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| 1 | FGF21 treatment ameliorates alcoholic fatty liver through activation of AMPK-SIRT1 pathway显示文摘成纤维细胞生长因素 21 (FGF21 ) , FGF 总科的一个最近识别的成员,主要从肝和脂肪质的纸巾被分泌并且在改进新陈代谢的症候群和动态平衡起一个重要作用。这研究的目的是在含酒精的脂肪肝疾病(AFLD ) 评估 FGF21 的角色并且决定它是否在 AFLD 上有治疗学的效果。在这份报纸,我们在长期的乙醇 gavage 和对待白酒的 HepG2 房间的一个鼠科的模型在导致白酒的肝损害上测试了 FGF21 的效果。男千米;公里老鼠每天收到了 5 g/kg 乙醇 gavage 的单个剂量 6 个星期,它导致了重要脂肪肝和肝损害。导致白酒的脂肪肝房间模型被在 75 公里的最后的集中增加乙醇进 HepG2 房间文化的媒介 9 天完成。结果与 recombinant FGF21 显示出那个处理在长期的乙醇 gavage 和对待白酒的 HepG2 房间的一个鼠科的模型的改善含酒精的脂肪肝和肝损害。另外, FGF21 处理下面调整丰满的酸的肝的表示合成的关键酶,激活的肝的 AMPK-SIRT1 小径和显著地下面调整的肝的氧化压力蛋白质。一起拿, FGF21 由 AMPK-SIRT1 小径的激活在 vitro 并且在 vivo 改正 AFLD 的多重新陈代谢的参数。 | Shenglong Zhu Lei Ma Yunzhou Wu Xianlong Ye Tianyuan Zhang Qingyang Zhang Lubna Muhi Rasoul Yunye Liu MO Guo Bing Zhou Guiping Ren Deshan Li | 2014 | Acta Biochimica et Biophysica Sinica2014，46，12： | 11 |
| 2 | Suitable internal control genes for qRT-PCR normalization in cotton fiber development and somatic embryogenesis显示文摘The mechanisms of cotton fiber development and somatic embryogenesis have been explored sys-tematically with microarray and suppression subtractive hybridization. Real-time RT-PCR provides the simultaneous measurement of gene expression in many different samples,with which the data from microarray or others can be confirmed in detail. To achieve accurate and reliable gene expression re-sults,normalization of real-time PCR data against one or several internal control genes is required,which should not fluctuate in different tissues during various stages of development. We assessed the gene expression of 7 frequently used housekeeping genes,including 18S rRNA,Histone3,UBQ7,Actin,Cyclophilin,Gbpolyubiquitin-1 and Gbpolyubiquitin-2,in a diverse set of 21 cotton samples. For fiber developmental series the expression of all housekeeping genes had the same down tendency after 17 DPA. But the expression of the AGP gene(arabinogalactan protein) that has high expression level at the later fiber development stage was up-regulated from 15 to 27 DPA. So the relative absolute quanti-fication should be an efficient and convenient method for the fiber developmental series. The expres-sion of nonfiber tissues series varied not so much against the fiber developmental series. And three best control genes Histone3,UBQ7 and Gbpolyubiquitin-1 have to be used in a combinated way to get better normalization. | TU LiLi ZHANG XianLong LIU DiQiu JIN ShuangXia CAO JingLin ZHU LongFu DENG FengLin TAN JiaFu ZHANG CunBin | 2007 | Chinese Science Bulletin2007，52，22： | 10 |
| 3 | SNORD126 promotes HCC and CRC cell growth by activating the PI3K-AKT pathway through FGFR2显示文摘小核仁的 RNA (snoRNA ) 机能障碍与癌症开发被联系了。SNORD126 是在它的主机基因的 introns 5-6 以内被编码的孤儿 C/D 框 snoRNA, cyclin 交往 B1 蛋白质 1 (CCNB1IP1 ) 。SNORD126 触发的联系癌症的分子的机制充分没被理解。这里,我们证明 SNORD126 高度在 hepatocellular 癌(HCC ) 被表示, colorectal 癌症(CRC ) 病人取样。SNORD126 在裸体老鼠增加了 Huh-7 和 SW480 细胞生长和 tumorigenicity。SNORD126 击倒禁止的 HepG2 和 LS174T 房间生长。我们证实 SNORD126 没与 miRNA 活动被处理成小 RNA。而且, SNORD126 没在 HCC 样品与 CCNB1IP1 显示出重要表示关联或调整 CCNB1IP1 表示。我们的基因表示侧面分析显示了基因经常印射到 PI3K-AKT 小径的那 SNORD126-upregulated。SNORD126 overexpression 增加了 phosphorylated AKT, GSK-3,和 p70S6K 的层次并且提高了成纤维细胞生长因素受体 2 (FGFR2 ) 表示。在 SNORD126-overexpressing Huh-7 细胞的 FGFR2 的调停 siRNA 的击倒或调停 AZD4547 的 inactivation 禁止了 AKT phosphorylation 并且压制了细胞生长。这些调查结果在癌症为 SNORD126 显示一个 oncogenic 角色并且作为一个治疗学的目标建议它的潜力。 | Xianlong Fang Dongmei Yang Hongping Luo Shuai Wu Wenjie Dong Jing Xiao Sujing Yuan Aimin Ni Kang-Jian Zhang Xin-Yuan Liu Liang Chu | 2017 | Journal of Molecular Cell Biology2017，9，3： | 5 |
| 4 | Zeolite P synthesis based on fly ash and its removal of Cu(Ⅱ) and Ni(Ⅱ) ions显示文摘Zeolite P was synthesized through hydrothermal method based on a kind of Class C fly ash(FA). X-ray diffraction(XRD), scanning electron microscopy(SEM), and Brunauer–Emmett–Teller(BET) were used to analyze and characterize the synthetic sample. The kinetics and thermodynamics of copper and nickel ions removed by the zeolite samples were experimentally explored in detail. The results of kinetic treatment showed the second-order exchange second-order saturation model(SESSM) can well describe the removal process of copper ions, while the first-order empirical kinetic model(FEKM) is the best kinetic model for nickel ions. Langmuir and Freundlich isotherms were used to fit the equilibrium concentration of Cu(Ⅱ) or Ni(Ⅱ) under certain conditions. Whether for copper or nickel ion, the Langmuir model is in good agreement with the experimental equilibrium concentration.The apparent theoretical removal capacities for Cu(Ⅱ) and Ni(Ⅱ) can reach to 138.1 mg·g^(-1) and 77.0 mg·g^(-1),respectively. | Yong Liu Guodong Wang Lu Wang Xianlong Li Qiong Luo Ping Na | 2019 | Chinese Journal of Chemical Engineering2019，27，2： | 4 |
| 5 | Clonal analysis reveals remarkable functional heterogeneity during hematopoietic stem cell emergence显示文摘 | Hui Ye Xiaobo Wang Zongcheng Li Fan Zhou Xianlong Li Yanli Ni Weijing Zhang Fuchou Tang Bing Liu Yu Lan | 2017 | Cell Research2017，27，8： | 4 |
| 6 | Operando HERFD-XANES and surface sensitive Δμ analyses identify the structural evolution of copper(Ⅱ) phthalocyanine for electroreduction of CO_(2)显示文摘The quantitative understanding of how atomic-level catalyst structural changes affect the reactivity of the electrochemical CO_(2)reduction reaction is challenging.Due to the complexity of catalytic systems,conventional in situ X-ray spectroscopy plays a limited role in tracing the underlying dynamic structural changes in catalysts active sites.Herein,operando high-energy resolution fluorescence-detected X-ray absorption spectroscopy was used to precisely identify the dynamic structural transformation of well-defined active sites of a representative model copper(Ⅱ)phthalocyanine catalyst which is of guiding significance in studying single-atom catalysis system.Comprehensive X-ray spectroscopy analyses,including surface sensitive△μspectra which isolates the surface changes by subtracting the disturb of bulk base and X-ray absorption near-edge structure spectroscopy simulation,were used to discover that Cu species aggregated with increasing applied potential,which is responsible for the observed evolution of C_(2)H_(4).The approach developed in this work,characterizing the active-site geometry and dynamic structural change,is a novel and powerful technique to elucidate complex catalytic mechanisms and is expected to con tribute to the rational design of highly effective catalysts. | Bingbao Mei Cong Liu Ji Li Songqi Gu Xianlong Du Siyu Lu Fei Song Weilin Xu Zheng Jiang | 2022 | Journal of Energy Chemistry2022，31，1： | 3 |
| 7 | Regeneration and identification of interspecific asymmetric somatic hybrids obtained by donor-recipient fusion in cotton显示文摘Asymmetric hybrids between Gossypium hirsutum (YZ-1) and G. davidsonii were obtained by donor-recipient fusion. YZ-1 was considered the recipient and was pretreated with iodoacetamide (IOA), while G. davidsonii was considered the donor and was irradiated with ultraviolet (UV) before fusion. YZ-1 protoplasts stopped growth when treated with 0.5 mmol/L IOA for 20 min, and G. davidsonii protoplasts stopped growth when irradiated with 38.7 J/cm2 UV for 30 s. Asymmetric somatic hybrids were obtained by electrofusion between the separately treated protoplasts of the 2 species. The regenerated plants were identified by morphological, cytological, and molecular analysis. Most regenerated plants derived from fused protoplasts displayed new morphology; some were intermediate between the two parents and a few displayed recipient-like morphology. Chromosome numbers in these somatic hybrids mostly ranged from 40 to 73. The hybridity was confirmed by random amplified polymorphic DNA and simple sequence repeat analysis. Organelle DNA inheritance of the YZ-1 and G. davidsonii somatic hybrid was investigated by cleaved amplified polymorphism sequence and chloroplast simple sequence repeat analysis, which indicated that recombination and rearrangements might have occurred in some regions of mitochondrial and chloroplastic DNA. This is the first report of completely asymmetric hybrid production via donor–recipient fusion between G. hirsutum and G. davidsonii, which is a novel case in hybrid production following the symmetric fusion and asymmetric fusion based on UV irradiation in cotton. | FU LiLi YANG XiYan ZHANG XianLong WANG ZhiWei FENG ChangHui LIU ChuanXiang JIANG Pei-Yong ZHANG JinLong | 2009 | Chinese Science Bulletin2009，54，17： | 3 |
| 8 | Evaluation of channel-like porous-structured titanium in mechanical properties and osseointegration显示文摘The porous titanium with a channel-like pore structure fabricated by infiltration casting followed by selectively dissolving the precursor woven three dimensional(3D)structure technique was comprehensively investigated by means of mechanical tests,in vitro and in vivo evaluation.Such porous structure exhibited superiority in compressive,tensile strength and osseointegration.At 40%porosity,the average compressive and tensile strength reached about 145MPa and 85 MPa,which was superior to that of other porous titanium,e.g.,Selective Laser Melting or powder sintered ones,and was comparable to that of the human cortical bone.Without any bioactive surface treatment,this porous titanium exhibited good cell adhesion,rapid cell proliferation and excellent osseointegration.Based on the study,the 0.4mm pore size resulted in the most rapid cell proliferation and the maximal BV/TV ratio and trabecular bone number of the new bone that ingrew into the porous titanium.To balance the excellent osseointegration and adequate mechanical properties,the optimal structural parameters were 0.4mmpore size with 40%porosity.This porous titanium is very promising for orthopedic applications where compressive and tensile load-bearing is extremely important. | Dong Wang Guo He Ye Tian Ning Ren Jiahua Ni Wei Liu Xianlong Zhang | 2020 | Journal of Materials Science & Technology2020，44，9： | 2 |
| 9 | STRENGTH ANALYSIS OF CLAMPING IN MICRO/NANO SCALE EXPERIMENTS显示文摘Two kinds of clamping in micro/nano scale experiments are investigated in this paper,one based on electron-beam-induced deposition,and the other on the van der Waals interaction.The clamping strength and mechanism are analyzed both theoretically and experimentally.The influence of relative humidity on the micro/nano clamping and the method of electrostatic clamping are discussed.The clamping strength and performance of different clamping methods are compared considering the size and material of the clamped objects,and the application environments. | Liang Liu Dujuan Zeng Xianlong Wei Qing Chen Xide Li | 2009 | Acta Mechanica Solida Sinica2009，22，6： | 2 |
| 10 | PM_(2.5)and water-soluble inorganic ion concentrations decreased faster in urban than rural areas in China显示文摘We investigated variations of PM_(2.5)and water-soluble inorganic ions chemical characteristics at nine urban and rural sites in China using ground-based observations.From 2015 to 2019,mean PM_(2.5)concentration across all sites decreased by 41.9μg/m~3with a decline of 46%at urban sites and 28%at rural sites,where secondary inorganic aerosol(SIAs)contributed to 21%(urban sites)and 17%(rural sites)of the decreased PM_(2.5).SIAs concentrations underwent a decline at urban locations,while sulfate(SO_(4)^(2–)),nitrate(NO_(3)^(–)),and ammonium(NH_(4)^(+))decreased by 49.5%,31.3%and 31.6%,respectively.However,only SO_(4)^(2–)decreased at rural sites,NO_(3)^(–)increased by 21%and NH_(4)^(+)decreased slightly.Those changes contributed to an overall SIAs increase in 2019.Higher molar ratios of NO_(3)^(–)to SO_(4)^(2–)and NH_(4)^(+)to SO_(4)^(2–)were observed at urban sites than rural sites,being highest in the heavily polluted days.Mean molar ratios of NH_(3)/NH_xwere higher in 2019 than 2015 at both urban and rural sites,implying increasing NH_xremained as free NH_(3).Our observations indicated a slower transition from sulfate-driven to nitrate-driven aerosol pollution and less efficient control of NO_(x)than SO_(2)related aerosol formation in rural regions than urban regions.Moreover,the common factor at urban and rural sites appears to be a combination of lower SO_(4)^(2–)levels and an increasing fraction of NO_(3)^(–)to PM_(2.5)under NH_(4)^(+)-rich conditions.Our findings imply that synchronous reduction in NO_(x)and NH_(3)emissions especially rural areas would be effective to mitigate NO_(3)^(–)-driven aerosol pollution. | Yangyang Zhang Aohan Tang Chen Wang Xin Ma Yunzhe Li Wen Xu Xiaoping Xia Aihua Zheng Wenqing Li Zengguo Fang Xiufen Zhao Xianlong Peng Yuping Zhang Jian Han Lijuan Zhang Jeffrey L.Collett Jr Xuejun Liu | 2022 | Journal of Environmental Sciences2022，34，12： | 2 |
| 11 | Growth mechanism of primary Ti_(5)Si_(3) phases in special brasses and their effect on wear resistance显示文摘In the present work, in-situ Ti_(5)Si_(3) reinforced special brasses were prepared by melt reaction method. The synthesized Ti_(5)Si_(3) phase shows various morphologies in brasses with different Ti_(5)Si_(3) content, and the3 D morphological evolution of primary Ti_(5)Si_(3)and its growth mechanism were investigated. The Ti_(5)Si_(3) crystal, which bears D8_(8) hexagonal crystal structure, grows along <0001> direction and is revealed by{1010} faces during growth. With the increase of Ti_(5)Si_(3) content in the brasses, the morphology of primary Ti_(5)Si_(3)significantly changes from fibers to hexagonal prisms to short-rods with hollow. In addition,the influence of Ti_(5)Si_(3) volume fraction and morphology on the wear behavior of special brass was also revealed. It was substantiated that the wear resistance increases with the increasing volume fraction of Ti_(5)Si_(3), and the corresponding wear mechanism changes from delamination to slight adhesive wear and abrasive wear. However, the friction coefficient shows an abnormal increase when most of the Ti_(5)Si_(3) containing hollows appears in the brass. That is mainly due to the fact that the Ti_(5)Si_(3) is easier to break and fall off resulted by the hollow as a crack source, which makes it unable to resist the plastic deformation of the contact surface during the sliding. | Xianlong Wang Jinchuan Jie Shichao Liu Zhuangzhuang Dong Guomao Yin Tingju Li | 2021 | Journal of Materials Science & Technology2021，，2： | 2 |
| 12 | Heterogeneity in endothelial cells and widespread venous arterialization during early vascular development in mammals显示文摘Arteriogenesis rather than unspecialized capillary expansion is critical for restoring effective circulation to compromised tissues in patients.Deciphering the origin and specification of arterial endothelial cells during embryonic development will shed light on the understanding of adult arteriogenesis.However,during early embryonic angiogenesis,the process of endothelial diversification and molecular events underlying arteriovenous fate settling remain largely unresolved in mammals.Here,we constructed the single-cell transcriptomic Iandscape of vascular endothelial cells(VECs)during the time window for the occurrenee of key vasculogenic and angiogenic events in both mouse and human embryos.We uncovered two distinct arterial VEC types,the major artery VECs and arterial plexus VECs,and un expectedly diverge nt arteriove nous characteristics among VECs that are located in morphologically undistinguishable vascular plexus intra-embryonically.Using computational prediction and further lineage tracing of venous-featured VECs with a newly developed Nr2f2^(CrexER) | Siyuan Hou Zongcheng Li Ji Dong Yun Gao Zhilin Chang Xiaochen Ding Shuaili Li Yunqiao Li Yang Zeng Qian Xin Baihan Wang Yanli Ni Xiaowei Ning Yuqiong Hu Xiaoying Fan Yu Hou Xianlong Li Lu Wen Bin Zhou Bing Liu Fuchou Tang Yu Lan | 2022 | Cell Research2022，32，4： | 2 |
| 13 | Effect of cyclic mechanical loading on immunoinflammatory microenvironment in biofabricating hydroxyapatite scaffold for bone regeneration显示文摘It has been proven that the mechanical microenvironment can impact the differentiation of mesenchymal stem cells(MSCs).However,the effect of mechanical stimuli in biofabricating hydroxyapatite scaffolds on the inflammatory response of MSCs remains unclear.This study aimed to investigate the effect of mechanical loading on the inflammatory response of MSCs seeded on scaffolds.Cyclic mechanical loading was applied to biofabricate the cell-scaffold composite for 15 min/day over 7,14,or 21 days.At the predetermined time points,culture supernatant was collected for inflammatory mediator detection,and gene expression was analyzed by qRT-PCR.The results showed that the expression of inflammatory mediators(IL1B and IL8)was downregulated(p<0.05)and the expression of ALP(p<0.01)and COL1A1(p<0.05)was upregulated under mechanical loading.The cell-scaffold composites biofabricated with or without mechanical loading were freeze-dried to prepare extracellular matrix-based scaffolds(ECM-based scaffolds).Murine macrophages were seeded on the ECM-based scaffolds to evaluate their polarization.The ECM-based scaffolds that were biofabricated with mechanical loading before freeze-drying enhanced the expression of M2 polarization-related biomarkers(Arginase 1 and Mrc1,p<0.05)of macrophages in vitro and increased bone volume/total volume ratio in vivo.Overall,these findings demonstrated that mechanical loading could dually modulate the inflammatory responses and osteogenic differentiation of MSCs.Besides,the ECM-based scaffolds that were biofabricated with mechanical loading before freeze-drying facilitated the M2 polarization of macrophages in vitro and bone regeneration in vivo.Mechanical loading may be a promising biofabrication strategy for bone biomaterials. | Penghui Zhang Xizhe Liu Peng Guo Xianlong Li Zhongyuan He Zhen Li Martin J.Stoddart Sibylle Grad Wei Tian Dafu Chen Xuenong Zou Zhiyu Zhou Shaoyu Liu | 2021 | Bioactive Materials2021，6，10： | 2 |
| 14 | Hidden Blood Loss After Total Hip Arthroplasty显示文摘 | Xudong Liu Xianlong Zhang Yunsu Chen Qi Wang Yao Jiang Bingfang Zeng | 2011 | The Journal of Arthroplasty2011，，7： | 2 |
| 15 | In hibition effect of H2O on V2O5/AC catalyst for catalytic re duction of NO with NH3 at low temperature显示文摘 | HUANG Zhanggen LIU Zhenyu ZHANG Xianlong | 2006 | Applied Ca talysis B: Environmental2006，63，34： | 1 |
| 16 | Scintillation index of a multi-Gaussian Schell-model beam in turbulent atmosphere显示文摘 | Yangsheng Yuan Xianlong Liu Fei Wang Yahong Chen Yangjian Cai Jun Qu Halil T. Eyyubo?lu | 2013 | Optics Communications2013，，： | 1 |
| 17 | Analysis of geological conditions and thermal reservoir characteristics of Guantao Formation in new coastal region显示文摘Geothermal resources is one of the most practical and competitive new energy at present,and there is abundant geothermal resources in the new coastal region.The article get the three following conclusion through the geothermal geological condition by the drilling strata and the condition of the reducing test:stratigraphic division is done by the analysis of formation lithology and the drilling aging;the water yield is higher than 100m3/h,the flow temperature is 67℃--71℃;the average geothermal gradient of the overlying strata is 3.08℃--3.33℃/100 m. | JIANG Guosheng HUANG Xianlong HU Liangjun ZHANG Liandi LIU Zan LU Bao | 2013 | Global Geology2013，16，4： | 1 |
| 18 | Hidden Blood Loss After Total Hip Arthroplasty显示文摘 | Xudong Liu Xianlong Zhang Yunsu Chen Qi Wang Yao Jiang Bingfang Zeng | 2011 | The Journal of Arthroplasty2011，，7： | 1 |
| 19 | Hidden blood loss after total hip arthroplasty 显示文摘 | Xudong Liu Xianlong Zhang Yunsu Chen | 2011 | Journal of Arthro- plasty2011，26，7： | 1 |
| 20 | High Per- formanee Silicon Carbon Composite Anode Materials for Lithium Ion Bat- teries显示文摘 | Luo Zhaojun Fan Dongdong Liu Xianlong | 2009 | J Power Sources2009，189，： | 1 |
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