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| 1 | Stable classi?cation with limited sample: transferring a 30-m resolution sample set collected in 2015 to mapping 10-m resolution global land cover in 2017显示文摘As the world strives to reduce the impact of population growth, urbanization, agricultural expansion, and climate change on food security, energy and water shortage, resource over-exploration, biodiversity loss, environmental pollution, and ultimately human health, timely and higher resolution land cover information is urgently needed to achieve the sustainable development goals of the United Nations. | Peng Gong Han Liu Meinan Zhang Congcong Li Jie Wang Huabing Huang Nicholas Clinton Luyan Ji Wenyu Li Yuqi Bai Bin Chen Bing Xu Zhiliang Zhu Cui Yuan Hoi Ping Suen Jing Guo Nan Xu Weijia Li Yuanyuan Zhao Jun Yang Chaoqing Yu Xi Wang Haohuan Fu Le Yu Iryna Dronova Fengming Hui Xiao Cheng Xueli Shi Fengjin Xiao Qiufeng Liu Lianchun Song | 2019 | Science Bulletin2019，64，6： | 166 |
| 2 | Therapeutic Effects of Selaginella tamariscina on the Model of Acute Gout with Hyperuricemia in Rats Based on Metabolomics Analysis显示文摘 | Weijia Chen Yi Wu Rongbing Bi Shu Liu Zhongying Liu Zhiqiang Liu Fengrui song Yi Shi | 2017 | Chinese Journal of Chemistry2017，35，7： | 5 |
| 3 | A high quality image reconstruction method based on nonconvex decoding显示文摘The article proposes a fast reconstruction algorithm for l0≤p≤1 norm nonconvex model,called Gradient projection nonconvex sparse recovery(GPNSR),which makes a good performance in high-quality image reconstruction.We apply the GPNSR into canonical multiple description coding theory and propose a robust high-quality compressed sensing-based coding method.Combined with iterative weighted technique and fast gradient descent method,the proposed method implicitly implements matrix inverse operations to highly reduce the storage pressure.Also the weighted norm method is taken to optimize the descent steps,which highly increases convergent speed of the algorithm.Taking an image has sparse Fourier representations as an example,the paper presents the detailed image sparse coding and fast reconstruction procedure.By integrating the compressive sensing multi-description coding framework,the simulation demonstrates the superior reconstruction performance of the proposed algorithm.Most importantly,with p close to zero,the reconstruction performance of GPNSR can approximate that of l0 norm optimization result. | ZHAO GuangHui SHEN FangFang WANG ZhengYang WU WeiJia SHI GuangMing LIU DanHua | 2013 | Science China(Information Sciences)2013，56，11： | 3 |
| 4 | Safety,tolerability,and pharmacokinetics of BAT8001 in patients with HER2-positive breast cancer:An open-label,dose-escalation,phase I study显示文摘Background:The introductions of anti-human epidermal growth factor receptor-2(HER2)agents have significantly improved the treatment outcome of patients with HER2-positive breast cancer.BAT8001 is a novel antibodydrug conjugate targeting human epidermal growth factor receptor-2(HER2)-expressing cells composed of a trastuzumab biosimilar linked to the drug-linker Batansine.This dose-escalation,phase I study was designed to assess the safety,tolerability,pharmacokinetics,and preliminary anti-tumor activity of BAT8001 in patients with HER2-positive locally advanced or metastatic breast cancer.Methods:This trial was conducted in subjects with histologically confirmed HER2-positive breast cancer(having evaluable lesions and an Eastern Cooperative Oncology Group performance status of 0 or 1)using a 3+3 design of escalating BAT8001 doses.Patients received BAT8001 intravenously in a 21-day cycle,with dose escalation in 5 cohorts:1.2,2.4,3.6,4.8,and 6.0 mg/kg.The primary objective was to evaluate the safety and tolerability of BAT8001.Preliminary activity of BAT8001 was also assessed as a secondary objective.Results:Between March 2017 to May 2018,29 HER2-positive breast cancer patients were enrolled.The observed dose-limiting toxicities were grade 4 thrombocytopenia and grade 3 elevated transaminase.The maximum tolerated dose was determined to be 3.6 mg/kg.Grade 3 or greater adverse events(AEs)occurred in 14(48.3%)of 29 patients,including thrombocytopenia in 12(41.4%)patients,aspartate aminotransferase increased in 4(13.8%)patients,γ-glutamyl transferase increased in 2(6.9%)patients,alanine aminotransferase increased in 2(6.9%)patients,diarrhea in 2(6.9%)patients.Objective response was observed in 12(41.4%,95%confidence interval[CI]=23.5%-61.1%)and disease control(including patients achieving objective response and stable disease)was observed in 24(82.8%,95%CI=64.2%-94.2%)patients.Conclusions:BAT8001 demonstrated favorable safety profiles,with promising anti-tumor activity in patients with HER2-positive locally advanced or metastatic breast cancer.BAT8001 has the potential to provide a new therapeutic option in patients with metastatic HER2-positive breast cancer. | Ruoxi Hong Wen Xia Liye Wang Kaping Lee Qianyi Lu Kuikui Jiang Shengfeng Li Jinquan Yu Jin Wei Weijia Tang Danyang Zhou Xin An Jiajia Huang Cong Xue Xiwen Bi Yanxia Shi Zhongyu Yuan Fei Xu Shusen Wang | 2021 | Cancer Communications2021，41，2： | 2 |
| 5 | A specific genomic organization and a novel promoter sequence for both ZP2 and ZP3 gene expressions in the Pingxiang red transparent crucian carp, Carassius auratus var. pingxiangnensis显示文摘 | Jianwu Shi Kou Peng Junqing Sheng Junhua Wang Weijia Yi Haijun Wu Qing Gu Yijiang Hong | 2013 | Comparative Biochemistry and Physiology - Part D:2013，，4： | 1 |
| 6 | Bortezomib in combination with dexamethasone and subsequent thalidomide for newly-diagnosed multiple myeloma: A Chinese experience显示文摘 | Weiyan Zheng Guoqing Wei Xiujin Ye Jingsong He Li Li Wenjun Wu Jimin Shi Jie Zhang Weijia Huang Wanzhuo Xie Yi Luo Xingkui Xue Maofang Lin He Huang Zhen Cai | 2009 | Leukemia Research2009，，12： | 1 |
| 7 | [3+3] Formal Cycloadditions of Nitrones from Isatins and Azaoxyallyl Cations for Construction of Spirooxindoles显示文摘一[3+3 ] 正式 cycloaddition 反应在之间在 situ,从靛红的形成的 azaoxyallyl 阳离子和 nitrones 被开发了,供应 spiro 的一个系列[1,2,4-oxadiazinan-5-one ] oxindoles 在对有优秀 diastereoselectivity 的优秀收益好。这个方法提供直接、有效的存取给潜在地合并六成员的杂环的脚手架的 bioactive spirooxindoles。 | Weijia Lin Gu Zhan Minglin Shi Wei Du Yingchun Chen | 2017 | Chinese Journal of Chemistry2017，35，6： | 1 |
| 8 | Enhanced cephalosporin C production with a combinational ammonium sulfate and DO-Stat based soybean oil feeding strategy显示文摘 | Shengbing Duan Guoqiang Yuan Yanli Zhao Hongfei Li Weijia Ni Meina Sang Liming Liu Zhongping Shi | 2011 | Biochemical Engineering Journal2011，，： | 1 |
| 9 | A MDM 2‐dependent positive‐feedback loop is involved in inhibition of mi R ‐375 and mi R ‐106b induced by H elicobacter pylori lipopolysaccharide显示文摘 | Feng Ye Chunli Tang Weijia Shi Juan Qian Shuping Xiao Min Gu Yini Dang Jianping Liu Yan Chen Ruihua Shi Guoxin Zhang | 2015 | Cancer2015，，9： | 1 |
| 10 | A biomimetic liver cancer on-a-chip reveals a critical role of LIPOCALIN-2 in promoting hepatocellular carcinoma progression显示文摘Hepatic stellate cells(HSCs)represent a significant component of hepatocellular carcinoma(HCC)microenvironments which play a critical role in tumor progression and drug resistance.Tumor-ona-chip technology has provided a powerful in vitro platform to investigate the crosstalk between activated HSCs and HCC cells by mimicking physiological architecture with precise spatiotemporal control.Here we developed a tri-cell culture microfluidic chip to evaluate the impact of HSCs on HCC progression.Onchip analysis revealed activated HSCs contributed to endothelial invasion,HCC drug resistance and natural killer(NK)cell exhaustion.Cytokine array and RNA sequencing analysis were combined to indicate the iron-binding protein LIPOCALIN-2(LCN-2)as a key factor in remodeling tumor microenvironments in the HCC-on-a-chip.LCN-2 targeted therapy demonstrated robust anti-tumor effects both in vitro 3D biomimetic chip and in vivo mouse model,including angiogenesis inhibition,sorafenib sensitivity promotion and NK-cell cytotoxicity enhancement.Taken together,the microfluidic platform exhibited obvious advantages in mimicking functional characteristics of tumor microenvironments and developing targeted therapies. | Peiliang Shen Yuanyuan Jia Weijia Zhou Weiwei Zheng Yueyao Wu Suchen Qu Shiyu Du Siliang Wang Huilian Shi Jia Sun Xin Han | 2023 | Acta Pharmaceutica Sinica B2023，13，11： | 0 |
| 11 | A local toolpath smoothing method for a five-axis hybrid machining robot显示文摘Smooth transitions between two adjacent five-axis toolpaths can reduce feedrate fluctuation,improving machining quality and efficiency.Hybrid robots’flexibility to adjust the orientation is advantageous in five-axis machining,but their kinematic issues raise challenges for toolpath smoothing.This paper proposes a G3continuous toolpath smoothing method for a hybrid robot.B-splines in the machine coordinate system(MCS)are inserted at corners to synchronize five-axis transitions.The transition errors of the tool position and orientation paths are estimated with the golden section method.These approximation errors are constrained by adaptively modifying the B-splines,i.e.,adding anchor points and optimizing the control points.A bisection search method is proposed for these geometric modifications,guaranteeing the user-defined error tolerance limit.Compared to the method based on the workpiece coordinate system(WCS),the proposed framework generates a smoother trajectory under the same error tolerance limit.Simulations and experiments are provided to validate the effectiveness. | SHI ZiKang ZHANG WeiJia DING Ye | 2023 | Science China(Technological Sciences)2023，66，3： | 0 |
| 12 | Split-Ring Structured All-Inorganic Perovskite Photodetector Arrays for Masterly Internet of Things显示文摘Photodetectors with long detection distances and fast response are important media in constructing a non-contact human-machine interface for the Masterly Internet of Things(MIT).All-inorganic perovskites have excellent optoelectronic performance with high moisture and oxygen resistance,making them one of the promising candidates for high-performance photodetectors,but a simple,low-cost and reliable fabrication technology is urgently needed.Here,a dual-function laser etching method is developed to complete both the lyophilic split-ring structure and electrode patterning.This novel split-ring structure can capture the perovskite precursor droplet efficiently and achieve the uniform and compact deposition of CsPbBr3 films.Furthermore,our devices based on laterally conducting split-ring structured photodetectors possess outstanding performance,including the maximum responsivity of 1.44×105 mA W^(−1),a response time of 150μs in 1.5 kHz and one-unit area<4×10-2 mm2.Based on these split-ring photodetector arrays,we realized three-dimensional gesture detection with up to 100 mm distance detection and up to 600 mm s^(−1) speed detection,for low-cost,integrative,and non-contact human-machine interfaces.Finally,we applied this MIT to wearable and flexible digital gesture recognition watch panel,safe and comfortable central controller integrated on the car screen,and remote control of the robot,demonstrating the broad potential applications. | Bori Shi Pingyang Wang Jingyun Feng Chang Xue Gaojie Yang Qingwei Liao Mengying Zhang Xingcai Zhang Weijia Wen Jinbo Wu | 2023 | Nano-Micro Letters2023，15，1： | 0 |
| 13 | Long-term feeding of sand rice(Agriophyllum squarrosum seed)can improve the antioxidant capacity of mice显示文摘Unhealthy eating habits with sugar-rich and high-fat foods can bring nutritional imbalance and other chronic diseases. At present, there is an increasing demand in regulating human sub-health through functional foods. Agriophyllum squarrosum(L.) Moq., a pioneer plant native to sand dunes with ecological restoration function, is a traditional food plant of sand regions and Mongolian folk medicine. Numerous studies have confirmed that A. squarrosum seed, also called sand rice, has high nutritional value. However, the long-term health effects of eating sand rice remain unclear. To better explore and evaluate its long-term effects, hereby, ICR mice were fed with sand rice flour at different ratios(control, 60% and 95%) for 100 days. Results show that the growth and blood glucose level curve of these experimental mice were lower and more stable than that of the control. In addition, mice fed pure sand rice ingredient(95%) gained more stable body weight and blood glucose after 28 days, which revealed that sand rice is a food with comprehensive nutritional value and rarely negatively impacts the body growth performance. Our data also demonstrates that, the content of triglyceride(TG), total cholesterol(TC), low-density lipoprotein cholesterol(LDL-C) and high-density lipoprotein cholesterol(HDL-C) provided the lowest level in the blood of mice with a diet of pure sand rice ingredient, 0.48, 4.14, 0.91, 3.03 mmol/L, respectively. Also, T-SOD and GSH-PX activity provided a high level in mice with pure sand rice gradient, which significantly increased by 36%(T-SOD)and 19%(GSH-PX) compared to the control. These results suggest that long term intake of the pure sand rice ingredients is more helpful for stabilizing blood lipid and improve antioxidant capacity and beneficial to people suffering from chronic disease. This study supplies the first animal evidence to support the claim that sand rice is a promising functional food with comprehensive nutrition in the future. We are confident that, with increasing demands of daily sand rice usage, planting A. squarrosum in the vast desert regions will further increase the local economy and ecological restoration when coping with global warming. | PengShu Zhao Liang Shi Xia Yan ChaoJu Qian WeiJia Zhao Yan Chang XiaoYue Yin XingKe Fan TingZhou Fang YuQiu Liao ShanShan Zhou XiaoFei Ma | 2023 | Research in Cold and Arid Regions2023，15，2： | 0 |
| 14 | 材料、能源、机械工程中高效的电流变技术——从机理到应用显示文摘电流变(ER)技术是一种基于电流变效应的先进技术。电流变技术中最常见的材料是电流变液(ERF)。电流变液是一种软物质智能材料,其黏度可以通过施加电场来可逆地调节。电流变液的衍生物、一种新型的电响应软物质材料——电流变弹性体(ERE),由于其不沉降、易封装的优点也得到了越来越多的关注。电流变材料由于其可逆可调、快速响应、低能耗等特性在机械工程中有着广泛的应用。除了基础的电流变材料的合成和应用以外,电流变技术还应用在了能源材料制备、石油运输、储能等诸多领域。电流变技术在能源领域的应用为其在其他领域的潜在应用提供了一个很好的范例。本文结合最新的研究成果,从机理到应用,系统地综述了电流变技术在材料、能源和机械工程等领域的研究现状和未来发展前景。 | Yudai Liang Dongyang Huang Xuefeng Zhou Ziqiu Wang Quan Shi Yaying Hong Huayan Pu Mengying Zhang Jinbo Wu Weijia Wen | 2023 | Engineering2023，，5： | 0 |
| 15 | An adjustable anti-resonance frequency controller for a dual-stage actuation semi-active vibration isolation system显示文摘In the semiconductor manufacturing industry,the dynamic model of a controlled object is usually obtained from a frequency sweeping method before motion control.However,the existing isolators cannot properly isolate the disturbance of the inertial force on the platform base during frequency sweeping(the frequency is between 0 Hz and the natural frequency).In this paper,an adjustable anti-resonance frequency controller for a dual-stage actuation semi-active vibration isolation system(DSASAVIS)is proposed.This system has a significant anti-resonance characteristic;that is,the vibration amplitude can drop to nearly zero at a particular frequency,which is called the anti-resonance frequency.The proposed controller is designed to add an adjustable anti-resonance frequency to fully use this unique anti-resonance characteristic.Experimental results show that the closed-loop transmissibility is less than−15 dB from 0 Hz to the initial anti-resonance frequency.Furthermore,it is less than−30 dB around an added anti-resonance frequency which can be adjusted from 0 Hz to the initial anti-resonance frequency by changing the parameters of the proposed controller.With the proposed controller,the disturbance amplitude of the payload decays from 4 to 0.5 mm/s with a reduction of 87.5%for the impulse disturbance applied to the platform base.Simultaneously,the system can adjust the anti-resonance frequency point in real time by tracking the frequency sweeping disturbances,and a good vibration isolation performance is achieved.This indicates that the DSA-SAVIS and the proposed controller can be applied in the guarantee of an ultra-low vibration environment,especially at frequency sweeping in the semiconductor manufacturing industry. | Bo ZHAO Weijia SHI Bingquan WANG Jiubin TAN | 2021 | Frontiers of Information Technology & Electronic Engineering2021，22，10： | 0 |
| 16 | Discovery and development of tricyclic matrinic derivatives as anti-diabetic candidates by AMPKαactivation显示文摘We found compound 12N-p-trifluoromethylbenzenesulfonyl matrinane(1)was a potent anti-diabetic agent.Thirty-five tricyclic matrinic derivatives were synthesized and determined for their stimulatory effects on glucose consumption in L6 myotubes,taking 1 as the lead.In high-fat diet(HFD)and STZ induced diabetic mice,9a significantly lowers blood glucose,improves glucose tolerance,and especially alleviates diabetic nephropathy and islet damage.Mechanism study indicates that 9a simultaneously targets mitochondrial complex I to increase AMP/ATP ratio,as well as liver kinase B1(LKB1)and calcium/calmodulindependent protein kinase(Ca MKK),which synergistically activates AMPKαand then stimulates glucose transporter 4(GLUT4)membrane translocation and 2-deoxyglucose(2-DG)uptake to exert anti-diabetic efficacy.Therefore,compound 9a with a novel structure is a promising anti-diabetic candidate with the advantage of multiple-target mechanism,worthy of further investigation. | Yinghong Li Yuanhui Zhang Tianyu Niu Yudong Pang Yulong Shi Qingxuan Zeng Jingpu Zhang Jingyang Zhu Xiuli Zhong Yanxiang Wang Yan Wang Sheng Tang Weijia Kong Danqing Song Jiandong Jiang | 2023 | Chinese Chemical Letters2023，34，1： | 0 |
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