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| 1 | pORF5 plasmid protein of Chlamydia trachomatis induces MAPK-mediated pro-inflammatory cytokines via TLR2 activation in THP-1 cells显示文摘Infection with Chlamydia trachomatis induces inflammatory pathologies in the urogenital tract that can lead to infertility and ectopic pregnancy.Pathogenesis of infection has been mostly attributed to excessive cytokine production.However,precise mechanisms on how C.trachomatis triggers this production,and which protein(s) stimulate inflammatory cytokines remains unknown.In the present study,the C.trachomatis pORF5 protein induced tumor necrosis factor alpha(TNF-α),interleukin-1 beta(IL-1β) and interleukin-8(IL-8) in dose-and time-dependent manners in the THP-1 human monocyte cell line.We found that intracellular p38/mitogen-activated protein kinase(MAPK) and extracellular signal-regulated kinase(ERK)/MAPK signaling pathways were required for the induction of TNF-α,IL-1β and IL-8.Blockade of toll-like receptor 2(TLR2) signaling reduced induction levels of TNF-α,IL-8 and IL-1β.We concluded that the C.trachomatis pORF5 protein might contribute to the inflammatory processes associated with chlamydial infections. | ZHOU Hui HUANG QiuLin LI ZhongYu WU YiMou XIE XiaoBing MA KangKang CAO WenJuan ZHOU Zhou LU ChunXue ZHONG GuangMing | 2013 | Science China(Life Sciences)2013，56，5： | 26 |
| 2 | Controllability of multi-agent systems based on agreement protocols显示文摘This paper investigates the controllability of multi-agent systems based on agreement protocols. First, for a group of single-integrator agents, the controllability is studied in a unified framework for both networks with leader-following structure and networks with undirected graph. Some new necessary/sufficient conditions for the controllability of networks of single-integrator agents are established. Second, we prove that, under the same topology and same prescribed leaders, a network of high-order dynamic agents is completely controllable if and only if so is a network of single-integrator agents. Third, how the selection of leaders and the coupling weights of graphs affect the controllability is analyzed. Finally, some numerical simulations are presented to demonstrate the effectiveness of the theoretical results. | WANG Long JIANG FangCui XIE GuangMing JI ZhiJian | 2009 | Science in China(Series F)2009，52，11： | 19 |
| 3 | Interfacial Microstructure and Properties of a Vacuum Hot Roll-bonded Titanium-Stainless Steel Clad Plate with a Niobium Interlayer显示文摘Vacuum hot roll bonding(VHRB)was used to bond pure titanium(Ti)plate to a 304 stainless steel(SS)plate with a niobium(Nb)interlayer,with the aim of producing a high-quality Ti-SS clad plate.The roll-bonding process was performed at diferent temperatures in the range of 850–1000 C,followed by characterization of microstructure and mechanical properties.The study demonstrates that the interfaces are free from cracks and discontinuities,and interdifusion between the stainless steel and the titanium is efectively prevented by inserting a layer of pure Nb foil.No intermetallic reaction layer occurred at the Nb-Ti interface at any of the investigated temperatures.An intermetallic FeNb phase was formed at the Nb-SS interface when bonding was performed at 950 C and above.The presence of the FeNb layer was confirmed by x-ray difraction.The maximum shear strength of^396 MPa was obtained when bonding is carried out at 900 C.However,the formation of the FeNb layer at roll bonding temperature greater than 900 C led to decrease in shear strength.Ductile fracture occurred through the Ti-Nb interface for roll-bonded temperatures of up to 900 C.On the other hand,at temperature of 950 C and above,failure occurred through the Nb-SS interface,with brittle fracture characteristics. | Zongan LUO Guanglei WANG Guangming XIE Lipeng WANG Kun ZHAO | 2013 | Acta Metallurgica Sinica(English Letters)2013，26，6： | 18 |
| 4 | Consensus of high-order dynamic multi-agent systems with switching topology and time-varying delays显示文摘This paper studies the consensus problems for a group of agents with switching topology and time-varying communication delays,where the dynamics of agents is modeled as a high-order integrator.A linear distributed consensus protocol is proposed,which only depends on the agent's own information and its neighbors'partial information.By introducing a decomposition of the state vector and performing a state space transformation,the closed-loop dynamics of the multi-agent system is converted into two decoupled subsystems.Based on the decoupled subsystems,some sufficient conditions for the convergence to consensus are established,which provide the upper bounds on the admissible communication delays.Also,the explicit expression of the consensus state is derived.Moreover,the results on the consensus seeking of the group of high-order agents have been extended to a network of agents with dynamics modeled as a completely controllable linear time-invariant system.It is proved that the convergence to consensus of this network is equivalent to that of the group of high-order agents.Finally,some numerical examples are given to demonstrate the effectiveness of the main results. | Fangcui JIANG,Long WANG,Guangming XIE(Institute of Intelligent Engineering,Center for Systems and Control,College of Engineering,and Key Laboratory of Machine Perception(Ministry of Education),Peking University,Beijing 100871,China) | 2010 | 控制理论与应用(英文版)2010，8，1： | 11 |
| 5 | Event-triggered Tracking Consensus with Packet Losses and Time-varying Delays显示文摘This paper mainly investigates the event-triggered tracking control for leader-follower multi-agent systems with the problems of packet losses and time-varying delays when both the first-order and the second-order neighbors' information are used. Event-triggered control laws are adopted to reduce the frequency of individual actuation updating under the sampleddata framework for discrete-time agent dynamics. The communication graph is undirected and the loss of data across each communication link occurs at certain probability, which is governed by a Bernoulli process. One numerical example is given to demonstrate the effectiveness of the proposed methods.It is found that the tracking consensus is sped up by using the second-order neighbors' information when packet losses and time-varying delays occur. | Mei Yu Chuan Yan Dongmei Xie Guangming Xie | 2016 | IEEE/CAA Journal of Automatica Sinica2016，3，2： | 7 |
| 6 | Biosorption of zinc(Ⅱ) from aqueous solution by dried activated sludge显示文摘The biosorption potential of dried activated sludge as a biosorbent for zinc(Ⅱ) removal from aqueous solution was investigated.The effects of initial pH,contact time,initial zinc ion concentration,and adsorbent dosage on the biosorption processes were determined,and the equilibrium data were modeled by the Langmuir and Freundlich isotherms.The Langmuir isotherm model (R 2=0.999) was proved to fit the equilibrium data much better than the Freundlich isotherm model (R 2=0.918).The monolayer adsorption capacity of dried activated sludge for zinc(Ⅱ) was found to be 17.86 mg/g at pH of 5 and 25°C.The kinetic data were tested using pseudo firstand second-order models.The results suggested that the pseudo second-order model (R 2 > 0.999) was better for the description of the adsorption behavior of zinc(Ⅱ) onto the dried activated sludge.Fourier transform infrared spectral analysis showed that the dominant mechanism of zinc(Ⅱ) biosorption onto the dried activated sludge was the binding between amide groups and zinc ions. | Chunping Yang Jiaqiang Wang Min Lei Gengxin Xie Guangming Zeng Shenglian Luo | 2010 | Journal of Environmental Sciences2010，22，5： | 6 |
| 7 | Characteristics of Pegmatite-Related Fluids and Significance to Ore-Forming Processes in the Zhaxikang Pb-Zn-Sb Polymetallic Deposit,Tibet,China显示文摘The Zhaxikang Pb-Zn-Sb polymetallic deposit is one of the most important deposits in the newly recognized southern Tibet antimony-gold metallogenic belt.Compared to the porphyry deposits in the Gangdese belt,much less researches have addressed these deposits,and the genesis of the Zhaxikang deposit is still controversial.Based on field investigation,petrographic,microthermometric,Laser Raman Microprobe(LRM) and SEM/EDS analyses of fluid,melt-fluid,melt and solid inclusions in quartz and beryl from pegmatite,this paper documents the characteristics and the evolution of primary magmatic fluid which was genetically related to greisenization,pegmatitization,and silification in the area.The results show that the primary magmatic fluids were derived from unmixing between melt and fluid and underwent a phase separation process soon after the exsolution.The primary magmatic fluids are of low salinity,high temperature,and can be approximated by the H_2O-NaCl-CO_2 system.The presence of Mn-Fe carbonate in melt-fluid inclusions and a Zn-bearing mineral(gahnite) trapped in beryl and in inclusions from pegmatite indicates high Mn,Fe,and Zn concentrations in the parent magma and magmatic fluids,and implies a genetic link between pegmatite and Pb-Zn-Sb mineralization.High B and F concentrations in the parent magma largely lower the solidus of the magma and lead to late fluid exsolution,thus the primary magmatic fluids related to pegmatite have much lower temperature than those in most porphyry systems.Boiling of the primary magmatic fluids leads to high-salinity and high-temperature fluids which have high capacity to transport Pb,Zn and Sb.The decrease in temperature and mixing with fluids from other sources may have caused the precipitation of Pb-Zn-Sn(Au) minerals in the distal fault systems surrounding the causative intrusion. | XIE Yuling WANG Bogong LI Yingxu LI Guangming DONG Suiliang GUO Xiang WANG Lei | 2015 | Acta Geologica Sinica(English Edition)2015，89，3： | 6 |
| 8 | A switched system approach to stabilization of networked control systems显示文摘A switched system approach is proposed to model networked control systems (NCSs) with communication constraints. This enables us to apply the rich theory of switched systems to analyzing such NCSs. Sufficient conditions are presented on the stabilization of NCSs. Stabilizing state/output feedback controllers can be constructed by using the feasible solutions of some linear matrix inequalities (LMIs). The merit of our proposed approach is that the behavior of the NCSs can be studied by considering switched system without augmenting the system. A simulation example is worked out to illustrate the effectiveness of the proposed approach. | Mei YU Long WANG Guangming XIE | 2006 | 控制理论与应用(英文版)2006，4，1： | 4 |
| 9 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 10 | Microstructure Control of Nanoporous Silica Thin Film Prepared by Sol-gel Process显示文摘Nanoporous 硅石电影被大音阶的第五音胶化过程与底准备,酸 andbase/acid 二拍子的圆舞催化作用。传播电子显微镜(TEM ) 和粒子尺寸分析器被用来描绘微观结构和粒子尺寸 sols.Scanningelectron 显微镜学(SEM ) 的分发,原子力量显微镜学(AFM ) 和分光镜的 ellipsometer 被用来描绘表面微观结构和硅石电影的光性质。大音阶的第五音的稳定性在长期的存储期间被调查。而且,硅石电影的光常数的分散关系,和微观结构的控制和由在大音阶的第五音胶化期间改变催化作用条件的电影的性质处理也被讨论。 | Yiqun XIAO Jun SHEN Zhiyong XIE Bin ZHOU Guangming WU | 2007 | Journal of Materials Science & Technology2007，23，4： | 4 |
| 11 | Induction of xenogeneic islet transplantation tolerance by simultaneously blocking CD28-B7 and OX40-OX40L co-stimulatory pathways显示文摘It has been demonstrated that prolonged graft survival can be achieved through inhibiting the activation of T cells, and addition of soluble CTLA4Ig and OX40Ig proteins to mixed lymphocyte reactions can effectively inhibit T cell proliferation. To explore the potential of this type of treatment in xenotransplantation, we infected streptozotocin-induced diabetic BalB/c mice (H-2d) (200 mg/kg, IV) with 5×108 pfu AdCTLA4Ig-IRES-OX40Ig on day 1 before islets trans-plantation through the tail vein. The results showed that this treatment prolonged the islet xeno-grafts survival significantly. The reaction to exogenous glucose stimulation was normal and the cytokine secretion of the type Th1 cells was inhibited. The AdCTLA4Ig-IRES-OX40Ig-mediated treatment effectively induced the T cells into anergy and the Th1/Th2 cells into deviation. These results strongly supported the therapeutic potential of blockade of costimulation by Ad-CTLA4Ig-IRES-OX40Ig genes transfer in inducing the organ transplantation tolerance. | WANG Guangming FENG Yougang HAO Jie LI Ailing GAO Xiang XIE Shusheng | 2005 | Science China(Life Sciences)2005，48，5： | 4 |
| 12 | GROUP CONSENSUS FOR MULTIPLE NETWORKED EULER-LAGRANGE SYSTEMS WITH PARAMETRIC UNCERTAINTIES显示文摘In this paper,a group consensus problem is investigated for multiple networked agents with parametric uncertainties where all the agents are governed by the Euler-Lagrange system with uncertain parameters.In the group consensus problem,the agents asymptotically reach several different states rather than one consistent state.A novel group consensus protocol and a time-varying estimator of the uncertain parameters are proposed for each agent in order to solve the couple-group consensus problem.It is shown that the group consensus is reachable even when the system contains the uncertain parameters.Furthermore,the multi-group consensus is discussed as an extension of the couple-group consensus,and then the group consensus with switching topology is considered.Simulation results are finally provided to validate the effectiveness of the theoretical analysis. | HU Hongxiang ZHANG Zhe YU Li YU Wenwu XIE Guangming | 2014 | Journal of Systems Science & Complexity2014，27，4： | 3 |
| 13 | A damage-based constitutive model for rock under impacting load显示文摘Using the Splitting Hopkinson Pressure Bar(SHPB) experimental system, investigations were made into the dynamic mechanical performances of underground soft rocks. The experiments proved that the measured stress–strain curves display the characteristics of plastic deformation. By making use of a revised overstress constitutive formula for the stress model and by taking into account that the strain rate and strain are a function of 1 E(t)/E0, a revised overstress constitutive formula for the stress model was simplified by applying dimensional analysis and consequently, a simplified overstress formula was obtained for the stress model. Then, by taking into consideration the effects of damage under a dynamic load on the dynamic loading strength of the rock, the continuous damage theory and the statistical strength theory were introduced into the development of the simplified overstress constitutive formula for the stress model. Hence, a damage-based constitutive formula for an overstress model, which can be appropriately applied to the analysis of full dynamic stress–strain curves, was developed. By using the simplified damage-based constitutive formula for an overstress model, the actually measured curves are fitted, indicating that the fitting curves and those actually measured are in good agreement. | Guangming Zhao Lixiang Xie Xiangrui Meng | 2014 | International Journal of Mining Science and Technology2014，24，4： | 3 |
| 14 | Spectroscopic studies of dye-surfactant interactions with the co-existence of heavy metal ions for foam fractionation显示文摘The interaction between a cationic dye Methylene Blue(MB) and an anionic surfactant sodium dodecyl sulfate(SDS) with the presence of Cd2+ was investigated spectrophotometrically in a certain concentration range.The spectrophotometric measurements of dye-metal ion-surfactant system were carried out.The results indicated that the SDS concentration had a significant influence on the dye spectrum,while the addition of Cd2+ hardly caused change of the maximum value of absorbance.According to this observation,we concluded that electrostatic and hydrophobic interaction between dye and surfactant occurred up to a certain level,and the homo-ions Cd2+ almost exerted no effect on the dye-surfactant complexation,establishing a theoretical foundation for simultaneous removal of organic dye and heavy metal using foam fractionation.Meanwhile,the effects of their interaction on foam performance were investigated.The results showed that the addition of Cd2+ favored the tendency to ameliorate foam properties just contrary to MB.The feasibility of foam separation for dye and heavy metal removal from simulated wastewater was also confirmed using a continuous foam fractionator.In the simultaneous removal process,with the initial SDS concentration ranging from 0.5 to 5.0mmol/L,the maximum removal efficiencies of MB and Cd2+ were obtained as 99.69% and 99.61%,respectively.The enrichment ratios were reduced from24.34 to 7.65 for MB and from22.01 to 3.35 for Cd2+. | Dongmei Zhang Guangming Zeng Jinhui Huang Wenkai Bi Gengxin Xie | 2012 | Journal of Environmental Sciences2012，24，12： | 2 |
| 15 | Fish Lateral Line Inspired Flow Sensors and Flow-aided Control: A Review显示文摘Any phenomenon in nature is potential to be an inspiration for us to propose new ideas.Lateral line is a typical example which has attracted more interest in recent years.With the aid of lateral line,fish is capable of acquiring fluid information around,which is of great significance for them to survive,communicate and hunt underwater.In this paper,we briefly introduce the morphology and mechanism of the lateral line first.Then we focus on the development of artificial lateral line which typically consists of an array of sensors and can be installed on underwater robots.A series of sensors inspired by the lateral line with different sensing principles have been summarized.And then the applications of artificial lateral line systems in hydrodynamic environment sensing and vortices detection,dipole oscillation source detection,and autonomous control of underwater robots have been reviewed.In addition,the existing problems and future foci in this field have been further discussed in detail.The current works and future foci have demonstrated that artificial lateral line has great potentials of applications and contributes to the development of underwater robots. | Yufan Zhai Xingwen Zheng Guangming Xie | 2021 | Journal of Bionic Engineering2021，18，2： | 2 |
| 16 | Stabilization of switched linear systems with time-delay in detection of switching signal 显示文摘 | Xie Guangming Wang Long | 2005 | Journal of Mathematical Analysis and Appli- cations2005，305，1： | 1 |
| 17 | Mixed strategy under generalized public goods games显示文摘 | Yanling Zhang Te Wu Xiaojie Chen Guangming Xie Long Wang | 2013 | Journal of Theoretical Biology2013，，： | 1 |
| 18 | Experimental Investigation and Visualization Study of the Condensation Characteristics in a Propylene Loop Heat Pipe显示文摘At present,the structural design of a loop heat pipe(LHP)condenser mostly relies on experience.To analyze the condensation flow pattern in an LHP and to find a more accurate empirical correlation that can better guide condenser design in existing empirical correlations,a test system was designed and fabricated to observe the condensation phenomenon in the condenser and to evaluate the LHP’s heat transfer performance.Since propylene has a wide temperature range to different temperature control requirements,it was chosen as the working fluid.In this paper,the condensation process in the condenser was observed,and the operating parameters of a propylene LHP were measured at 283 K.The condensation flow patterns in the 2.5 mm×2.5 mm channel mainly included stratified flow,wavy flow and intermittent flow.By comparing the experimental results with four typical condensation flow regime maps,it was found that the Breber and Cavallini flow regime maps can successfully predict most of the condensation flow patterns of the LHP even with ultra-small mass flux.In addition,four condensation heat transfer coefficient correlations were selected to compare the predicted values of heat transfer coefficient with the experimental results.The study showed that the predicted values from the correlation by Cavallini et al.matched 90%of the experimental values well with an error of less than 20%,and this correlation is recommended for highly accurate LHP design. | YAN Kaifenu XIE Rongjian LI Nanxi XU Guangming WU Yinong | 2021 | Journal of Thermal Science2021，30，5： | 1 |
| 19 | Adaptive Task Assignment for Multiple Mobile Robots via Swarm Intelligence Approach显示文摘 | Zhang Dandan Xie Guangming Yu Junzhi | 2007 | Robotics and Autonomous Systems2007，55，7： | 1 |
| 20 | Experimental Re-search on Effects of Initial Joints on Surface Displacement Duo to Coal Mining 显示文摘 | Xie Heping Yu Guangming and Yang Lun etc | 1999 | Journal of Coal Science & Engineering1999，5，1： | 1 |
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