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| 1 | Clinical characteristics and effectiveness of antiviral agents in hospitalized children with infectious mononucleosis in China:A multicenter retrospective study显示文摘Importance:The clinical characteristics of infectious mononucleosis(IM)in Chinese children have not been evaluated in multicenter studies,and the effectiveness of antiviral treatment are controversial.Objective:To investigate the clinical characteristics of Chinese children with IM and current status of antiviral therapy for affected patients.Methods:Hospitalized patients with IM were enrolled between 2018 and 2020 in five children’s hospitals in China.The clinical characteristics were compared among four age groups:<3 years,3-<6 years,6-<10 years,and≥10 years.The clinical characteristics of IM and effectiveness of antiviral therapy were compared among patients receiving acyclovir(ACV),ganciclovir(GCV),and no antiviral therapy(i.e.,non-antiviral group).Results:In total,499 patients were analyzed;most patients were 3-<6 years of age.The most common symptoms and signs included fever(100%),lymphadenopathy(98.6%),pharyngitis(86.4%),eyelid edema(76.8%),and snoring(72.9%).There were significant differences in rash,hepatomegaly,and liver dysfunction among the four age groups.Patients aged<3 years had a lower incidence of liver dysfunction and a higher incidence of rash.Among the 499 patients,50.1%were treated with GCV,26.3%were treated with ACV,and 23.6%received no antiviral therapy.Compared with the non-antiviral group,patients in the ACV and GCV groups had longer durations of fever(P<0.001).There were no significant differences in the incidences of complications among the three treatment groups.Interpretation:The incidence of IM in Chinese children peaked at 3-<6 years of age.Clinical features of IM varied according to age.Patients receiving antiviral therapy exhibited more serious clinical manifestations than did patients without antiviral therapy.The effectiveness of antiviral therapy for IM requires further analysis. | Huili Hu Huiling Deng Jing Bi Yi Xu Shuangjie Li Yue Xie Xinrong Sun Dongmeng Wang Xufang Li Wenxian Ouyang Bing Hu Yufeng Zhang He Tang Chunxiao Fang Hui Zhang Lingyun Guo Chen Wang Tianyi Wang Fengxia Yang Tao Jiang Zhengde Xie Gang Liu | 2021 | Pediatric Investigation2021，5，3： | 12 |
| 2 | Effect of Calcium Oxide Additive on the Performance of Iron Oxide Sorbent for High-Temperature Coal Gas Desulfurization显示文摘The effect of calcium oxide additive in iron oxide sorbent for hot gas desulfurization was investigated by XRD and TPR techniques.XRD characterization showed that CaO was highly dispersed after the calcination of sorbents.Calcium sulfate formed in the desulfurization was decomposed and regenerated to CaO by reacting with CO before the next sulfidation process.Calcium participated in every sulfidation/regeneration cycle and contributed to the enhancement of sulfur capacity.The TPR results showed that the reduction temperature of the sorbent increased with the increase of the content of calcium.Calcium played a role of retarding reduction.Therefore,the addition of calcium oxide additive will benefit the utilization of iron oxide sorbent in strongly reducing atmospheres. | Huiling Fan Kechang Xie Ju Shangguan Fang Shen Chunhu Li | 2007 | Journal of Natural Gas Chemistry2007，16，4： | 7 |
| 3 | MiR-29a/b/c regulate human circadian gene hPER1 expression by targeting its 3/UTR显示文摘在哺乳动物的几必要生物进步被生理节奏的节奏调整。不过分子的机制 ofoscillating 这些生理节奏的节奏被揭开了,生理节奏的基因的特定的功能不是很, clear.It 被报导了那由 microRNA 将生理节奏的基因击倒是有用策略探索 circadianrhythms 的功能。在这研究,通过屏蔽途径的前面的生物信息学,我们作为有势力 inhibitorsfor 识别了 miR-29a/b/c 人的生理节奏的基因 hPER1。我们进一步发现 miR-29a/b/c 能直接在人的 A549 房间在 mRNA 和蛋白质表示层次指向 hPER1 3untranslated 区域(UTR ) 和下面调整 hPER1。因此,我们的调查结果建议 hPER1 的表示被 miR-29a/b/c 调整,它可以也为 hPER1 的功能提供新线索。 | Xiyan Zhao Xueqiang Zhu Shuting Cheng Yizhou Xie Zhengrong Wang Yanyou Liu Zhou Jiang Jing Xiao Huiling Guo Yuhui Wang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，4： | 7 |
| 4 | miR-106a confers cisplatin resistance by regulating PTEN/Akt pathway in gastric cancer cells显示文摘最近的研究证明了 microRNA-106a (miR-106a ) 是在胃的癌症的 overexpressed 并且贡献肿瘤生长。在这研究,我们调查了 miR-106a 是否调停了到化学疗法的代理人 cisplatin (DDP ) 的胃的癌症房间线 SGC7901 的抵抗。MiR-106a 表示与它的父母线 SGC7901 相比在 DDP 抵抗房间线 SGC7901/DDP 是起来调整的。miR-106a 的 Transfection 在 SGC7901 导致了 DDP 抵抗,当在 SGC7901/DDP 的 miR-106a 的抑制导致了提高的 DDP cytotoxicity 时。进一步的学习显示 miR-106a-induced DDP 抵抗的机制包含了从染色体 10 删除的磷酸酶和 tensin 相当或相同的事物(PTEN ) 的表示蛋白质和它的下游的 phosphatidylinositol 3 kinase (PI3K )/protein kinase B (AKT ) 小径。这研究在胃的癌症提供 DDP 抵抗的新奇机制。 | Yue Fang Huiling Shen Hao Li Yuan Cao Rong Qin Lulu Long Xiaolan Zhu Chanjuan Xie Wenlin XU | 2013 | Acta Biochimica et Biophysica Sinica2013，45，11： | 6 |
| 5 | A nanocleaner specifically penetrates the blood-brain barrier at lesions to clean toxic proteins and regulate inflammation in Alzheimer's disease显示文摘Insurmountable blood-brain barrier(BBB) and complex pathological features are the key factors affecting the treatment of Alzheimer's disease(AD).Poor accumulation of drugs in lesion sites and undesired effectiveness of simply reducing Aβ deposition or TAU protein need to be resolved urgently.Herein,a nanocleaner is designed with a rapamycin-loaded ROS-responsive PLGA core and surface modification with KLVFF peptide and acid-cleavable DAG peptide [R@(ox-PLGA)-KcD].DAG can enhance the targeting and internalization effect of nanocleaner towards neurovascular unit endothelial cells in AD lesions,and subsequently detach from nanocleaner in response to acidic microenvironment of endosomes to promote the transcytosis of nanocleaner from endothelial cells into brain parenchyma.Then exposed KLVFF can capture and carry Aβ to microglia,attenuating Aβ-induced neurotoxicity.Strikingly,rapamycin,an autophagy promoter,is rapidly liberated from nanocleaner in the high ROS level of lesions to improve Aβ degradation and normalize inflammatory condition.This design altogether accelerates Aβ degradation and alleviates oxidative stress and excessive inflammatory response.Collectively,our finding offers a strategy to target the AD lesions precisely and multi-pronged therapies for clearing the toxic proteins and modulating lesion microenvironment,to achieve efficient AD therapy. | Ting Lei Zhihang Yang Xue Xia Yuxiu Chen Xiaotong Yang Rou Xie Fan Tong Xiaolin Wang Huile Gao | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 4 |
| 6 | The fabrication and optimization of OTFT formaldehyde sensors based on Poly(3-hexythiophene)/ZnO composite films显示文摘Formaldehyde(HCHO),a colorless and pungent-smelling gas,is confirmed be a huge threat to human health.The detection of formaldehyde is necessary and important.The Poly(3-hexythiophene)(P3HT)/ZnO organic-inorganic composite thin film was fabricated and used as the sensitive layer of organic thin film transistors(OTFT) by spray-deposited method to detect HCHO at room temperature.The process parameters such as P3HT/ZnO weight ratios and airbrushed masses were optimized.The results showed that P3HT/ZnO OTFT exhibited good sensing response to HCHO.Airbrushed mass of 1ml was the optimal mass,and the 1:1 and 1:5 weight ratios of P3HT/ZnO exhibited better sensing properties compared with others.OTFT gas sensors based on P3HT/ZnO composite film provides a novel promising approach to the detection of HCHO. | LI Xian JIANG YaDong TAI HuiLing XIE GuangZhong DAN WenChao | 2013 | Science China(Technological Sciences)2013，56，8： | 3 |
| 7 | Flexible organic thin-film transistors based on poly(3-hexylthiophene) films for nitrogen dioxide detection显示文摘Flexible nitrogen dioxide(NO_2) gas sensors based on organic thin-film transistors(OTFTs) were developed in this work, in which conductive indium tin oxide(ITO) coated polyethylene naphthalene-2,6-dicarboxylate(PEN) was designed for the flexible substrates, and poly methyl methacrylate(PMMA) and poly(3-hexylthiophene)(P3HT) was spin-coated as the gate dielectric layer and spray-deposited as the active layer, respectively. The effects of PMMA concentrations and P3HT solution volume on performances of flexible OTFTs were systematically investigated. The results showed that the optimized flexible OTFT exhibited high field-effect mobility(9.51×10^(–3) cm^2/(V s) at a gate bias of –50 V) and excellent response characteristics,including high sensitivity(up to 0.169 ppm^(–1)), good repeatability and selectivity. The flexibility of the developed OTFT sensor was also investigated, and the results showed that the electrical and gas-sensing properties were affected by the bending cycles,thus further work should be done for improving the flexibility of the sensor. This work provides an effective approach in developing high performance flexible OTFT NO_2 gas sensor. | YANG Jing XIE GuangZhong SU YuanJie ZHANG QiuPing DU HongFei TAI HuiLing DU XiaoSong JIANG YaDong | 2018 | Science China(Technological Sciences)2018，61，11： | 3 |
| 8 | Synthesis and DNA Adsorption of Poly(2-Vinyl-4,6-Diamino-1,3,5-Triazine)Coated Polystyrene Microspheres显示文摘To take advantage of the polymer's special properties, we synthesized PVDAT coated polystyrene(PVDAT@PS) microspheres through semi-continuous precipitation polymerization, and demonstrated the possibility of controlling the size of microspheres by using different sized PS cores. Mechanism of the microsphere synthesis was investigated. Preliminary application studies indicated that the synthesized microspheres adsorbed double-stranded DNAs(dsDNAs) comprising A-T base pairs in pH7.4 phosphate buffered saline, and the adsorption capacity was in a range of 3.28 mg to 5.58 mg per gram PVDAT@PS microspheres depending on A-T base pair percentage and chain length of the dsDNAs. | 黄雷 王小涛 XIE Xun XIE Weihong LI Xuefeng GONG Xinghou LONG Shijun GUO Huiling 刘最芳 | 2018 | Journal of Wuhan University of Technology(Materials Science)2018，33，4： | 3 |
| 9 | The potato amylase inhibitor gene Sb AI regulates cold‐induced sweetening in potato tubers by modulating amylase activity显示文摘 | Huiling Zhang Jun Liu Juan Hou Ying Yao Yuan Lin Yongbin Ou Botao Song Conghua Xie | 2014 | Plant Biotechnol J2014，，7： | 2 |
| 10 | StInvInh2 as an inhibitor of Stvac INV 1 regulates the cold‐induced sweetening of potato tubers by specifically capping vacuolar invertase activity显示文摘 | Xun Liu Yuan Lin Jun Liu Botao Song Yongbin Ou Huiling Zhang Meng Li Conghua Xie | 2013 | Plant Biotechnol J2013，，5： | 2 |
| 11 | miR‐145 sensitizes ovarian cancer cells to paclitaxel by targeting Sp1 and Cdk6显示文摘 | Xiaolan Zhu Yuefeng Li Chanjuan Xie Xinming Yin Yueqin Liu Yuan Cao Yue Fang Xin Lin Yao Xu Wenlin Xu Huiling Shen Jian Wen | 2014 | Int. J. Cancer2014，，： | 2 |
| 12 | Poly(ADP-ribose) mediates asymmetric division of mouse oocyte显示文摘在授精前,哺乳动物的卵母细胞经历取决于形成极的身体和一个鸡蛋的在卵母细胞外皮的锭子的怪癖的放的一个不对称的部门。因为中吣粒是不在的,作为结果,极的数组微导管充分没在卵母细胞被开发,微导管是为锭子的怪癖的放要求了很少被考虑了,当肌动朊相关的力量相反被建议了为这进程主要负责时。然而,存在模型大部分正在冲突,不对称的分割的内在的机制仍然是逃犯的。这里,我们证明(自动数据处理核糖)( 同等) 那 poly 在老鼠卵母细胞被充实在整个成熟分裂的外皮的区域。在一支宫外的锭子和不对称的分割的失败的外皮的同等结果的特定的移动。在锭子移植期间,当锭子由细胞质的肌动朊的推的力量从卵母细胞的中心背离时,从 juxtacortical 锭子杆发出的短极的数组微导管延长到外皮并且渗透进外皮的同等,停靠并且稳定在便于不对称的部门的外皮的锭子。这个过程取决于与同等和联系微导管的蛋白质例如的亲密关系细长纤弱,它为外皮的同等和锭子贡献一个物理连接。尤其是,熔化同等绑定域到结束绑定蛋白质 3,在极的数组微导管的正结束的追踪蛋白质,恢复卵母细胞的不对称的部门与细长纤弱击倒。因此,我们的工作为卵母细胞锭子放和不对称的分割表明全面机制。 | Bingteng Xie Lu Zhang Huiling Zhao Qingyun Bai Yong Fan Xiaohui Zhu Yang Yu Rong Li Xin Liang Qing-Yuan Sun Mo Li Jie Qiao | 2018 | Cell Research2018，28，4： | 2 |
| 13 | Gas sensors for CO_2 detection based on RGO–PEI films at room temperature显示文摘In this paper,polyethyleneimine(PEI)and reduced graphene oxide(RGO)were selected as sensing materials for carbon dioxide detection.Two kinds of sensors with different sensitive film structures,i.e.,RGO–PEI composite film and RGO–PEI bi-layer film were fabricated by airbrushing the sensitive films on interdigitated electrodes.Response performances of both sensors at room temperature were investigated.Results showed that sensors with bi-layer film exhibited smaller baseline drift and more stable sensing characteristics than the counterparts with composite film.Furthermore,bi-layer film sensors with different quantity of PEI solution deposited were studied.Performances of long-time stability,repeatability,low concentration of detection for carbon dioxide,and measurements of response time and recovery time were investigated.It was found that appropriate weight ratio of RGO and PEI was critical for sensing response.In addition,the sensor with bi-layer film exhibited a better repeatability but had longer response time and recovery time than RGO single-layer sensor,and both of them could detect as low as20 parts per million carbon dioxide gas.Sensing responses of the prepared sensors to carbon dioxide under dry air or nitrogen were compared.The relevant sensing mechanisms were studied as well. | Yong Zhou Yadong Jiang Guangzhong Xie Mei Wu Huiling Tai | 2014 | Chinese Science Bulletin2014，59，17： | 2 |
| 14 | Adsorption behaviors of gas molecules on the surface of ZnO nanocrystals under UV irradiation显示文摘A UV-activated room temperature chemiresistive gas sensor based on ZnO nanocrystals film was fabricated. Its gas sensing properties under various conditions were also investigated in detail. The results shed new insight into the adsorption behaviors of gas molecules on the surface of ZnO nanocrystals under UV irradiation. The chemisorbed oxygen species(O^-2(ads)(hv)) induced by UV light govern the adsorption and desorption ways of other gas molecules on the surface of ZnO nanocrystals, which is dependent on the electron affinity of gas molecules. Gas molecules with higher electron affinity than oxygen molecules can be adsorbed on the surface by the competitive adsorption way, extracting electrons from the surface. Gas molecules with lower electron affinity than oxygen molecules are attracted by the adsorbed O^-2(ads)(hv)layer, releasing electrons to the surface. These processes can influence the gas sensing properties of the sensor. Our findings will pave the way for the fundamental understanding and design of UV-activated gas sensor in the future. | ZHANG QiuPing XIE GuangZhong DU HongFei YANG Jing SU YuanJie TAI HuiLing XU Ming ZHAO Kang | 2019 | Science China(Technological Sciences)2019，62，12： | 1 |
| 15 | Selenium-enriched Cardamine violifolia protects against sepsis-induced intestinal injury by regulating mitochondrial fusion in weaned pigs显示文摘Sepsis is a life-threatening organ dysfunction caused by the dysregulated response of the host to an infection, and treatments are limited. Recently, a novel selenium source, selenium-enriched Cardamine violifolia(SEC) has attracted much attention due to its anti-inflammatory and antioxidant properties, but little is known about its role in the treatment of sepsis. Here, we found that SEC alleviated LPS-induced intestinal damage, as indicated by improved intestinal morphology, and increased disaccharidase activity and tight junction protein expression. Moreover, SEC ameliorated the LPS-induced release of pro-inflammatory cytokines, as indicated by decreased IL-6 level in the plasma and jejunum. Moreover, SEC improved intestinal antioxidant functions by regulating oxidative stress indicators and selenoproteins. In vitro, TNF-α-challenged IPEC-1 cells were examined and showed that selenium-enriched peptides, which are the main functional components extracted from Cardamine violifolia(CSP), increased cell viability, decreased lactate dehydrogenase activity and improved cell barrier function. Mechanistically, SEC ameliorated LPS/TNF-α-induced perturbations in mitochondrial dynamics in the jejunum and IPEC-1 cells. Moreover, CSPmediated cell barrier function is primarily dependent on the mitochondrial fusion protein MFN2 but not MFN1. Taken together,these results indicate that SEC mitigates sepsis-induced intestinal injury, which is associated with modulating mitochondrial fusion. | Dan Wang Yanling Kuang Qingqing Lv Wenshuai Xie Xiao Xu Huiling Zhu Yue Zhang Xin Cong Shuiyuan Cheng Yulan Liu | 2023 | Science China(Life Sciences)2023，66，9： | 1 |
| 16 | DDR1 promotes LoVo cell proliferation by regulating energy metabolism显示文摘Cellular energy metabolism dysregulation is associated with colorectal cancer(CRC)development and progression.Discoidin domain receptor 1a(DDR1a),one of the five DDR1 isoforms,is closely related to cell proliferation,invasion,and apoptosis in various tumors.Whether it participates in cellular metabolic reprogramming and regulates CRC initiation and progression remains unclear.In this study,we compared the expression of DDR1 in CRC tissues and adjacent tissues from 126 postoperative CRC samples.Moreover,lentivirus-mediated DDR1a overexpression and knockdown were performed in LoVo cells,and cell viability and proliferation were determined by CCK-8 and BrdU assays,respectively.Oxygen consumption rate,extracellular acidification rate,and lactate production were used to determine the effect of DDR1a on metabolic reprogramming.Clinically,CRC patients with high DDR1 expression had poor differentiation and were at an advanced TNM stage.DDR1a promoted LoVo cell proliferation,mitochondrial function,and extracellular acidification.Moreover,DDR1a knockdown inhibited intracellular lactic acid production in LoVo cells,while a pyruvate kinase inhibitor(diamide,200μM)significantly reversed this progression.Taken together,our results reveal that DDR1 plays a crucial role in maintaining intracellular environment homeostasis through metabolic reprogramming. | Bin Xiong Zehui Xie Feixue Song Huiling Chen Xiaojuan Wang Zhengxu Jin Tiyun Han Yi Li Dekui Zhang | 2022 | Acta Biochimica et Biophysica Sinica2022，54，5： | 1 |
| 17 | Influence of polymerization temperature on NH3 response of PANI/TiO2 thin film gas sensor 显示文摘 | Tai Huiling Jiang Yadong Xie Guangzhong | 2008 | Sensors and Actuators B: Chemical2008，129，1： | 1 |
| 18 | Integrated dispatch of generation and load: A pathway towards smart grids显示文摘 | Haiwang Zhong Qing Xia Ye Xia Chongqing Kang Le Xie Wen He Huiling Zhang | 2014 | Electric Power Systems Research2014，，： | 1 |
| 19 | Fabrication and gas sensitivity of polyaniline–titanium dioxide nanocomposite thin film显示文摘 | Huiling Tai Yadong Jiang Guangzhong Xie Junsheng Yu Xuan Chen | 2007 | Sensors & Actuators: B Chemical2007，，2： | 1 |
| 20 | A carbon monoxide sensor based on single-walled carbon nanotubes doped with copper chloride显示文摘A carbon monoxide gas sensor based on single-walled carbon nanotube(SWCNT)has been developed for detection of carbon monoxide(CO)at room temperature.Copper chloride(CuCl)was mixed with SWNT by mechanical blending.The thin film was deposited on interdigitated electrodes by using airbrush technology.This paper described the fabrication of the sensor for detecting carbon monoxide with concentrations from 20 ppm to 100 ppm.The performance of CO gas sensor was measured by using relevant apparatus to obtain the continuous sensor electric resistance change on exposure to CO and air atmosphere at room temperature,respectively.The results exhibited that the senor presented a larger sensitivity and a good recoverability.The experimental results suggested the potential use of CuCl doped SWCNT for CO detecting. | ZHANG GuangDi TAI HuiLing XIE GuangZhong JIANG YaDong ZHOU Yong | 2013 | Science China(Technological Sciences)2013，56，10： | 1 |
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