model, EM, or EM plus HAM groups.All rats were injected with recombinant human granulocyte colony-stimulating factor 30μg·kg-1·d-1for7 days and treated with EMor EM plus HAM at 1.6 or 1.9 g·kg-1·d-1 for 3 or 6 weeks, respectively. Chondrocyte apoptosis and cartilage matrix components were tested by transferase-mediated deoxyuridine triphosphate-biotin nick end labeling assay and special staining. Levels of interleukin-1 beta(IL-1β) tumor necrosis factor alpha(TNF-α) nitric oxide(NO), and inducible nitric oxide synthase(iNOS) in serum were detected by enzyme-linked immunosorbent assay or radioimmunoassay. Matrix metalloproteinases(MMPs)-13,tissue inhibitors of metalloproteinases(TIMPs)-1,Bromodeoxyuridine(BrdU), cluster of differentiation 34(CD34), and stromal cell-derived factor 1(SDF-1) were measured by immunohistochemical assay.RESULTS:The EM and EM plus HAM groups had significantly less cartilage damage and synovium inflammation the model group. Moreover, the EM and EM plus HAM groups had less chondrocyte apoptosis and more proteoglycan and collagen content than the model group.The EM and EMplus HAM groups had obviously higher MMPs-13 and TIMPs-1 expression in the cartilage than the model group. Moreover, the two formula groups had less release of IL-1β, TNF-α, NO, and iNOS than model group. Importantly, the expressions of BrdU, CD34,and SDF-1 in cartilage were significantly higher in the EM and EM plus HAM-Medtreated rats than model group. Notably, the EM plus HAM treatment seemed to have the greatest effects.CONCLUSION: HAM improves the therapeutic effects of EM on OA rats by enhancing BMSC directional homing to the focal zone. | Ying Xu Guojing Dai Qian Liu Hongwei Zhu Weiheng Chen Ping Zhang Tiejun Zhao Na Lin | 2014 | Journal of Traditional Chinese Medicine2014，34，4： | 3 |
| 7 | Mechanism of Boron Oxide as a Phase Regulator for Modification of Manganese Slag显示文摘The current research focused on adjusting the low hydration activity of the metallurgical slag by phase reconstruction technique. Boron oxide was used as a phase regulator to improve the amorphous phase composition of the manganese slag, consequently enhancing its hydraulic activity. The effects of boron oxide dosage and calcination temperature on the manganese slag amorphous phase content were investigated. XRD and DTG were performed to analyze the hydration mechanism of the manganese slag powder and cement. Results show that, when boron oxide dosage is 15%, calcination temperature is 1 300 ℃, and holding time for 1 hour, the amorphous content of the modified manganese slag reaches 95% and its 28-day activity index reaches 81.7%. The manganese slag powder can then be used as cement or concrete admixtures for the building materials industry. | 陈平 LI Zhibo 刘荣进 XIANG Weiheng QI Aixiang | 2014 | Journal of Wuhan University of Technology(Materials Science)2014，29，1： | 3 |
| 8 | Deciphering the superior thermoelectric property of posttreatment-free PEDOT:PSS/IL hybrid by X-ray and neutron scattering characterization显示文摘In this work,a polymer and ionic liquid(IL)hybrid with superior thermoelectric performance is prepared via a system design of the chemical composition,molar ratio of the constituent molecules and manipulating the structure in solution and dried films.The solution-casted hybrid film,consisting of poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate)(PEDOT:PSS)and 1-ethyl-3-methylimidazolium tricyanomethanide(EMIM:TCM),shows the highest power factor of 175μW m^(−1) K^(−2) in the polymer hybrid prepared by a post-treatment-free method.With a set of complementary structure characterization methods,it is found that EMIM:TCM can induce the structure reorganization of PEDOT:PSS in solution from a core-shell model to a rod-like model,during which PEDOT partially separates from PSS that eases the conductive network formation.In addition,the oxidation level of PEDOT:PSS is reduced by adding EMIM:TCM.Based on which,the PEDOT:PSS/IL hybrid shows the best performance in optimizing the conductivity(1163 S cm^(−1))and Seebeck coefficient(38.8μV K^(−1))simultaneously. | Xin Li Ruike Zou Zhen Liu Jitendra Mata Ben Storer Yu Chen Weiheng Qi Zekun Zhou Peng Zhang | 2022 | npj Flexible Electronics2022，6，1： | 2 |
| 9 | Molecular analysis of cell-free DNA identifies distinct molecular features in patients with chemosensitive and chemorefractory small cell lung cancer显示文摘Dear Editor,Lung cancer is the predominant cause of cancer-related death worldwide[1].Non-small cell lung cancer accounts for 80%-85%and small cell lung cancer(SCLC)accounts for 15%-20%of all lung cancer cases[2].Patients with SCLC,a highly aggressive and poorly differentiated malignancy,have an alarming average 5-year overall sur-vival rate of less than 10%[3].Most patients with SCLC already show clinically detectable metastases at diag-nosis and have extremely poor prognoses,even when treated with multimodality therapy[4].Before the addi-tion of atezolizumab to chemotherapy became the first-line treatment of extensive-stage SCLC,chemotherapy is the primary treatment of SCLC[5]. | Jie Zhang Chen Tian Fang Lv Jianfei Wang Wenbo Han Jun Nie Ling Dai Weiheng Hu Xiaoling Chen Xiangjuan Ma Guangming Tian Di Wu Sen Han Yang Wang Jieran Long Ziran Zhang Jian Fang Henghui Zhang | 2019 | Cancer Communications2019，39，1： | 2 |
| 10 | Identification of Cinobufagin and Resibufogenin as Inhibitors of Enterovirus 71 Infection显示文摘 | CHEN Jiawen XU Lin SUN Shiyang ZHANG Huafei MA Tonghui SU Weiheng JIANG Chunlai | 2014 | Chemical Research in Chinese Universities2014，30，6： | 1 |
| 11 | Integrated photonic RF self-interference cancellation on a silicon platform for full-duplex communication显示文摘In-band full-duplex(IBFD) technology can double the spectrum utilization efficiency for wireless communications,and increase the data transmission rate of B5G and 6G networks and satellite communications. RF self-interference is the major challenge for the application of IBFD technology, which must be resolved. Compared with the conventional electronic method, the photonic self-interference cancellation(PSIC) technique has the advantages of wide bandwidth, high amplitude and time delay tuning precision, and immunity to electromagnetic interference.Integrating the PSIC system on chip can effectively reduce the size, weight, and power consumption and meet the application requirement, especially for mobile terminals and small satellite payloads. In this paper, the silicon integrated PSIC chip is presented first and demonstrated for IBFD communication. The integrated PSIC chip comprises function units including phase modulation, time delay and amplitude tuning, sideband filtering, and photodetection, which complete the matching conditions for RF self-interference cancellation. Over the wide frequency range of C, X, Ku, and K bands, from 5 GHz to 25 GHz, a cancellation depth of more than 20 dB is achieved with the narrowest bandwidth of 140 MHz. A maximum bandwidth of 630 MHz is obtained at a center frequency of10 GHz. The full-duplex communication experiment at Ku-band by using the PSIC chip is carried out. Cancellation depths of 24.9 dB and 26.6 dB are measured for a bandwidth of 100 MHz at central frequencies of 12.4 GHz and14.2 GHz, respectively, and the signal of interest(SOI) with 16-quadrature amplitude modulation is recovered successfully. The factors affecting the cancellation depth and maximum interference to the SOI ratio are investigated in detail. The performances of the integrated PSIC system including link gain, noise figure, receiving sensitivity, and spurious free dynamic range are characterized. | XIUYOU HAN XINXIN SU MENG CHAO XINDI YANG WEIHENG WANG SHUANGLING FU YICHENG DU ZHENLIN WU MINGSHAN ZHAO | 2023 | Photonics Research2023，11，10： | 1 |
| 12 | Effects of processing parameters on the surface area of Mn2O3 at elevated temperatures显示文摘 | Zhao Qiang Shi Weiheng | 2002 | Microporous and Mesoporous Materials2002，53，： | 1 |
| 13 | Combining radiation and the ATR inhibitor berzosertib activates STING signaling and enhances immunotherapy via inhibiting SHP1 function in colorectal cancer显示文摘Background:Immune checkpoint inhibitors(ICIs)targeting programmed cell death protein 1(PD-1)and programmed death-ligand 1(PD-L1)have shown a moderate response in colorectal cancer(CRC)with deficient mismatch repair(dMMR)functions and poor response in patients with proficientMMR(pMMR).pMMRtumors are generally immunogenically“cold”,emphasizing combination strategies to turn the“cold”tumor“hot”to enhance the efficacy of ICIs.ATR inhibitors(ATRi)have been proven to cooperate with radiation to promote antitumor immunity,but it is unclear whether ATRi could facilitate the efficacy of IR and ICI combinations in CRCs.This study aimed to investigate the efficacy of combining ATRi,irradiation(IR),and anti-PD-L1 antibodies in CRC mouse models with different microsatellite statuses.Methods:The efficacy of combining ATRi,IR,and anti-PD-L1 antibodies was evaluated in CRC tumors.The tumor microenvironment and transcriptome signatures were investigated under different treatment regimens.The mechanisms were explored via cell viability assay,flow cytometry,immunofluorescence,immunoblotting,co-immunoprecipitation,and real-time quantitative PCR in multiple murine and human CRC cell lines.Results:Combining ATRi berzosertib and IR enhanced CD8+T cell infiltration and enhanced the efficacy of anti-PD-L1 therapy in mouse CRC models with different microsatellite statuses.The mechanistic study demonstrated that IR+ATRi could activate both the canonical cGAS-STING-pTBK1/pIRF3 axis by increasing cytosolic double-stranded DNA levels and the non-canonical STING signaling by attenuating SHP1-mediated inhibition of the TRAF6-STINGp65 axis,via promoting SUMOylation of SHP1 at lysine 127.By boosting the STING signaling,IR+ATRi induced type I interferon-related gene expression and strong innate immune activation and reinvigorated the cold tumor microenvironment,thus facilitating immunotherapy.Conclusions:The combination of ATRi and IR could facilitate anti-PD-L1 therapy by promoting STING signaling in CRC models with different microsatellite statuses.The new combination strategy raised by our study isworth investigating in the management of CRC. | Chaofan Liu Xi Wang Wan Qin Jingyao Tu Chunya Li Weiheng Zhao Li Ma Bo Liu Hong Qiu Xianglin Yuan | 2023 | Cancer Communications2023，43，4： | 1 |
| 14 | Interpretation of the Spatial Distribution Characteristics of the Co-seismic Landslides Induced by the 1920 Haiyuan M81/2 Earthquake Using Remote Sensing Images显示文摘Analyzing the spatial distribution characteristics of earthquake-induced secondary disasters based on advanced techniques is significantly important,especially in understanding the process of strong earthquakes in the Loess Pateau.Using ArcGIS,this study interprets multi-temporal high-resolution satellite images,field investigation data,and historical seismic records.Major conclusions are obtained as follows:①Landslides induced by the Haiyuan earthquake are mainly distributed in the intersection area of the end of the Haiyuan fault and Liupanshan fault,as indicated by multiple dense distribution centers;②The landslide distribution of the Haiyuan Earthquake is determined by the distance to the fault,topographic relief,slope,lithology,and other factors.In detail,the closer the distance to the fault,the greater the density of the landslide.The greater the slope and relief of the terrain,the greater the density and the smaller the average area of a landslide.Compared with tertiary strata,Quaternary strata has a larger average area,and the density of the landslides is smaller;③The density curve of the death toll in the Haiyuan earthquake can be used as a reference for the distribution of co-seismic landslides.Several Haiyuan co-seismic landslides are distributed in the Tongwei landslide area;however,the major landslides here are induced by the 1718 Tongwei earthquake rather than the 1920 Haiyuan earthquake;④The co-seismic landslides of the Haiyuan earthquake exhibits the“slope effect”in the south-west plate of Haiyuan fault,presenting the dominant sliding direction towards the fault and epicenter;however,the“slope effect”is not evident in the northeast plate of the fault. | ZHANG Weiheng XU Yueren DU Peng LI Wenqiao TIAN Qinjian CHEN Lize | 2020 | Earthquake Research in China2020，34，4： | 1 |
| 15 | Analysis of multiple factors involved in acute progressive cerebralinfarction and extra? and intracranial arterial lesions显示文摘 | Yuefu Chen Yajie Liu Chenghong Luo Weiheng Lu Binru Su | 2014 | Experimental and Therapeutic Medicine2014，，6： | 1 |
| 16 | Stable aqoueous ZnS quantum dots obtained using (3-mercaptopropyl) trimethoxyvsilane as a capping molecule 显示文摘 | Li Hui Shih Wan Y Shih Weiheng | 2007 | Nanotechnology2007，18，49： | 1 |
| 17 | Improved aqueous dispersion of silicon nitride with aminosilanes 显示文摘 | BUCHTAM A SHI Weiheng | 1996 | J Am Ceram Soc1996，79，11： | 1 |
| 18 | Synthesis of mesoporous aluminum oxide with aluminum alkoxide and tartaric acid 显示文摘 | Liu Xinghua Wei Yen Jin Danliang Shih Weiheng | 2000 | Materials Letters2000，42，3： | 1 |
| 19 | Addition of aprepitant improves protection against cisplatin-induced emesis when a conventional anti-emetic regimen fails显示文摘 | Weiheng Hu Jian Fang Jun Nie Ling Dai Xiaoling Chen Jie Zhang Xiangjuan Ma Guangming Tian Jindi Han | 2014 | Cancer Chemotherapy and Pharmacology2014，，6： | 1 |
| 20 | Influence of maleic anhydride grafted polypropylene on the dispersion of clay in polypropylene/clay nanocomposites 显示文摘 | Yuan Weiheng Guo Min Miao Zhuang etal | 2010 | Polymer Journal2010，42，9： | 1 |
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