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| 1 | Functional assembly of root-associated microbial consortia improves nutrient efficiency and yield in soybean显示文摘Root-associated microbes are critical for plant growth and nutrient acquisition. However, scant information exists on optimizing communities of beneficial root-associated microbes or the mechanisms underlying their interactions with host plants. In this report, we demonstrate that rootassociated microbes are critical influencers of host plant growth and nutrient acquisition. Three synthetic communities(SynComs) were constructed based on functional screening of 1,893 microbial strains isolated from root-associated compartments of soybean plants. Functional assemblage of SynComs promoted significant plant growth and nutrient acquisition under both N/P nutrient deficiency and sufficiency conditions.Field trials further revealed that application of SynComs stably and significantly promoted plant growth, facilitated N and P acquisition, and subsequently increased soybean yield. Among the tested communities, SynCom1 exhibited the greatest promotion effect, with yield increases of up to 36.1% observed in two field sites. Further RNA-seq implied that SynCom application systemically regulates N and P signaling networks at the transcriptional level, which leads to increased representation of important growth pathways, especially those related to auxin responses. Overall,this study details a promising strategy for constructing SynComs based on functional screening,which are capable of enhancing nutrient acquisition and crop yield through the activities of beneficial root-associated microbes. | Cunhu Wang Yanjun Li Mingjia Li Kefei Zhang Wenjing Ma Lei Zheng Hanyu Xu Baofeng Cui Ran Liu Yongqing Yang Yongjia Zhong Hong Liao | 2021 | Journal of Integrative Plant Biology2021，63，6： | 5 |
| 2 | PhaseⅠdose-escalation and expansion study of PARP inhibitor,fluzoparib(SHR3162),in patients with advanced solid tumors显示文摘Objective:Fluzoparib(SHR3162)is a novel,potent poly(ADP-ribose)polymerases(PARP)1,2 inhibitor that showed anti-tumor activity in xenograft models.We conducted a phaseⅠ,first-in-human,dose-escalation and expansion(D-Esc and D-Ex)trial in patients with advanced solid cancer.Methods:This was a 3+3 phaseⅠD-Esc trial with a 3-level D-Ex at 5 hospitals in China.Eligible patients for DEsc had advanced solid tumors refractory to standard therapies,and D-Ex enrolled patients with ovarian cancer(OC).Fluzoparib was administered orally once or twice daily(bid)at 11 dose levels from 10 to 400 mg/d.Endpoints included dose-finding,safety,pharmacokinetics,and antitumor activity.Results:Seventy-nine patients were enrolled from March,2015 to January,2018[OC(47,59.5%);breast cancer(BC)(16,20.3%);colorectal cancer(8,10.1%),other tumors(8,10.1%)];48 patients were treated in the D-Esc arm and 31 in the D-Ex arm.The maximum tolerated dose(MTD)was 150 mg bid,with a half-life of 9.14 h.Grade 3/4 adverse events included anemia(7.6%)and neutropenia(5.1%).The objective response rate(ORR)was 30%(3/10)in patients with platinum-sensitive OC and 7.7%(1/13)in patients with BC.Among patients treated with fluzoparib≥120 mg/d,median progression-free survival(m PFS)was 7.2[95%confidence interval(95%CI),1.8-9.3]months in OC,9.3(95%CI,7.2-9.3)months in platinum-sensitive OC,and 3.5(range,2.0-28.0)months in BC.In patients with germline BC susceptibility gene mutation(g BRCAMut)(11/43 OC;2/16 BC),m PFS was 8.9 months for OC(range,1.0-23.2;95%CI,1.0-16.8)and 14 and 28 months for BC(those two patients both also had somatic BRCAMut).Conclusions:The MTD of fluzoparib was 150 mg bid in advanced solid malignancies.Fluzoparib demonstrated single-agent antitumor activity in BC and OC,particularly in BRCAMut and platinum-sensitive OC. | Huiping Li Rongrui Liu Bin Shao Ran Ran Guohong Song Ke Wang Yehui Shi Jihong Liu Wenjing Hu Fu Chen Xiaoran Liu Gairong Zhang Chuanhua Zhao Ru Jia Quanren Wang Hope S.Rugo Yifan Zhang Guangze Li Jianming Xu | 2020 | Chinese Journal of Cancer Research2020，32，3： | 4 |
| 3 | The SWI/SNF chromatin-remodeling factors BAF60a, b, and c in nutrient signaling and metabolic control显示文摘新陈代谢的症候群成为了不利地影响人的健康的全球流行病。基因、环境的因素贡献新陈代谢的混乱的致病;然而,集成这些暗示到的机制调整新陈代谢的生理学和不完全地定义的新陈代谢的混乱遗体的发展。新兴的证据建议 SWI/SNF 改变染色质的建筑群为指导新陈代谢的 reprogramming 和改编响应是批评的营养并且另外的生理的信号。ATP 依赖的 SWI/SNF 改变染色质的建筑群包括多达 11 个子单元, BAF60 子单元在之中用作在核心建筑群和特定的 transcriptional 因素之间的一个关键连接。BAF60 子单元有三个成员, BAF60a, b,和 c。不同织物分发模式和 BAF60 蛋白质的规章的机制在不同新陈代谢的房间类型与专业化功能授与每 isoform。在这评论,我们在滋养的察觉到和精力新陈代谢在下面的规定总结 BAF60 蛋白质的新兴的角色和机制生理并且疾病条件。 | Ruo-Ran Wang Ran Pan Wenjing Zhang Junfen Fu Jiandie D. Lin Zhuo-Xian Meng | 2018 | Protein & Cell2018，9，2： | 2 |
| 4 | Corporate Social Responsibility, Ownership Structure, and Political Interference: Evidence from China显示文摘 | Wenjing Li Ran Zhang | 2010 | Journal of Business Ethics2010，，4： | 2 |
| 5 | Corporate Social Responsibility, Ownership Structure, and Political Interference: Evidence from China显示文摘 | Wenjing Li Ran Zhang | 2010 | Journal of Business Ethics2010，，4： | 1 |
| 6 | Circulating Sfrp5 Is a Signature of Obesity-Related Metabolic Disorders and Is Regulated by Glucose and Liraglutide in Humans显示文摘 | Wenjing Hu Ling Li Mengliu Yang Xiaohe Luo Wenxia Ran Dongfang Liu Zhengai Xiong Hua Liu Gangyi Yang | 2013 | The Journal of Clinical Endocrinology & Metabolism2013，，： | 1 |
| 7 | Corporate Social Responsibil- ity, Ownership Structure, and Political Interference: Evidence from China 显示文摘 | Wenjing Li Ran Zhang | 2010 | Journal of Business Ethics2010，，96： | 1 |
| 8 | Corporate social responsibil-ity,ownership structure,and political interference:evidencefrom China显示文摘 | Wenjing Li and Ran Zhang | 2010 | Journal of Business Ethics2010，，96： | 1 |
| 9 | Design and experiment of the double-seed hole seeding precision seed metering device for peanuts显示文摘A secondary seeding precision double-seed peanut hole seeding seed metering device was designed to improve the performance of the peanut planting equipment and provide a solution for problems on the high seed charge that can cause poor cavitation and uniformity easily.The main structure and operation parameters in terms of groove length,seed charge height,seed-bed belt speed,and rotation speed of the seed metering wheel were determined through theoretical analysis.Single-factor and orthogonal tests were carried out through the JPS-12 seed metering device test bench,and the peanut variety Jinonghua-3 was selected as the test object.The single hole double-seed rate,qualified rate,the variation coefficient of hole spacing,and hole rate were chosen for evaluating the working performance.The results of the single-factor test showed that the seed metering performance is mainly affected by the groove length,the speed of the seed-bed belt and the rotation speed of the seed metering wheel,and the influence of the cavitation rate is minimal.The optimal seeding height is determined to be 40 mm.The results of the orthogonal test showed that the groove length was 27.3 mm,the seed-bed belt speed was 1.51 km/h,and the rotation speed of the seed metering wheel was 14.11 r/min.What’s more,a regression model based on the orthogonal test results was established,the qualified rate of the number of holes obtained after optimizing the model was 98.84%,the variation coefficient of hole spacing was 9.74%,and the hole rate was 1.40%.Notably,the working performances of the device can meet the requirement of precision seeding. | Xiaoshun Zhao Wenjing Ran Jianjun Hao Wenjie Bai Xinlei Yang | 2022 | International Journal of Agricultural and Biological Engineering2022，15，3： | 1 |
| 10 | Optical Trapping of a Single Molecule of Length Sub-1 nm in Solution显示文摘Plasmonic optical manipulation has emerged as an affordable alternative to manipulate single chemical and biological molecules in nanoscience.Although the theoretical models of sub-5 nm single-molecule trapping have been considered promising,the experimental strategies remain a challenge due to the Brownian motions and weak optical gradient forces with significantly reduced molecular polarizability.Herein,we address direct trapping and in situ sensing of single molecules with unprecedented size,down to∼5Åin solution,by employing an adjustable plasmonic optical nanogap and single-molecule conductance measurement.The theoretical simulations demonstrate that local fields with a high enhancement factor,over 103,were generated at such small nanogaps,resulting in optical forces as large as several piconewtons to suppress the Brownian motion and trap a molecule of length sub-1 nm.This work demonstrates a strategy for directly manipulating the small molecule units,promising a vast multitude of applications in chemical,biological,and materials sciences at the single-molecule level. | Biao-Feng Zeng Ran Deng Yu-Ling Zou Chun-An Huo Jing-Yu Wang Wei-Ming Yang Qing-Man Liang Sheng-Jie Qiu Anni Feng Jia Shi Wenjing Hong Zhilin Yang Zhong-Qun Tian Yang Yang | 2023 | CCS Chemistry2023，5，4： | 1 |
| 11 | Facile one-pot synthesis of superfine palladium nanoparticles on polydopamine-functionalized carbon nanotubes as a nanocatalyst for the Heck reaction显示文摘Heterogeneous Pd nanocatalysts are efficient catalysts for the Heck reaction but require multi-step,sophisticated procedures and harsh reaction conditions.In this work,a green and facile strategy has been developed to decorate Pd nanoparticles on polydopamine(PDA)-coated multi-walled carbon nanotubes(Pd/CNTs-PDA)via a one-pot method.The obtained nanoparticles were characterized by various techniques including transmission electron microscopy,X-ray diffraction,and X-ray photoelectron spectroscopy,which proved that Pd NPs are well-dispersed on the PDA and between the surfaces of the PDA and CNTs.The resultant Pd/CNTs-PDA catalysts exhibit excellent catalytic reactivity toward the Heck reaction at low temperatures.Moreover,by DFT simulation,we found that during the PDA polymerization process,a large number of unsaturated—N=and C=O species are more active than the groups on the PDA end product to anchor Pd NPs.The results provide evidence that the catalyst synthesized by the onepot method exhibited good activity because sufficient active sites could be created to effectively promote Pd NPs dispersion during the dopamine polymerization process.Additionally,the Pd/CNTs-PDA catalyst was successfully employed in Heck cross-coupling reactions with various functionalized substrates.This method opens a window for the fabrication of high-performance nanocomposite catalysts under mild conditions using simple methods and has several potential applications. | Zhengxiu Luo Ning Wang Xiaoyan Pei Tao Dai Zhigang Zhao Congmei Chen Maofei Ran Wenjing Sun | 2021 | Journal of Materials Science & Technology2021，，23： | 0 |
| 12 | A Corpus-Based Critical Discourse Analysis of Trump and Biden Administrations’China Policies显示文摘The theory of proximization is an effective discourse strategy to study the speaker’s ability to achieve his own legitimacy or reinforce the other’s illegitimacy,and its superiority can be maximized by means of quantitative and comparative analysis.In this study,we collected reports on Trump’s and Biden’s policies on China to build two small corpora,with a total of 11,030 words in the Trump corpus and 17,566 words in the Biden corpus.The critical discourse analysis is combined with proximization theory.With the help of BFSU Qualitative Coder 1.2,Antconc 3.5.7,and Log-Likelihood and Chi-Square Calculator 1.0,a critical cognitive score of the relevant discourse was conducted from the perspective of proximization theory.It has been found that:(1)Both Trump and Biden administrations resort to a large number of spatial proximization strategies to build ODCs converging to IDCs with China as the ODC,posing a threat to internal physical IDCs;(2)in the use of temporal proximization strategy,both administrations use primarily modal verbs and various entities to construct ODCs that extend indefinitely into the present and future,emphasizing the urgency and the threat of the effect and reinforcing the legitimacy of their actions;(3)in terms of axiological proximization strategy,the two administrations differ greatly from each other,indicating that there are still discursive biases. | ZHI Yongbi YIN Wenjing ZHI Ran | 2022 | International Relations and Diplomacy2022，10，4： | 0 |
| 13 | Consistent apparent Young’s modulus of human embryonic stem cells and derived cell types stabilized by substrate stiffness regulation promotes lineage specificity maintenance显示文摘Background:Apparent Young’s modulus(AYM),which reflects the fundamental mechanical property of live cells measured by atomic force microscopy and is determined by substrate stiffness regulated cytoskeletal organization,has been investigated as potential indicators of cell fate in specific cell types.However,applying biophysical cues,such as modulating the substrate stiffness,to regulate AYM and thereby reflect and/or control stem cell lineage specificity for downstream applications,remains a primary challenge during in vitro stem cell expansion.Moreover,substrate stiffness could modulate cell heterogeneity in the single-cell stage and contribute to cell fate regulation,yet the indicative link between AYM and cell fate determination during in vitro dynamic cell expansion(from single-cell stage to multi-cell stage)has not been established.Results:Here,we show that the AYM of cells changed dynamically during passaging and proliferation on substrates with different stiffness.Moreover,the same change in substrate stiffness caused different patterns of AYM change in epithelial and mesenchymal cell types.Embryonic stem cells and their derived progenitor cells exhibited distinguishing AYM changes in response to different substrate stiffness that had significant effects on their maintenance of pluripotency and/or lineage-specific characteristics.On substrates that were too rigid or too soft,fluctuations in AYM occurred during cell passaging and proliferation that led to a loss in lineage specificity.On a substrate with‘optimal’stiffness(i.e.,3.5 kPa),the AYM was maintained at a constant level that was consistent with the parental cells during passaging and proliferation and led to preservation of lineage specificity.The effects of substrate stiffness on AYM and downstream cell fate were correlated with intracellular cytoskeletal organization and nuclear/cytoplasmic localization of YAP.Conclusions:In summary,this study suggests that optimal substrate stiffness regulated consistent AYM during passaging and proliferation reflects and contributes to hESCs and their derived progenitor cells lineage specificity maintenance,through the underlying mechanistic pathways of stiffness-induced cytoskeletal organization and the downstream YAP signaling.These findings highlighted the potential of AYM as an indicator to select suitable substrate stiffness for stem cell specificity maintenance during in vitro expansion for regenerative applications. | Anqi Guo Bingjie Wang Cheng Lyu Wenjing Li Yaozu Wu Lu Zhu Ran Bi Chenyu Huang Jiao Jiao Li Yanan Du | 2020 | Cell Regeneration2020，9，1： | 0 |
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