|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Elevated G6PD expression contributes to migration and invasion of hepatocellular carcinoma cells by inducing epithelial-mesenchymal transition显示文摘改变的新陈代谢是癌症房间的特点之一。戊糖磷酸盐小径(PPP ) 是细胞的新陈代谢的一个基本部件。Glucose-6-phosphate 脱氢酶(G6PD ) , PPP 的限制率的酶,在许多癌症被提高并且由通过 PPP 生产 ribose-5-phosphate 和 NADPH 贡献肿瘤生长。然而,在 hepatocellular 的 G6PD 的角色癌(HCC ) 转移和在 HCC 前进和预后的 G6PD 的临床的意义一直不是很好坚定的。在这研究,由从 HCC 病人和 HCC 房间线调查织物样品,我们发现那提高的 G6PD 表情显著地与 HCC 转移和差的预后被联系 HCC,和那 G6PD 击倒在 vitro 禁止 HCC 房间线的增长,移植和侵略。进一步的研究表明 G6PD 由通过信号变换器的激活和抄写 3 的使活跃之物(STAT3 ) 导致上皮间充质的转变贡献 HCC 移植和 hepatocellular 癌房间的侵略小径。我们的调查结果建议那指向的 G6PD 能为转移干预开创可能性并且为 HCC 改进病人结果。 | Ming Lu Lu Lu Qiongzhu Dong Guangyang Yu Jinhong Chen Lunxiu Qin Lianxin Wang Wenwei Zhu Huliang Jia | 2018 | Acta Biochimica et Biophysica Sinica2018，50，4： | 10 |
| 2 | Down-regulation of SDFI-α expression in tumor microenvironment is associated with aspirin- mediated suppression of the pro-metastasis effect of sorafenib in hepatocellular carcinoma显示文摘 | Lu Lu Ming Lu Yuan Pei Jinhong Chen Lunxiu Gin Wenwei Zhu Huliang Jia | 2015 | Acta Biochimica et Biophysica Sinica2015，47，12： | 6 |
| 3 | GOLM1 exacerbates CD8^(+)T cell suppression in hepatocellular carcinoma by promoting exosomal PD-L1 transport into tumor-associated macrophages显示文摘The immunosuppressive microenvironment plays an important role in tumor progression and immunotherapy responses.Golgi membrane protein 1(GOLM1)is correlated to hepatocellular carcinoma(HCC)progression and metastasis.However,little is known about the role of GOLM1 in regulating the immunosuppressive environment and its impact on immunotherapeutic efficacy in HCC.In this study,GOLM1 was positively correlated with infiltrating tumor-associated macrophages(TAMs)expressed high levels of programmed death-ligand 1(PD-L1)and CD8^(+)T cell suppression in HCC tissues.Both gain-and loss-of-function studies determined a close correlation between GOLM1 and immunosuppression.In the mechanism,GOLM1 promoted COP9 signalosome 5-mediated PD-L1 deubiquitination in HCC cells and increased the transport of PD-L1 into exosomes via suppression of Rab27b expression.Furthermore,co-culture with exosomes derived from HCC cells upregulated the expression of PD-L1 on macrophages.Zoledronic acid in combination with anti-PD-L1 therapy reduced PD-L1^(+)TAMs infiltration and alleviated CD8^(+)T cell suppression,resulting in tumor growth inhibition in the mouse HCC model.Together,our study unveils a mechanism by which GOLM1 induces CD8^(+)T cells suppression through promoting PD-L1 stabilization and transporting PD-L1 into TAMs with exosome dependent.Targeting PD-L1^(+)TAM could be a novel strategy to enhance the efficacy of anti-PD-L1 therapy in HCC. | Jinhong Chen Zhifei Lin Lu Liu Rui Zhang Yan Geng Minghao Fan Wenwei Zhu Ming Lu Lu Lu Huliang Jia Jubo Zhang Lun-Xiu Qin | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 5 |
| 4 | Human Vγ9Vδ2-T cells efficiently kill influenzavirus-infected lung alveolar epithelial cells显示文摘 | Hong Li Zheng Xiang Ting Feng Jinrong Li Yinping Liu Yingying Fan Qiao Lu Zhongwei Yin Meixing Yu Chongyang Shen Wenwei Tu | 2013 | Cellular & Molecular Immunology2013，10，2： | 3 |
| 5 | Key technologies for the construction of the Xiluodu high arch dam on the Jinsha River in the development of hydropower in western China显示文摘Hydropower development in China is concentrated in the country's western regions.Among all the rivers in China,the lower course of the Jinsha River contains the richest hydro-energy resource,and therefore,4 mammoth hydropower plants are under construction on this particular section of the river at Wudongde,Baihetan,Xiluodu,and Xiangjiaba.The water-blocking structures of the hydropower facilities at Wudongde,Baihetan and Xiluodu are all arch dams of around 300 m high.In view of changes in the geological conditions at the foundation of the Xiluodu dam on the riverbed after excavation started,the designs of expanding foundation surface excavation and dovetailing the dam body and foundation rock on both upstream and downstream sides were introduced,allowing the arch dam and foundation to fit each other and improving the stress conditions of the dam body and foundation.By dividing the dam body into various concrete sections,the dynamic properties of concrete were adequately adjusted to the distribution of stress in the dam body.In addition,the use of the most optimal concrete material and mixture ratio allowed thermodynamics of concrete to satisfy the requirements of the strength,durability,temperature control and crack prevention of the concrete.Moreover,rigorous temperature control measures were introduced to prevent harmful cracking,thus enhancing the integrity of the arch dam.Furthermore,sophisticated construction machinery,scientific testing methods,and sound construction techniques were employed to ensure the uniformity and reliability of concrete placement.The 'Digital Dam' for the Xiluodu project,which is based on the theory of total life cycle,has supplied strong support for construction process control and decision-making. | Lu Youmei Fan Qixiang Zhou Shaowu Li Bingfeng Li Wenwei | 2012 | Engineering Sciences2012，10，2： | 3 |
| 6 | Glucose metabolism controls humanγδ-cell-mediated tumor immunosurveillance in diabetes显示文摘Patients with type 2 diabetes mellitus(T2DM)have an increased risk of cancer.The effect of glucose metabolism onγδT cells and their impact on tumor surveillance remain unknown.Here,we showed that high glucose induced Warburg effect type of bioenergetic profle in Vy9vδ2 T cells,leading to excessive lactate accumulation,which further inhibited lytic granule secretion by impairing the traffcking of cytolytic machinery to the Vy9vδ2 T-cell-tumor synapse by suppressing AMPK activation and resulted in the loss of antitumor activity in vitro,in vivo and in patients.Strikingly,activating the AMPK pathway through glucose control or metformin treatment reversed the metabolic abnormalities and restored the antitumor activity of Vy9vδ2 T cells.These results suggest that the impaired antitumor activity of Vy9vδ2 T cells induced by dysregulated glucose metabolism may contribute to the increased cancer risk in T2DM patients and that metabolic reprogramming by targeting the AMPK pathway with metformin may improve tumor immunosurveillance. | Xiaofeng Mu Zheng Xiang Yan Xu Jing He Jianwen Lu Yuyuan Chen Xiwei Wang Chloe Ran Tu Yanme Wenyue Zhang Zhinan Yin Wing-hang Leung Yu-Lung Lau Yinping Liu Wenwei Tu | 2022 | Cellular & Molecular Immunology2022，19，8： | 2 |
| 7 | Vγ9Vδ2-T lymphocytes have impaired antiviral function in small-for-gestational-age and preterm neonates显示文摘 | Jinrong Li Hong Li Huawei Mao Meixing Yu Ting Feng Fan Yang Yingying Fan Qiao Lu Chongyang Shen Zhongwei Yin Wenwei Tu Meng Mao | 2013 | Cellular & Molecular Immunology2013，10，3： | 1 |
| 8 | An iterative algorithm for the solution of the discrete-time algebraic Riccati equation显示文摘 | Lu Linzhang Lin Wenwei | 1993 | Linear Algebra and Its Applications1993，，188189： | 1 |
| 9 | Direct ubiquiti- nation of pattern recognition receptor FLS2 attenuates plant in- nate immunity显示文摘 | Lu Dongping Lin Wenwei Gao Xiquan | 2011 | Science2011，332，6036： | 1 |
| 10 | A lead isotope record of shanghai atmospheric lead emissions in total suspended particles during the period of phasing out of leaded gasoline显示文摘 | Jianmin Chen Mingguang Tan Yulan Li Yuanmao Zhang Wenwei Lu Yongpeng Tong Guilin Zhang Yan Li | 2004 | Atmospheric Environment2004，，7： | 1 |
| 11 | Economic Critical Resources for the Industrial Exploitation of Natural Gas Hydrate显示文摘Since the implementation of several pilot production tests were in natural gas hydrate(NGH) reservoirs in terrestrial and marine settings, the study of NGH has entered a new stage of technological development for industrial exploitation. Prior to the industrial exploitation of any given NGH reservoir, the economic feasibility should be examined. The first step of economic evaluation of a NGH reservoir is to know whether its resource amount meets the requirement for industrial exploitation. Unfortunately, few relevant studies have been conducted in this regard. In this study, the net present value(NPV) method is employed to estimate the economic critical resources required for the industrial exploitation of NGHs under different production scenarios. Sensitivity analysis is also performed in order to specify the effects of key factors, such as the number of production wells, gas price, technological improvement and tax incentive, on the economic critical resources. The results indicate that China requires the lowest economic critical resource for a NGH reservoir to be industrially exploited, ranging from 3.62 to 24.02 billion m3 methane. Changes in gas price and tax incentives also play significant roles in affecting the threshold and timeline for the industrial exploitation of NGH. | CHEN Xuejun LU Hailong ZHANG Jiecheng YE Jianliang XIE Wenwei | 2022 | Acta Geologica Sinica(English Edition)2022，96，2： | 1 |
| 12 | Research on Features and Applications of Jadeite Jewelryand Product in Tengchong,China显示文摘Tengchong,an ancient border town located in southwest China,has more than 500years of history in the trading and processing of jadeite.It is an important distribution center for jadeite and the birthplace of China’s jadeite culture.Tengchong has three key advantages:location,culture and history,and is able to integrate local culture to form the unique style of“Yunnan Jade Carving”.This article combines physical objects with related results of previous studies,based on the different usage and functions of jadeite jewelry and products in Tengchong,in order to analyze and summarize their classification and application.The four aspects of pattern,material,colour and technique are also been analyzed,as well as the linguistic features of jadeite jewelry and products in Tengchong,with the hope of providing ideas and references for the creation of modern jadeite jewelry. | Wenwei Wang Ren Lu Zuowei Yin | 2023 | 宝石和宝石学杂志(中英文)2023，25，1： | 0 |
| 13 | Experts consensus on the procedure of dental operative microscope in endodontics and operative dentistry显示文摘The dental operative microscope has been widely employed in the field of dentistry,particularly in endodontics and operative dentistry,resulting in significant advancements in the effectiveness of root canal therapy,endodontic surgery,and dental restoration.However,the improper use of this microscope continues to be common in clinical settings,primarily due to operators’insufficient understanding and proficiency in both the features and established operating procedures of this equipment.In October 2019,Professor Jingping Liang,Vice Chairman of the Society of Cariology and Endodontology,Chinese Stomatological Association,organized a consensus meeting with Chinese experts in endodontics and operative dentistry.The objective of this meeting was to establish a standard operation procedure for the dental operative microscope.Subsequently,a consensus was reached and officially issued.Over the span of about four years,the content of this consensus has been further developed and improved through practical experience. | Bin Liu Xuedong Zhou Lin Yue Benxiang Hou Qing Yu Bing Fan Xi Wei Lihong Qiu Zhengwei Huang Wenwei Xia Zhe Sun Hanguo Wang Liuyan Meng Bin Peng Chen Zhang Shuli Deng Zhaojie Lu Deqin Yang Tiezhou Hou Qianzhou Jiang Xiaoli Xie Xuejun Liu Jiyao Li Zuhua Wang Haipeng Lyu Ming Xue Jiuyu Ge Yi Du Jin Zhao Jingping Liang | 2023 | International Journal of Oral Science2023，15，3： | 0 |
| 14 | Morphological and Sulfur-Isotopic Characteristics of Pyrites in the Deep Sediments from Xisha Trough,South China Sea显示文摘Pyrite is one of the common authigenic minerals in marine sediments.Previous studies have shown that the morphological and isotopic characteristics of pyrite are closely related to the geochemical environment where it is formed.To better understand the for-mation mechanism of authigenic pyrite,we analyzed the isotopic composition,morphology,and distribution of pyrite in the sediment at 500m below the seafloor from Xisha Trough,South China Sea.Mineral morphologies were observed by scanning electron micros-copy and Raman spectrography.X-Ray computed tomography was applied to measure the particle size of pyrite.The size of pyrite crystals in the matrix sediment mainly ranged between 25 and 65µm(av.ca.40µm),although crystals were larger(av.ca.50μm)in the veins.The pyrites had a fine-grained truncated octahedral shape with occasionally well-developed growth steps,which implies the low growth rate and weak anaerobic oxidation of methane-sulfate reduction when pyrite was formed.Theδ^(34)S values of pyrites ranged from+20.8‰Vienna-defined Canyon Diablo Troilite(V-CDT)to+33.2‰V-CDT and from+44.8‰V-CDT to+48.9‰,which suggest two growth stages.In the first stage,with the continuous low methane flux,the pyrite possibly formed in an environment with good access to seawater.In the second stage,the pyrites mainly developed in sediment fractures and appeared in veins,probably due to the limited availability of sulfate.The less exposure of pyrite to the environment in the second stage was probably caused by sediment accumulation or perturbation.In this study,an episodic pyritization process was identified,and the paleoenvironment was reconstructed for the sediment investigated. | CHANG Jingyi LIU Yujia LU Hailong LU Jing’an SU Xin YE Jianliang XIE Wenwei | 2024 | Journal of Ocean University of China2024，23，1： | 0 |
| 15 | Promotion mechanism of self-transmissible degradative plasmid transfer in maize rhizosphere and its application in naphthalene degradation in soil显示文摘Rhizospheres can promote self-transmissible plasmid transfer,however,the corresponding mechanism has not received much attention.Plant-microbe remediation is an effective way to promote pollutant biodegradation;however,some pollutants,such as naphthalene,are harmful to plants and result in inefficient plant-microbe remediation.In this study,trans-fer of a TOL-like plasmid,a self-transmissible plasmid loaded with genetic determinants for pollutant degradation,among different bacteria was examined in bulk and rhizosphere soils as well as addition of maize root exudate and its artificial root exudate(ARE).The results showed that the numbers of transconjugants and recipients as well as bacterial metabolic activities,such as xylE mRNA expression levels and catechol 2,3-dioxygenase(C23O)activ-ities of bacteria,remained high in rhizosphere soils,when compared with bulk soils.The number of transconjugants and bacterial metabolic activities increased with the increasing exudate and ARE concentrations,whereas the populations of donor and recipient bacteria were substantially unaltered at all concentrations.All the experiments consistently showed that a certain number of bacteria is required for self-transmissible plasmid transfer,and that the increased plasmid transfer might predominantly be owing to bacterial metabolic activ-ity stimulated by root exudates and ARE.Furthermore,ARE addition increased naphthalene degradation by transconjugants in both culture medium and soil.Thus,the combined action of a wide variety of components in ARE might contribute to the increased plasmid transfer and naphthalene degradation.These findings suggest that ARE could be an effectively al-ternative for plant-microbe remediation of pollutants in environments where plants cannot survive. | Qiuyan Jiang Wenwei Lu Lei Zhang Yeqing Jin Yujing Wang Jun Chen Ziyi Ye Ming Xiao | 2022 | Journal of Environmental Sciences2022，34，5： | 0 |
| 16 | Sustainable Development Plan Based on Mathematic Model Analysis显示文摘 | Liang LV Wenwei ZENG Xinyun LU | 2015 | International Journal of Technology Management2015，，7： | 0 |
| 17 | Characteristics of Gray Skin Chewing Sugarcane and Its Precise Cultivation Techniques显示文摘[Objectives] The aim was to provide technical supports for the popularization and application of gray skin chewing sugarcane in large areas in suitable regions. [Methods] Field planting tests were conducted in 2012-2016 to study the yield,major economic traits,disease resistances,growth periods,adaptability and cultivation techniques of gray skin chewing sugarcane. [Results]The characteristics and a set of precise cultivation techniques for gray skin chewing sugarcane were summarized. [Conclusions] The technology can be widely applied in the areas with altitude of less than 1 500 m and areas with similar climate in Yunnan Province. | Zhiming YANG Lin ZENG Xiao ZHAO Shunsheng LU Yunfei SONG Chaozhong ZHANG Wenwei TIAN | 2018 | Agricultural Biotechnology2018，7，4： | 0 |
| 18 | Introduction and Application of ‘Mini Star White'——A New Variety of Gazania rigens L.显示文摘G.rigens L.as a new quality ground cover plant can be applied in parks,yards,roadsides and tree pools,and contributes to the beauty of urban landscapes.This paper introduces biological characters and adaptability of‘Mini Star White’,a new variety of G.rigens L.introduced from Japan,and studied the color improvement of the variety on the basis of applying it in various landscape forms,which enriches ground cover diversity of Suzhou area,and provides new materials for the hybridization of G.rigens L.. | LIU Yang YANG Haiqin XU Wenwei ZHOU Xiaohui LU Xiaoping | 2013 | Journal of Landscape Research2013，5，9： | 0 |
| 19 | Experimental study on sand production and coupling response of silty hydrate reservoir with different contents of fine clay during depressurization显示文摘To further understand the characteristics of clay and sand production(hereafter collectively referred to as sand production)and to provide optimization designs of sand control schemes are critical for gas production from clayey silt natural gas hydrate reservoirs in the South China Sea.Thus,gas-water-sand production behavoirs and coupling reservoir subsidence characteristics before,during,and after hydrate dissociation of the clayey silt hydrate reservoirs with different clay contents(5%,10%,15%,20%,25%,and 30%)have been studied through a self-developed experimental system.The results show that with the increase of clay content,the total mass of sand production first increases and then decreases,and it reaches maximum when the clayey content is 20%.The sand production is the lowest before hydrate dissociation and increases significantly during hydrate dissociation,which mainly occurs in the high-speed gas and water production stage at the beginning of hydrate dissociation.After hydrate dissociation,the sand production decreases significantly.During the whole depressurization process,the clay and free sand particles generally move to the sand outlet due to the fluid driving force and overlying stress extrusion.However,for conditions of high clay contents,those particles fail to pass through the sand control screen and gradually accumulate and block the screen by forming a mud cake,which greatly reduce the permeability of the screen and limite sand production as well as gas and water production.Our research lays a foundation for sand production prediction and sand control scheme selection during gas recovery from clayey silty hydrate reservoirs that greatly need to consider a balance between sand control and gas productivity. | Xiangyu Fang Dianheng Yang Fulong Ning Linjie Wang Zhichao Liu Yanjiang Yu Wenwei Xie Hongfeng Lu Yanlong Li Meng Xu | 2023 | Petroleum2023，9，1： | 0 |
| 20 | mpaired NK cell antiviral cytokine response against nfluenza virus in small-for-gestational-age neonates显示文摘 | Jinrong Li Hong Li Huawei Mao Meixing Yu Fan Yang Ting Feng Yingying Fan Qiao Lu Chongyang Shen Zhongwei Yin Meng Mao Wenwei Tu | 2013 | Cellular & Molecular Immunology2013，10，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员