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| 1 | Homozygous loss-of-function mutations in FSIP2 cause male infertility with asthenoteratospermia显示文摘Male infertility, as a major issue of human reproduction health, prevents successful natural conception. Asthenoteratospermia mainly presents one or multiple anomalies in head, neck and tail of spermatozoa, and impairs sperm function and motility (Coutton et al., 2015). Recurrent abnormalities of the fibrous sheath lead to multiple morphological abnormaliries of the sperm flagella (MMAF), which is a quite frequent type of asthenoteratospermia in male infertility (Chemes et al., 1987;Ben Khelifa et al, 2014). | Wangjie Liu Huan Wu Li Wang Xiaoyu Yang Chunyu Liu Xiaojin He Weiyu Li Jiajia Wang Yujie Chen Hongyan Wang Yang Gao Shuyan Tang Shenmin Yang Li Jin Feng Zhang Yunxi Cao | 2019 | Journal of Genetics and Genomics2019，46，1： | 7 |
| 2 | In vivo retention of poloxamer-based in situhydrogels for vaginal application in mouse and rat models显示文摘The purpose of this study is to evaluate the in vivo retention capabilities of poloxamer-based in situ hydrogels for vaginal application with nonoxinol-9 as the model drug. Two in situ hydrogel formulations, which contained 18% poloxamer 407 plus 1% poloxamer 188(GEL1, relative hydrophobic)or 6% poloxamer 188(GEL2, relative hydrophilic), were compared with respect to the rheological properties, in vitro hydrogel erosion and drug release. The vaginal retention capabilities of these hydrogel formulations were further determined in two small animal models, including drug quantitation of vaginal rinsing fluid in mice and isotope tracing with99 m Tc in rats. The two formulations exhibited similar phase transition temperatures ranging from 27 to 32 1C. Increasing the content of poloxamer 188 resulted in higher rheological moduli under body temperature, but slightly accelerated hydrogel erosion and drug release. When compared in vivo, GEL1 was eliminated significantly slower in rat vagina than GEL2,while the vaginal retention of these two hydrogel formulations behaved similarly in mice. In conclusion,increases in the hydrophilic content of formulations led to faster hydrogel erosion, drug release andintravaginal elimination. Rats appear to be a better animal model than mice to evaluate the in situ hydrogel for vaginal application. | Yu Liu Fujin Yang Linglin Feng Long Yang Lingyun Chen Gang Wei Weiyue Lu | 2017 | Acta Pharmaceutica Sinica B2017，7，4： | 5 |
| 3 | Folic acid-conjugated liposomal vincristine for multidrug resistant cancer therapy显示文摘We encapsulated vincristine into folic acid-conjugated PEGylated liposomes to improve the anti-tumor efficacy on multidrug resistant cancers.It was observed that the drug delivery system we constructed exhibited maximum cytotoxicity on KBv200 cells(multidrug resistant variant)compared with any other formulations.The semi-quantitative analysis of region of interest revealed that there was a great increase in area under curve(AUC)of a near-infrared fluorescein in solid tumors due to folic acid-mediated accumulation.Folic acid-conjugated PEGylated liposomes showed a significant tumor growth inhibiting effect in vitro and in vivo.TUNEL assay revealed that folic acid-conjugated PEGylated liposomes could induce cell apoptosis much more greatly than others.This study demonstrated that it had potential application prospective for the treatment of multidrug resistant cancer. | Chenyu Wang Linglin Feng Xiangkun Yang Fei Wang Weiyue Lu | 2013 | Asian Journal of Pharmaceutical Sciences2013，8，2： | 3 |
| 4 | Acute toxicity of nanoand micro-scale zinc powder in healthy adult mice显示文摘 | Bing Wang WeiYue Feng TianCheng Wang | 2006 | Toxicology Letters2006，161，2： | 1 |
| 5 | Neurotoxicity of low-dose repeatedly intranasal instillation of nano- and submicron-sized ferric oxide particles in mice显示文摘 | Bing Wang Weiyue Feng Motao Zhu Yun Wang Meng Wang Yiqun Gu Hong Ouyang Huajian Wang Ming Li Yuliang Zhao Zhifang Chai Haifang Wang | 2009 | Journal of Nanoparticle Research2009，，1： | 1 |
| 6 | Philadelphia chromosome-positive acute myeloid leukemia with masses and osteolytic lesions: finding of 18F-FDG PET/CT显示文摘 | Zhan Su Fengyu Wu Weiyu Hu Xiaodan Liu Shaoling Wu Xianqi Feng Zhongguang Cui Jie Yang Zhenguang Wang Hongzai Guan Hongguo Zhao Wei Wang Chunting Zhao Jun Peng | 2017 | Frontiers of Medicine2017，11，3： | 1 |
| 7 | Comparative study of pulmonary responses to nano-and suhmicron-sized ferric oxide in rats 显示文摘 | ZHU Motao FENG Weiyue WANG Bing | 2008 | Toxicology2008，247，2： | 1 |
| 8 | Particokinetics and extrapulmonary translocation of intratracheally instilled ferric oxide nanoparticles in rats and the potential health risk assessment 显示文摘 | ZHU Motao FENG Weiyue WANG Yun | 2009 | Toxicological Sciences2009，107，2： | 1 |
| 9 | Co-delivery of TRAIL gene enhances the anti-glioblastoma effect of paclitaxel in vitro and in vivo显示文摘 | Changyou Zhan Xiaoli Wei Jun Qian Linglin Feng Jianhua Zhu Weiyue Lu | 2012 | Journal of Controlled Release2012，，3： | 1 |
| 10 | Development of a mild mercaptoethanol extraction method for determination of mercury species in biological samples by HPLC-ICP-MS 显示文摘 | WANG Meng FENG Weiyue SHI Junwen | 2007 | Talanta2007，71，5： | 1 |
| 11 | Acute toxicological impact of nano- and submicro-scaled zinc oxide powder on healthy adult mice显示文摘 | Bing Wang Weiyue Feng Meng Wang Tiancheng Wang Yiqun Gu Motao Zhu Hong Ouyang Junwen Shi Fang Zhang Yuliang Zhao Zhifang Chai Haifang Wang Jing Wang | 2008 | Journal of Nanoparticle Research2008，，2： | 1 |
| 12 | The improving effects on hepatic fibrosis of interferon-γ liposomes targeted to hepatic stellate cells显示文摘 | Qinghua Li Zhiqiang Yan Feng Li Weiyue Lu Jiyao Wang Chuanyong Guo | 2012 | Nanotechnology2012，，26： | 1 |
| 13 | Micelle‐Based Brain‐Targeted Drug Delivery Enabled by a Nicotine Acetylcholine Receptor Ligand显示文摘 | Changyou Zhan Bian Li Luojuan Hu Xiaoli Wei Linyin Feng Wei Fu Weiyue Lu | 2011 | Angew Chem Int Ed2011，，24： | 1 |
| 14 | Professor Zhifang Chai:Scientific contributions and achievements显示文摘Prof.Zhifang Chai,born in October 1942,is a radioanalytical chemist working at the Institute of High Energy Physics,Chinese Academy of Sciences and Soochow University.He graduated from Fudan University in 1964.As an Alexander von Humboldt Foundation fellow,he worked at Cologne University,Germany from1980 to 1982. | Yuliang Zhao Chunying Chen Weiyue Feng Zhiyong Zhang Diandou Xu Weiqun Shi Shuao Wang Yu-Feng Li | 2022 | Chinese Chemical Letters2022，33，7： | 1 |
| 15 | Acute toxicity of nano-and micro-scale zinc powder in healthy adult mice 显示文摘 | Wang Bin Feng Weiyue Wang Tiancheng | 2006 | Toxicology Letters2006，161，2： | 1 |
| 16 | A SARS-CoV-2 neutralizing antibody discovery by single cell sequencing and molecular modeling显示文摘Although vaccines have been developed,mutations of SARS-CoV-2,especially the dominant B.1.617.2(delta)and B.1.529(omicron)strains with more than 30 mutations on their spike protein,have caused a significant decline in prophylaxis,calling for the need for drug improvement.Antibodies are drugs preferentially used in infectious diseases and are easy to get from immunized organisms.The current study combined molecular modeling and single memory B cell sequencing to assess candidate sequences before experiments,providing a strategy for the fabrication of SARS-CoV-2 neutralizing antibodies.A total of 128 sequences were obtained after sequencing 196 memory B cells,and 42 sequences were left after merging extremely similar ones and discarding incomplete ones,followed by homology modeling of the antibody variable region.Thirteen candidate sequences were expressed,of which three were tested positive for receptor binding domain recognition but only one was confirmed as having broad neutralization against several SARS-CoV-2 variants.The current study successfully obtained a SARS-CoV-2 antibody with broad neutralizing abilities and provided a strategy for antibody development in emerging infectious diseases using single memory B cell BCR sequencing and computer assistance in antibody fabrication. | Zheyue Wang Qi Tang Bende Liu Wenqing Zhang Yufeng Chen Ningfei Ji Yan Peng Xiaohui Yang Daixun Cui Weiyu Kong Xiaojun Tang Tingting Yang Mingshun Zhang Xinxia Chang Jin Zhu Mao Huang Zhenqing Feng | 2023 | The Journal of Biomedical Research2023，37，3： | 0 |
| 17 | A SARS-CoV-2 neutralizing antibody discovery by single cell sequencing and molecular modeling显示文摘 | Zheyue Wang Qi Tang Bende Liu Wenqing Zhang Yufeng Chen Ningfei Ji Yan Peng Xiaohui Yang Daixun Cui Weiyu Kong Xiaojun Tang Tingting Yang Mingshun Zhang Xinxia Chang Jin Zhu Mao Huang Zhenqing Feng | 2023 | The Journal of Biomedical Research2023，37，3： | 0 |
| 18 | A highly efficient atomically thin curved Pd Ir bimetallene electrocatalyst显示文摘The multi-metallene with an ultrahigh surface area has great potential in precise tuning of surface heterogeneous d-electronic correlation by surface strain effect for the distinctive surface electronic structure,which is a brand new class of promising 2 D electrocatalyst for sustainable energy device application.However,achieving such an atomically thin multi-metallene still presents a great challenge.Herein,we present a new synthetic method for an atomic-level palladium-iridium(Pd Ir)bimetallene with an average thickness of only~1.0 nm for achieving superior catalysis in the hydrogen evolution reaction(HER)and the formic acid oxidation reaction(FAOR).The curved Pd Ir bimetallene presents a top-ranked high electrochemical active area of 127.5±10.8 m^(2)g Pd+Ir^(-1)in the reported noble alloy materials,and exhibits a very low overpotential,ultrahigh activity and improved stability for HER and FAOR.DFT calculation reveals that the Pd Ir bimetallene herein has a unique lattice tangential strain,which can induce surface distortion while concurrently creating a variety of concave-convex featured micro-active regions formed by variously coordinated Pd sites agglomeration.Such a strong strain effect correlates the abnormal on-site active 4 d^(10)-t_(2g)-orbital Coulomb correlation potential and directly elevates orbital-electronegativity exposure within these active regions,resulting in a preeminent barrier-free energetic path for significant enhancement of FAOR and HER catalytic performance. | Fan Lv Bolong Huang Jianrui Feng Weiyu Zhang Kai Wang Na Li Jinhui Zhou Peng Zhou Wenxiu Yang Yaping Du Dong Su Shaojun Guo | 2021 | National Science Review2021，8，9： | 0 |
| 19 | Correction to “Folic acid-conjugated liposomal vincristine for multidrug resistant cancer therapy”显示文摘In the original version of this article on p 122, two inappropriate images were placed in B and C of Fig. 1, which didn’t represent the group of FA-PEG-LS and PEG-LS/VCR. In the revised graphic provided below, the appropriate images are used.These corrections do not change the results and conclusions of this work. | Chenyu Wang Linglin Feng Xiangkun Yang FeiWang Weiyue Lu | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，4： | 0 |
| 20 | Simultaneous regulation on coordination environment and interfacial chemistry via taurine for stabilized Zn metal anode显示文摘Aqueous Zn-ion batteries(AZIBs)are the potential options for the next-generation energy storage scenarios due to the cost effectiveness and intrinsic safety.Nevertheless,the industrial application of AZIBs is still impeded by a series of parasitic reactions and dendrites at zinc anodes.In this study,taurine(TAU)is used in electrolyte to simultaneously optimize the coordination condition of the ZnSO4electrolyte and interfacial chemistry at the anode.TAU can preferentially adsorb with the zinc metal and induce an in situ stable and protective interface on the anode,which would avoid the connection between H_(2)O and the zinc metal and promote the even deposition of Zn^(2+).The resulting Zn//Zn batteries achieve more than 3000 hours long cyclic lifespan under 1 mA cm^(-2)and an impressive cumulative capacity at 5 mA cm^(-2).Moreover,Zn//Cu batteries can realize a reversible plating/stripping process over 2,400cycles,with a desirable coulombic efficiency of 99.75%(1 mA cm^(-2)).Additionally,the additive endows Zn//NH_(4)V_(4)O_(10)batteries with more stable cyclic performance and ultrafast rate capability.These capabilities can promote the industrial application of AZIBs. | Xin Xu Junyi Yin Ruimin Qin Haoliang Liu Xiang Feng Minghui Wang Mingyan Li Weiyu Sun Weichen Shi Bing Xiao Yaqiong Su Yonghong Cheng | 2023 | Journal of Energy Chemistry2023，，11： | 0 |
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