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| 1 | Pathological bacterial translocation in liver cirrhosis显示文摘 | Reiner Wiest Melissa Lawson Markus Geuking | 2014 | Journal of Hepatology2014，，1： | 8 |
| 2 | Analysis of monocyte chemotactic protein-1 gene polymorphism in patients with spontaneous bacterial peritonitis显示文摘AIM:To investigate a genetic polymorphism of the monocyte chemotactic protein-1 (MCP-1 ) gene in patients with spontaneous bacterial peritonitis (SBP).METHODS:MCP-1 genotyping was performed in 23 patients with SBP and 83 cirrhotic control patients with non-infected ascites.RESULTS:The frequency of carriers of the G-allele was lower in SBP patients but this difference did not reach statistical significance. However,in the subgroup of patients with alcoholic cirrhosis (n=80),carriers of the G-allele were significantly less frequent in SBP-patients (38.1%) than in cirrhotic controls (67.8%,P=0.021). CONCLUSION:In patients with alcoholic liver cirrhosis,the-2518 MCP-1 genotype AA is a risk factor for the development of SBP. | Erwin Gbele Marcus Mhlbauer Hartwig Paulo Monika Johann Christin Meltzer Franz Leidl Norbert Wodarz Reiner Wiest Jrgen Schlmerich Claus Hellerbrand | 2009 | World Journal of Gastroenterology2009，15，44： | 7 |
| 3 | Heme oxygenase-1 overexpression increases liver injury after bile duct ligation in rats显示文摘AIM: To investigate the effects of heme oxygenase-1 (HO-1) against oxidant-induced injury caused by bile duct ligation (BDL). METHODS: Either cobalt protoporphyrin (CoPP), a HO-1 inducer, or saline were injected intraperitoneally in male SD-rats. Three days later, BDL or sham-operations were performed. Rats were sacrificed 3 wk after BDL and livers were harvested for histology. Fibrosis was evaluated by sirius red staining and image analysis. Alpha-smooth muscular actin, which indicates activation of stellate cells, was detected by immunohistochemical staining, and cytokine and collagen-Ⅰα (Col-Ⅰα) mRNA expression was detected using RNase protection assays. RESULTS: Serum alanine transaminase increased 8-fold above normal levels one day after BDL. Surprisingly, enzyme release was not reduced in rats receiving CoPP. Liver fibrosis was evaluated 3 wk after BDL and the sirius red-positive area was found to be increased to about 7.8%. However, in CoPP pretreated rats sirius red- positive areas were increased to about 11.7% after BDL. Collagen-Ⅰα and TGF-β mRNA increased significantly by BDL. Again, this effect was increased by HO-1 overexpression.CONCLUSION: Hepatic fibrosis due to BDL is not reduced by the HO-1 inducer CoPP. In contrast, HO-1 overexpression increases liver injury in rats under conditions of experimental chronic cholestasis. | Matthias Froh Lars Conzelmann Peter Walbrun Susanne Netter Reiner Wiest Michael D Wheeler Mark Lehnert Takehiko Uesugi Jurgen Scholmerich Ronald G Thurman | 2007 | World Journal of Gastroenterology2007，13，25： | 4 |
| 4 | Role of HSP-90 for increased nNOS-mediated vasodilation in mesenteric arteries in portal hypertension显示文摘AIM:To explore the role of heat shock protein-90 (HSP-90) for nitrergic vasorelaxation in the splanchnic circulation in rats with and without portal hypertension. METHODS: Neuronal nitric oxide synthase (nNOS) and HSP-90 were analyzed by immunofluorescence, western blotting and co-immunoprecipitation in the mesenteric vasculature and isolated nerves of portal-vein-ligated (PVL) rats and sham operated rats. In vitro perfused de-endothelialized mesenteric arterial vasculature was preconstricted with norepinephrine (EC80) and tested for nNOS-mediated vasorelaxation by periarterial nerve stimulation (PNS, 2-12 Hz, 45V) before and after incubation with geldanamycin (specific inhibitor of HSP-90 signalling, 3 μg/mL) or L-NAME (non-specific NOSblocker, 10-4 mol/L). RESULTS: nNOS and HSP-90 expression was significantly increased in mesenteric nerves from PVL as compared to sham rats. Moreover, nNOS and HSP-90 were visualized in mesenteric nerves by immunofluorescence and immunoprecipitation of nNOS co-immunoprecitated HSP-90 in sham and PVL rats. PNS induced a frequencydependent vasorelaxation which was more pronounced in PVL as compared to sham rats. L-NAME and geldanamycin markedly reduced nNOS-mediated vasorelaxation abrogating differences between the study groups. The effect of L-NAME and geldanamycin on nNOS-mediated vasorelaxation was significantly greater in PVL than in sham animals. However, no difference in magnitude of effect between L-NAME and geldanamycin was noted. CONCLUSION: HSP-90 acts as a signalling mediator of nNOS-dependent nerve mediated vascular responses in mesenteric arteries, and the increased nitrergic vasorelaxation observed in portal hypertension is mediated largely by HSP-90. | Lukas Moleda Lars Jurzik Matthias Froh Erwin Gbele Claus Hellerbrand Rainer H Straub Jürgen Schlmerich Reiner Wiest | 2010 | World Journal of Gastroenterology2010，16，15： | 4 |
| 5 | Intestinal bacterial translocation in rats with cirrhosis is related to compromised paneth cell antimicrobial host defense显示文摘 | Zora Teltschik Reiner Wiest Julia Beisner Sabine Nuding Claudia Hofmann Juergen Schoelmerich Charles L. Bevins Eduard F. Stange Jan Wehkamp | 2012 | Hepatology2012，，： | 2 |
| 6 | 7088 A lipidomic analysis of non-alcoholic fatty liver disease (NAFLD)显示文摘 | P. Puri R.A. Baillie M. Wiest F. Mirshahi A.J. Sanyal | 2006 | Journal of Hepatology2006，，： | 2 |
| 7 | A Major Lung Cancer Susceptibility Locus Maps to Chromosome 6q23–25显示文摘 | J.E. Bailey-Wilson C.I. Amos S.M. Pinney G.M. Petersen M. de Andrade J.S. Wiest P. Fain A.G. Schwartz M. You W. Franklin C. Klein A. Gazdar H. Rothschild D. Mandal T. Coons J. Slusser J. Lee C. Gaba E. Kupert A. Perez X. Zhou D. Zeng Q. Liu Q. Zhang D. Se | 2004 | The American Journal of Human Genetics2004，，3： | 2 |
| 8 | Sensor: A tool for the simulation of hyperspectral remote sensing systems显示文摘 | Borner A Wiest L Keller P | 2001 | ISPRS Journal of Pho- togrammetry and Remote Sensing2001，55，56： | 1 |
| 9 | Evaluation of an auto-CPAP device for treatment of obstructive sleep apnoea显示文摘 | Ficker JH Wiest GH Lehnert G | 1998 | Thorax1998，53，： | 1 |
| 10 | Immunolocalization of type X collagen in human lumbar intervertebral discs during ageing and degeneration显示文摘 | N. Boos Andreas G. Nerlich Irmgard Wiest Klaus von der Mark Max Aebi | 1997 | Histochemistry and Cell Biology1997，，6： | 1 |
| 11 | Ultrasound-guided per- cutaneous endoscopic gastrostomy in patients with negative diapha- noscopy 显示文摘 | Schlottmann K Klebl F Wiest R | 2007 | Endoscopy2007，39，8： | 1 |
| 12 | Function of the malesex organs in heroin and methadone显示文摘 | Cicero TJ Bell RD Wiest WG | 1975 | N Eng l J Med1975，292，17： | 1 |
| 13 | Bacterial transloeation(BT)in cirrhosis显示文摘 | Wiest R Garcia-Tsao G | 2005 | Hepatology2005，41，： | 1 |
| 14 | Expression of the tumor markers sialyl Lewis A, Sialyl Lewis X, Lewis Y, Thomsen-Friedenreich antigen, galectin-1 and galectin-3 in human osteoblasts in vitro显示文摘 | Ttibel J Saldamli B Wiest I | 2012 | Anticancer Res2012，32，5： | 1 |
| 15 | Gene expression in human peripheral blood mononuclear cells upon acute ischemic stroke显示文摘 | Grond-Ginsbach C Hummel M Wiest T | 2008 | J Neurol2008，255，5： | 1 |
| 16 | CT scanning:patterns of use and dose显示文摘 | Mettler FA Wiest PW Locken JA | 2000 | Radiol Prot2000，20，： | 1 |
| 17 | Synergy of combining sonoly- sis and pbotocatalysis in the degradation and mineralization of chlorinated aromatic compounds 显示文摘 | Peller J Wiest O Kamat P V | 2003 | Environmental Sci- ence & Technology2003，37，9： | 1 |
| 18 | Morbidity due to schistosomiasis japonica in the People's Republic of China显示文摘 | Wiest PM Wu GL Zhang SJ | 1992 | Trans R Soc Trop Med Hyg1992，86，1： | 1 |
| 19 | Bacterial translocation(BJ) in cirrhosis显示文摘 | Wiest R Garcia-Tsao G | 2005 | Hepatology2005，41，3： | 1 |
| 20 | A lipidomic analysis of nonalcoholic fatty liver disease显示文摘 | Puri P Baillie RA Wiest MM | 2007 | Hepatology2007，46，4： | 1 |
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