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| 1 | Adjustment Model and Algorithm Based on Ellipsoid Uncertainty显示文摘In surveying adjustment models,there is usually some uncertain additional information or prior information on parameters,which can constrain the parameters,and guarantee the uniqueness and stability of parameter solution.In this paper,we firstly use ellipsoidal sets to describe uncertainty,and establish a new adjustment model with ellipsoidal uncertainty.Furthermore,we give a new adjustment criterion based on minimization trace of an outer ellipsoid with two ellipsoid intersections,and analyze the propagation law of uncertainty.Correspondingly,we give a new algorithm for the adjustment model with ellipsoid uncertainty.Finally,we give three examples to test and verify the effectiveness of our algorithm,and illustrate the relation between our result and the weighted mixed estimation. | Yingchun SONG Yuguo XIA Xuemei XIE | 2020 | Journal of Geodesy and Geoinformation Science2020，3，3： | 7 |
| 2 | Quaternary pyrite-structured nickel/cobalt phosphosulfide nanowires on carbon cloth as efficient and robust electrodes for water electrolysis显示文摘元素替换的策略是在催化剂调节活跃地点的电子结构的一个有效方法,从而在催化活动和稳定性导致改进。此处,我们设计并且综合黄铁矿类型镍 / 磷共同做碳布(NiCoPS/CC ) 上的公司 2 nanowires 为水电解的同样有效、持久的电极。镍和磷的介绍由于催化剂的活跃地点的电子结构的规定在氢进化反应生产了电极的表演的逐步、出色的改进并且在一个宽 pH 范围(014 ) 上加速了费用转移。也交付的 NiCoPS/CC 电极一将近 undecayed 10 | Jiayuan Li Zhaoming Xia Xuemei Zhou Yuanbin Qin Yuanyuan Ma Yongquan Qu | 2017 | Nano Research2017，10，3： | 7 |
| 3 | Protection strategy for improved catalytic stability of silicon photoanodes for water oxidation显示文摘Silicon-based electrodes have attracted great attention in the artificial photosynthetic systems that mimic natural photosynthesis and directly convert the solar energy into chemical energy. Despite significant efforts to date,catalytic stability of the silicon photoelectrodes is limited by their poor electrochemical stability. The formation of passivation or protective layers provides a feasible strategy to improve the photocatalytic stability of silicon photoelectrodes. Many candidates including metals, metal oxides, metal silicides and polymers have been explored as the protection layers for silicon photoelectrodes. The present review gives a concise overview of the protected silicon photoanodes for water oxidation with a focus on the relationship between the structural architecture of silicon photoanodes and their photocatalytic activity and stability. | Zhaoming Xia Xuemei Zhou Jing Li Yongquan Qu | 2015 | Science Bulletin2015，60，16： | 5 |
| 4 | The Crosstalk of mTOR/S6K1 and Hedgehog Pathways显示文摘 | Yan Wang Qingqing Ding Chia-Jui Yen Weiya Xia Julie G. Izzo Jing-Yu Lang Chia-Wei Li Jennifer L. Hsu Stephanie A. Miller Xuemei Wang Dung-Fang Lee Jung-Mao Hsu Longfei Huo Adam M. LaBaff Dongping Liu Tzu-Hsuan Huang Chien-Chen Lai Fuu-Jen Tsai Wei-Chao Ch | 2012 | Cancer Cell2012，，3： | 2 |
| 5 | Role of gut microbiota in the development of non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD)is a chronic liver disease characterized by hepatic steatosis in the absence of other causes,such as chronic alcohol consumption,that cause secondary hepatic fat accumulation.NAFLD has become the most common liver disease worldwide over the past two decades,and the prevalence of NAFLD is 20e30%in Western countries.However,the mechanism of NAFLD re-mains unclear.The gut microbiota plays an important role in the metabolism of the host;in fact,it has been implicated in inflammatory diseases,metabolic syndrome and cardiovascular disease.Accumu-lating evidence has indicated that gut microbiota component changes are linked to human obesity,in-sulin resistance(IR),type 2 diabetes and NAFLD.Here,we provide insight into the role of gut microbiota,especially bile salt hydrolase(BSH)in modulating the bile acid pool and farnesoid X receptor(FXR),which promotes the synthesis of ceramide and contributes to the development of NAFLD. | Xuemei Wang Jialin Xia Changtao Jiang | 2019 | Liver Research2019，3，1： | 2 |
| 6 | Parthenolide attenuates LPS-induced activation of NF-κB in a time-dependent manner in rat myocardium显示文摘Parthenolide(PTN),a selective nuclear factor kappa B(NF-κB)inhibitor,has been used extensively to inhibit NF-κB activation.The duration of the inhibitory effect of PTN on NF-κB in vivo remains unclear.This study was to determine whether a lipopolysaccharide(LPS)challenge 6,12 and 24 h after the administration of PTN could activate NF-κB.Rats were devided into five groups.The rats in the PTN,PTN+LPS and DMSO groups were injected intraperitoneally with PTN or DMSO.After 6,12 or 24 h,LPS was administered in LPS and PTN+LPS groups.The expressions of NF-κB p50,IκBα and p-IκBα were inhibited in both PTN and PTN+LPS group at end of 6 and 12 h and no effects at 24 h.In summary,myocardial NF-κB expression occurs 1 h after the administration of LPS.PTN blocks this effect given at 6 h and no inhibitory effect 24 h after administration in vivo. | Hong Xie Chen Wang Xuemei Wu Xia Liu Shigang Qiao Chunfeng Liu Hong Liu | 2012 | The Journal of Biomedical Research2012，26，1： | 2 |
| 7 | Crystal structures of GI.8 Boxer virus P dimers in complex with HBGAs, a novel evolutionary path selected by the Lewis epitope显示文摘人的 noroviruses (huNoVs ) 作为附件因素,在 genogroup (G) ,我和 GII huNoVs 使用不同有约束力的接口认出 histo 血组抗原(HBGA ) 。在由主人 HBGA 的选择下面的 GII huNoVs 的基因、进化的关系很好经由很多结构的研究被阐明了;然而,在官方补给的 11 月之中的如此的关系由于仅仅有类似的有约束力的侧面的三个官方补给的 11 月的 HBGA 有约束力的接口的结构被知道的事实仍然保持不太清楚。在水晶吊楔绑定紧张的 P dimers 组织的这研究,不绑 A 和 H 抗原的 GI.8 拳击手病毒( BV ),在有吊楔 b 的建筑群( Le <啜class=“ a-plus-plus ”> b )和 Le <啜class=“ a-plus-plus ”>分别地, y 抗原被决定并且与那些相比三以前已知的官方补给的 huNoVs ,即 GI.1 Norwalk 病毒( NV ), GI.2 FUV258 ( FUV )和绑 A/H/Le 抗原的 GI.7 TCH060 ( TCH )。 BV 的 HBGA 有约束力的接口由与先锋的半乳糖交往的一个保存中央有约束力的衣袋( CBP )组成,并且一个开发得好的 Le epitope有约束力的地点由五氨基酸形成了,包括从长P环的三连续残余和从 P1 子域的海岸炮舰的残余,没在另一方面在另外的官方补给的11月被看见的一个特征,在另外的官方补给的11月观察的 H epitope/acetamido 绑定地点极大地在 BV 被堕落。这些数据解释多态的人的 HBGA 选择的官方补给的 11 月的进化路径。当 CBP 被保存时,包围 CBP 的区域是灵活的,提供为变化的自由。H epitope/acetamido 绑定地点的损失和 GI.8 BV 的 Le 有约束力的地点的加强是主机路易斯 epitope 选择的如此的变化的一个典型例子。 | Ning Hao Yutao Chen Ming Xia Ming Tan Wu Liu Xiaotao Guan Xi Jiang Xuemei Li | 2015 | Protein & Cell2015，6，2： | 1 |
| 8 | Overexpression of a cuticle -degrading protease Verll2 increasesthe nematicidal activity of Paecilomyces lilacinus显示文摘 | JINKUI Yang XUNA Zhao UANMING Liang ZHENYUAN Xia UPING Lei XUEMEI Niu CHENGGANG Zou KEQIN Zhang | 2011 | Appl Microbi-ol Biotechnol2011，89，： | 1 |
| 9 | Adaptive parameter identification of linear SISO systems with unknown time-delay显示文摘 | Jing Na Xuemei Ren Yuanqing Xia | 2014 | Systems & Control Letters2014，，： | 1 |
| 10 | Arabidopsis DXO1 possesses deNADding and exonuclease activities and its mutation affects defense-related and photosynthetic gene expression^FA显示文摘RNA capping and decapping tightly coordinate with transcription,translation,and RNA decay to regulate gene expression.Proteins in the DXO/Rai1 family have been implicated in mRNA decapping and decay,and mammalian DXO was recently found to also function as a decapping enzyme for NAD+-capped RNAs(NAD-RNA).The Arabidopsis genome contains a single gene encoding a DXO/Rai1 protein,AtDXO1.Here we show that AtDXO1 possesses both NAD-RNA decapping activity and 5?-3?exonuclease activity but does not hydrolyze the m7G cap.The atdxo1 mutation increased the stability of NAD-RNAs and led to pleiotropic phenotypes,including severe growth retardation,pale color,and multiple devel-opmental defects.Transcriptome profiling analysis showed that the atdxo1 mutation resulted in upregulation@of defense-related genes but downregulation of photo-synthesis-related genes.The autoimmunity phenotype of the mutant could be suppressed by either eds1 or npr1 mutation.However,the various phenotypes associated with the atdxo1 mutant could be complemented by an enzymatically inactive AtDXO1.The atdxo1 mutation ap-parently enhances post-transcriptional gene silencing by elevating levels of siRNAs.Our study indicates that AtDXO1 regulates gene expression in various biological and physiological processes through its pleiotropic mo-lecular functions in mediating RNA processing and decay. | Shuying Pan Kai-en Li Wei Huang Huan Zhong Huihui Wu Yuan Wang He Zhang Zongwei Cai Hongwei Guo Xuemei Chen Yiji Xia | 2020 | Journal of Integrative Plant Biology2020，62，7： | 1 |
| 11 | Biocompatibility of Fe3O4/DNR magnetic nanoparticles in the treatment of hematologic malignancies显示文摘 | Baoan Chen Feng Gao Jing Chen Jun Wang Wei Hulai Jian Cheng Xia Guohua Baoan Chen Liu Lijie Chuanlu Xu Wu Weiwei Bao wen Zhang Yi Ding Jiahua Yang Liya Shen Huiling Yang Mimgming Xu Wenlin Xuemei Wang | 2010 | 2010 (defa)2010，，： | 1 |
| 12 | Direct UV detection of underivatized amino acids using capillary electrophoresis with online sweeping enrichment 显示文摘 | Xuemei Jiang Zhining Xia Weili Wei | 2009 | J Sep Sci2009，32，11： | 1 |
| 13 | Electrochemical biosensor for detection of adenosine based on structure-switching aptamer and amplification with reporter probe DNA modified Au nanopartieles显示文摘 | Zhang Shusheng Xia Jianping Li Xuemei | 2008 | Analytical Chemistry2008，80，22： | 1 |
| 14 | Impact of Cold Spells on Ischemic Stroke Severity and Clinical Outcomes in Tianjin, China显示文摘There are several studies on the impact of extreme weather on the incidence and mortality of stroke, but the research on the effect of extreme weather events on severity and outcome of ischemic stroke is scarce. This study aimed to evaluate the impact of cold spells on the severity and clinical outcomes of patients with initial acute ischemic stroke in a hospital-based study. We enrolled 553 patients with initial ischemic stroke during the cold seasons between 2016 and 2019. Patients were separated into the mild stroke group and moderate-to-severe stroke group according to the National Institutes of Health Stroke Scale(NIHSS) of the U.S., and good outcome group and poor outcome group according to modified Rankin Scale(mRS) scores. There are nine different definitions of cold spells according to intensities and duration time. After adjustment for climate factors, air quality index, and common risk factors, it is found that cold spells were associated with moderate-to-severe neurological deficits and clinical outcomes in overall ischemic stroke patients. Furthermore, the delay effect for stroke severity started at the beginning of the cold wave(Lag 0) and lasted up to 14 days(Lags 0–14). In addition, when a cold spell was set as a daily mean temperature < 3rd or 5th percentile and with a duration ≥ 2 or 3 consecutive days, cold spells had a significant impact on clinical outcomes, and there was a definite delay effect of at least 7 days(Lags 0–7) and it lasted up to 14days(Lags 0–14). At last, we concluded that cold spells may be a contributory factor for more severe neurological deficits and worse outcomes in patients with initial ischemic stroke. | Juanjuan XUE Chanjuan WEI Xiaoshuang XIA Xuemei QI Yumeng GU Zhongyan WANG Suqin HAN Lin WANG Xin LI | 2023 | Journal of Meteorological Research2023，37，4： | 0 |
| 15 | Genetic Architecture of Childhood Kidney and Urological Diseases in China显示文摘Kidney disease is manifested in a wide variety of phenotypes,many of which have an important hereditary component.To delineate the genotypic and phenotypic spectrum of pediatric nephropathy,a multicenter registration system is being imple-mented based on the Chinese Children Genetic Kidney Disease Database(CCGKDD).In this study,all the patients with kidney and urological diseases were recruited from 2014 to 2020.Genetic analysis was conducted using exome sequencing for families with multiple affected individuals with nephropathy or clinical suspicion of a genetic kidney disease owing to early-onset or extrarenal features.The genetic diagnosis was confirmed in 883 of 2256(39.1%)patients from 23 provinces in China.Phenotypic profiles showed that the primary diagnosis included steroid-resistant nephrotic syndrome(SRNS,23.5%),glomerulonephritis(GN,32.2%),congenital anomalies of the kidney and urinary tract(CAKUT,21.2%),cystic renal disease(3.9%),renal calcinosis/stone(3.6%),tubulopathy(9.7%),and chronic kidney disease of unknown etiology(CKDu,5.8%).The pathogenic variants of 105 monogenetic disorders were identified.Ten distinct genomic disorders were identified as pathogenic copy number variants(CNVs)in 11 patients.The diagnostic yield differed by subgroups,and was highest in those with cystic renal disease(66.3%),followed by tubulopathy(58.4%),GN(57.7%),CKDu(43.5%),SRNS(29.2%),renal calcinosis/stone(29.3%)and CAKUT(8.6%).Reverse phenotyping permitted correct identification in 40 cases with clinical reassessment and unexpected genetic conditions.We present the results of the largest cohort of children with kidney disease in China where diagnostic exome sequencing was performed.Our data demonstrate the utility of family-based exome sequencing,and indicate that the combined analysis of genotype and phenotype based on the national patient registry is pivotal to the genetic diagnosis of kidney disease. | Ye Fang Hua Shi Tianchao Xiang Jiaojiao Liu Jialu Liu Xiaoshan Tang Xiaoyan Fang Jing Chen Yihui Zhai Qian Shen Guomin Li Li Sun Yunli Bi Xiang Wang Yanyan Qian Bingbing Wu Huijun Wang Wenhao Zhou Duan Ma Jianhua Mao Xiaoyun Jiang Shuzhen Sun Ying Shen Xiaorong Liu Aihua Zhang Xiaowen Wang Wenyan Huang Qiu Li Mo Wang Xiaojie Gao Yubin Wu Fang Deng Ruifeng Zhang Cuihua Liu Li Yu Jieqiu Zhuang Qing Sun Xiqiang Dang Haitao Bai Ying Zhu Siguang Lu Bili Zhang Xiaoshan Shao Xuemei Liu Mei Han Lijun Zhao Yuling Liu Jian Gao Ying Bao Dongfeng Zhang Qingshan Ma Liping Zhao Zhengkun Xia Biao Lu Yulong Wang Mengzhun Zhao Jianjiang Zhang Shan Jian Guohua He Huifeng Zhang Bo Zhao Xiaohua LI Feiyan Wang Yufeng Li Hongtao Zhu Xinhui Luo Jinghai Li Jia Rao Hong Xu | 2021 | Phenomics2021，1，3： | 0 |
| 16 | Current Situation of Rural Eco-Tourism Development and Countermeasures显示文摘 | XIA Xuemei SUN Lian WANG Fengli | 2016 | International English Education Research2016，，4： | 0 |
| 17 | EXPONENTIAL STABILITY OF DISCRETE-TIME CELLULAR NEURAL NETWORKS WITH DELAYS显示文摘In this paper, a new sufficient condition for the global exponential stability of a unique equilibrium point of discrete-time cellular neural networks is given. It is shown that the condition relies on the feedback matrices and is independent of the delay parameter. Furthermore, this condition is less restrictive than those given in the literature. | Xia Fei Li Xuemei (Dept. of Math., Hunan Normal University, Changsha 410081) | 2006 | Annals of Differential Equations2006，22，3： | 0 |
| 18 | Enhancement of CAR-T cell activity against cholangiocarcinoma by simultaneous knockdown of six inhibitory membrane proteins显示文摘Background:Existing treatments for cholangiocarcinoma have poor efficacy.However,chimeric antigen receptor-T(CAR-T)cells are emerging as a potential therapeutic strategy.Solid tumors possess multiple adverse factors in an immunosuppressive microenvironment that impair CAR-T cell infiltration and function.This study aimed to improve the function of CAR-T cells through knock down immune checkpoints and immunosuppressive molecular receptors.Methods:We evaluated the expression of epidermal growth factor receptor(EGFR)and B7 homolog 3 protein(B7H3)antigens in cholangiocarcinoma tissues using immunohistochemistry and screened specific immune checkpoints in the cholangiocarcinoma microenvironment via flow cytometry.Subsequently,we engineered CAR-T cells targeting EGFR and B7H3 antigens.We simultaneously knocked down immune checkpoints and immunosuppressive molecular receptors in CAR-T cells by constructing two clusters of small hairpin RNAs and evaluated the engineered CAR-T cells for antitumor activity both in vitro,using tumor cell lines and cholangiocarcinoma organoid models,and in vivo,using humanized mouse models.Results:We observed high expression of EGFR and B7H3 antigens in cholangiocarcinoma tissues.EGFR-CAR-T and B7H3-CAR-T cells demonstrated specific anti-tumor activity.We found an abundance of programmed cell death protein 1(PD-1),T cell immunoglobulin and mucin domain-containing protein 3(Tim-3),and T cell immunoglobulin and ITIM domain(Tigit)on infiltrated CD8^(+)T cells in the cholangiocarcinoma microenvironment.We then decreased the expression of these 3 proteins on the surface of CAR-T cells,named PTG-scFV-CAR-T cells.Furthermore,we knocked-down the expression of transforming growth factor beta receptor(TGFβR),interleukin-10 receptor(IL-10R),and interleukin-6 receptor(IL-6R)of PTG-scFV-CAR-T cells.Those cells,named PTG-T16R-scFVCAR-T cells,potently killed tumor cells in vitro and promoted apoptosis of tumor cells in a cholangiocarcinoma organoidmodel.Finally,the PTG-T16R-scFv-CART cells showed greater inhibitory effect on tumor growth in vivo,and were superior in prolonging the survival of mice.Conclusions:Our results revealed that PTG-T16R-scFV-CAR-T cells with knockdown of sextuplet inhibitory molecules exhibited strong immunity against cholangiocarcinoma and long-term efficacy both in vitro and in vivo.This strategy provides an effective and personalized immune cell therapy against cholangiocarcinoma. | Yidan Qiao Jie Chen Xuemei Wang Shumei Yan Jizhou Tan Baijin Xia Yongjian Chen Keming Lin Fan Zou Bingfeng Liu Xin He Yiwen Zhang Xu Zhang Hui Zhang Xiangyuan Wu Lijuan Lu | 2023 | Cancer Communications2023，43，7： | 0 |
| 19 | Study on the Characteristics and Problems of Water Tourism Development in China显示文摘 | XIA Xuemei SUN Lian | 2017 | International English Education Research2017，，2： | 0 |
| 20 | Gamma knife treatment for refractory epilepsy in seizure focus localized by positron emission tomography/CT显示文摘A total of 80 patients with refractory epilepsy were recruited from the Inner Mongolia Medical College Affiliated Hospital. The foci of 60% of the patients could be positioned using a combined positron emission tomography/CT imaging modality. Hyper- and hypometabolism foci were examined as part of this study. Patients who had abnormal metabolism in positron emission tomography/CT imaging were divided into intermittent-phase group and the seizure-phase group. The intermittent-phase group was further divided into a single-focus group and a multiple-foci group according to the number of seizure foci detected by imaging. Following gamma knife treatment, seizure frequency was significantly lower in the intermittent-phase group and the seizure-phase group. Wieser's classification reached Grade Ⅰ or Ⅱ in nearly 40% of patients. Seizure frequency was significantly lower following treatment, but Wieser's classification score was significantly higher in the seizure-phase group compared with the intermittent-phase group. Seizure frequency was significantly lower following treatment in the single-focus group, but Wieser's classification score was significantly higher in the single-focus group as compared with the multiple-foci group. | Xia Bai Xuemei Wang Hongwei Wang Shigang Zhao Xiaodong Han Linjun Hao Xiangcheng Wang | 2012 | Neural Regeneration Research2012，7，36： | 0 |
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