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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 3 | 油炸食品与心血管病风险和全因死亡率的关系:观察性研究的荟萃分析显示文摘研究者进行了一项荟萃分析,包括剂量反应分析,以定量确定油炸食品摄入与普通成年人群心血管病风险和全因死亡率之间的关系。方法:研究者在PubMed、EMBASE和Web of Science上检索2020年4月11日之前的所有文章。应用随机效应模型估计总的相对危险度(relative risks,RR)和95%CI。结果:与最低油炸食品摄入量相比,最高摄入量者主要心血管事件的总RR(95%CI)=1.28(1.15~1.43),n=17,I^(2)=82.0%,其中前瞻性研究:1.24(1.12~1.38),n=13,I^(2)=75.7%. | 刘青(译) 练桂丽(审校) Qin P Zhang M Han M Liu D Luo X Xu L Zeng Y Chen Q Wang T Chen X Zhou Q Li Q Qie R Wu X Li Y Zhang Y Wu Y Hu D Hu F | 2021 | 中华高血压杂志2021，29，2： | 3 |
| 4 | 甜菜碱对肥育猪生长激素脉冲释放和血清代谢的影响显示文摘用添加含量为0和0.125%甜菜碱的日粮饲喂肥育猪,试验对杂交肥育猪日粮中甜菜碱对猪的生长性能、生长激素(GH)脉冲释放及血清代谢的影响进行研究。每试验组3个重复,每个重复8头猪(4头去势公猪,4头母猪),试验在饲喂后3h内每15min采集一次血液样本,测定生长激素脉冲释放。结果表明:添加甜菜碱组平均日增重增加5.45%(P〈0.05),而平均日采食量和饲料转化率则不受影响。 | Huang Q C Xu Z R Han X Y Li W F | 2007 | 饲料博览(技术版)2007，，7： | 2 |
| 5 | Alternate arrangement of PpL B3 domain and SpA D domain creates synergistic double-site binding to V (H) 3 and V (K) regions of Fab 显示文摘 | Jiang S H Wang J F Xu R | 2008 | DNA-Cell-Biol2008，27，8： | 1 |
| 6 | 显示文摘 | Cheng X Y Xu X F Hu R X | 2007 | Acta Phys Sin2007，56，： | 1 |
| 7 | Periodic Solution of a Lotka Voherra Predator-prey Model with Dispersion and Time Delays 显示文摘 | R Xu M A J Chaplain F A Davidson | 2004 | Applied Mathematics and Computation2004，148，： | 1 |
| 8 | Calcitonin gene-relatedpeptide dynamics in rat dorsal root ganglia and spinal cord fol lowing different sciatic nerve injuries显示文摘 | Zheng L F Wang R Xu Y Z | 2008 | Brain Res2008，1187，： | 1 |
| 9 | Model of passenger flow assignment for urban rail transit based on entry and exit time constraints显示文摘 | Zhou F Xu R | 2012 | Transportation Research Record:Journal of the Transportation Research Board2012，2284，1： | 1 |
| 10 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 11 | The molecular mechanisms of TRAIL resistance in cancer cells:help in designing new drugs显示文摘 | Wang F J Lin R Xu | 2014 | Curr Pharm Des2014，20，42： | 1 |
| 12 | Characteristics of degraded hemicellulosicpolymers obtained from steam exploded wheat straw 显示文摘 | X F Sun F Xu R C Sun | 2005 | Carbohydrate Polymers2005，60，： | 1 |
| 13 | Persistence and stability for a two-species ratio-dependent predator-prey system with distributed time delay 显示文摘 | Xu R Davidson F A Chaplain M A J | 2002 | Journal of Mathematical Analysis and Applications2002，269，： | 1 |
| 14 | A new approach to quality function deployment planning with financial consideration 显示文摘 | TANG J F FUNG R Y K XU B | 2002 | Computer and Operation Research2002，29，11： | 1 |
| 15 | A reconfigurable concurrent function block model and its implementation in real-time Java显示文摘 | BRENNAN R W ZHANG X K XU Y F | 2002 | Integrated Computer-Aided Engineering2002，9，1： | 1 |
| 16 | Effects of tungsten carbide onelectrochemical properties and microslructural features of AI/Pb-PANI-WC composite inert anodes used in zinc electrowinning 显示文摘 | XU R D HUANG L P ZHOU J F | 2012 | Hydrometallurgy2012，，： | 1 |
| 17 | Geochemistry of late Paleo- zoic mafic igneous rocks from the kuerti area,Xinjiang,northwest China;Impplications for back arc mantle evolution显示文摘 | Xu J F Castillo P R Chen F R | 2002 | Chemical Ge- ology2002，193，12： | 1 |
| 18 | TLR3signaling in macrophages is indispensable for the protective immunity of invariant natural killer T cells against enterovirus 71infection显示文摘 | Zhu K Yang J Luo K Yang C Zhang N Xu R Chen J Jin M Xu B Guo N Wang J Chen Z Cui Y Zhao H Wang Y Deng C Bai L Ge B Qin C F Shen H Yang C F Leng Q | 2015 | PLoS Pathog2015，11，10： | 1 |
| 19 | A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans显示文摘 | Xu E Y Moore F L Pera R A | 2001 | Proc Natl Acad Sci U S A2001，98，13： | 1 |
| 20 | Origin of Mesozoic adakitic intrusive rocks in the Ningzhen area of east China: Partial melting of delaminated lower continental crust? 显示文摘 | Xu J F Shinjo R Defant M J Wang Q Rapp R P | 2002 | Geology2002，30，12： | 1 |
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