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| 1 | Spatial patterns and driving forces of land use change in China during the early 21st century显示文摘Land use and land cover change as the core of coupled human-environment systems has become a potential field of land change science (LCS) in the study of global environmental change. Based on remotely sensed data of land use change with a spatial resolution of 1 km × 1 km on national scale among every 5 years, this paper designed a new dynamic regionalization according to the comprehensive characteristics of land use change including regional differentiation, physical, economic, and macro-policy factors as well. Spatial pattern of land use change and its driving forces were investigated in China in the early 21st century. To sum up, land use change pattern of this period was characterized by rapid changes in the whole country. Over the agricultural zones, e.g., Huang-Huai-Hai Plain, the southeast coastal areas and Sichuan Basin, a great proportion of fine arable land were engrossed owing to considerable expansion of the built-up and residential areas, resulting in decrease of paddy land area in southern China. The development of oasis agriculture in Northwest China and the reclamation in Northeast China led to a slight increase in arable land area in northern China. Due to the 'Grain for Green' policy, forest area was significantly increased in the middle and western developing regions, where the vegetation coverage was substantially enlarged, likewise. This paper argued the main driving forces as the implementation of the strategy on land use and regional development, such as policies of 'Western Development', 'Revitalization of Northeast', coupled with rapidly economic development during this period. | LIU Jiyuan ZHANG Zengxiang XU Xinliang KUANG Wenhui ZHOU Wancun ZHANG Shuwen LI Rendong YAN Changzhen YU Dongsheng WU Shixin JIANG Nan | 2010 | Journal of Geographical Sciences2010，20，4： | 154 |
| 2 | Spatiotemporal characteristics, patterns, and causes of land-use changes in China since the late 1980s显示文摘Land-use/land-cover 变化(LUCC ) 有连接到人和自然相互作用。瓷器 Land-Use/cover 数据集(CLUD ) 从 1980 年代末在 5 年的间隔定期被更新到 2010,与基于 Landsat TMETM+ 图象的标准过程。陆地使用动态区域化方法被建议分析主要陆地使用变换。在国家规模的陆地使用变化的空间与时间的特征,差别,和原因然后被检验。主要调查结果如下被总结。越过中国的陆地使用变化(LUC ) 在最后 20 年(19902010 ) 里在空间、时间的特征显示了一个重要变化。农田变化的区域在南方减少了并且在北方,而是仍然是的全部的区域增加了几乎未改变。回收农田从东北被转移到西北。布满建筑物陆地很快膨胀了,主要在东方被散布,并且逐渐地展开到中央、西方的中国。树林首先减少了,然后增加但是荒芜的区域是反面。草地继续减少。在中国的 LUC 的不同空间模式被发现在之间迟了第 20 世纪并且早第 21 世纪。原版 13 个 LUC 地区在一些地区被边界的变化由 15 个单位代替。包括的这些变化(1 ) 的主要空间特征加速的扩大布满建筑物在 Huang-Huai-Hai 区域,东南的沿海的区域,长江的中流区域,和四川盆登陆;(2 ) 从东北中国和东方内部蒙古在北方转移了陆地开垦到绿洲在西北中国的农业区域;(3 ) 从在到稻的东北中国的喂雨的农田的连续转变回答;并且(4 ) 为在内部蒙古,黄土高原,和西南的多山的区域的南部的农业牧剧的交错群落的格林工程的谷物的有效性。在最后二十年,尽管在北方的气候变化在农田影响了变化,政策规定和经济驱动力仍然是越过中国的 LUC 的主要原因。在第 21 世纪的第一十年期间,在陆地使用模式驾驶了变化的人为的因素从单程的陆地开发转移了强调到开发和保存。动态区域化方法被用来在单位的 zoning 边界,地区的内部特征,和生长和减少的空间模式分析变化。结果揭示了变化过程的模式,也就是 LUC 的过程和在在不同阶段的特征的地区性的差别。地区的生长和减少在这动态 LUC zoning,在统一边界的变化,和在前者和后者十年之间的变化紧张的特征期间被检验。在为在不同类型和陆地使用的不同区域的变化的陆地使用和原因的模式和过程之间的其他的转变的模式被探索。 | LIU Jiyuan KUANG Wenhui ZHANG Zengxiang XU Xinliang QIN Yuanwei NING Jia ZHOU Wancun ZHANG Shuwen LI Rendong YAN Changzhe WU Shixin SHI Xuezheng JIANG Nan YU Dongsheng PAN Xianzhang CHI Wenfeng | 2014 | Journal of Geographical Sciences2014，24，2： | 245 |
| 3 | Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion显示文摘The recent outbreak of coronavirus disease(COVID-19)caused by SARS-CoV-2 infection in Wuhan,China has posed a serious threat to global public health.To develop specific anti-coronavirus therapeutics and prophylactics,the molecular mechanism that underlies viral infection must first be defined.Therefore,we herein established a SARS-CoV-2 spike(S)protein-mediated cell-cell fusion assay and found that SARS-CoV-2 showed a superior plasma membrane fusion capacity compared to that of SARS-CoV.We solved the X-ray crystal structure of six-helical bundle(6-HB)core of the HR1 and HR2 domains in the SARS-CoV-2 S protein S2 subunit revealing that several mutated amino acid residues in the HR1 domain may be associated with enhanced interactions with the HR2 domain.We previously developed a pan-coronavirus fusion inhibitor,EK1,which targeted the HR!domain and could inhibit infection by divergent human coronaviruses tested,including SARS-CoV and MERS-CoV.Here we generated a series of lipopeptides derived from EK1 and found that EK1C4 was the most potent fusion inhibitor against SARS-CoV-2 S protein-mediated membrane fusion and pseudovirus infection with IC50s of 1.3 and 15.8 nM,about 241-and 149-fold more potent than the original EK1 peptide,respectively.EK1C4 was also highly effective against membrane fusion and infection of other human coronavirus pseudoviruses tested,including SARS-CoV and MERS-CoV,as well as SARSr-CoVs,and potently inhibited the replication of 5 live human coronaviruses examined,including SARS-CoV-2.Intranasal application of EK1C4 before or after challenge with HCoV-OC43 protected mice from infection,suggesting that EK1C4 could be used for prevention and treatment of infection by the currently circulating SARS-CoV-2 and other emerging SARSr-CoVs. | Shuai Xia Meiqin Liu Chao Wang Wei Xu Qiaoshuai Lan Siliang Feng Feifei Qi Linlin Bao Lanying Du Shuwen Liu Chuan Qin Fei Sun Zhengli Shi Yun Zhu Shibo Jiang Lu Lu | 2020 | Cell Research2020，30，4： | 81 |
| 4 | Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein显示文摘Very recently,a novel coronavirus,2019-nCoV,emerged in Wuhan,China and then quickly spread worldwide,resulting in>17,388 confirmed cases and 361 deaths as of 3 February 2020,thus calling for the development of safe and effective therapeutics and prophylatics.1,2 Similar to severe acute respiratory syndrome(SARS)-CoV,2019-nCoV belongs to lineage B betacoronavirus,and it has the ability to utilize human angiotensin-converting enzyme 2(ACE2)as a receptor to infect human cells. | Shuai Xia Yun Zhu Meiqin Liu Qiaoshuai Lan Wei Xu Yanling Wu Tianlei Ying Shuwen Liu Zhengli Shi Shibo Jiang Lu Lu | 2020 | Cellular & Molecular Immunology2020，17，7： | 27 |
| 5 | Evaluating the Provenance of Metasedimentary Rocks of the Jiangxian Group from the Zhongtiao Mountain Using Whole-Rock Geochemistry and Detrital Zircon Hf Isotope显示文摘在这研究,整个岩石的 geochemical 和 Nd,同位素的数据,以及从 Jiangxian 的沉积岩石组织的 Palaeoproterozoic 元的由岩屑形成的锆石 Hf 同位素被介绍评估他们的起源和构造历史的特征。专业和踪迹元素作文比得上Archean以后上面的大陆人外壳( PA-UCC ),但是在 LILE 有细微丰富,与例外 C 和 Sr ,和在含铁和镁的元素的细微弄空, HFS 元素例如 Nb 和 Ta ,并且一些主要元素,例如 CaO 和 Na 2 O 。 geochemical 数据表明收集了沉积岩石经历了中间的来源与化学索引捱过的元从 72~78 的改变值,K交代作用的变化的度,和 post-depositional Na 的损失,以及可以忽略的排序,并且从捱过被导出主要, felsic 和 non-mafic 摇。到 Trans 北方中国 Orogen 和作为为元的最可能的来源, Jiangxian 的沉积岩石组织的北方中国 craton 的东方块的由岩屑形成的锆石点上的选择的陆 Hf 同位素的分析。然而,从北方中国 craton 的西方的块的岩屑的贡献能被排除。沉积可能在一个活跃大陆人边缘背景以内在背弧盆被扔。 | LI Qiugen CHEN Xu LIU Shuwen WANG Zongqi ZHOU Yingkui ZHANG Jian WANG Tao | 2009 | Acta Geologica Sinica(English Edition)2009，83，3： | 15 |
| 6 | Xiba Granitic Pluton in the Qinling Orogenic Belt, Central China: Its Petrogenesis and Tectonic Implications显示文摘Xiba granitic pluton is located in South Qinling tectonic domain of the Qinling orogenic belt and consists mainly of granodiorite and monzogranite with significant number of microgranular quartz dioritic enclaves. SHRIMP zircon U-Pb isotopic dating reveals that the quartz dioritic enclaves formed at 214±3 Ma, which is similar to the age of their host monzogranite (218±1 Ma). The granitoids belong to high-K calc-alkaline series, and are characterized by enriched LILEs relative to HFSEs with negative Nb, Ta and Ti anomalies, and right-declined REE patterns with (La/Yb) N ratios ranging from 15.83 to 26.47 and δEu values from 0.78 to 1.22 (mean= 0.97). Most of these samples from Xiba granitic pluton exhibit εNd(t) values of 8.79 to 5.38, depleted mantle Nd model ages (T DM ) between 1.1 Ga and 1.7 Ga, and initial Sr isotopic ratios ( 87 Sr/ 86 Sr) i from 0.7061 to 0.7082, indicating a possible Meso-to Paleoproterozoic lower crust source region, with exception of samples XB01-2-1 and XB10-1 displaying higher ( 87 Sr/ 86 Sr) i values of 0.779 and 0.735, respectively, which suggests a contamination of the upper crustal materials. Quartz dioritic enclaves are interpreted as the result of rapid crystallization fractionation during the parent magmatic emplacement, as evidenced by similar age, texture, geochemical, and Sr-Nd isotopic features with their host rocks. Characteristics of the petrological and geochemical data reveal that the parent magma of Xiba granitoids was produced by a magma mingling process. The upwelling asthenosphere caused a high heat flow and the mafic magma was underplated into the bottom of the lower continent crust, which caused the partial melting of the lower continent crustal materials. This geodynamic process generated the mixing parent magma between mafic magma from depleted mantle and felsic magma derived from the lower continent crust. Integrated petrogenesis and tectonic discrimination with regional tectonic evolution of the Qinling orogen, it is suggested that the granitoids are most likely products in a post-collision tectonic setting. | ZHANG Fan LIU Shuwen CHEN Xu LI Qiugen DAI Junzhi YANG Kai WU Fenghui CHEN Youzhang | 2012 | Acta Geologica Sinica(English Edition)2012，86，5： | 13 |
| 7 | First mass measurement of short-lived nuclides at HIRFL-CSR显示文摘Recent commissioning of the HIRFL-CSR has demonstrated its ability to perform direct mass measurement for short-lived nuclides. Projectile fragments produced by the 78Kr ions at 481.88 MeV/u were separated with the new radioactive beam line in Lanzhou (RIBLL2), and injected into and stored in the experimental storage ring (CSRe). By operating the CSRe as an isochronous mass spectrometry, a typical mass resolution around 2.0×10?5 has been achieved. The masses for 63Ge, 65As and 67Se were measured for the first time. The measured masses are compared with theoretical predictions and the location of the proton drip-line for As isotopes is discussed. The implication of the 65As mass in the astrophysical rapid proton capture process has also been addressed. | XU HuShan TU XiaoLin YUAN YouJin XIA JiaWen ZANG YongDong WANG Meng MAO RuiShi HU ZhengGuo MEI Bo SHUAI Peng ZHU ZhiChao TANG ShuWen GENG Peng LIU Yong ZHAO TieCheng ZHANG XueYing YANG JianCheng MAO LiJun ZHANG YuHu ZHOU XiaoHong HUANG WenXue XIAO GuoQing ZHAO HongWei ZHAN WenLong | 2009 | Chinese Science Bulletin2009，54，24： | 11 |
| 8 | Inhibition of Rac1-dependent forgetting alleviates memory deficits in animal models of Alzheimer's disease显示文摘Accelerated forgetting has been identified as a feature of Alzheimer's disease(AD),but the therapeutic efficacy of the manipulation of biological mechanisms of forgetting has not been assessed in AD animal models.Ras-re-lated C3 botulinum toxin substrate 1(Rac1),a small GTPase,has been shown to regulate active forgetting in Drosophila and mice?Here,we showed that Rac1 activity is aberrantly elevated in the hippocampal tissues of AD patients and AD animal models.Moreover,amyloid-beta 42 could induce Rac1 activation in cultured cells.The elevation of Rac1 activity not only accelerated 6-hour spatial memory decay in 3-month-old APP/PS1 mice,but also significantly contributed to severe memory loss in aged APP/PS1 mice.A similar age-dependent Rac1 activity-based memory loss was also observed in an AD fly model.Moreover,inhibition of Rac1 activity could ameliorate cognitive defects and synaptic plasticity in AD animal models.Finally,two novel compounds,identified through behavioral screening of a randomly selected pool of brain permeable small molecules for their positive effect in rescuing memory loss in both fly and mouse models,were found to be capable of inhibiting Rac1 activity.Thus,multiple lines of evidence corroborate in supporting the idea that inhibition of Rac1 activity is effective for treating AD-related memory loss. | Wenjuan Wu Shuwen Du Wei Shi Yunlong Liu Ying Hu Zuolei Xie Xinsheng Yao Zhenyu Liu Weiwei Ma Lin Xu Chao Ma Yi Zhong | 2019 | Protein & Cell2019，10，10： | 10 |
| 9 | Use of Intensity Analysis to Measure Land Use Changes from 1932 to 2005 in Zhenlai County, Northeast China显示文摘Analyzing spatiotemporal dynamics of land use and land cover over time is widely recognized as important to better understand and provide solutions for social, economic, and environmental problems, especially in ecologically fragile region. In this paper, a case study was taken in Zhenlai County, which is a part of farming-pastoral ecotone of Northeast China. This study seeks to use multi-temporal satellite images and other data from various sources to analyze spatiotemporal changes from 1932 to 2005, and applied a quantitative methodology named intensity analysis in the time scale of decades at three levels: time interval, category, and transition. The findings of the case study are as follows: 1) the interval level of intensity analysis revealed that the annual rate of overall change was relatively fast in 1932–1954 and 1954–1976 time intervals. 2) The category level showed that arable land experienced less intensively gains and losses if the overall change was to have been distributed uniformly across the landscape while the gains and losses of forest land, grassland, water, settlement, wetland and other unused land were not consistent and stationary across the four time intervals. 3) The transition level illustrated that arable land expanded at the expense of grassland before 2000 while it gained intensively from wetland from 2000 to 2005. Settlement targets arable land and avoids grassland, water, wetland and other unused land. Besides, the loss of grassland was intensively targeted by arable land, forest land and wetland in the study period while the loss of wetland was targeted by water except for the time interval of 1976–2000. 4) During the early reclamation period, land use change of the study area was mainly affected by the policy, institutional and political factors, followed by the natural disasters. | YANG Yuanyuan LIU Yansui XU Di ZHANG Shuwen | 2017 | Chinese Geographical Science2017，27，3： | 9 |
| 10 | Salvianolic acid C potently inhibits SARS-CoV-2 infection by blocking the formation of six-helix bundle core of spike protein显示文摘Dear Editor,The pandemic of COVID-19 caused by SARS-CoV-2 infection has posed a serious threat to global public health and the economy.Up to now,although several potentially effective antiviral drugs are under evaluating in clinical trials around the world,1 there are still no specific antiviral countermeasures beyond supportive therapies have been established.We herein report that the hydrophilic compound Salvianolic acid C(Sal-C)from Danshen,a traditional Chinese medicine(TCM),potently inhibit SARS-CoV-2 infection by blocking the formation of six-helix bundle(6-HB)core of spike(S)protein. | Chan Yang Xiaoyan Pan Xinfeng Xu Chen Cheng Yuan Huang Lin Li Shibo Jiang Wei Xu Gengfu Xiao Shuwen Liu | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 11 | Zooarchaeological perspective on the Broad Spectrum Revolution in the Pleistocene-Holocene transitional period,with evidence from Shuidonggou Locality 12,China显示文摘Based on optimal foraging theory,prey animals from the Shuidonggou Locality 12(SDG12) are divided into three types according to body size and defense traits:high-ranked large game,low-ranked slow small game,and low-ranked fast small game.Application of the Reciprocal of Simpson's Index to the three types of animals from SDG12 yields a relatively high level of evenness,which implies a broader meat diet of the SDG12 hominids.Compared to values of taxonomic evenness from Mediterranean sites,it is suggested that this dietary expansion probably resulted from the occurrence of the Broad Spectrum Revolution rather than from climatic changes in the Shuidonggou area.Comparative studies between the Natufian phases in Hayonim Cave and the SDG12 validate this argument. | ZHANG Yue ZHANG ShuangQuan XU Xin LIU DeCheng WANG ChunXue PEI ShuWen WANG HuiMin GAO Xing | 2013 | Science China Earth Sciences2013，56，9： | 5 |
| 12 | Performance analysis of multi-channel order statistics detector for range-spread target显示文摘The problem of two order statistics detection schemes for the detection of a spatially distributed target in white Gaussian noise are studied.When the number of strong scattering cells is known,we first show an optimal detector,which requires many processing channels.The structure of such optimal detector is complex.Therefore,a simpler quasi-optimal detector is then introduced.The quasi-optimal detector,called the strong scattering cells' number dependent order statistics(SND-OS) detector,takes the form of an average of maximum strong scattering cells with a known number.If the number of strong scattering cells is unknown in real situation,the multi-channel order statistics(MC-OS) detector is used.In each channel,a various number of maximums scattered from target are averaged.Then,the false alarm probability analysis and thresholds sets for each channel are given,following the detection results presented by means of Monte Carlo simulation strategy based on simulated target model and three measured targets.In particular,the theoretical analysis and simulation results highlight that the MC-OS detector can efficiently detect range-spread targets in white Gaussian noise. | Shuwen Xu Penglang Shui | 2012 | Journal of Systems Engineering and Electronics2012，23，5： | 5 |
| 13 | Elastic Scattering of 7Be on Pb Target显示文摘 | Yang Yanyun Wang Jiansong Wang Qi Huang Meirong Ma Junbing Ma Peng Cao Xiguang Han Jianlong Bai Zhen Jin Shilong Hu Qiang Jin Lei Chen Jiangbo Zhang Xueying Chen Ruofu Hu Zhengguo Xu Shiwei Zhen Chuan Xu Zhiguo Xu Hushan Duan Liming Sun Zhiyu Chen Zhiqiang He Jianjun Li Songlin Lei Xiangguo Fu Fen Zhang Xueheng Yuan Xiaohua Du Chengming Yan Xinshuang Hu Jun Tang Shuwen Ye Ruiping Yang Kun Shi Fudong Zhang Wei Chen Ze Li Long Xu Xing Liu Longxiang Zhang Liyong Lin Qingyun Gou Boxing Xu Ge Zhou Xionghong Zhang Yuhu Xiao Guoqing | 2011 | IMP & HIRFL Annual Report2011，，1： | 4 |
| 14 | Technology and engineering application of cross area HVDC interconnection system high-precision simulation modeling based on ADPSS显示文摘In recent years, a large number of high voltage direct current(HVDC) transmission projects have been connected to AC systems. This has started to have an impact on AC/DC hybrid power grids, particularly receiving terminal power grids. An HVDC system is a large-scale power electronic integrated nonlinear system, and it includes a primary system and a control and protection system. Hence, the precision and degree of detail of HVDC systems directly affect the actual effect of simulation. In recent years, in the case of the normal operation and failure of AC power grids, the abnormal fluctuation and even locking of HVDC systems caused by the inappropriate strategies of the control and protection system component have strongly affected power grids. This has significantly affected the safety and stability of receiving power grids and normal operation. In this study, the actual engineering HVDC control logic provided by a manufacturer is analyzed and simulated based on the user defined component library of the ADPSS electromagnetic transient calculation program, and an HVDC control model based on an actual system is established. The accuracy of the DC control custom model based on ADPSS is verified through the simulation of an actual power grid. | Weijie Zheng Jianfeng Yan Xujiang Chen Shuwen Xu Yalou Li | 2018 | Global Energy Interconnection2018，1，5： | 3 |
| 15 | MicroRNA-21 suppresses PTEN and hSulf-1 expression and promotes hepatocellular carcinoma progression through AKT/ERK pathways显示文摘 | Longlong Bao Yan Yan Can Xu Weidan Ji Shuwen Shen Gaoya Xu Yong Zeng Bin Sun Haihua Qian Lei Chen Mengchao Wu Changqing Su Jie Chen | 2013 | Cancer Letters2013，，2： | 3 |
| 16 | Sensing and lasing applications of whispering gallery mode microresonators显示文摘 | Yu Zheng Zhifang Wu Perry Ping Shum Zhilin Xu Gerd Keiser Georges Humbert Hailiang Zhang Shuwen Zeng Xuan Quyen Dinh | 2018 | Opto-Electronic Advances2018，1，9： | 3 |
| 17 | Advantage of dual wavelength light-emitting diodes with dip-shaped quantum wells显示文摘Dual-wavelength light-emitting diodes (DW-LEDs) with dip-shaped quantum wells have been studied by numerical simulation.The emission spectra,light output power,carrier concentration in the quantum wells and internal quantum efficiency are investigated.The simulation results indicate that the DW-LEDs with dip-shaped quantum wells perform better than conventional LEDs with rectangular quantum wells in terms of light output power,leakage current and efficiency droop.These improvements in the electrical and optical characteristics are mainly attributed to the alleviation of the electrostatic field in the dip-shaped quantum wells. | XU YiQin FAN GuangHan ZHOU DeTao LI Xin LU TaiPing ZHAO Fang ZHANG YunYan ZHENG ShuWen GONG ChangChun | 2012 | Chinese Science Bulletin2012，57，20： | 2 |
| 18 | OCDMA Network and Key Technology显示文摘OCDMA's network application on LAN, metro-ring and backbone networks are discussed. Its simple tell-go protocol makes it a powerful competitor with CSMA/CD in optical LANs. Its large soft capacity could erase the wavelength routing algorithm of WDM based metro-ring. And its content susceptibility could be largely used in label switching backbone network. And why should be 2D CODEC as well as interference cancellation is although mentioned as OCDMA key technology. | Li Yuquan, Pu Tao, Xu Ming, Yang Shuwen PLA University of Science and Technology, Institute of Communication Engineering, Nanjing, Jiangsu P. R. China,Tel: 86-25-3384990, Fax: 86-25-3384990, Email: proflyq@etang.com Shenzhen University, Advanced Technology Research Centre, Shenzhen, Guangdong, P.R.China | 2003 | 光学学报2003，23，S1： | 2 |
| 19 | MicroRNA-21 suppresses PTEN and hSulf-1 expression and promotes hepatocellular carcinoma progression through AKT/ERK pathways显示文摘 | Longlong Bao Yan Yan Can Xu Weidan Ji Shuwen Shen Gaoya Xu Yong Zeng Bin Sun Haihua Qian Lei Chen Mengchao Wu Changqing Su Jie Chen | 2013 | Cancer Letters2013，，2： | 1 |
| 20 | Range-spread target detection using consecutive HRRPs显示文摘 | Shui Penglang Xu Shuwen Liu Hongwei | 2011 | IEEE Transactions on Aerospace and Electronic Systems2011，47，1： | 1 |
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