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| 1 | Impact of hypoglycemic agents on myocardial ischemic preconditioning显示文摘Murry et al in 1986 discovered the intrinsic mechanism of profound protection called ischemic preconditioning. The complex cellular signaling cascades underlying this phenomenon remain controversial and are only partially understood. However, evidence suggests that adenosine, released during the initial ischemic insult, activates a variety of G protein-coupled agonists, such as opioids, bradykinin, and catecholamines, resulting in the activation of protein kinases, especially protein kinase C(PKC). This leads to the translocation of PKC from the cytoplasm to the sarcolemma, where it stimulates the opening of the ATP-sensitive K+ channel, which confers resistance to ischemia. It is known that a range of different hypoglycemic agents that activate the same signaling cascades at various cellular levels can interfere with protection from ischemic preconditioning. This review examines the effects of several hypoglycemic agents on myocardial ischemic preconditioning in animal studies and clinical trials. | Rosa Maria Rahmi Garcia Paulo Cury Rezende Whady Hueb | 2014 | World Journal of Diabetes2014，5，3： | 4 |
| 2 | Conservative strategy for treatment of stable coronary artery disease显示文摘Patients with coronary artery disease vary widely in terms of prognosis, which is mainly dependent on ventricular function. In relation to the major outcomes of death and myocardial infarction, it is not clear in the literature if an invasive strategy of myocardial revascularization is superior to a conservative strategy of optimized medical therapy. Moreover, with the exception of patients with left main coronary disease, this similarity in prognosis also occurs in different subgroups of patients. | Paulo Cury Rezende Thiago Luis Scudeler Leandro Menezes Alves da Costa Whady Hueb | 2015 | World Journal of Clinical Cases2015，3，2： | 3 |
| 3 | Medicine, Angioplasty or Surgery Study (MASS):a prospective randomized trial of medical therapy ,ballcon angioplasty or bypass surgery for single proximal left anterior descending artery atenosis 显示文摘 | Whady A Giovanni B Sergio A | | J Am Coll Cardia0，，： | 1 |
| 4 | Effect of complete revascularization on 10-year survival of patients with stable multivessel coronary artery disease: MASS ]I trial显示文摘 | RICARDO D V WHADY H BERNARD J | 2012 | Circulation2012，126，： | 1 |
| 5 | Ten-Year Follow-Up Survival of the Medicine, Angioplasty, or Surgery Study (MASS II): A Randomized Controlled Clinical Trial of 3 Therapeutic Strategies for Multivessel Coronary Artery Disease显示文摘 | Whady Hueb Neuza Lopes Bernard J. Gersh Paulo R. Soares Expedito E. Ribeiro Alexandre C. Pereira Desiderio Favarato Antonio Sérgio C. Rocha Alexandre C. Hueb Jose A.F. Ramires | 2010 | Circulation2010，，10： | 1 |
| 6 | Effect of Complete Revascularization on 10-Year Survival of Patients With Stable Multivessel Coronary Artery Disease显示文摘 | Ricardo D’Oliveira Vieira Whady Hueb Bernard J. Gersh Eduardo Gomes Lima Alexandre Costa Pereira Paulo Cury Rezende Cibele Larrosa Garzillo Alexandre Ciappina Hueb Desiderio Favarato Paulo Rogério Soares José Antonio Franchini Ramires Roberto Kalil Filho | 2012 | Circulation . 2012 (11 s)2012，，： | 1 |
| 7 | Effects of Optimal Medical Treatment With or Without Coronary Revascularization on Angina and Subsequent Revascularizations in Patients With Type 2 Diabetes Mellitus and Stable Ischemic Heart Disease显示文摘 | Gilles R. Dagenais Jiang Lu David P. Faxon Kenneth Kent Rodrigo M. Lago Carlos Lezama Whady Hueb Melvin Weiss James Slater Robert L. Frye | 2011 | Circulation2011，，14： | 1 |
| 8 | Effect of a hypoglycemic agent on ischemic preconditioning in patients with type 2 diabetes and stable angina pectoris显示文摘 | Whady Hueb Augusto H. Uchida Bernard J. Gersh Roberto T.B. Betti Neuza Lopes Paulo J. Moffa Beatriz M.A. Ferreira Jose A.F. Ramires Bernardo L. Wajchenberg | 2007 | Coronary Artery Disease2007，，1： | 1 |
| 9 | The Medicine, Angioplasty or Surgery Study (MASS): A prospective, randomized trial of medical therapy, balloon angioplasty or bypass surgery for single proximal left anterior descending artery stenoses显示文摘 | Whady A. Hueb Giovanni Bellotti Sergio Almeida de Oliveira Shiguemituzo Arie Cicero Piva de Albuquerque Adib D. Jatene Fulvio Pileggi | 1995 | Journal of the American College of Cardiology1995，，7： | 1 |
| 10 | Impact of Diabetes on Five-Year Outcomes of Patients With Multivessel Coronary Artery Disease显示文摘 | Whady Hueb Bernard J. Gersh Fernando Costa Neuza Lopes Paulo R. Soares Paulo Dutra Fabio Jatene Alexandre C. Pereira Aécio F.T. Góis Sergio A. Oliveira José A.F. Ramires | 2007 | The Annals of Thoracic Surgery2007，，1： | 1 |
| 11 | Long-Term Safety and Efficacy of Percutaneous Coronary Intervention With Stenting and Coronary Artery Bypass Surgery for Multivessel Coronary Artery Disease: A Meta-Analysis With 5-Year Patient-Level Data From the ARTS, ERACI-II, MASS-II, and SoS Trials显示文摘 | Joost Daemen Eric Boersma Marcus Flather Jean Booth Rod Stables Alfredo Rodriguez Gaston Rodriguez-Granillo Whady A. Hueb Pedro A. Lemos Patrick W. Serruys | 2008 | Circulation2008，，11： | 1 |
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