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| 1 | First dark matter search results from the PandaX-Ⅰ experiment显示文摘We report on the first dark-matter(DM)search results from PandaX-I,a low threshold dual-phase xenon experiment operating at the China JinPing Underground Laboratory.In the 37-kg liquid xenon target with 17.4 live-days of exposure,no DM particle candidate event was found.This result sets a stringent limit for low-mass DM particles and disfavors the interpretation of previously-reported positive experimental results.The minimum upper limit,3.7×10-44cm2,for the spin-independent isoscalar DM-particle-nucleon scattering cross section is obtained at a DM-particle mass of 49 GeV/c2at 90%confidence level. | XIAO MengJiao XIAO Xiang ZHAO Li CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HU Jie HUANG XingTao JI XiangDong JU YongLin LEI SiAo LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing STEPHENSON Scott TAN AnDi TARL Greg WANG HongWei WANG JiMin WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIE PengWei YOU YingHui ZENG XiongHui ZHANG Hua ZHANG Tao ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，11： | 10 |
| 2 | PandaX: a liquid xenon dark matter experiment at CJPL显示文摘PandaX is a large liquid-xenon detector experiment usable for direct dark-matter detection and 136Xe double-beta decay search.The central vessel was designed to accommodate a staged target volume increase from initially 120 kg(stage I)to 0.5 t(stage II)and eventually to a multi-ton scale.The experiment is located in the Jinping Deep-Underground Laboratory in Sichuan,China.The detector operates in dual-phase mode,allowing detection of both prompt scintillation,and ionization charge through proportional scintillation.In this paper a detailed description of the stage I detector design and performance as well as results established during the commissioning phase are presented. | CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HE Ming HU Jie HUANG XingTao JI XiangDong JU YongLin LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing SHI YuJie STEPHENSON Scott TAN AnDi TARLé Greg WANG HongWei WANG JiMing WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIAO MengJiao XIAO Xiang XIE PengWei YE Tao YOU YingHui ZEN XiongHui ZHANG Hua ZHANG Tao ZHAO HaiYing ZHAO Li ZHOU XiaoPeng ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，8： | 9 |
| 3 | Clinical phenotype network: the underlying mechanism for perso- nalized diagnosis and treatment of traditional Chinese medicine显示文摘繁体中文药(TCM ) 在个性化的药的一个典型纲要调查临床的诊断和治疗整齐,它意味着有一样的疾病的个性化的病人将从不同 TCM 医生获得不同诊断和最佳的治疗。这个原则被 TCM 临床的专业人员认出并且粘住几千年了。然而,个性化的药不是的 TCM 的内在的机制到目前为止充分调查了并且仍然保持未知。这份报纸讨论 TCM 的框架在经典文学并且在真实世界的临床的背景的个性化的药,并且调查 TCM 的内在的机制从网络药的观点的个性化的药。在失眠上基于 246 个设计得好的门诊病人记录,由评估表明观察的个人偏爱和植物药方的偏爱,我们注意了每张植物药方的重要类似和每相遇的症状类似。为了调查 TCM 的内在的机制,个性化药,我们构造了一个临床的显型网络(CPN ) ,在哪个临床的显型实体喜欢症状并且诊断作为连接表现为在这些实体之间的节点和关联。这 CPN 被用来调查症候群和症状的同现的混杂的边界。小世界的拓扑的特征与高聚类结构在 CPN 被注意,它在 TCM 的合理性上提供卓见个性化的诊断和处理。这个网络上的调查将帮助我们在 TCM 的内在的机制上获得理解个性化的药并且将为 TCM 的精炼建议一个新观点个性化的临床的技巧。 | Xuezhong Zhou Yubing Li Yonghong Peng Jingqing HU Runshun Zhang Liyun He Yinghui Wang Lijie Jiang Shiyan Yan Peng Li Qi Xie Baoyan Liu | 2014 | Frontiers of Medicine2014，8，3： | 7 |
| 4 | Oceanic internal solitary waves at the Indonesian submarine wreckage site显示文摘On 21 April 2021 local time(20 April UTC),the Indonesian Navy submarine(KRI Nanggala-402)sank near the Lombok Strait,~100 km north of the Bali Island(see magenta star in Fig.1a),with 53 crew members dead.On the basis of Moderate Resolution Imaging Spectroradiometer(MODIS)satellite images(Jackson,2007)。 | Yankun Gong Jieshuo Xie Jiexin Xu Zhiwu Chen Yinghui He Shuqun Cai | 2022 | Acta Oceanologica Sinica2022，41，3： | 3 |
| 5 | Adaptive synchronization between two different chaotic neu-ral networks with time delay显示文摘 | ZHANG Huaguang XIE Yinghui WANG Zhiliang | 2007 | IEEE Trans Neural Network2007，18，6： | 1 |
| 6 | Adaptive synchronization between two different chaotic neural networks with time delay显示文摘 | Zhang Huaguang Xie Yinghui Wang Zhiliang | 2007 | IEEE Transactions on Neural Networks2007，18，6： | 1 |
| 7 | Synthesis of lithium ion-sieve with fractional steps 显示文摘 | JiZhiyong Yuan Junsheng Xie Yinghui | 2010 | Advanced Materials Research2010，96，： | 1 |
| 8 | On the generation and propagation of internal solitary waves in the southern Andaman Sea:A numerical study显示文摘Numerous internal solitary waves(ISWs)have been observed in the southern Andaman Sea.In this study,the twodimensional Massachusetts Institute of Technology general circulation model is applied to investigate the dynamics of ISWs and explore the effects of the bottom topography and tidal forcing on the generation and propagation of ISWs in the southern Andaman Sea.The results show that the large-amplitude depression ISWs are mainly generated via the oscillating tidal flow over the sill of the Great Channel,and the generation of ISWs is subject to the lee wave regime.The Dreadnought Bank cannot generate ISWs itself;however,it can enhance the amplitudes of eastward-propagating ISWs generated from sill A,owing to constructive interference of internal tide generation between the sill of the Great Channel and the Dreadnought Bank.The eastward-propagating ISWs generated by the eastern shallow sill near the continental shelf can propagate to the shelf,where they evolve into elevation waves because of the shallow water.Sensitivity runs show that both the semidiurnal and diurnal tides over the sill of the Great Channel can generate ISWs in this area.However,the ISWs generated by diurnal tides are much weaker than those generated by semidiurnal tides.Mixed tidal forcing has no significant effect on the generation of ISWs. | Shuqun CAI Yuqi WU Jiexin XU Zhiwu CHEN Jieshuo XIE Yinghui HE | 2021 | Science China Earth Sciences2021，64，10： | 1 |
| 9 | Effect of background parabolic current on characteristics and energetics of internal solitary waves by numerical simulation显示文摘Based on modifications of the observed background parabolic current in upper layer of the northeastern South China Sea(SCS), the effects of eight kinds of background currents on the characteristics and energy conversion of internal solitary waves(ISWs) are investigated by an Internal Gravity Wave(IGW) model. It is found that, although the background current has little effect on the number of the generated ISWs, it reduces the resulted phase speed of ISW. When the background parabolic current appears with its lower boundary near or above the main thermocline, the ISW amplitude and the depth of the isopycnal undergoing maximum displacement increase;when the background parabolic current curvature is reduced, the ISW amplitude and the ratio of baroclinic to barotropic energy reduce, whilst the phase speed of ISW, the baroclinic energy, and the ratio of baroclinic kinetic energy(KE) to available potential energy(APE) increase; when the lower boundary of background parabolic current extends down to the seabed and the background current curvature is reduced, the ISW amplitude and phase speed decrease, whilst the barotropic kinetic energy, the baroclinic energy and the ratio of KE to APE increase. At a whole depth, when the lower background current curvature is reduced and the upper current curvature is increased, the ISW amplitude, and phase speed, the ratio of baroclinic to barotropic energy, the baroclinic energy, and the ratio of KE to APE all increase. | Lü Haibin XIE Jieshuo YAO Yuan XU Jiexin CHEN Zhiwu HE Yinghui CAI Shuqun | 2016 | Acta Oceanologica Sinica2016，35，1： | 1 |
| 10 | Internal Waves Generated by Tidal Flows over a Triangular Ridge with Critical Slopes显示文摘Direct numerical simulations are performed to investigate the generation of internal waves by tide-topography interaction in a lab-scale model.The bottom topography is a triangular ridge with two critical slopes.With increasing tidal forcing,subharmonic instabilities are identified,which cause internal wave beams to become unstable and turbulent.Kinetic energy densities in the upward going beams from the ridge top are stronger than those from the ridge bottom,whereas the reverse is true for the energy flux.This disparity between energy and energy flux is due to the existence of strong pressure disturbances near the ridge bottom.On each side of the critical ridge,there exists an amphidromic point,from which internal wave beams are emitted in opposite directions.The calculated energy conversion rate scales linearly with the square of the forcing amplitude and agrees within 13%of theoretical prediction,even when turbulence occurs.The fraction of radiated baroclinic energy becomes saturated in the range of low excursion parameter considered,which agrees with the behavior in large-scale systems wherein mixing parameterizations must be used.The present work enriches the studies on the generation of internal waves over a critical triangular ridge. | NIE Yuhua CHEN Zhiwu XIE Jieshuo XU Jiexin HE Yinghui CAI Shuqun | 2019 | Journal of Ocean University of China2019，18，5： | 1 |
| 11 | Downregulation of peroxiredoxin-1 by β-elemene enhances the radiosensitivityof lung adenocarcinoma xenografts显示文摘 | Guoquan Li Bingbing Xie Xiaolong Li Yinghai Chen Yinghui Xu Meng Xu-Welliver Lijuan Zou | 2015 | Oncology Reports2015，，3： | 1 |
| 12 | U6 is not a suitable endogenous control for the quantification of circulating microRNAs显示文摘 | Mengqin Xiang Ying Zeng Ruirui Yang Haifan Xu Zhuo Chen Jing Zhong Hailong Xie Yinghui Xu Xi Zeng | 2014 | Biochemical and Biophysical Research Communications2014，，： | 1 |
| 13 | Effect of dendritic cell/cytokine-induced killer cell immunobiological cancer therapy combined with adjuvant chemotherapy in patients with triple-negative breast cancer显示文摘Objective The aim of the present study was to investigate the effect of dendritic cell(DC)/cytokine-induced killer cell(CIK) immunobiological cancer therapy in patients with triple-negative breast cancer(TNBC) who underwent adjuvant chemotherapy. Methods From January 2010 to October 2013, 120 patients with postoperative TNBC were recruited and included in the study. Patients were enrolled in one of two groups according to whether they accepted DC/CIK immunobiological cancer therapy during adjuvant chemotherapy; the patients in the DC/CIK group underwent adjuvant chemotherapy combined with DC/CIK immunobiological cancer therapy, and the control group underwent adjuvant chemotherapy alone. When six cycles of adjuvant chemotherapy and six cycles of DC/CIK immunobiological cancer therapy had been completed, differences between the two groups with regard to quality of life(Qo L), immunological indicators(CD3, CD4, CD8, and NK cell levels), disease-free survival(DFS), and side effects of chemotherapy and DC/CIK treatment were evaluated.Results In the DC/CIK group, the proportion of NK cells and CD3+ and CD4+ T-cell subgroups significantly increased, and the proportion of CD8+ cells decreased when they were compared before and after DC/CIK therapy(P < 0.05). However, there were no significant changes in the control group. By the final follow-up, DFS of the treatment group and the control group was 38.4 and 34.2 months, respectively. The Qo L improved in the patients treated with chemotherapy plus DC/CIK therapy compared with the patients treated with chemotherapy alone, and the difference between groups was significant(P < 0.05). The side effects of two groups were tolerable and not significantly different between the two groups.Conclusion The DC/CIK treatment had potential benefits for patients with TNBC compared with the control group, and was not associated with any obvious side effects. Therefore, DC/CIK therapy is a safe and effective method for the treatment of TNBC. | Ranran Zhang Wanqing Xie Tao Han Yongye Liu Zhaozhe Liu Fang Guo Yaling Han Zhenyu Ding Yinghui Sun Dongchu Ma Xiaodong Xie | 2015 | The Chinese-German Journal of Clinical Oncology2015，14，1： | 1 |
| 14 | Contaminations of Heavy Metals in Surface Soils of Various Lands and Their Health Risks in Tianjin Qilihai Ancient Lagoon Wetlands,China显示文摘A total of 36 surface soil profiles were set at the wetlands in Qilihai Ancient Lagoon Wetlands,Tianjin,the surface soils of 0-20 cm depth were sampled at various use types of lands to provide information on the concentrations of heavy metals in the coastal wetlands.Total concentrations of arsenic(As),cadmium(Cd),copper(Cu),lead(Pb),chromium(Cr)and zinc(Zn)were determined using inductively coupled plasma atomic absorption spectrometry(ICP-AES)to address the pollution levels in the sampling sites.The results showed that the concentrations of Cd,Cu in the soils disturbed by human activities intensively,the Phragmites australis marshes,the farmland,the brushes decreased in turn;among the sites,the concentrations of As,Cd and Cu were the highest in the soil of build-up areas,while the concentrations of Pb and Zn were the higher in the soil of farmland.The mean concentrations of Cu,Cr,Cd,Pb,Zn and As in the soils of 0-20 cm depth were 38.74 mg/kg,83.52 mg/kg,0.19 mg/kg,34.27 mg/kg,121.7 mg/kg and 18.77 mg/kg,respectively.The contamination indices of As were on the high pollution level in the soils of farmland and disturbed by human activities intensively;the concentrations of Cd in the soils of the marshes and farmland were at the moderate pollution level,while that in the soil disturbed by human activities intensively was at high pollution level.The values of comprehensive contamination index demonstrated that the variation of As contents was the maximum in the soils,Cd pollution reached to a high level.Geoaccumulation index showed that As pollution was at moderate level,and Cd,Cu and Zn pollution were at slight level,and the Pb and Cr pollution wasn't found in the build-up areas. | XIANG Lixiong XIE Zhenglei DU Zebing JIANG Yinghui XIE Chao LONG Ting | 2016 | 湿地科学2016，14，5： | 0 |
| 15 | Evaluation of P-glycoprotein-targeting circulating microRNAs as peripheral biomarkers for medically intractable epilepsy显示文摘Background Early diagnosis of medically intractable epilepsy is challenging in clinical work.P-glycoprotein(P-gp)is one of the most important multidrug efux transporters,which has been demonstrated to contribute to the drug resistance of intractable epilepsy.The present study was aimed to explore the diagnostic value of microRNAs(miRNAs)targeting P-gp for medically intractable epilepsy.Methods Thirty-six patients with intractable epilepsy and 36 epilepsy patients responsive to anti-epilepsy drugs,who visited Jinshan Hospital of Fudan University from September 2014 to September 2016,were enrolled in this study.Clinical information of the patients was obtained by retrospectively reviewing medical records.MiRNAs with diferential serum expression between the two groups of patients were detected by microarray assay.Meanwhile,miRNAs that were confrmed to regulate P-gp in vitro by western blot were selected for further validation.In the validation phase,reverse transcription quantitative PCR(RT-qPCR)was conducted to confrm the diferential expression of the candidate miRNAs in the epilepsy cohorts.Receiver operating characteristic(ROC)curve analysis was carried out to evaluate the diagnostic value of the miRNAs for intractable epilepsy.Results Three miRNAs including miR-6514-3p,miR-6076-5p,and miR-6855-3p were identifed to be candidate miRNAs by microarray assay.The results of western blotting validated that miR-146a-5p and miR-138-5p could regulate P-gp expression in vitro,so they were included in the candidate miRNAs for further validation.In the validation phase,the results of RT-qPCR indicated that compared with drug-responsive patients,the patients with intractable epilepsy showed decreased level of miR-138-5p and increased level of miR-146a-5p.The results of ROC curve analysis indicated that miR-138-5p(AUC=0.877)and miR-146a-5p(AUC=0.866)had high diagnostic value for intractable epilepsy.In addition,the miR-panel composed of miR-138-5p and miR-146a-5p showed higher diagnostic value(AUC=0.926)than the miRNAs selected by microarray assay.Conclusions Our results indicated that the dysregulated miR-138-5p and miR-146a-5p which target P-gp expression have high potential as peripheral biomarkers for medically intractable epilepsy. | Yangmei Xie Yiye Shao Xue Gong Ming Wang Yinghui Chen | 2023 | Acta Epileptologica2023，6，1： | 0 |
| 16 | Facile construction of honeycomb-shaped porous carbon electrode materials using recyclable sodium chloride template for efficient lithium storage显示文摘Carbon materials are the preferred anode materials for Li-ion batteries.Here,we propose an easy and sustainable strategy to prepare honeycomb-shaped porous carbon(HPC)electrode materials through a process involving simple calcination and subsequent water washing by using polyvinyl-pyrrolidone(PVP)as carbon source and NaCl as pore-forming agent.A controllable cavity size and distribution of the carbon materials can be readily obtained solely by adjusting the NaCl amount.Results showed that the optimized HPC sample had a relatively uniform cavity distribution and a highly porous structure.Moreover,the special honeycomb-shaped structure was conducive to the electronic conductivity of the electrode materials,provided a short path for Li-ion transport and a wide interface with the electrolyte,and buffered the volume change of active materials.The special honeycomb-shaped structure was also maintained well after long cycles,which improved electrode stability.When used as anode materials for Li-ion batteries(LIBs),the sample demonstrated excellent cycling stability and rate performance,with a high specific capacity of 230 mA hg^-1 and a reversible capacity of 197 mA hg^-1,after 1200 cycles at 2 C.Overall,we introduced a simple strategy for the potential mass production of porous carbon materials for LIBs. | FANG ShiQing HE HaoXuan YU YingHui LI Xiao XIE WeiCheng LI Wei JIN LuQiao YANG ZhenYu CAI JianXin | 2020 | Science China(Technological Sciences)2020，63，10： | 0 |
| 17 | Prolyl hydroxylase 2 is dispensable for homeostasis of intestinal epithelium in mice显示文摘 | Yinghui Xie Tanglong Yuan Yanqing Qin Zhonghui Weng Jing Fang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，6： | 0 |
| 18 | Lignin-assisted construction of sub-10 nm supramolecular self-assembly for photothermal immunotherapy and potentiating anti-PD-1 therapy against primary and distant breast tumors显示文摘Photothermal therapy(PTT)has brought hope for cancer treatments,with hyperthermia-induced immunogenic cell death(ICD),which is a critical part of therapeutically induced antitumor immune responses.Limited immune stimulation response in PTT is the primary reason for incomplete tumor ablation,therefore demonstrating urgent requirements for ICD amplifier.Herein,a sub-10 nm supramolecular nanoassembly was formed by coassembly of clinically approved aluminum adjuvant and commonly used indocyanine green(ICG)under the assistance of lignosulfonate(LS,a green and sustainable multifunctional lignin derivative)for localized photothermal-immunotherapy of breast cancer.The overall results revealed that LS-Al-ICG is capable of inducing amplified ICD,efficiently eliciting solid immune responses through dendritic cells(DCs)activation and cytotoxic T-cell responses initiation for tumor killing.Moreover,anti-PD-1 therapy blocked the PD-1 pathway and led to remarkable anti-tumor efficacy against laser-irradiated primary tumors and distant tumors by potentiating systemic tumor specific T cell immunity.The results of this study demonstrate a handy and extensible approach for engineering green natural lignin nanoparticles for cancer immunotherapy,which shows promise for delivering other therapeutics in biomedical applications. | Xudong Fan Tianxiang Yue Aidi Liu Xiaowei Xie Weixiang Fang Yinghui Wei Hangsheng Zheng Hongyue Zheng Meiqi Zhou Jigang Piao Fanzhu Li | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，5： | 0 |
| 19 | Phase-field simulation of lack-of-fusion defect and grain growth during laser powder bed fusion of Inconel 718显示文摘The anisotropy of the structure and properties caused by the strong epitaxial growth of grains during laser powder bed fusion(L-PBF)significantly affects the mechanical performance of Inconel 718 alloy components such as turbine disks.The defects(lack-of-fusion Lo F)in components processed via L-PBF are detrimental to the strength of the alloy.The purpose of this study is to investigate the effect of laser scanning parameters on the epitaxial grain growth and LoF formation in order to obtain the parameter space in which the microstructure is refined and LoF defect is suppressed.The temperature field of the molten pool and the epitaxial grain growth are simulated using a multiscale model combining the finite element method with the phase-field method.The LoF model is proposed to predict the formation of LoF defects resulting from insufficient melting during L-PBF.Defect mitigation and grain-structure control during L-PBF can be realized simultaneously in the model.The simulation shows the input laser energy density for the as-deposited structure with fine grains and without LoF defects varied from 55.0–62.5 J·mm^(-3)when the interlayer rotation angle was 0°–90°.The optimized process parameters(laser power of 280 W,scanning speed of 1160 mm·s^(-1),and rotation angle of 67°)were computationally screened.In these conditions,the average grain size was 7.0μm,and the ultimate tensile strength and yield strength at room temperature were(1111±3)MPa and(820±7)MPa,respectively,which is 8.8%and10.5%higher than those of reported.The results indicating the proposed multiscale computational approach for predicting grain growth and Lo F defects could allow simultaneous grain-structure control and defect mitigation during L-PBF. | Miaomiao Chen Renhai Shi Zhuangzhuang Liu Yinghui Li Qiang Du Yuhong Zhao Jianxin Xie | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，11： | 0 |
| 20 | Erratum to:Phase-field simulation of lack-of-fusion defect and grain growth during laser powder bed fusion of Inconel 718显示文摘The original online version of this article unfortunately contained a mistake.The reference[24]in the original online version is incorrect.The correct version is given below:Y.H.Cheng,Numerical Simulation and Experimental Research of Selective Laser Melting on Nickel Based Alloy Powder GH4169[Dissertation],North University of China,Taiyuan,2016. | Miaomiao Chen Renhai Shi Zhuangzhuang Liu Yinghui Li Qiang Du Yuhong Zhao Jianxin Xie | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，11： | 0 |
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