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| 1 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 2 | Facile synthesis of thiourea derivatives in ionic liquid显示文摘The synthesis of cinnamoyl thiourea derivatives from cinnamoyl isothiocyanate (CIT) with substituted aniline (RC6H4NH2) was investigated in the mostly used ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate, [Bmim][BF4]. Significant enhance-ments in reactivity, yield and reaction rate were achieved. The products could be recovered by simple filtration. [Bmim][BF4] couldbe recycled simply by removing water under vacuum and reused at least 9 times without significant decrease in activity. | Min Liang Xiao Feng Huang Chen Zhi Juan Chen Bao Shou Guo Xian Hai Lv Wen Ming Tang | 2007 | Chinese Chemical Letters2007，18，3： | 4 |
| 3 | Azithromycin inhibits neutrophil accumulation in airways by affecting interleukin- 17 downstream signals显示文摘 | Nguyen Van Luu Yang Jiong Qu Xue-ju Guo Ming Wang Xin Xian Qiao-yang Tang Zhi-jiao Huang Zhi-xiang Wang Yong | 2012 | Chinese Medical Journal2012，，3： | 3 |
| 4 | A novel process integrating vacuum distillation with atmospheric chlorination reaction for flexible production of tetrachloroethane and pentachloroethane显示文摘In this paper, we developed a novel process integrating vacuum distillation with atmospheric chlorination reaction(VD-ACR) to realize the flexible production of tetrachloroethane(TeCA) and pentachloroethane(PCA)from 1,2-dichloroethane(DCA). During the simulation, the distillation column and reactors were operated for separation and chlorination respectively under variable pressures and temperatures. It is interesting to note that VD-ACR processes producing pure TeCA or PCA can exhibit the similar configuration parameters after optimization, which enables the flexible production of TeCA and PCA with different molar ratios via changing operating parameters. The molar ratio of TeC A/PCA can be fine-tuned within the range of 0.9:0.1-0.1:0.9 through adjusting the amount of chlorine pumped into side reactors, giving rise to the increase of the heat duty of reboiler by five times. A pilot-scale experiment was then operated based-upon this VD-ACR process and the result matched well with the simulation. Therefore, the VD-ACR model presented in this study will be beneficial for the industrial-scale flexible production of TeCA and PCA from DCA. | Xian Chen Yunpeng Li Ge Xu Jihai Tang Zhuxiu Zhang Ming Chen Zhaoyang Fei Mifen Cui Xu Qiao | 2018 | Chinese Journal of Chemical Engineering2018，26，4： | 2 |
| 5 | Comparison of Clinical Characteristics and Outcomes of Pediatric and Adult Patients with Coronavirus Disease 2019 in Shenzhen,China显示文摘Objective Here we aimed to investigate the difference in clinical characteristics and outcomes between pediatric and adult patients with COVID-19.Methods A total of 333 consecutive patients with laboratory-confirmed SARS-CoV-2 infection treated in the departments of Internal medicine of Shenzhen Third People’s Hospital from January 11 th to February 10 th,2020 were included.The data were obtained from electronic medical records.The epidemiological data,clinical characteristics,length of hospital stays,and outcomes of pediatric and adult patients were compared.Results Compared with adult patients,pediatric patients had a shorter time of symptom onset to hospitalization than adults[median time,1(IQR,1.0-1.0)d vs.3(IQR,2.0-6.0)d,P<0.001],milder or fewer symptoms,less severe chest CT findings.The clinical severity classification of children was less severe than adults.Up to 15 th March,the end of the follow-up,33(100%)children and 292(97.3%)adult patients had been discharged from hospital.Only 2(0.7%)adult patients died,with an overall case mortality of 0.6%.The median length of hospital stay of pediatric patients was shorter than that of adult patients[19(95%CI:16.6-21.4)d vs.21(95%CI:19.9-22.1)d,P=0.024].Conclusion Pediatric patients with COVID-19 had milder or less clinical symptoms,less evident pulmonary imaging changes,better prognosis,and shorter length of hospital stay. | WANG Fang LAI Chang Xiang HUANG Peng Yu LIU Jia Ming WANG Xian Feng TANG Qi Yuan ZHOU Xuan XIAN Wen Jie CHEN Rui Kun LI Xuan LI Zhi Yu LIAO Li Qun HE Qing LIU Lei | 2020 | Biomedical and Environmental Sciences2020，33，12： | 2 |
| 6 | Synthesis of peptide-diazeniumdiolate conjugate:towards enzyme activated antitumor agents显示文摘 | Tang Xiaoping Xian Ming Wang Peng George | 2001 | Tetrahedron Lett2001，42，： | 1 |
| 7 | Nitric oxide do- nors: chemical activities and biological applications 显示文摘 | Wang PG Xian Ming Tang Xiaoping | 2002 | Chem Rev2002，102，4： | 1 |
| 8 | Glycosylated diazeniumdiolates:a novel class of enzyme-activated nitric oxide donors显示文摘 | Wu Xuejun Tang Xiaoping Xian Ming | 2001 | Tetrahedron Lett2001，42，23： | 1 |
| 9 | 查看详情显示文摘 | Jun Ni Tang Fei Long Xian Ming Shi | | 0，，08： | 1 |
| 10 | Liver dynamic contrast‐enhanced MRI for staging liver fibrosis in a piglet model显示文摘 | Li Zhou Tian‐wu Chen Xiao‐ming Zhang Zhi Yang Hong‐jie Tang Dan Deng Nan‐lin Zeng Li‐ying Wang Xiao‐li Chen Hang Li Chun‐ping Li Li Li Xian‐yong Xie Jiani Hu | 2014 | J. Magn. Reson. Imaging2014，，4： | 1 |
| 11 | Strain influence on Jc behavior of Nb3Sn multifilamentary strands fabricated by internal tin process for ITER显示文摘 | Zhang Ping xiang Liang Ming Tang Xian de | 2008 | Physica C2008，46，1520： | 1 |
| 12 | AIWW:a new nutrition-screening tool for the oncologic population显示文摘Malnutrition is a common comorbidity among patients with cancer.However,no nutrition-screening tool has been recognized in this population.A quick and easy screening tool for nutrition with high sensitivity and easy-to-use is needed.Based on the previous 25 nutrition-screening tools,the Delphi method was made by the members of the Chinese Society of Nutritional Oncology to choose the most useful item from each category.According to these results,we built a nutrition-screening tool named age,intake,weight,and walking(AIWW).Malnutrition was defined based on the scored patient-generated subjective global assessment(PG-SGA).Concurrent validity was evaluated using the Kendall tau coefficient and kappa consistency between the malnutrition risks of AIWW,nutritional risk screening 2002(NRS-2002),and malnutrition screening tool(MST).Clinical benefit was calculated by the decision curve analysis(DCA),integrated discrimination improvement(IDI),and continuous net reclassification improvement(c NRI).A total of 11,360 patients(male,n=6,024(53.0%)were included in the final study cohort,and 6,363 patients had malnutrition based on PG-SGA.Based on AIWW,NRS-2002,and MST,7,545,3,469,and1,840 patients were at risk of malnutrition,respectively.The sensitivities of AIWW,NRS-2002,and MST risks were 0.910,0.531,and 0.285,and the specificities were 0.768,0.946,and 0.975.The Kendall tau coefficients of AIWW,NRS-2002,and MST risks were 0.588,0.501,and 0.326,respectively.The area under the curve of AIWW,NRS-2002,and MST risks were0.785,0.739,and 0.630,respectively.The IDI,c NRI,and DCA showed that AIWW is non-inferior to NRS-2002(IDI:0.002(-0.009,0.013),c NRI:-0.015(-0.049,0.020)).AIWW scores can also predict the survival of patients with cancer.The missed diagnosis rates of AIWW,NRS-2002,and MST were 0.09%,49.0%,and 73.2%,respectively.AIWW showed a better nutritionscreening effect than NRS-2002 and MST for patients with cancer and could be recommended as an alternative nutritionscreening tool for this population. | Yi-Zhong Ge Zhen-Ming Fu Qi Zhang Meng-Meng Song Guo-Tian Ruan Xi Zhang Xiao-Wei Zhang Xiang-Rui Li Kang-Ping Zhang Meng Tang Xiao-Yue Liu Ming Yang Tong Liu Hai-Lun Xie He-Yang Zhang Zi-Wen Wang Chun-Lei Hu Shi-Qi Lin Rui Zhang Hong-Xia Xu Wei Li Chun-Hua Song Ming Liu Jun-Qiang Chen Kun-Hua Wang Li Bo Ming-Hua Cong Zeng-Ning Li Zeng-Qin Guo Xiao-Bin Wang Bin-Yan Wang Benjamin Xu Xian-Hui Qin Xi-Ping Xu Rocco Barazzoni Qing-Hua Yao Min Weng Xian Shen Han-Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2023 | Science China(Life Sciences)2023，66，8： | 1 |
| 13 | Two new C-glucoside oxanthrones from Rumex gmelini显示文摘二新 C 配糖物 oxanthrones, 6-methoxyl-10-hydroxyaloin A (1 ) 和 6-methoxyl-10-hydroxyaloin B (2 ) ,从 Rumex gmelini Turcz 的根被孤立。他们的结构根据分光镜的技术和化学工具被阐明。 | Zhen Yue Wang Hai Peng Zhao Yue Ming Zuo Zong Quan Wang Xian Ming Tang | 2009 | Chinese Chemical Letters2009，20，7： | 1 |
| 14 | Purification and anti-tumour activity of cyanidin-3- O -glucoside from Chinese bayberry fruit显示文摘 | Chongde Sun Yixiong Zheng Qingjun Chen Xianglian Tang Ming Jiang Jiukai Zhang Xian Li Kunsong Chen | 2011 | Food Chemistry2011，，4： | 1 |
| 15 | The One-Dimensional Distribution and Construction of Semi-Markov Processes显示文摘In this paper,we obtain the transition probability of jump chain of semi-Markov pro- cess,the distribution of sojourn time and one-dimensional distribution of semi-Markov process. Furthermore,the semi-Markov process X(t,ω)is constructed from the semi-Markov matrix and it is proved that two definitions of semi-Markov process are equivalent. | TANG Rong GUO Xian Ping LIU Zai Ming | 2008 | Journal of Mathematical Research and Exposition2008，28，3： | 1 |
| 16 | Stopping Transmission of COVID-19 in Public Facilities and Workplaces:Experience from China显示文摘The main transmission routes of Coronavirus Disease 2019(COVID-19)include droplet and contact transmission.Airborne transmission may be possible in specific circumstances and settings in which aerosol-generating procedures are performed^([1]).In2020,more than 83.4 million confirmed cases of COVID-19,including more than 1.8 million deaths. | WANG Jiao YANG Wen Jing TANG Song PAN Li Jun SHEN Jin John S.Ji WANG Xian Liang LI Li YING Bo ZHAO Kang Feng ZHANG Liu Bo WANG Lin SHI Xiao Ming | 2022 | Biomedical and Environmental Sciences2022，35，3： | 0 |
| 17 | DEVELOPMENT OF A NEUTRAL PARTICLE ANALYZER FOR THE HL-1M TOKAMAK显示文摘A neutral particle energy analyzer (NPA) has been developed to investigate the energy spectra of neutral particles emitted from the HL1M tokamak plasma. The NPA consists of a pair of 45o parallel electrostatic plates, a gas stripping cell, a column of channeltrons for recording ions,and the relevant instrumentation and software. There are eight energy channels in the NPA with energy ratio of 8 between the lowest energy channel and the highest one. Calibration experiment is the key issue for the development of NPA. Calibrations of energy, energy resolution and registration efficiency have been carried out. The scattering of neutrals through the stripping gas impingement, which is severe for the particle energy we concerned, has also been measured to calibrate the registration efficiency accurately. With the NPA, the heating effects of lower hybrid wave on the plasma ions in the HL1M tokamak for different plasma parameters, especially for different plasma density, have been investigated. | ZHONG Guangwu, ZHANG Jiquan, SONG Xianming, LU Jie, ZHENG Yinjia,ZHANG Guangyang, WANG Quanming, TANG Nianyi, DENG Zhongchao, DING Xuantong, LIU Yong, WANG Enyao (Southwestern Institute of Physics, Chengdu 610041) | 2003 | 核聚变与等离子体物理2003，23，3： | 0 |
| 18 | CLINICAL REPORT OF MODIFIED MAZE PROCEDURE显示文摘CLINICALREPORTOFMODIFIEDMAZEPROCEDURECLINICALREPORTOFMODIFIEDMAZEPROCEDUREZhuJiaGuang;HeZhongLiang;LuoWei;DongAiQiang;XuShiWe... | Zhu Jia Guang He Zhong Liang Luo Wei Dong Ai Qiang Xu Shi Wei Chen Fang Zhang Chang Ming Shang Jing Ma lie Xian Tang Chao He Qi Cai.(The Second Affiliated Hospital, Zhe Jiang Medical University 68 Jianfang Rood, Hangzhou 310009, China) | 1994 | Chinese Journal of Biomedical Engineering(English Edition)1994，3，3： | 0 |
| 19 | Chlorine-induced mixed valence of CuO_(x)/C to promote the electroreduction of carbon dioxide to ethylene显示文摘Electrochemical conversion of CO_(2)(CO_(2)RR)into high-value fuel is identified as one of the promising approaches to achieve carbon neutrality.The synthesis of high-efficiency CO_(2)reduction electrocatalysts with high C_(2):C_(1) selectivity remains a field of intense interest.Previous studies have shown that the presence of Cu(I)is beneficial for the reduction of CO_(2)into C_(2)products.However,the stable presence of Cu(I)remains controversial,especially in the negative potential window.Here we report a simple and easily scalable catalyst precursor Cu_(2)(OH)_(3)Cl/C,which automatically forms in-situ chlorine-doped Cu/Cu_(2)O heterointerface during electrocatalysis.The catalyst not only exhibits a Faradaic efficiency of 33.03%but also provides a long-term stability of Cu^(+),gaining a stable electrolysis of 11 h,with an ethylene/methane ratio over 50.The experimental results and mechanistic studies confirm that the presence of Cl^(-)inhibits the reduction of Cu^(+),inducing the formation of Cu^(0)/Cu^(+),and reduces the reaction energy of the intermediate ^(*)CO dimerization,thereby facilitating the formation of C_(2)products.This work provides a feasible way to synthesize copper ions with long-term and stable positive charge in CO_(2)RR and expands a new way to synthesize ethylene industrial products in the future. | Xin Wang Ming Miao Bowen Tang Haotian Duan Fulong Zhu Huigang Zhang Xian Zhang Wen-jin Yin Yongzhu Fu | 2023 | Nano Research2023，16，7： | 0 |
| 20 | Development and evaluation of a double-plane detector system for multi-radionuclide imaging显示文摘Purpose To develop a multi-radionuclide imaging system with a flexible and compact structure that has a potential for breast and other applications,and to evaluate its performances under both positron emission tomography and single photon emission imaging conditions.Methods The plane detector was composed of 5×6 blocks with an effective detection area of 168.6 mm×202.4 mm.Each block consisted of a 16×16 LYSO array.The pixel size is 1.9 mm×1.9 mm×15 mm.An 8×8 silicon photomultiplier(SiPM)array with SensL’s C-30035 sensors was coupled to the LYSO array,separated by a 1.5-mm-thick glass.To minimize the influence of temperature on the detector,the active part of the front-end electronics was kept away from SiPMs.Self-designed data acquisition system and reconstruction software were utilized to evaluate the performances of the whole system.Results All the blocks had excellent pixels identification.An average energy resolution of 11.39%for 511 keV and 21.37%for 140 keV was obtained.In the PET mode,the best spatial resolution was better than 2 mm and the system sensitivity reached up to 11.05%at 60 mm distance.In the single photon emission imaging mode,a spatial resolution better than 3 mm was obtained.Conclusion The results indicated that the system has a good overall performance and can be used in breast imaging and other general PET applications.It also has the potential to be used for single photon emission imaging.In pursuit of a better spatial resolution of cross-plane,PSF and DOI technology will be developed in the next work.For specific applications,further improvement of the detector system such as performance evaluation with phantoms will be carried out. | Zhen‑Rui Lu Xian‑Chao Huang Zhi‑Ming Zhang Ying‑Jie Wang Da‑Quan Cao Wei Zhou Xiao‑Yue Gu Xiao‑li Sun Pei Chai Hao‑Hui Tang Dao‑Wu Li Lin Li Chuang‑Xin Ma Long Wei | 2019 | Radiation Detection Technology and Methods2019，3，3： | 0 |
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