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| 1 | Quasi-solid-state nanocrystalline TiO2 solar cells using gel network polymer electrolytes based on polysiloxanes显示文摘A quasi-solid-state dye-sensitized nanocrystal-line porous TiO2 film solar cell was fabricated using a novel gel network polymer electrolyte based on polysiloxanes with both polyethylene oxide internal plasticized side chains and quaternary ammonium groups. The cell exhibited better photoelectrical conversion performance under 60 mW/cm2 irradiation. The short photocurrent (Isc) of 5.0 mA/cm2 and open voltage (Voc) of 0.68 V were achieved, and the energy conversion efficiency (h ) and fill factor (ff) were 3.4% and 0.60, respectively. | LI Weiying, KANG Junjie, LI Xueping, FANG Shibi, LIN Yuan, WANG Guiqiang & XIAO Xurui Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China | 2003 | Chinese Science Bulletin2003，48，7： | 11 |
| 2 | Phase Diagram Prediction of the Al_2O_3-SiO_2-La_2O_3 System显示文摘Rare earth oxide systems Al2O3-La2O3 and SiO2-La2O3 were thermodynamically assessed and optimized with the substitution model. The obtained model parameters and Gibbs free energy of tine compounds and pure components were applied to the prediction of the liquidus surface and isothermal sections of Al2O3-SiO2-La2O3 | Lin LI and Zhujun TANG(Department of Materials Science & Engineering, Shanghai University, Shanghai 200072, China) To whom correspondence should be addressedE-mail: liling@public6.sta.net.cn Weiying SUN and Peiling WANG(Shanghai Institute of Ceramics, Chi | 1999 | Journal of Materials Science & Technology1999，15，5： | 3 |
| 3 | Pollen-like self-supported FeIr alloy for improved hydrogen evolution reaction in acid electrolyte显示文摘Ir is recognized as efficient catalyst for hydrogen evolution reaction(HER).The high price,however,has hindered its application in the production of hydrogen.In this work,we prepared the self-supported FeIr alloy nanoparticles,taking advantage of solid-state synthesis method.The as-prepared FeIr alloy possesses a novel morphology of pollen,which is consist of smaller FeIr nanoparticles.DFT calculations reveal that the change of the free Gibbs for Ir is negative after the adsorption of active H,while it is positive for the case of Fe.Thus,the alloying of Fe and Ir not only effectively reduces the cost,but also can achieve more adequate adsorption of active H species.Benefitting from this,the as-prepared FeIr alloy nanoparticle exhibits superior HER performance with an overpotential of 19 m V at a current density of 10 m V/cm^(2)and a Tafel slope of 32 m V/dec,when tested in 0.5 M H_(2)SO_(4),better than pure Ir and Pt/C.This work paves the way to the exploration of efficient alloy electrocatalysts for HER. | Shengyu Ma Jun Deng Yaping Xu Weiying Tao Xiaoqi Wang Zhiping Lin Qinghua Zhang Lin Gu Wenwu Zhong | 2022 | Journal of Energy Chemistry2022，31，3： | 1 |
| 4 | Development of a Two-photon Ratiometric Fluorescent Probe for Glutathione and Its Applications in Living Cells显示文摘 | XU Gaoping TANG Yonghe LIN Weiying | 2018 | Chemical Research in Chinese Universities2018，34，4： | 1 |
| 5 | Single-cell brain atlas of Parkinson's disease mouse model显示文摘Parkinson's disease(PD)is a neurodegenerative disease,leading to the impairment of movement execution.PD pathogenesis has been largely investigated,either limited to bulk transcriptomic levels or at certain cell types,which failed to capture the cellular heterogeneity and intrinsic interplays among distinct cell types.Here,we report the application of single-nucleus RNA-seq on midbrain,striatum,and cerebellum of theα-syn-A53 T mouse,a well-established PD mouse model,and matched controls,generating the first single cell transcriptomic atlas for the PD model mouse brain composed of 46,174 individual cells.Additionally,we comprehensively depicte the dysfunctions in PD pathology,covering the elevation of NF-k B activity,the alteration of ion channel components,the perturbation of protein homeostasis network,and the dysregulation of glutamatergic signaling.Notably,we identify a variety of cell types closely associated with PD risk genes.Taken together,our study provides valuable resources to systematically dissect the molecular mechanism of PD pathogenesis at the single-cell resolution,which facilitates the development of novel approaches for diagnosis and therapies against PD. | Jixing Zhong Gen Tang Jiacheng Zhu Weiying Wu Ge Li Xiumei Lin Langchao Liang Chaochao Chai Yuying Zeng Feiyue Wang Lihua Luo Jiankang Li Fang Chen Zhen Huang Xiuqing Zhang Yu Zhang Hongde Liu Xin Qiu Shengping Tang Dongsheng Chen | 2021 | Journal of Genetics and Genomics2021，48，4： | 1 |
| 6 | Recent progress in the fluorescent probes for the specific imaging of small molecular weight thiols in living cells显示文摘 | CHEN Hua TANG Yonghe LIN Weiying | 2015 | Trac trends in analytical chemistry2015，76，： | 1 |
| 7 | A Unique ap- proach to development of infrared near fluorescent sensors for in vivo imaging 显示文摘 | Yuan in Lin Weiying Zhao Sheng | 2012 | J Am Chcm Soc2012，134，13： | 1 |
| 8 | Far-red to near infrared analyte-responsive fluorescent probes based on organic fluorophore platforms for fluorescence imaging 显示文摘 | Lin Yuan Lin Weiying Zheng Kaibo | 2013 | Chemical Society Reviews2013，42，： | 1 |
| 9 | Layered CuNi-Cu_(2)O/NiAlO_(x) nanocatalyst for rapid conversion of p-nitrophenol to p-aminophenol显示文摘In order to well arrange active sites and avoid byproducts, the reasonable structured carrier nanocatalyst plays a crucial role in high catalytic performance, but still remains a challenge. Herein, the layered CuNi-Cu_(2)O/NiAlO_(x) nanosheets have been constructed through hydrothermal synthesis followed by calcination and H_(2) reduction treatment process. The in-situ formed CuNi nanoalloys (NAs) and nano-Cu_(2)O were evenly distributed on the bilateral surface of layered NiAlOx nanosheets. Based on the planar structure of nanosheet, the synergy between catalytic active CuNi NAs and photocatalytic active nano-Cu_(2)O endows CuNi-Cu_(2)O/NiAlO_(x) nanosheets with rapid conversion efficiency for catalyzing p-nitrophenol (p-NP, 14 mg·L^(−1)) to p-aminophenol (p-AP) in 32 s with the reaction rate constant k up to 0.1779 s−1, and no obvious performance decay can be observed even over 27 cycles. Moreover, high concentration of p-NP at 10 and 20 g·L^(−1) could be reduced to p-AP within 14 and 20 min, respectively. Such designed nanoalloy/bimetal-oxide heterostructure can provide a solution for rapid conversion of aminoaromatics from nitroaromatics wastewater even at a large concentration range. | Lin Fu Wei Zhou Ming Wen Qingsheng Wu Weiying Li Dandan Wu Quanjing Zhu Jiaqi Ran Panpan Ren | 2021 | Nano Research2021，14，12： | 1 |
| 10 | Three-channel fluorescent sensing via organic white light-emitting dyes for detection of hydrogen sulfide in living cells显示文摘 | Jiaoliang Wang Weiying Lin Weiling Li | 2013 | Biomaterials2013，，30： | 1 |
| 11 | Fuzzy-based power factor control for brushless doubly-fed Machines 显示文摘 | HUANG S D WEIY LIN Y J | 2001 | In : WCICA Paper2001，，： | 1 |
| 12 | Enhancement of ultraviolet emissions from ZnO films by Ag doping显示文摘 | Li Duan Lin Bixia Zhang Weiying | 2006 | Appl Phys Lett2006，88，23： | 1 |
| 13 | Cysteine-activated fluorescence/photoacoustic integrated probe for non-invasive diagnosis of drug-induced liver injury显示文摘Hepatotoxicity is a serious problem faced by clinical drugs,and long-term administration or overdose may lead to liver failure and even death of patients.Therefore,developing a reliable detection method for the early diagnosis and therapy of drug-induced liver injury(DILI)has significant meaning.Nearinfrared fluorescence(NIRF)and photoacoustic(PA)dual-modality tomography probes can be used for imaging with high sensitivity and high-resolution of disease-related markers in deep tissues.Here,we developed a novel Cys-activated NIRF and PA dual-modality imaging probe(CDR)for early diagnosis of DILI,for the first time.The organic molecular probe CDR could respond rapidly to Cys,resulting in the absorption peak red-shifted from 560 nm to 725 nm,which also leads to the activation of the PA725signal and NIRF765signal.In addition,the new probe CDR could be used for NIRF/PA imaging of exogenous and endogenous Cys level in live cells and mice.More importantly,CDR has also been successfully used for in situ detection of Cys in early DILI mice and evaluate the therapeutic effect of NAC.Therefore,the CDR might become a powerful tool to research the physiological effect of Cys and evaluate the degree of DILI. | Rui Chen Wenxiu Li Rong Li Sixin Ai Huayong Zhu Weiying Lin | 2023 | Chinese Chemical Letters2023，34，5： | 0 |
| 14 | Estimation of Solid Phase Relationship in the Al_2O_3-SiO_2-Re_2O_3 Systems显示文摘Nine limiting binaries of A12O3-SiO2- Re2O3 (Re=Nd, Sm, Gd and La) system are assessed. The binary diagrams or experimental information from Toropov, Mizuno, Aramaki, Bondar, Rolin and Coutures are optimized with the substitutional model of Kaufman and Nesor and the approximate formula of fusion free energy for rare earth element oxides of Wu and Pelton. The extracted Gibbs free energies of pure solid oxides and stoichiometric phases and the solution parameters are used to estimate the corresponding binaries, and a series of isothermal sections of four ternaries Al2O,-SiO2-Nd2O3, A12O3-SiO2-SiO2O3 , A12O3-SiO2-Gd2O3 and A12O3-SiO2-La2O3. In the Al2O3-SiO2-Gd2O3 system samples as fired at exact temperature with different compositions were analyzed by x-ray diffractometer and the detected results are fitted with the calculation of isothermal sections. | Li Lin, Sun Weiying, Wang PeEling, Tang Zhujun 1.School of Materials Science & Engineering, Shanghai University, Shanghai 200072, China 2.State Key Lab of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Ac | 2000 | Journal of Shanghai Jiaotong university(Science)2000，5，1： | 0 |
| 15 | Study on Molecular Mechanism of Liver Metastasis in Patients with Late Colorectal Cancer by NGS Technique显示文摘[Objectives]To analyze the difference of gene expression between primary lesion and metastatic lesion in patients with advanced colorectal cancer with liver metastasis by NGS detection,and to further explore the molecular mechanism of liver metastasis in patients with advanced colorectal cancer.[Methods]In a case-control study combined with cohort study,NGS sequencing was performed in 9 patients with postoperative first-line cetuximab combined with chemotherapy,and retrospective analysis was made to find the biomarker that can predict the curative effect;then 9 samples of biomarker were prospectively verified;at the same time,9 cases of primary lesions(2 sites)and 9 cases of liver metastases were detected by WES.[Results]The mutation type of primary lesion was mainly Missense(missense mutation):a total of 1802 mutations were detected in the primary lesion samples of 9 patients,of which Missense accounted for 88.01%;a total of 2150 mutations were detected in the metastatic samples of 9 patients,of which Missense accounted for 87.67%.The results of Venn diagram showed that there were 1010 common mutations in primary and metastatic lesions,accounting for 42.4%.There were 819 genes in metastatic lesions,accounting for 34.4%;there were 553 unique genes in the primary lesion,accounting for 23.2%.The results of thermography showed that there were 7 mutant genes with more than 33.3%primary lesions,including APC,TTN,HDAC2,RELN,RHPN2,RYR3 and TP53;there were 13 mutant genes with metastatic lesions of more than 33.3%,including APC,RHPN2,TTN,TP53,COBLL1,DNAH12,DNAH17,EVC2,RYR3,SVEP1,SYNE1,ZNF197 and ZNF423,and the mutation rate of APC increased from 66.7%to 77.8%;TTN increased from 44.4%to 66.7%;RHPN2 rose from 33.3%to 66.7%;TP53 rose from 33.3%to 55.6%.COBLL1,DNAH17 and EVC2 rose from 22.2%to 33.3%.SVEP1,SYNE1,ZNF197 and ZNF423 were only expressed in metastatic lesions,and the expression increased from 0%to 33.3%.The results of GO enrichment showed that the top five mutant genes in colon cancer were KRAS,BRAF,TP53,APC and PI3 KCA.[Conclusions]The primary and metastatic lesions were mainly Missense;APC,TP53 mutation was a common mutant gene with high expression;the expression of PHPN2 and TTN mutant genes increased by 33.3%and 11.1%,respectively;the mutation rate of BRAF gene was the second in GO enrichment. | Jing WU Bin HU Juanna DONG Xiuqiang LIN Weiying DENG Wei WANG | 2022 | Medicinal Plant2022，13，4： | 0 |
| 16 | Luminescent Properties of Ca2 Y8 ( SiO4 ) 6O2: Eu3 + Phosphors Prepared by Spray Pyrolysis Process显示文摘Using CaCO3, metal oxides (all dissolved by nitric acid) and tetraethoxysilane Si (OC2H5 )4 (TEOS) as the main starting materials, Ca2Y8 (SiO4 )6O2: Eu3+ phosphors were synthesized by spray pyrolysis.X-ray diffraction (XRD), scanning electron microscopy (SEM) and photoluminescence (PL) spectra as well as lifetimes were used to characterize the resulting phosphors.The results of XRD indicated that the 1000 ℃ annealed powders crystallize with the silicate oxyapatite structure.SEM study revealed that the phosphors consist of spherical particles with an average size of about 1 ~ 3 μm.In the crystalline Ca2 Y8 (SiO4)6O2: Eu3+ phosphor, the Eu3+ shows its characteristic emission corresponding to 5 D0 - 7 FJ ( J = 0, 1,2, 3, 4) transitions, with 5D0 - 7 F2 red emission (613 nm) as the most prominent group, agreeing well with the structure of the host material. | Shen Weiying Lin Jun | 2004 | Journal of Rare Earths2004，22，z1： | 0 |
| 17 | QTL Mapping for Plant Height of Wheat under Different Irrigation Modes显示文摘In order to mine gene loci associated with drought resistance and water use efficiency,and provide guidance for the breeding of drought-resistant wheat varieties,quantitative trait loci(QTLs)for plant height(PH)and stem height(SH)of wheat were evaluated using a population of 302 recombinant inbred lines(RILs)derived from a cross between drought-tolerant cultivar Luohan 2 and water-sensitive cultivar Weimai 8 under different water regimes in six environments.Totally 17 additive QTLs for PH and SH were identified and distributed on chromosomes 2B,3A,3B,4A,5A,5D,6B,7A and 7B,respectively,which explained3.3%to 26.95%phenotypic variations,with additive effect of 1.919 6 to 5.382 8 cm.Among them,14 QTLs,24 times and 5 QTLs,7 times were detected in three irrigation environments and three drought stress environments,respectively.Both the number of QTLs for PH and the times detected in drought stress environments were significantly less than those in irrigation environments.Of all the 17 QTLs for PH,12 were detected only in irrigation environment,three QTLs were detected only in drought stress environment,and two QTLs were detected in both environments,suggesting that the expression of the genes is greatly influenced by environmental condition.QPh-WL-7A.3 detected between maker Xbarc049 and Xgwm273 on chromosome 7A in all the three drought stress environments,can enhance2.481 5-3.697 2 cm of PH,explain 8.6%-10.0%additive effect,so it is useful for the genetic improvement of drought tolerance and molecular marker-assisted selection in wheat. | Yanyun REN Ling HUANG Minmin SHAO Leiming SUN Kai ZHAO Jinping WANG Xingke XU Weiying FENG Jifeng WANG Lu YAN Shichong WANG Lin WANG | 2017 | Agricultural Biotechnology2017，6，4： | 0 |
| 18 | Effect of Irrigation and Fertilization on Population Structure and Yield of Wheat显示文摘[Objectives] This study was conducted to investigate the effects of irrigation and fertilization on population structure and yield of wheat.[Methods]With Shannong 29 as an experimental material,the effects of irrigation and fertilization on population,dry matter accumulation and yield of wheat were studied.[Results]Integrated water-saving irrigation and fertilization of ridged field was the best with the highest population,dry matter accumulation and yield of wheat.[Conclusions]This study provides a theoretical basis for high-yield and high-efficiency wheat production with saved water and fertilizers. | Minmin SHAO Leiming SUN Xingke XU Kai ZHAO Ling HUANG Weiying FENG Jifeng WANG Lu YAN Lin WANG | 2020 | Agricultural Biotechnology2020，9，2： | 0 |
| 19 | BioinformaticsAnalysis of the Muscle-invasive Bladder Cancer Subtypes显示文摘Objective In order to improve the accuracy in distinguishing subtypes of bladder cancer and to explore its potential therapeutic targets,we identify differences between two kinds of bladder cancer subtypes(basal-like and luminal)in molecular mechanism and molecular characteristics based on the bioinformatics analysis.Methods In this study,the RMA(robust multichip averaging)was applied to normalize the mRNA profile which included 22 samples from basal-like subtype and 132 from luminal subtype,and the differential expression analysis of genes with top 1000 highest standard deviation was performed.Then,the Gene Ontology and KEGG pathway enrichment analysis of differentially expressed genes was performed.In addition,the proteinprotein interactions networks analysis for the top 100 most significant differentially expressed genes was performed.Results A total of 742 differentially expressed genes distinguishing basal-like and luminal subtypes were found,of which 405 were upregulated and 337 genes were down-regulated in basal-like subtype.GO enrichment analysis showed that differentially expressed genes were significantly enriched in the extracellular matrix,chemotaxis and inflammatory response.KEGG pathway enrichment analysis showed that the differentially expressed genes were significantly enriched in the pathway of extracellular matrix receptor interaction.The hub proteins we founded in protein-protein interaction networks were LNX1,MSN and PPARG.Conclusion In this study,the mainly difference of molecular mechanism between basal-like and luminal subtypes are alteration in extracellular matrix region,cell chemotaxis and inflammatory response.Genes such as LNX1,MSN and PPARG were forecast to play important roles in the classification of bladder carcinoma subtypes. | Xu Wenbin Zheng Weiying Xia Hong Hua Lin | 2018 | Proceedings of Anticancer Research2018，2，2： | 0 |
| 20 | Evaluating the tumor stratification with a lysosomal pH sensitive-probe by fluorescence lifetime imaging显示文摘Owing to the anaerobic metabolism in the tumor,abundant acidic metabolites are produced and accumulated in the cells.Therefore,the cells in different tumor layers are directly linked to the pH micro-environment.Nevertheless,due to the lack of robust tools,the high-efficient evaluation of the acidic micro-environment of tumor stratification faces the challenge of accurate diagnosis.We designed a new pH sensitive fluorescent lifetime probe target to lysosomes.As we expected,the fluorescence lifetime of PLN possesses a good linear fit to the pH value,which could detect the pH change at a single lysosome level in real time,and then evaluate the different acidity of tumor stratification.The probe PLN is successfully used to evaluate the tumor stratification by fluorescence lifetime imaging microscopy(FLIM)for the first time,which is of great significance in the preoperative diagnosis of clinical tumor treatment or evaluation of drug delivery effect. | Jun Yan Xing Liang Qian Zhang Luolin Wang Weiying Lin | 2024 | Chinese Chemical Letters2024，35，3： | 0 |
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