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| 1 | Application of human umbilical cord blood-derived mesenchymal stem cells in disease models显示文摘Human umbilical cord blood-derived mesenchymal stem cells(hUCB-MSCs) are regarded as an alternative source of bone marrow-derived mesenchymal stem cells because collection of cord blood is less invasive than that of bone marrow.hUCB-MSCs have recently been studied for evaluation of their potential as a source of cell therapy.In this review,the general characteristics of hUCBMSCs and their therapeutic effects on various diseases in vitro and in vivo will be discussed. | Ju-Yeon Kim Hong Bae Jeon Yoon Sun Yang Wonil Oh Jong Wook Chang | 2010 | World Journal of Stem Cells2010，2，2： | 14 |
| 2 | Prospects for the therapeutic development of umbilical cord bloodderived mesenchymal stem cells显示文摘Umbilical cord blood(UCB)is a primitive and abundant source of mesenchymal stem cells(MSCs).UCB-derived MSCs have a broad and efficient therapeutic capacity to treat various diseases and disorders.Despite the high latent selfrenewal and differentiation capacity of these cells,the safety,efficacy,and yield of MSCs expanded for ex vivo clinical applications remains a concern.However,immunomodulatory effects have emerged in various disease models,exhibiting specific mechanisms of action,such as cell migration and homing,angiogenesis,anti-apoptosis,proliferation,anti-cancer,anti-fibrosis,anti-inflammation and tissue regeneration.Herein,we review the current literature pertaining to the UCB-derived MSC application as potential treatment strategies,and discuss the concerns regarding the safety and mass production issues in future applications. | Soyoun Um Jueun Ha Soo Jin Choi Wonil Oh Hye Jin Jin | 2020 | World Journal of Stem Cells2020，12，12： | 4 |
| 3 | Discovery of Curcumin, a Component of the Golden Spice,and Its Miraculous Biological Activities显示文摘 | Subash C Gupta Sridevi Patchva Wonil Koh | 2012 | Clin Exp Pharmacol Physiol2012，39，3： | 1 |
| 4 | Immunological properties of umbilical cord blood-derived mesenchymal stromal cells显示文摘 | Wonil Oh Dal-Soo Kim Yoon Sun Yang Jae Kwon Lee | 2008 | Cellular Immunology2008，，2： | 1 |
| 5 | Millimeter-wave Beamforming as an Enabling Technology for 5G Cel-lular Communications : Theoretical Feasibility and Proto-type Results 显示文摘 | Wonil Roh Seol Ji-Yun Park Jeongho | 2014 | Communications Magazine IEEE2014，52，2： | 1 |
| 6 | An approachto mitigate DoS a ttack based on routing misbehavior inwireless ad hoc networks显示文摘 | GUNHEE L WONIL K KANGSEOK K | 2013 | Peer-to-Peer Networking andApplications2013，，8： | 1 |
| 7 | Local failure after complete resection of N0–1 non-small cell lung cancer显示文摘 | Mert Saynak Nirmal K. Veeramachaneni Jessica L. Hubbs Jiho Nam Bahjat F. Qaqish Janet E. Bailey Wonil Chung Lawrence B. Marks | 2010 | Lung Cancer2010，，： | 1 |
| 8 | Millimeter-Wave Beamforming as an Enabling Technology for 5G Cellular Communications:Theoretical Feasibility and Prototype Results显示文摘 | Wonil Roh Ji-Yun Seol Jeongho Parket | 2014 | IEEE Communications Magazine2014，52，2： | 1 |
| 9 | Metabolic syndrome is associated with venous thromboembolism in the Korean population显示文摘 | Moon JJ Wonil C Bang S | 2009 | Arterioscler Thromb Vasc Biol2009，29，3： | 1 |
| 10 | Immunological properties of umbilical cord blood-derived mesenchymal stromal cells显示文摘 | Wonil Oh Dal-Soo Kim Yoon Sun Yang Jae Kwon Lee | 2008 | Cellular Immunology2008，，2： | 1 |
| 11 | 脐的绳索血间充质的干细胞经由 paracrine 保护 amyloid-42 neurotoxicity显示文摘 AIM:To understand the neuroprotective mechanism of human umbilical cord blood-derived mesenchymal stem cells(hUCB-MSCs) against amyloid-β42(Aβ42) exposed rat primary neurons.METHODS:To evaluate the neuroprotective effect of hUCB-MSCs,the cells were co-cultured with Aβ42-exposed rat primary neuronal cells in a Transwell apparatus.To assess the involvement of soluble fac-tors released from hUCB-MSCs in neuroprotection,an antibody-based array using co-cultured media was conducted.The neuroprotective roles of the identified hUCB-MSC proteins was assessed by treating recombi-nant proteins or specific small interfering RNAs(siRNAs) for each candidate protein in a co-culture system.RESULTS:The hUCB-MSCs secreted elevated levels ofdecorin and progranulin when co-cultured with rat pri-mary neuronal cells exposed to Aβ42.Treatment with recombinant decorin and progranulin protected from Aβ42-neurotoxicity in vitro.In addition,siRNA-mediat-ed knock-down of decorin and progranulin production in hUCB-MSCs reduced the anti-apoptotic effects of hUCB-MSC in the co-culture system.CONCLUSION:Decorin and progranulin may be involved in anti-apoptotic activity of hUCB-MSCs exposed to Aβ42. | Ju-Yeon Kim Dong Hyun Kim Ji Hyun Kim Yoon Sun Yang Wonil Oh Eun Hui Lee Jong Wook Chang | 2012 | World Journal of Stem Cells2012，4，11： | 1 |
| 12 | CXCR4-transfected human umbilical cord blood-derived mesenchymal stemcells exhibit enhanced migratory capacity toward gliomas显示文摘 | Soon Park Chung Ryu Seong Kim Jung Lim Sang Park Chang Jeong Jin Jun Ji Oh Sun Park Wonil Oh Sin-Soo Jeun | 2011 | International Journal of Oncology2011，，1： | 1 |
| 13 | CXC chemokine receptor 1 enhances the ability of human umbilical cord blood-derived mesenchymal stem cells to migrate toward gliomas显示文摘 | Seong Muk Kim Dal-Soo Kim Chang Hyun Jeong Dong Hyun Kim Ji Hyun Kim Hong Bae Jeon Soon-Jae Kwon Sin-Soo Jeun Yoon Sun Yang Wonil Oh Jong Wook Chang | 2011 | Biochemical and Biophysical Research Communications2011，，4： | 1 |
| 14 | Reactive oxygen species involved in sulforaphane-induced STAT3 inactivation and apoptosis in DU145 prostate cancer cells显示文摘Signal transducer and activator of transcription factor 3(STAT3)is a transcription factor that regulates various cellular processes such as proliferation,survival and angiogenesis in cancer cells.In the present study,we investigated the mechanisms whereby isothiocyanate sulforaphane(SFN)suppresses STAT3 activation in DU145 prostate cancer cells.SFN significantly inhibited SFN-inhibited STAT3 phosphorylation at Tyr705 as well as the deoxyribonucleic acid(DNA)binding capability in electrophoresis mobility shift assay(EMSA)in time-and concentration-dependent manner.SFN also abrogated the Janus activated kinase 2(JAK2)phosphoraylation.In addition,SFN down-regulated STAT3-related gene products including Bcl-2,Bcl-xL,and cyclin D1 and vascular endothelial growth factor(VEGF),and inhibited the proliferation and induced apoptosis.Moreover,SFN mediated reactive oxygen species(ROS)production at the early time.Overall,these results demonstrate that ROS generation may be involved in the inhibition of JAK2/STAT3 activation and apoptosis in DU145 cells. | KOH Wonil AHN Kwang Seok JEONG Soo-Jin LEE Hyo-Jung KIM Minseok LEE Hyo-Jeong LEE Eun-Ok KIM Sung-Hoon | 2010 | Chinese Science Bulletin2010，55，34： | 0 |
| 15 | Scalable nanolaminated SERS multiwell cell culture assay显示文摘This paper presents a new cell culture platform enabling label-free surface-enhanced Raman spectroscopy(SERS)analysis of biological samples.The platform integrates a multilayered metal-insulator-metal nanolaminated SERS substrate and polydimethylsiloxane(PDMS)multiwells for the simultaneous analysis of cultured cells.Multiple cell lines,including breast normal and cancer cells and prostate cancer cells,were used to validate the applicability of this unique platform.The cell lines were cultured in different wells.The Raman spectra of over 100 cells from each cell line were collected and analyzed after 12h of introducing the cells to the assay.The unique Raman spectra of each cell line yielded biomarkers for identifying cancerous and normal cells.A kernel-based machine learning algorithm was used to extract the high-dimensional variables from the Raman spectra.Specifically,the nonnegative garrote on a kernel machine classifier is a hybrid approach with a mixed nonparametric model that considers the nonlinear relationships between the higher-dimension variables.The breast cancer cell lines and normal breast epithelial cells were distinguished with an accuracy close to 90%.The prediction rate between breast cancer cells and prostate cancer cells reached 94%.Four blind test groups were used to evaluate the prediction power of the SERS spectra.The peak intensities at the selected Raman shifts of the testing groups were selected and compared with the training groups used in the machine learning algorithm.The blind testing groups were correctly predicted 100% of the time,demonstrating the applicability of the multiwell SERS array for analyzing cell populations for cancer research. | Xiang Ren Wonil Nam Parham Ghassemi Jeannine S.Strobl Inyoung Kim Wei Zhou Masoud Agah | 2020 | Microsystems & Nanoengineering2020，6，1： | 0 |
| 16 | 移动毫米波大变身显示文摘这是因为蜂窝通信行业在其存在的40年内,一直都只能依靠被称为特高频频段的一小段频谱,这段频谱仅占监管频谱资源的百分之一左右。无线工程师们一直认为这段频率范围(即300兆赫到3000兆赫之间)是移动组网的“黄金频段”。该频段内电磁波的波长适宜,既可以使用适合手机的小型天线接收,又能绕过或穿透建筑物、植物等障碍。即便使用低功率发射,这些电磁波也可以在任何无线传播环境下(无论是东京市中心还是爱荷华州的农场)可靠地传播若干公里。 | Theodore S. Rappaport Wonil Roh Kyungwhoon Cheun | 2014 | 科技纵览2014，0，9： | 0 |
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