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| 1 | Polysaccharides from Angelica sinensis alleviate neuronal cell injury caused by oxidative stress显示文摘Angelica sinensis has antioxidative and neuroprotective effects. In the present study, we aimed to determine the neuroprotective effect of polysaccharides isolated from Angelica sinensis. In a preliminary experiment, Angelica sinensis polysaccharides not only protected PC12 neuronal cells from H 2 O 2-induced cytotoxicity, but also reduced apoptosis and intracellular reactive oxygen species levels, and increased the mitochondrial membrane potential induced by H 2 O 2 treatment. In a rat model of local cerebral ischemia, we further demonstrated that Angelica sinensis polysaccharides enhanced the antioxidant activity in cerebral cortical neurons, increased the number of microvessels, and improved blood flow after ischemia. Our findings highlight the protective role of polysaccharides isolated from Angelica sinensis against nerve cell injury and impairment caused by oxidative stress. | Tao Lei Haifeng Li Zhen Fang Junbin Lin Shanshan Wang Lingyun Xiao Fan Yang Xin Liu Junjian Zhang Zebo Huang Weijing Liao | 2014 | Neural Regeneration Research2014，9，3： | 17 |
| 2 | Clonal analysis reveals remarkable functional heterogeneity during hematopoietic stem cell emergence显示文摘 | Hui Ye Xiaobo Wang Zongcheng Li Fan Zhou Xianlong Li Yanli Ni Weijing Zhang Fuchou Tang Bing Liu Yu Lan | 2017 | Cell Research2017，27，8： | 4 |
| 3 | Akt mediates metastasis-associated gene 1 (MTA1) regulating the expression of E-cadherin and pro?moting the invasiveness of prostate cancer cells显示文摘 | Wang H Fan L WeiJ | 2012 | PloS one2012，7，46： | 1 |
| 4 | Efficacy and safety of Danhong injection in the treatment of arteriosclerosis obliterans:a meta-analysis of randomized controlled trials显示文摘目的:系统评价丹红注射液治疗动脉硬化闭塞症的临床有效性和安全性。方法:计算机检索中国知网(CNKI)、维普中文期刊数据库(VIP)、万方数据知识服务平台、中国生物医学文献数据库(CBM)、Pubmed、科学引文索引(SCI)数据库、Cochrane Library在内的8个中英文数据库,2位研究者对符合入选标准者采用Cochrane推荐的偏倚风险评估方法评价偏倚风险,提取资料,并应用Review Manager软件进行Meta分析和系统评价。结果:最终纳入13项研究,总病例数884例,结果显示,丹红注射液治疗动脉硬化闭塞症与常规治疗方式相比较,临床有效性更高,差异有统计学意义,[OR=3.08,95%CI(2.07,4.60),P<0.00001];对动脉硬化程度改善更加明显,[OR=0.15,95%CI(0.12,0.19),P<0.00001];对血流动力学改善更加明显,[OR=-0.19,95%CI(-0.33,-0.04),P=0.01];未有任何不良反应发生。结论:丹红注射液治疗动脉硬化闭塞症,临床有效性更高,对动脉硬化程度和血流动力学改善更加明显,且具有较高安全性。但由于文献研究质量偏低,需要更多高质量、大样本、随机对照双盲临床试验提供高级别证据,以进一步验证丹红注射液治疗动脉硬化闭塞症有效性和安全性。 | Weijing Fan Qiuyan Zhang Changgeng Fu Xiao Jin Tong Xing Zeji Chen Xin Zhao Zhonghui Zhao Lina Miao Baozhong Yang | 2018 | TMR Clinical Research2018，1，1： | 0 |
| 5 | Lynch syndrome pre-screening and comprehensive characterization in a multi-center large cohort of Chinese patients with colorectal cancer显示文摘Objective:Lynch syndrome(LS)pre-screening methods remain under-investigated in colorectal cancers(CRCs)in Asia.Here,we aimed to systematically investigate LS pre-screening and comprehensively characterize LS CRCs.Methods:Microsatellite instability(MSI)and germline variants of DNA mismatch repair(MMR)genes were examined in 406 deficient MMR(dMMR)and 250 proficient MMR CRCs.The genetic differences between LS and sporadic CRCs were studied with whole exome sequencing analysis.Results:The incidence of dMMR in Chinese patients with CRCs was 13.8%.Consistency analysis between MMR immunohistochemistry(IHC)and MSI testing showed the kappa value was 0.758.With next-generation sequencing(NGS),germline variants were detected in 154 CRCs.Finally,88 patients with CRC were identified as having LS by Sanger sequencing.Among them,we discovered 21 previously unreported pathogenic germline variants of MMR genes.Chinese patients with LS,compared with sporadic CRCs,tended to be early-onset,right-sided,early-stage and mucinous.Overall,the performance of MMR IHC and MSI testing for LS pre-screening was comparable:the area under the ROC curve for dMMR,MSI-H,and MSI-H/L was 0.725,0.750,and 0.745,respectively.dMMR_MSI-H LS and sporadic CRCs showed substantial differences in somatic genetic characteristics,including different variant frequencies of APC,CREBBP,and KRAS,as well as different enriched pathways of VEGF,Notch,TGFβR,mTOR,ErbB,and Rac protein signal transduction.Conclusions:MMR IHC and MSI testing were effective methods for LS pre-screening.The revealed clinical and somatic genetic characteristics in LS CRCs may have the potential to improve the performance of LS pre-screening in combination with dMMR/MSI. | Yan Li Lihong Fan Jianming Zheng Xiu Nie Yu Sun Qin Feng Shenyi Lian Wenqi Bai Weijing Cai Yanan Yang Bo Su Yanfeng Xi Dongmei Lin | 2022 | Cancer Biology & Medicine2022，19，8： | 0 |
| 6 | Conservative Treatment of Fetal Goitrous Hypothyroidism Due to Thyroglobulin Mutations:A Case Report and Literature Review显示文摘With the advances in fetal medicine,there will be more cases of congenital hypothyroidism(CH)diagnosed in the fetal period.However,there is no consensus on the management protocol.We present a successful case of conservatively managed fetal goitrous hypothyroidism due to compound heterozygous TG mutations.Goiter was observed in a fetus at 23 weeks of gestation.Because there was no evidence of transplacental passage of antithyroid antibody and drugs,iodine overload,and iodine deficiency,the fetus was highly suspected to have CH.Considering the potential risks of amniocentesis/cordocentesis,and lack of available parenteral levothyroxine in China,the fetus was closely monitored thereafter.A male neonate was delivered vaginally without complications at 39 weeks of gestation.We verified severe hypothyroidism in the infant and immediately initiated levothyroxine therapy.His growth and mental development were normal at the age of 8 month.Whole-exome sequencing showed that the neonate had two compound heterozygous mutations in the TG gene.We also performed a literature review of the prognosis of postnatal treatment of CH due to TG mutations and the result showed that postnatal treatment of CH due to TG mutations has a favorable prognosis.However,further prospective studies are warranted to verify this conclusion. | Shiping Liu Wei Bai Ying Gao Chunyan Shi Lixin Fan Junya Chen Jian Shi Weije Sun Xinlin Hou Huixia Yang | 2023 | Maternal-Fetal Medicine2023，5，3： | 0 |
| 7 | Investigation and Analysis of Crop Germplasm Resources in Coastal Areas of Shandong Province显示文摘This study focused on the investigation of crop germplasm resources in coastal areas of Shandong Province, including132 villages in 82 towns of 34 counties. The survey collected local varieties and wild resources of grain crops, economic crops,vegetables and fruit trees, and a total of 848 samples were collected, belonging to 54 species of 39 genera in 15 families. In this study, the current situation and growth and decline conditions of crop germplasm resources were investigated, and their botanical classification and utilization importance were analyzed. Furthermore, the conservation, development and utilization of crop germplasm resources in coastal areas of Shandong Province were also discussed in this paper. | Dong WANG Xiaodong ZHANG Runfang LI Zhan LI Yumin MA Yu ZHANG Nana LI Weijing CHEN Zhongxue FAN Shoujin FAN Libin ZHANG Hui ZHANG Yingjie LIN Hanfeng DING | 2017 | Agricultural Science & Technology2017，18，10： | 0 |
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