|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Postnatal feeding with high-fat diet induces obesity and precocious puberty in C57BL/6J mouse pups: a novel model of obesity and puberty显示文摘童年肥胖和肥胖相关的新陈代谢的复杂并发症被一本高脂肪的出生后的食谱导致。然而,一个合适的动物模型的缺乏在肥胖研究仍然是可观的挑战。在当前的学习,我们在断奶以后在哺乳期间并且到小狗提供了高脂肪的饮食(HFD ) 给水坝。我们也与导致 HFD 的出生后的肥胖开发了 C57BL/6J 老鼠小狗的一个新奇模型。结果证明用 HFD 喂在小狗导致胖免职和肥胖。而且, HFD 更 potently 比女小狗增加了男性的身体重量(BW ) 。喂 HFD 的女小狗是肥胖的,经历了早熟的发身,并且显示出在视下丘的增加的 kisspeptin 表示。然而,父母肥胖和早熟的发身没在导致 HFD 的出生后的重量获得和小狗的发身发作上施加 synergistic 效果。有趣地,有正常 BW 的一些喂 HFD 的崽也展出了早熟的发身。这发现建议了那篇食谱作文然而并非 BW 扳机发身发作。我们的模型建议肥胖和早熟的发身的好构造有效性。而且,我们的模型能也被用来探索在 dietinduced 之间的相互的相互作用出生后的童年肥胖和发身。 | Rahim Ullah Yan Su Yi Shen Chunlu Li Xiaoqin Xu Jianwei Zhang Ke Huang Naveed Rauf Yang He Jingjing Cheng Huaping Qin Yu-Dong Zhou Junfen Fu | 2017 | Frontiers of Medicine2017，11，2： | 5 |
| 2 | Synthesis, Antitumor Activity and Preliminary Structure-activity Relationship of 2-Aminothiazole Derivatives显示文摘In this paper, we described the synthesis of 2-aminoflfiazole sublibrary containing methyl, bromo, phenylor butylidene at 4- or/and 5-position of its core. All target compounds were evaluated tbr their antitumor activitiesagainst human lung cancer cell line H1299 and human glioma cell line SHG-44. Among the compotmds screened,4,5,6,7-tetrahydrobenzo[d]thiazole(26b) exhibited the most potent antittunor activities with IC50 values of 4.89 and4.03 μmol/L against the two tested cell lines, respectively. Preliminary structure-activity relationship(SAR) studies ofthese compound were subsequently investigated. | LI Hongshuang WANG Xinran DUAN Guiyun XIA Chengcai XIAO Yuliang LI Furong GE Yanqing YOU Guirong HAN Junfen FU Xiaopan | 2016 | Chemical Research in Chinese Universities2016，32，6： | 3 |
| 3 | The SWI/SNF chromatin-remodeling factors BAF60a, b, and c in nutrient signaling and metabolic control显示文摘新陈代谢的症候群成为了不利地影响人的健康的全球流行病。基因、环境的因素贡献新陈代谢的混乱的致病;然而,集成这些暗示到的机制调整新陈代谢的生理学和不完全地定义的新陈代谢的混乱遗体的发展。新兴的证据建议 SWI/SNF 改变染色质的建筑群为指导新陈代谢的 reprogramming 和改编响应是批评的营养并且另外的生理的信号。ATP 依赖的 SWI/SNF 改变染色质的建筑群包括多达 11 个子单元, BAF60 子单元在之中用作在核心建筑群和特定的 transcriptional 因素之间的一个关键连接。BAF60 子单元有三个成员, BAF60a, b,和 c。不同织物分发模式和 BAF60 蛋白质的规章的机制在不同新陈代谢的房间类型与专业化功能授与每 isoform。在这评论,我们在滋养的察觉到和精力新陈代谢在下面的规定总结 BAF60 蛋白质的新兴的角色和机制生理并且疾病条件。 | Ruo-Ran Wang Ran Pan Wenjing Zhang Junfen Fu Jiandie D. Lin Zhuo-Xian Meng | 2018 | Protein & Cell2018，9，2： | 2 |
| 4 | Metabolic syndrome inobese children bom large for gestational age显示文摘 | Wang X Liang L Junfen FU | 2007 | Indian J Pediatr2007，74，6： | 1 |
| 5 | Prevention and control strategies for emergency,limited-term,and elective operations in pediatric surgery during the epidemic period of COVID-19显示文摘The outbreak of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has spread to more than 100 countries.Children approved to be susceptible to SARS-CoV-2 infection.Preventing and controlling the epidemic while ensuring orderly flows of pediatric surgery clinical work has proven to be a big challenge for both patients and clinicians during the epidemic.Based on the transmission characteristics of SARS-CoV-2 and the requirements for prevention and control of COVID-19,the authors proposed some concrete measures and practical strategies of managing emergency,limited-term,and elective pediatric surgeries during the epidemic period. | Daxing Tang Jinfa Tou Jinhu Wang Qingjiang Chen Wei Wang Jinjin Huang Hangyan Zhao Jia Wei Zheming Xu Dongyan Zhao Junfen Fu Qiang Shu | 2020 | World Journal of Pediatric Surgery2020，3，1： | 0 |
| 6 | Novel function of biguanides in inhibition of phospholipase D1 expression via a translational mechanism in cancer cells显示文摘Phospholipase D(PLD)and its product phosphatidic acid(PA)function as pleiotropic factors in the regulation of cancer progression,which includes the promotion of cell growth,survival,cell migration,and angiogenesis.1 Chemical inhibition of the enzymatic activity of PLD1 and PLD2,or genetic down-regulation of their expression both induce tumor suppression,1 while the compounds for PLD expression inhibition are barely reported.Here,we astonishingly found that the anti-hyperglycemic agents biguanides decreased PLD1 protein expression in cancer cells and further investigated its underlying regulatory mechanism. | Yuanfa Yao Hanbing Li Xinyi Wang Yuanhai Sun Xuqin Zhao Weiwei Zha Jiaqiang Zhou Derek Toomre Junfen Fu Yingke Xu | 2023 | Genes & Diseases2023，10，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员