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| 1 | Auto-compensation of velocity-height ratio for Chang’E-2 satellite CCD stereo camera显示文摘The TDI-CCD imaging method using auto-compensation of velocity-height ratio (VHR) was applied to Chang’E-2 satellite CCD stereo camera.Factors that influence the image quality of the camera were discussed,among which the mismatch error in VHR was found to be the main cause.An auto-compensation scheme for VHR was developed.The validity and effectiveness were proved by the on-orbit high quality images. | XUE Bin ZHAO BaoChang YANG JianFeng GAO Weit QIAO WeiDong MA XiaoLong ZHANG Bo LIU JiaHang ZHAO Wei JING Juan Juan | 2011 | Science China(Technological Sciences)2011，54，9： | 4 |
| 2 | Culture of yeast cells immobilized by alginate-chitosan microcapsules in aqueous-organic solvent biphasic system显示文摘Immobilization biocatalysis is a potential technology to improve the activity and stability of biocatalysts in nonaqueous systems for efficient industrial production.Alginate-chitosan(AC)microcapsules were prepared as immobilization carriers by emulsifi cation-internal gelation and complexation reaction,and their contribution on facilitating the growth and metabolism of yeast cells were testifi ed successfully in culture medium-solvent biphasic systems.The cell growth in AC microcapsules is superior to that in alginate beads,and the cells in both immobilization carriers maintain much higher activity than free cells,which demonstrates AC microcapsules can confer yeast cells the ability to resist the adverse effect of solvent.Moreover,the performance of AC microcapsules in biphasic systems could be improved by adjusting the formation of outer polyelectrolyte complex(PEC)membrane to promote the cell growth and metabolic ability under the balance of resisting solvent toxicity and permitting substrate diffusion.Therefore,these findings are quite valuable for applying AC microcapsules as novel immobilization carriers to realize the biotransformation of value-added products in aqueous-solvent biphasic systems. | HOU Dandan YU Weiting ZHANG Demeng ZHAO Lili LIU Xiudong MA Xiaojun | 2019 | Journal of Oceanology and Limnology2019，37，3： | 4 |
| 3 | Bosonic quantum error correction codes in superconducting quantum circuits显示文摘Quantum information is vulnerable to environmental noise and experimental imperfections,hindering the reli-ability of practical quantum information processors.Therefore,quantum error correction(QEC)that can pro-tect quantum information against noise is vital for universal and scalable quantum computation.Among many different experimental platforms,superconducting quantum circuits and bosonic encodings in superconducting microwave modes are appealing for their unprecedented potential in QEC.During the last few years,bosonic QEC is demonstrated to reach the break-even point,i.e.the lifetime of a logical qubit is enhanced to exceed that of any individual components composing the experimental system.Beyond that,universal gate sets and fault-tolerant operations on the bosonic codes are also realized,pushing quantum information processing towards the QEC era.In this article,we review the recent progress of the bosonic codes,including the Gottesman-Kitaev-Preskill codes,cat codes,and binomial codes,and discuss the opportunities of bosonic codes in various quantum applications,ranging from fault-tolerant quantum computation to quantum metrology.We also summarize the challenges associated with the bosonic codes and provide an outlook for the potential research directions in the long terms. | Weizhou Cai Yuwei Ma Weiting Wang Chang-Ling Zou Luyan Sun | 2021 | Fundamental Research2021，1，1： | 3 |
| 4 | Preparation of protein-loaded microspheres with size ≤ 10 μm by electrostatic droplet generation technology显示文摘The development of non-injection route for protein drugs, especially oral administration, has been the main focus of controlled release of drugs. To overcome obstacles unsolved such as enzyme degradation and penetration barrier of intestinal epi- thelium, technologies using microspheres as carrier of protein drugs have been proven potential to realize oral administration. It has been demonstrated that microspheres can not only protect proteins, but also facilitate the penetration and absorption through Peyer’s patches when the size is smaller than 10 μm. Therefore, the objective of this paper is to prepare protein-loaded microspheres with size ≤ 10 μm. Electrostatic droplet generation technology was used with insulin and hemoglobin as drug models and so- dium alginate as microsphere material. By decreas- ing the surface tension of feed solution by adding surfactant, and improving electric field distribution by changing the shape of container and electrode for gelation solution, protein-loaded microspheres with mean size less than 10 μm were successfully pro- duced through needle with diameter of 400 μm. The microspheres showed good sphericity and narrow size distribution. The mean standard variance of size distribution was 1.61. The encapsulation efficiency of proteins was over 70%. Moreover, the significance analysis of factors influencing the size of protein loaded microspheres was carried out through or- thogonal experiments, which showed that output voltage (U), needle diameter (D) and the distance between needle tips to the surface of gelation solu- tion (δ ) influenced significantly the size of micro-spheres. Finally, the statistic analysis showed that when confidence level was α=0.05, and α=0.1, con- fidence interval of microsphere size can be (6.2545, 10.1735) and (6.6022, 9.8258) correspondingly, suggesting that there is good repeatability and reli- ability for improving electrostatic droplet generation technology to prepare protein-loaded microspheres with size ≤10 μm. | XUE Weiming LIU Xiudong YU Weiting MA Xiaojun | 2006 | Chinese Science Bulletin2006，51，3： | 3 |
| 5 | Amphiphilic sodium alginate-vinyl acetate microparticles for drug delivery显示文摘To overcome the fast or burst release of hydrophilic drugs from hydrophilic alginate-based carriers,hydrophobic molecule(vinyl acetate,VAc)was grafted on alginate(Alg),which was further used to prepare drug carriers.Amphiphilic Alg-g-PVAc hydrogel beads were firstly prepared by emulsification/internal gelation technique for the loading of bovine serum albumin(BSA).Then,chitosan was coated on the surface of beads to form novel amphiphilic Alg-g-PVAc/chitosan(Alg-g-PVAc/CS)microcapsules.The BSA-loading amphiphilic Alg-g-PVAc/chitosan(Alg-g-PVAc/CS)microcapsules display similar morphology and size to the hydrophilic alginate/chitosan(AC)microcapsules.However,the drug loading and loading efficiency of BSA in Alg-g-PVAc/CS microcapsules are higher,and the release rate of BSA from Alg-g-PVAc/CS microcapsules is slower.The results demonstrate that the introduction of hydrophobic PVAc on alginate can effectively help retard the release of BSA,and the higher degree of substitution is,the slower the release rate is.In addition,the complex membrane can also be adjusted to delay the release of BSA.As a whole,amphiphilic sodium alginate-vinyl acetate/CS microparticles could be developed for macromolecular drug delivery. | YU Weiting ZHANG Demeng LIU Xiudong WANG Yunhong TONG Jun ZHANG Mengxue MA Xiaojun | 2019 | Journal of Oceanology and Limnology2019，37，3： | 2 |
| 6 | Vapor phase growth of two-dimensional PdSe2 nanosheets for high-photoresponsivity near-infrared photodetectors显示文摘Palladium diselenide(PdSe2),a stable layered material with pentagonal structure,has attracted extensive interest due to its excellent electrical and optoelectronic performance.Here,we report a reliable process to synthesize PdSe2 via chemical vapor deposition(CVD)method.Through systematic regulation of temperature in the growth process,we can tune the thickness,size,nucleation density and morphology of PdSe2 nanosheets.Field-effect transistors based on PdSe2 nanosheets exhibit n-type behavior and present a high electron mobility of 105 cm^2·V^−1·s^−1.The electrical property of the devices after 6 months keeping in the air show little change,implying outstanding air-stability of PdSe2.In addition,PdSe2 near-infrared photodetector shows a photoresponsivity of 660 A·W^−1 under 914 nm laser.These performances are better than those of most CVD-grown 2D materials,making ultrathin PdSe2 a highly qualified candidate material for next-generation optoelectronic applications. | Weiting Xu Jiayang Jiang Huifang Ma Zhengwei Zhang Jia Li Bei Zhao Ruixia Wu Xiangdong Yang Hongmei Zhang Bailing Li Weining Shu Zucheng Zhang Bo Li Yuan Liu Lei Liao Xidong Duan | 2020 | Nano Research2020，13，8： | 1 |
| 7 | Microencapsulated probiotics using emulsification technique coupled with internal or external gelation process显示文摘 | Huiyi Song Weiting Yu Meng Gao Xiudong Liu Xiaojun Ma | 2013 | Carbohydrate Polymers2013，，1： | 1 |
| 8 | Toughening Effects through Optimizing Cell Structure and Deformation Behaviors of Al–Mg Foams显示文摘As widely used protective materials,the application of Al foams is still limited by their low intrinsic mechanical properties caused by the brittleness of struts.The introduction of Mg is recently demonstrated effective to improve the mechanical performance of Al foams;however,the mechanism of Mg modification is still not clear.In this work,Al-Mg foams are developed through a powder metallurgy process with excellent compression performance and high energy absorption capacity.The effects of Mg modification on the cell structure,toughness,and deformation behavior are investigated systematically.As a result,the small cell size of~1.8 mm and the high sphericity of 0.92 are achieved with 5% of Mg addition,delivering high compression stress of 8.5±0.43 MPa and energy absorption capacity of 6.9±0.36 MJ/m^(3),simultaneously.The synergistic mechanism for the improved mechanical performance is also demonstrated to be the combination of stress transfer and plastic deformation behavior of cells.The results provide a new strategy to develop high-performance foam materials by improving toughness and further promote the practical application. | Hao Yu Xudong Yang Weiting Li Xudong Rong Siyuan Guo Lishi Ma Lizhuang Yang Junwei Sha Naiqin Zhao | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，12： | 1 |
| 9 | Bronsted-acidic ionic liquids as catalysts for synthesizing trioxane显示文摘The batch reaction experiments have been made for the first time to investigate the effect of ionic structure on the reactivity and selectivity of the trioxane-forming reaction catalyzed by a Br?nsted-acidic ionic liquid(IL).The ILs considered include 1-cyclohexyl-2-pyrrolidinonium trifluoromethanesulfonate([NCy P][TfO ]),1-cyclohexyl-2-pyrrolidinonium benzenesulfonate([NCyP ][BSA]),1-cyclohexyl-2-pyrrolidinonium p-toluenesulfonate([NCyP ][pTSA]),1-octyl-2-pyrrolidinonium 2,4-dinitrobenzenesulfonate([NOP][DNBSA]),1-octyl-2-pyrrolidinonium benzenesulfonate([NOP][BSA]),1-octyl-2-pyrrolidinonium methanesulfonate([NOP][MSA]),and 1-octyl-2-pyrrolidinonium trifluoromethanesulfonate([NOP][Tf O]).It is found that the yield of trioxane in the reaction solution correlates inversely with the Hammett acidity function H0 of the aqueous solution of the corresponding ILs.Variation of the cation structure from [NCyP ]+to [NOP]+exerts little influence on the yield and the selectivity of trioxane in the reaction solution.Using [TfO ]-or [DNBSA]-in place of [MSA]-or [BSA]-apparently increases the yield of trioxane,but only slightly increases the concentration of formic acid in the reaction solution.The continuous production experiments have been made to investigate the performance of [NOP][MSA],[NOP][DNBSA],[NCyP ][TfO ],and H2SO4 as an extraction distillation agent.Such effect of [NCyP ][TfO ] considerably overrides that of H2SO4.The yield and the selectivity of trioxane are both increased when [NCyP ][TfO ] is used instead of H2SO4 at a reaction time 5 h. | Yamei Zhao Yufeng Hu Jianguang Qi Weiting Ma | 2016 | Chinese Journal of Chemical Engineering2016，24，10： | 1 |
| 10 | Behavior of microbial growth and metabolism in alginate-chitosan-alginate (ACA) microcapsules 显示文摘 | Qi Wentao Ma Juan Yu Weiting | 2006 | Enzyme Microb Technol2006，38，： | 1 |
| 11 | Personal glucose meters coupled with signal amplification technologies for quantitative detection of non-glucose targets:Recent progress and challenges in food safety hazards analysis显示文摘Ensuring food safety is paramount worldwide.Developing effective detection methods to ensure food safety can be challenging owing to trace hazards,long detection time,and resource-poor sites,in addition to the matrix effects of food.Personal glucose meter(PGM),a classic point-of-care testing device,possesses unique application advantages,demonstrating promise in food safety.Currently,many studies have used PGM-based biosensors and signal amplification technologies to achieve sensitive and specific detection of food hazards.Signal amplification technologies have the potential to greatly improve the analytical performance and integration of PGMs with biosensors,which is crucial for solving the challenges associated with the use of PGMs for food safety analysis.This review introduces the basic detection principle of a PGM-based sensing strategy,which consists of three key factors:target recognition,signal transduction,and signal output.Representative studies of existing PGM-based sensing strategies combined with various signal amplification technologies(nanomaterial-loaded multienzyme labeling,nucleic acid reaction,DNAzyme catalysis,responsive nanomaterial encapsulation,and others)in the field of food safety detection are reviewed.Future perspectives and potential opportunities and challenges associated with PGMs in the field of food safety are discussed.Despite the need for complex sample preparation and the lack of standardization in the field,using PGMs in combination with signal amplification technology shows promise as a rapid and cost-effective method for food safety hazard analysis. | Feng He Haijie Wang Pengfei Du Tengfei Li Weiting Wang Tianyu Tan Yaobo Liu Yanli Ma Yuanshang Wang A.M.Abd El-Aty | 2023 | Journal of Pharmaceutical Analysis2023，13，3： | 0 |
| 12 | Decorating Covalent Organic Frameworks with High-density Chelate Groups for Uranium Extraction显示文摘The extraction of uranium from aqueous solution is highly desirable for sustaining the increasing demand for environmental safety and nuclear fuel.Herein,we report a strategy using a two-step covalent modification for the synthesis of covalent organic frameworks(COFs)with high-density amidoxime chelate groups at periphery.The introduction of dense amidoxime groups plays a pivotal role in uranium adsorption.The resulting COF exhibits strong affinity with the distribution coefficient of 5.2×104 mL/g and a high adsorption capacity of 319.9 mg/g.The strategy could be expanded to identify and remove different contaminants by introducing special functional groups. | QIN Xudong TANG Xiaohui MA Yu XU Hong XU Qing YANG Weiting GU Cheng | 2022 | Chemical Research in Chinese Universities2022，38，2： | 0 |
| 13 | A PD-L1-targeting chimeric switch receptor enhances efficacy of CAR-T cell for pleural and peritoneal metastasis显示文摘Pleural and peritoneal metastasis accompanied by malignant pleural effusion(MPE)or malignant ascites(MA)is frequent in patients with advanced solid tumors that originate from the lung,breast,gastrointestinal tract and ovary.Regional delivery of CAR-T cells represents a new strategy to control tumor dissemination in serous cavities.However,malignant effusions constitute an immune-suppressive environment that potentially induces CAR-T cell dysfunction.Here,we demonstrated that the anti-tumor cytotoxicity of conventional 2nd-generation CAR-T cells was significantly inhibited by both the cellular and non-cellular components of MPE/MA,which was primarily attributed to impaired CAR-T cell proliferation and cytokine production in MPE/MA environment.Interestingly,we found that PD-L1 was widely expressed on freshly-isolated MPE/MA cells.Based on this feature,a novel PD-L1-targeting chimeric switch receptor(PD-L1.BB CSR)was designed,which can bind to PD-L1,switching the inhibitory signal into an additional 4-1BB signal.When co-expressed with a 2nd-generation CAR,PD-L1.BB CSR-modified CAR-T cells displayed superior fitness and enhanced functions in both culture medium and MPE/MA environment,causing rapid and durable eradication of pleural and peritoneal metastatic tumors in xenograft models.Further investigations revealed elevated expressions of T-cell activation,proliferation,and cytotoxicity-related genes,and we confirmed that PD-L1 scFv and 4-1BB intracellular domain,the two important components of PD-L1.BB CSR,were both necessary for the functional improvements of CAR-T cells.Overall,our study shed light on the clinical application of PD-L1.BB CSR-modified dual-targeting CAR-T cells.Based on this study,a phase I clinical trial was initiated in patients with pleural or peritoneal metastasis(NCT04684459). | Qizhi Ma Xia He Benxia Zhang Fuchun Guo Xuejin Ou Qiyu Yang Pei Shu Yue Chen Kai Li Ge Gao Yajuan Zhu Diyuan Qin Jie Tang Xiaoyu Li Meng Jing Jian Zhao Zeming Mo Ning Liu Yao Zeng Kexun Zhou Mingyang Feng Weiting Liao Wanting Lei Qiu Li Dan Li Yongsheng Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，12： | 0 |
| 14 | The HY5 transcription factor negatively regulates ethylene production by inhibiting ACS1 expression under blue light conditions in pear显示文摘Ethylene is the main factor controlling fruit ripening of pear(Pyrus ussuriensis).Ethylene production rate is negatively correlated with fruit shelf life;therefore,it is important to decrease the ethylene levels for optimal fruit storage.Here,we observed that blue light treatment could inhibit ethylene production and promote the expression of ELONGATED HYPOCOTYL 5(PuHY5),a basic leucine zipper domain(bZIP)transcription factor.The following studies showed that PuHY5 could bind to the promoter of ACC synthase 1(PuACS1),a rate-limiting enzyme in ethylene biosynthesis,and inhibit its expression.For pears in which Pu HY5 was silenced,the ethylene production and PuACS1 expression were much higher than those in the control fruit.These results demonstrated that blue light inhibited ethylene production through the induction of Pu HY5 in pear.Our finding provides a new method for prolonging fruit shelf life. | Weiting Liu Lichao Zhang Li Ma Hui Yuan Aide Wang | 2023 | Horticultural Plant Journal2023，9，5： | 0 |
| 15 | Concentration of linoleic acid from cottonseed oil by starch complexation显示文摘The extraction of linoleic acid from fatty acids(FA) of the cottonseed oil using starch–FA complexes was developed for the first time. We showed that starch can form inclusion complexes of different strengths with FA and that the different strengths stem from the differences in chain length, degree of unsaturation, and position of double bonds of FA. The optimal separation conditions were determined as follows: The inclusion temperature is 69 °C, the inclusion time is 30 min, the starch/FA mass ratio is 10:1, and the ratio of the volume of methanol–water solution and the mass of FA is 18:1. Compared to urea inclusion complexation, starch complexation has milder reaction temperature and shorter reaction time. Under these conditions, linoleic acid can be concentrated from 38.9% to 70.04% by one-off extraction. Moreover, the experimental results demonstrate the almost perfect reusability of starch. These results show that starch complexation is a promising method that can be used to obtain highly concentrated linoleic acid from cottonseed oil. | Dan Liang Yufeng Hu Weiting Ma Zhengtang Zhao Siqi Jiang Yichuan Wang Xianming Zhang | 2019 | Chinese Journal of Chemical Engineering2019，27，4： | 0 |
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