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| 1 | Excessive UBE3A dosage impairs retinoic acid signaling and synaptic plasticity in autism spectrum disorders显示文摘孤独性光谱混乱(ASD ) 是有异构的病原学的许多人的神经病学的混乱。E3 ubiquitin (Ub ) 的活动过度 ligase UBE3A,不完全地源自 15q11-q13 拷贝数字变化,为世界范围的 ASD 盒子的 1%-3% 的报道,而是内在的机制遗体描绘了。这里,我们报导 ALDH1A2 的功能, retinoic 酸(RA ) 的限制率的酶合成,被 UBE3A 否定地以一种 ubiquitylation 依赖的方式调整。过多的 UBE3A 剂量被发现损害调停 RA 的 neuronal homeostatic synaptic 粘性。象 ASD 一样症状被 overexpressing UBE3A 在前额的外皮或由一个 ALDH1A 对手的管理在老鼠概括,而 RA 补充显著地减轻了过多的 UBE3A 导致剂量的象 ASD 一样显型。由识别在 ASD 作为内在的机制发信号的减少的 RA,显型连接了到 UBE3A 活动过度,我们的调查结果介绍 ASD 病原学的新远景并且对这逐渐地流行的疾病便于治疗学的开发的一个模式。 | Xingxing Xu Chuanyin Li Xiaobo Gao Kun Xia Hui Guo Yali Li ZijianHao Lei Zhang Daming Gao Chenfan Xu Huatai Xu Zhi-Qi Xiong Zilong Qiu Ling Mei Xiaoduo Xie Kangcheng Ruan Ronggui Hu | 2018 | Cell Research2018，28，1： | 13 |
| 2 | Transmembrane domain-mediated Lck association underlies bystander and costimulatory ICOS signaling显示文摘The B7-family inducible costimulator(ICOS)activates phosphoinositide-3 kinase(PI3K)and augments calcium mobilization triggered by the T-cell receptor(TCR).We surprisingly found that the entire cytoplasmic domain of ICOS is dispensable for its costimulation of calcium mobilization.This costimulatory function relies on the unique transmembrane domain(TMD)of ICOS,which promotes association with the tyrosine kinase Lck.TMD-enabled Lck association is also required for p85 recruitment to ICOS and subsequent PI3K activation,and Lck underlies both the bystander and costimulatory signaling activity of ICOS.TMD-replaced ICOS,even with an intact cytoplasmic domain,fails to support T FH development or GC formation in vivo.When transplanted onto a chimeric antigen receptor(CAR),the ICOS TMD enhances interactions between T cells and antigen-presenting target cells.Therefore,by revealing an unexpected function of the ICOS TMD,our study offers a new perspective for the understanding and potential application of costimulation biology. | Zurong Wan Xingxing Shao Xingyu Ji Lihui Dong Jiacheng Wei Zhuqing Xiong Wanli Liu Hai Qi | 2020 | Cellular & Molecular Immunology2020，17，2： | 4 |
| 3 | PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis显示文摘In vitro studies have established the prevalent theory that the mitochondrial kinase PINK1 protects neurodegeneration by removing damaged mitochondria in Parkinson's disease(PD).However,difficulty in detecting endogenous PINK1 protein in rodent brains and cell lines has prevented the rigorous investigation of the in vivo role of PINK1.Here we report that PINK1 kinase form is selectively expressed in the human and monkey brains.CRISPR/Cas9-mediated deficiency of PINK1 causes similar neurodegeneration in the brains of fetal and adult monkeys as well as cultured monkey neurons without affecting mitochondrial protein expression and morphology.Importantly,PINK1 mutations in the primate brain and human cells reduce protein phosphorylation that is important for neuronal function and survival.Our findings suggest that PINK1 kinase activity rather than its mitochondrial function is essential for the neuronal survival in the primate brains and that its kinase dysfunction could be involved in the pathogenesis of PD. | Weili Yang Xiangyu Guo Zhuchi Tu Xiusheng Chen Rui Han Yanting Liu Sen Yan Qi Wang Zhifu Wang Xianxian Zhao Yunpeng Zhang Xin Xiong Huiming Yang Peng Yin Huida Wan Xingxing Chen Jifeng Guo Xiao-Xin Yan Lujian Liao Shihua Li Xiao-Jiang Li | 2022 | Protein & Cell2022，13，1： | 3 |
| 4 | Lattice constant effects of photonic crystals on the extraction of guided mode of GaN based light emitting diodes显示文摘We have fabricated a series of square-lattice hole photonic crystal (2PhC) arrays simultaneously at the un-current injection region on a special sample of GaN based light emitting diode (LED) by using focus ion beam milling (FIBM). The lattice constants of the 2PhC arrays vary from 230 to 1500 nm,while the 2PhC arrays have a constant area of about 9 μm×18 μm and a fixed depth of 150±10 nm which approaches but does not penetrate the active layer. Microscopic electroluminescence images and spectral measurements consistently confirm that the top emitting intensities from different 2PhCs are all enhanced compared with the unpatterned region. It is demonstrated that the output coupling of propagating guided modes is realized by the diffracted transmission of the 2PhCs. The enhancement factors of the guided modes compared with the unpatterned region are plotted as function of the lattice constant. It is found that the highest enhancements for the extraction of guided modes were obtained for the lattice constant of 230 and 460 nm of 2PhCs. The results are discussed by the two-dimensional rigorous coupled wave analysis (RCWA). | FU XingXing ZHANG Bei KANG XiangNing XU Jun XIONG Chang ZHANG GuoYi | 2011 | Science China(Technological Sciences)2011，54，1： | 2 |
| 5 | Z-scheme heterojunction of SnS_(2)-decorated 3DOM-SrTiO_(3) for selectively photocatalytic CO_(2) reduction into CH4显示文摘The rapid recombination of photoinduced electron-hole pairs as well as the deficiency of high-energy carriers restricted the redox ability and products selectivity.Herein,the heterojunction of SnS_(2)-deco rated three-dimensional ordered macropores(3DOM)-SrTiO_(3) catalysts were in-situ constructed to provide transmit channel for high-energy electron transmission.The suitable band edges of SnS_(2) and SrTiO_(3) contribute to the Z-scheme transfer of photogenerated carrier.The 3DOM structure of SrTiO_(3)-based catalyst possesses the slow light effect for enhancing light adsorption efficiency,and the surface alkalis strontium is benefit to the boosting adsorption for CO_(2).The in-situ introduced SnS_(2) decorated on the macroporous wall surface of 3DOM-SrTiO_(3) altered the primary product from CO to CH4.The Z-scheme electron transfer from SnS_(2) combining with the holes in SrTiO_(3) occurred under full spectrum photoexcitation,which improved the excitation and utilization of photogene rated electrons for C02 multi-electrons reduction.As a result,(SnS_(2))3/3 DOM-SrTiO_(3) catalyst exhibits higher activity for photocatalytic CO_(2) reduction to CH4 compared with single SnS_(2) or 3 DOM-SrTiO_(3),i.e.,its yield and selectivity of CH4 are 12.5μmol g^(-1) h^(-1) and 74.9%,re spectively.The present work proposed the theoretical foundation of Z-scheme heterojunction construction for enhancing photocatalytic activity and selectivity for CO_(2) conversion. | Wenjie He Xingxing Wu Yifei Li Jing Xiong Zhiling Tang Yuechang Wei Zhen Zhao Xiao Zhang Jian Liu | 2020 | Chinese Chemical Letters2020，31，10： | 2 |
| 6 | Multi-GNSS products and services at iGMAS Wuhan Innovation Application Center:strategy and evaluation显示文摘Over the past years the International Global Navigation Satellite System(GNSS)Monitoring and Assessment System(iGMAS)Wuhan Innovation Application Center(IAC)dedicated to exploring the potential of multi-GNSS signals and providing a set of products and services.This contribution summarizes the strategies,achievements,and innovations of multi-GNSS orbit/clock/bias determination in iGMAS Wuhan IAC.Both the precise products and Real-Time Services(RTS)are evaluated and discussed.The precise orbit and clock products have comparable accuracy with the precise products of the International GNSS Service(IGS)and iGMAS.The multi-frequency code and phase bias products for Global Positioning System(GPS),BeiDou Navigation Satellite System(BDS),Galileo navigation satellite system(Galileo),and GLObal NAvigation Satellite System(GLONASS)are provided to support multi-GNSS and multi-frequency Precise Point Positioning(PPP)Ambiguity Resolution(AR).Compared with dual-frequency PPP AR,the time to first fix of triple-frequency solution is improved by 30%.For RTS,the proposed orbit prediction strategy improves the three dimensional accuracy of predicted orbit by 1 cm.The multi-thread strategy and high-performance matrix library are employed to accelerate the real-time orbit and clock determination.The results with respect to the IGS precise products show the high accuracy of RTS orbits and clocks,4–9 cm and 0.1–0.2 ns,respectively.Using real-time satellite corrections,real-time PPP solutions achieve satisfactory performance with horizontal and vertical positioning errors within 2 and 4 cm,respectively,and convergence time of 16.97 min. | Xingxing Li Qingyun Wang Jiaqi Wu Yongqiang Yuan Yun Xiong Xuewen Gong Zhilu Wu | 2022 | Satellite Navigation2022，3，3： | 1 |
| 7 | Lattice-parameter effects on diffracted transmission of GaN two-dimensional square-lattice photonic crystals显示文摘The lattice-parameter effects on the diffracted transmission of GaN square-lattice photonic crystals (2PhC) at the wavelength of 460 nm were studied by using a rigorous coupled wave analysis (RCWA). The impacts of lattice parameters on the diffracted transmission are calculated in the ranges for lattice pitch from 100 nm to 2000 nm,fill factor from 0.1 to 0.9 and grating height from 100 nm to 1000 nm,respectively. Our simulation results confirm that the lattice pitch is the dominant factor of the diffraction. It determines how many orders of diffraction occur by the 2PhCs. The larger the lattice pitch,the higher the diffraction orders come into play. Moreover,besides the first-order Bragg diffraction,higher diffraction orders from large pitches of PhCs are also beneficial to the light extraction improvement. The higher enhancement factors of the integrated transmission were obtained from a wide range of pitches with micro-scale GaN 2PhCs. Three different diffraction mechanisms through wave vector analysis were used to discuss the simulation results. | XIONG Chang ZHANG Bei KANG XiangNing FU XingXing ZHANG GuoYi | 2011 | Science China(Technological Sciences)2011，54，1： | 1 |
| 8 | Security Enhancement of Arbiter-Based Physical Unclonable Function on FPGA显示文摘In order to reduce physical unclonable function(PUF)response instability and imbalance caused by the metastability and the bias of arbiter,this paper uses an improved balanced D flip-plop(DFF)based on the unbalanced DFF to reduce the bias in response output and enhances the security of PUF by adopting two balanced DFFs in series. The experimental results show that two cascaded balanced DFFs improve the stability of the DFF,and the output of two balanced DFFs is more reliable. The entropy of output is fixed at 98.7%. | WANG Jun LIU Shubo XIONG Xingxing LIANG Cai | 2017 | Wuhan University Journal of Natural Sciences2017，22，2： | 1 |
| 9 | Differentially Private Top-k Items Based on Least Mean Square——Take E-Commerce Platforms for Example显示文摘User preference data broadly collected from e-commerce platforms have benefits to improve the user’s experience of individual purchasing recommendation by data mining and analyzing,which may bring users the risk of privacy disclosure.In this paper,we explore the problem of differential private top-k items based on least mean square.Specifically,we consider the balance between utility and privacy level of released data and improve the precision of top-k based on post-processing.We show that our algorithm can achieve differential privacy over streaming data collected and published periodically by server provider.We evaluate our algorithm with three real datasets,and the experimental results show that the precision of our method reaches 85%with strong privacy protection,which outperforms the Kalman filter-based existing methods. | CAO Mengyue WU Fusheng NI Mingtao XIONG Xingxing LIU Shubo WANG Jun | 2019 | Wuhan University Journal of Natural Sciences2019，24，2： | 0 |
| 10 | Electro-chemo-mechanical design of polymer matrix in composited LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2) cathode endows solid-state batteries with superior performance显示文摘Nickel-rich LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811) cathode material has been widely concerned due to its high voltage,high specific capacity and excellent rate performance,which is considered as one of the most promising cathode materials for the next generation of high-energy-density solid-state lithium batteries.However,serious electro-chemo-mechanical degradation of Nickel-rich cathode during cycling,especially at a high voltage(over 4.5 V),constrains their large-scale application.Here,using the multiphysical simulation,highly-conductive polymer matrix with spontaneous stress-buffering effect was uncovered theoretically for reinforcing the electrochemical performance of composited NCM81 1 cathode through the visualization of uniform concentration distribution of Li-ion coupled with improved stress field inside NCM811 cathode.Thereupon,polyacrylonitrile(PAN) and soft polyvinylidene fluoride(PVDF) were selected as the polymer matrix to fabricate the composited NCM811 cathode(PVDFPAN@NCM811) for improving the electrochemical performance of the solid-state NMC811|Li full cells,which can maintain high capacity over 146.2 mA h g^(-1)after 200 cycles at a high voltage of 4.5 V.Suggestively,designing a multifunctional polymer matrix with high ionic conductivity and mechanical property can buffer the stress and maintain the integrity of the structure,which can be regarded as the door-opening avenue to realize the high electrochemical performance of Ni-rich cathode for solidstate batteries. | Haolong Jiang Xieyu Xu Qingpeng Guo Hui Wang Jiayi Zheng Yuhao Zhu Huize Jiang Olesya O.Kapitanova Valentyn S.Volkov Jialin Wang Yaqi Chen Yongjing Wang Yu Han Chunman Zheng Kai Xie Shizhao Xiong Yangyang Liu Xingxing Jiao | 2023 | Journal of Energy Chemistry2023，，3： | 0 |
| 11 | Reinforced interface endows the lithium anode with stable cycle at high-temperature of 80℃显示文摘Embracing ultrahigh theoretical capacity of 3860 mA h g^(-1)and the lowest reduction potential of-3.04 V(versus standard hydrogen electrode),lithium(Li) is considered as the 'holy grail' material for pursuing higher energy density,of which application has been challenged due to the unstable interface caused by the non-uniform electrodeposition as well as high chemical activity.Operating at higher temperature can be recommended to uniform electrodeposition of Li metal.Nevertheless,the intrinsic side-reaction between Li metal anode and electrolyte is inevitably aggravated and thus fosters the failure of Li metal anode rapidly with uneven electrodeposition.Here,a kind of temperature-tolerated ionic liquid(1-methyl-3-ethylimidazole bis(fluorosulfo nyl)imide/lithium bis(trifluoromethylsulfo nyl)imide,EF/LT)based electrolyte that matrixed with poly(vinylidene fluoride-hexafluoropropylene) was designed to maintain the interfacial stabilization of Li metal due to the weak interfacial reaction and uniform electrodeposition at high temperature of 80℃.It is the matter that the 660-h cycle with lower polarization is achieved with EF/LT-based electrolyte at temperature of 80 ℃ and the full cell embraces outstanding cyclic performance,without capacity fading within 100 cycles.Delighting,a door for practical application of Li metal anode for higher energy density as the carbon neutrality progresses in the blooming human society has been opened gradually. | Yuhao Zhu Xieyu Xu Qingpeng Guo Yu Han Haolong Jiang Huize Jiang Hui Wang Pavel V.Evdokimov Olesya O.Kapitanova Valentyn S.Volkov Yongjing Wang Shizhao Xiong Chunman Zheng Kai Xie Xingxing Jiao Yangyang Liu | 2023 | Journal of Energy Chemistry2023，，3： | 0 |
| 12 | A Uranium(Ⅳ) Alkyl Complex: Synthesis and Catalytic Property in Carbonyl Hydroboration显示文摘The strong oxophilicity of actinide complexes prevents their applications in the transformation of oxygen-containing substrates.Herein,we report the use of a uranium(Ⅳ)alkyl complex as a catalyst for the hydroboration of carbonyl compounds.This reaction has good functional group tolerance and chemo-selectivity under mild conditions.This study represents the rare example of catalytic reaction promoted by a uranium alkyl complex and highlights the potential of uranium complexes in synthetic chemistry. | Xiong Sun Xingxing Gong Zhuoyi Xie Congqing Zhu | 2022 | Chinese Journal of Chemistry2022，40，17： | 0 |
| 13 | Viability of all-solid-state lithium metal battery coupled with oxide solid-state electrolyte and high-capacity cathode显示文摘Owing to the utilization of lithium metal as anode with the ultrahigh theoretical capacity density of 3860 mA h g^(-1)and oxide-based ceramic solid-state electrolytes(SE),e.g.,garnet-type Li7La_(3)Zr_(2)O_(12)(LLZO),all-state-state lithium metal batteries(ASLMBs)have been widely accepted as the promising alternatives for providing the satisfactory energy density and safety.However,its applications are still challenged by plenty of technical and scientific issues.In this contribution,the co-sintering temperature at 500℃is proved as a compromise method to fabricate the composite cathode with structural integrity and declined capacity fading of LiNi_(0.5)Co_(0.2)Mn_(0.3)O_(2)(NCM).On the other hand,it tends to form weaker grain boundary(GB)inside polycrystalline LLZO at inadequate sintering temperature for LLZO,which can induce the intergranular failure of SE during the growth of Li filament inside the unavoidable defect on the interface of SE.Therefore,increasing the strength of GB,refining the grain to 0.4μm,and precluding the interfacial defect are suggested to postpone the electro-chemo-mechanical failure of SE with weak GB.Moreover,the advanced sintering techniques to lower the co-sintering temperature for both NCM-LLZO composite cathode and LLZO SE can be posted out to realize the viability of state-of-the-art ASLMBs with higher energy density as well as the guaranteed safety. | Xingxing Jiao Xieyu Xu Yongjing Wang Xuyang Wang Yaqi Chen Shizhao Xiong Weiqing Yang Zhongxiao Song Yangyang Liu | 2024 | Journal of Energy Chemistry2024，91，4： | 0 |
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