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| 1 | Efficacy of Atorvastatin combined with adipose-derived mesenchymal stem cell transplantation on cardiac function in rats with acute myocardial infarction显示文摘间充质的干细胞(MSC ) 广泛地被申请了在尖锐心肌的梗塞(AMI ) 以后的 cardiomyocytes 损失的恢复。然而,在 ischemic 心疾病的 MSC 的最佳的治疗学的功效被他们的差的幸存和低区分的率妨碍了。因此, MSC 幸存的改进和区分的率被保证并且为在 AMI 的 MSC 的功效批评。在这份报纸,从腹股沟的胖纸巾作为脂肪质导出被称为间充质的干细胞(ASC ) 的老鼠孤立的 MSC,和 ASC 的第四个段落被文化 co 在一个 transwell 系统与 cardiomyocytes 预先指定作为 co-ASCs 称为。十四天以后, GATA-4 (一个抄写因素) 和心脏的 troponin -- 我被细胞的 immunofluorescence 检测。Atorvastatin (Ator 组) 或车辆(控制组) 在老鼠在 AMI 生产以后为开始的 24 h 被管理。十四天以后,煽动性的参数和心脏的功能被评估。另外的幸存老鼠与 1 普物敭 ? 潴戠 ? 的一个总数被注射 ? 楤敲瑣琠牡敧 ? 敧敮漠 ? 業??? 祢攠桮湡散 ? 牧敥 ? 汦潵敲 ' 諟?牰瑯楥? 敲潰瑲牥攠灸牥浩湥吗? | Anping Cai Dongdan Zheng Yugang Dong Ruofeng Qiu Yuli Huang Yuanbin Song Zhigao Jiang Shaoqi Rao Xinxue Liao Jian Kuang Gang Dai Weiyi Mai | 2011 | Acta Biochimica et Biophysica Sinica2011，43，11： | 16 |
| 2 | Effect of Exogenous Ghrelin on Cell Differentiation Antigen 40 Expression in Endothelial Cells显示文摘Ghrelin 是为生长荷尔蒙促泌素受体(GHSR ) 用作自然配体的大脑勇气肽。它也在心血管的系统富有地存在。以便在动脉粥样硬化的发展评估 ghrelin 的可能的角色,房间区别抗原 40 的表示(CD40 ) 上的 ghrelin 的效果被学习。人的脐的静脉 endothelial 房间(HUVEC ) line-ECV 304 与 ghrelin 的不同集中被预先对待, des 酰 ghrelin 或[d-Lys ]-GHRP-6 (一个 ghrelin 受体对手) ,然后与肿瘤坏死 factor-alpha (TNF-alpha ) 和干扰素鲸鱼群妈(TFN-gamma ) 导致了。CD40 的 mRNA 层次被反向的抄写聚合酶链反应分析,并且在房间的 CD40 蛋白质的表情被流动 cytometry (FCM ) 并且西方的弄污测量。结果证明外长的 ghrelin 能显著地禁止 TNF-alpha/IFN-gamma 在以一种集中依赖者方式的 HUVEC 房间的导致的 CD40 表示。当与 ghrelin 的 1000 ng/ml 对待时,在房间的 CD40 的 mRNA 水平被约77%减少,但是当与 ghrelin 的 1000 ng/ml 和 1000 ng/ml 对待时[ d-Lys ]-GHRP-6,在房间的 CD40 的 mRNA 水平被减少由仅仅42%,建议那[ d-Lys ] -GHRP-6 能在这些房间抵抗 ghrelin 的禁止的效果。然而, CD40 表示没被 des 酰 ghrelin 在 1000 ng/ml 禁止。在 FCM 并且进一步的西方的弄污检测的蛋白质表示分析的结果证实了这些结果。我们的结果在心血管的系统建议了那, ghrelin 不仅有反煽动性的效果,而且有重要免疫可以通过 GHSR-1a 受体被调停的规章的效果。 | Min ZHANG Fang YUAN Hui CHEN Xingbiao QIU Weiyi FANG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，12： | 8 |
| 3 | Inhibition of proliferation and apoptosis of vascular smooth muscle cells by ghrelin显示文摘在动脉粥样硬化的发展评估 ghrelin 的可能的角色,它肿瘤上的效果脉管的光滑的肌肉房间(VSMC ) 的坏死因素(TNF )-α-induced 增长和 apoptosis 被调查。老鼠 VSMC 是有 ghrelin 的不同集中然后与 TNF-α 的 pretreated。VSMC 增长被 3-(4,5-dimethylthiazol-2-yl ) 测量 -2,5-diphenyl tetrazolium 溴化物试金和流动 cytometry 方法。Apoptosis 用 propidium 碘化物和 Annexin-V 标记方法被检测。外长的 ghrelin (10-1000 ng/ml ) 显著地以一种集中依赖者方式禁止了 VSMC 的 TNF-α-induced 增长。有 1000 ng/ml ghrelin 的处理在禁止 VSMC 增长率和增殖的房间的表示是很有效的原子抗原。然而,有 des 酰 ghrelin 的处理影响了既不增长也不 PCNA 表示。相反, VSMC 的 TNF-α-induced apoptosis 被 ghrelin 和 des 酰 ghrelin 在集中依赖者礼貌禁止,与为在 1000 ng/ml 的两混合物观察的最大的抑制。总起来说,我们的结果建议 ghrelin 禁止了老鼠 VSMC 的增长和 apoptosis。而且,以前的效果被生长荷尔蒙促泌素受体类型 la 受体可能调停,当后者效果可以通过另外的受体被调停时。 | Min Zhang Fang Yuan Hua Liu Hui Chen Xingbiao Qiu Weiyi Fang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，9： | 8 |
| 4 | Measures and dimensions of fractal sets in local fields显示文摘The study of fractal analysis over the local fields as underline spaces is very important since it can motivate new approaches and new ideas, and discover new techniques in the study of fractals. To study fractal sets in a local field K, in this paper, we define several kinds of fractal measures and dimensions of subsets in K. Some typical fractal sets in K are constructed. We also give out the Hausdorff dimensions and measures, Box-counting dimensions and Packing dimensions, and stress that there exist differences between fractal analysis on local fields and Euclidean spaces. Consequently, the theoretical foundation of fractal analysis on local fields is established. | QIU Hua SU Weiyi | 2006 | Progress in Natural Science:Materials International2006，16，12： | 3 |
| 5 | Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-[beta]-like signaling pathway显示文摘 | Ding Lihua Wang Zhaoyun Yan Jinghua Yang Xiao Liu Aijun Qiu Weiyi Zhu Jianhua Han Juqiang Zhang Hao Lin Jing Cheng Long Qin Xi Niu Chang Yuan Bin Wang Xiaohui Zhu Cui Zhou Yan Li Jiezhi Song Haifeng Huang Cuifen Ye Qinong | 2009 | Journal of Clinical Investigation2009，，2： | 1 |
| 6 | Insulin-like growth factor-2 enhances regulatory T cell functions and suppresses food allergy in an experimental model显示文摘 | Gui Yang Xiao-Rui Geng Jiang-Ping Song Yingying Wu Hao Yan Zhengke Zhan Litao Yang Weiyi He Zhi-Qiang Liu Shuqi Qiu Zhigang Liu Ping-Chang Yang | 2014 | The Journal of Allergy and Clinical Immunology2014，，： | 1 |
| 7 | Mechanoresponsive MiR-138-5p Targets MACF1 to Inhibit Bone Formation显示文摘Mechanical stimuli play an essential role in maintaining bone remodeling and skeletal integrity.Meanwhile,bone can respond to the changes of mechanical condition to adjust its mass and architecture.Clinical studies discover that bedridden patients showed osteoporotic T-scores and low bone mineral density,and long-term immobilized patients presented reduced markers of bone formation.However,as bone formation mediated by osteoblast differentiation is a complex process,the underlying molecular mechanism of mechanical stimuli regulating bone formation is still unclear.Recent evidences show that microRNAs(miRNAs)are involved in mechanical stimuli regulating bone formation or osteoblast differentiation.Nevertheless,no direct evidence identifies mechanoresponsive miRNA in both human and animal bones,and clarifies its mechanoresponsive role under different mechanical conditions(e.g.mechanical unloading,reloading,loading).In the current study,we screened for differentially expressed miRNAs in bone specimens of bedridden patients with fractures,then identified that the expression of miR-138-5p,but not the other miRNAs,altered withbedridden time and was negatively correlated with the expression of the bone formation marker genes Alp(alkaline phosphatase).Moreover,miR-138-5p was up-regulated with reduced bone formation during unloading and down-regulated with increased bone formation during reloading in hind4imb unloaded mice.In addition,miR-138-5p was verified to be responsive to different mechanical unloading condition and cyclic mechanical stretch condition in primary osteogenic cells,respectively.Further in vitro data suggested that mechanoresponsive miR-138-5p directly targeted microtubule actin crosslinking factor 1(MACF1)to inhibit osteoblast differentiation.In vivo,we constructed an osteoblastic miR-138-5p transgenic mice model(TG138)with the Runx2promoter,and found that overexpression miR-138-5p supressed bone formation.Moreover,osteoblast-targeted inhibition of miR-138-5p sensitized bone anabolic response to mechanical loading in TG138 mice.Predominantly,the osteoblast-targeted inhibition of miR-138-5p could counteract bone formation reduction induced by hind limb unloading.Taken together,the mechanoresponsive miR-138-5p inhibited bone anabolic response for developing a novel bone anabolic sensitization strategy. | Zhihao Chen Zhao Fan Liang Chao Lifang Hu Chen Lei Zhang Yan Yin Chong Dijie Li Tian Ye Wuxia Qiu Kewen Zhang Chaofei Yang Xiaona Li Li Yu Weiyi Chen Zhang Ge Qian Airong | 2019 | 医用生物力学2019，34，A01： | 1 |
| 8 | Increasing stability of antibody via antibody engineering: Stability engineering on an anti‐hVEGF显示文摘 | Shuang Wang Ming Liu Dadi Zeng Weiyi Qiu Pingping Ma Yunzhou Yu Hongyan Chang Zhiwei Sun | 2014 | Proteins2014，，： | 1 |
| 9 | Lipoprotein-associated phospholipase A2(Lp-PLA 2 ): A novel and promising biomarker forcardiovascular risks assessment显示文摘 | Anping Cai Dongdan Zheng Ruofeng Qiu Weiyi Mai Yingling Zhou | 2013 | Disease Markers2013，，： | 1 |
| 10 | Theoretical perspective on synthetic man-made life:Learning from the origin of life显示文摘Creating a man-made life in the laboratory is one of life science's most intriguing yet challenging problems.Advances in synthetic biology and related theories,particularly those related to the origin of life,have laid the groundwork for further exploration and understanding in this field of artificial life or man-made life.But there remains a wealth of quantitative mathematical models and tools that have yet to be applied to this area.In this paper,we review the two main approaches often employed in the field of man-made life:the top-down approach that reduces the complexity of extant and existing living systems and the bottom-up approach that integrates welldefined components,by introducing the theoretical basis,recent advances,and their limitations.We then argue for another possible approach,namely'bottom-up from the origin of life':Starting with the establishment of autocatalytic chemical reaction networks that employ physical boundaries as the initial compartments,then designing directed evolutionary systems,with the expectation that independent compartments will eventually emerge so that the system becomes free-living.This approach is actually analogous to the process of how life originated.With this paper,we aim to stimulate the interest of synthetic biologists and experimentalists to consider a more theoretical perspective,and to promote the communication between the origin of life community and the synthetic man-made life community. | Lu Peng Zecheng Zhang Xianyi Wang Weiyi Qiu Liqian Zhou Hui Xiao Chunxiuzi Liu Shaohua Tang Zhiwei Qin Jiakun Jiang Zengru Di Yu Liu | 2023 | Quantitative Biology2023，11，4： | 0 |
| 11 | ON HAUSDORFF DIMENSION OF CERTAIN RIESZ PRODUCT IN LOCAL FIELDS显示文摘在这篇论文,我们认为 Riesz 产品 d μ = Π _(j=1 )~ ∞(是 1 + a_jRe χ _(b_(jp ) λ _ j )(x)) dx 在本地人地,和我们获得它的 Hausdorffdimension 的上面、更低的界限。 | Hua Qiu Weiyi Su Yin Li | 2007 | Analysis in Theory and Applications2007，23，2： | 0 |
| 12 | Influence of pre-stretching on the tensile strength,fatigue properties and the in-plane anisotropy in Al-Cu-Li alloy AA2099显示文摘The influence of pre-stretching prior to artificial aging on microstructure,tensile properties,and fatigue behavior of AA2099-T8 sheets was investigated.The results showed that increased pre-strain level from 1%to 6%resulted in a more uniform distribution and increasing density of the T_(1)phase.The localized plastic deformation during pre-stretching led to the formation of dense precipitation bands(DPBs)and precipitation free bands(T_(1)-PFBs)in the sheets with the 1%pre-strain.The non-uniform distribution of the T_(1)phase with T_(1)-PFBs and DPBs resulted in a decrement in elongation and a strong in-plane anisotropy of tensile properties.An appropriate level of pre-strain should be executed aiming to improve elongation and reduce the tensile anisotropy by promoting a uniform distribution of the T_(1)phase.In-plane anisotropy of yield strength due to the presence of DPBs and T_(1)-PFBs was quantitatively analyzed by the modified Hall-Petch formula.The results of the calculation for the modified model showed good agreement with the experiment.In addition,resistances of fatigue crack propagation(FCP)in the same orientation were gradually decreased with the increment of pre-strain due to the increment in yield strength and more uniform distribution of the T_(1)phase.For the in-plane anisotropy of FCP resistance,the main reasons were the development of rough fracture surfaces and the transgranular fracture modes in L-T orientation. | Xianghui Zhu Xusheng Yang Weijiu Huang Weiyi Qiu Xin Wang Fei Guo Li Hu Miao Gong | 2023 | Journal of Materials Science & Technology2023，，14： | 0 |
| 13 | Cursor momentum for fascination measurement显示文摘We present a very different cause of search engine user behaviors ——fascination. It is generally identified as the initial effect of a product attribute on users' interest and purchase intentions. Considering the fact that in most cases the cursor is driven directly by a hand to move via a mouse (or touchpad), we use the cursor movement as the critical feature to analyze the personal reaction against the fascinating search results. This paper provides a deep insight into the goal-directed cursor movement that occurs within a remarkably short period of time (<30 milliseconds), which is the interval between a user's click-through and decision-making behaviors. Instead of the fundamentals, we focus on revealing the characteristics of the split-second cursor movement. Our empirical findings showed that a user may push or pull the mouse with a slightly greater strength when fascinated by a search result. As a result, the cursor slides toward the search result with an increased momentum. We model the momentum through a combination of translational and angular kinetic energy calculations. Based on Fitts' law, we implement goal-directed cursor movement identification. Supported by the momentum, together with other physical features, we built different fascination-based search result reranking systems. Our experiments showed that goal-directed cursor momentum is an effective feature in detecting fascination. In particular, they show feasibility in both the personalized and cross-media cases. In addition, we detail the advantages and disadvantages of both click-through rate and cursor momentum for re-ranking search results. | Yu HONG Kai WANG Weiyi GE Yingying QIU Guodong ZHOU | 2019 | Frontiers of Computer Science2019，13，2： | 0 |
| 14 | Amino-functionalized carbon nanotubes/polyphosphazene hybrids for improving the fire safety and mechanical properties of epoxy显示文摘To expand further modern industrial applications of epoxy resin(EP),the urgent problems of flammability and poor mechanical properties have to be solved.Therefore,amino-functionalized carbon nanotubes(AFP@CNTs)was designed and successfully synthesized to enhance the comprehensive properties,including fire safety and mechanical properties.Especially,the flame retardant mechanism,the combustion and pyrolysis process of EP/AFP@CNTs were investigated as well.With the addition of 1.5 wt%AFP@CNTs,the peak heat release rate(PHRR)and total heat release(THR)of EP were reduced by 27.6%and 29.0%,respectively,which may due to the cooperative effect between the phosphorus-nitrogen synergistic flame retardant of polyphosphazene and the cohesive phase flame retardant of carbon nanotubes.In addition,the mechanical performance of EP/AFP@CNTs composites were also investigated.The results showed that the impact strength,tensile strength and the storage modulus effectively increased by 65.0%,29.0%and 13.2%,respectively.Meanwhile,the change of the combustion and pyrolysis process of EP/AFP@CNTs may be attributed to the catalytic effect of the amino-functionalized polyphosphazene,which could participate in the formation of epoxy thermal curing crosslinking network and catalyze the degradation process of epoxy resin. | Mutian Zhou Desen Zeng Shuilai Qiu Xia Zhou Liang Cheng Zhoumei Xu Weiyi Xing Yuan Hu | 2022 | Progress in Natural Science:Materials International2022，32，2： | 0 |
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