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| 1 | Antidiabetic Effects of Gegen Qinlian Decoction via the Gut Microbiota Are Attributable to Its Key Ingredient Berberine显示文摘Gegen Qinlian Decoction(GQD),a traditional Chinese medicine(TCM)formula,has long been used for the treatment of common metabolic diseases,including type 2 diabetes mellitus.However,the main limitation of its wider application is ingredient complexity of this formula.Thus,it is critically important to identify the major active ingredients of GQD and to illustrate mechanisms underlying its action.Here,we compared the effects of GQD and berberine,a hypothetical key active pharmaceutical ingredient of GQD,on a diabetic rat model by comprehensive analyses of gut microbiota,short-chain fatty acids,proinflammatory cytokines,and ileum transcriptomics.Our results show that berberine and GQD had similar effects on lowering blood glucose levels,modulating gut microbiota,inducing ileal gene expression,as well as relieving systemic and local inflammation.As expected,both berberine and GQD treatment significantly altered the overall gut microbiota structure and enriched many butyrate-producing bacteria,including Faecalibacterium and Roseburia,thereby attenuating intestinal inflammation and lowering glucose.Levels of short-chain fatty acids in rat feces were also significantly elevated after treatment with berberine or GQD.Moreover,concentration of serum proinflammatory cytokines and expression of immune-related genes,including Nfkb1,Stat1,and Ifnrg1,in pancreatic islets were significantly reduced after treatment.Our study demonstrates that the main effects of GQD can be attributed to berberine via modulating gut microbiota.The strategy employed would facilitate further standardization and widespread application of TCM in many diseases. | Xizhan Xu Zezheng Gao Fuquan Yang Yingying Yang Liang Chen Lin Han Na Zhao Jiayue Xu Xinmiao Wang Yue Ma Lian Shu Xiaoxi Hu Na Lyu Yuanlong Pan Baoli Zhu Linhua Zhao Xiaolin Tong Jun Wang | 2020 | Genomics, Proteomics & Bioinformatics2020，18，6： | 29 |
| 2 | Adakite-type sodium-rich rocks in Awulale Mountain of west Tianshan:Significance for the vertical growth of continental crust显示文摘The sodium-rich dacites and albite porphyries of Permian in the Awulale Mountain of west Tianshan have unique chemical and trace element signatures identical to adakite. These intermediate-acidic igneous rocks are characterized by high Na2O, Al2O3 and Sr contents and high Sr/Y and La/Y ratios (>40 and >20, respectively), and low Y and Yb contents, and strong depletion in HREE, and positive Eu anomaly. The (143Nd/144Nd)i is in the range from0.51236 to 0.51248 and the εNd(t) is positive value (+0.79-+3.11); the (87Sr/86Sr)i is in the range from 0.7052 to 0.7054. These Nd and Sr isotopic composition features indicate that the source rocks of these adakite-type rocks are from a weakly depleted mantle, or a depleted mantle, but was contaminated by the crustal materials. These adakite-type rocks were most likely derived from the partial melting of new underplated basaltic rocks under the conditions of amphibo-lite to eclogite transition in the postcollisional environment of North Xinjiang during the Permian | XIONG Xiaolin ZHAO Zhenhua BAI Zhenghua MEI Houjun WANG Yixian WANG Qiang XU Jifeng Niu Hecai BAO Zhiwei | 2001 | Chinese Science Bulletin2001，46，10： | 25 |
| 3 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 4 | Geochemistry of Alkali-rich Igneous Rocks of Northern Xinjiang and Its Implications for Geodynamics显示文摘Five nearly E-W-trending alkali-rich igneous rock belts are distributed from north to south in northern Xinjiang, and they are composed mainly of riebeckite, K-feldspar granite and high-K and medium-K calc-alkaline volcanic rocks and shoshonite. They were mainly emplaced or erupted between the Carboniferous and Permian. The compositions of Sr, Nd, Pb, and O isotopes imply that their principal resource materials are derived from the upper mantle or juvenile crust, indicating obvious continental growth in the Phanerozoic. The trace element association implies that their tectonic settings are within plate and volcanic arc for alkali-rich granites, and post-collisional arc, late oceanic arc and continental arc for alkali-rich volcanic rocks. An archipelago model was suggested for the tectonic evolution in northern Xinjiang. It can be named the central-Asia-type orogeny, which is different from the so called circum-Pacific ocean-continent-type tectonics or the Alpine-Himalayan | ZHAO Zhenhua BAI Zhenghua XIONG Xiaolin MEI Houjun WANG Yixian | 2000 | Acta Geologica Sinica(English Edition)2000，74，2： | 16 |
| 5 | A new feathered maniraptoran dinosaur fossil that fills a morphological gap in avian origin显示文摘Recent fossil discoveries have substantially reduced the morphological gap between non-avian and avian dinosaurs, yet avians including Archaeopteryx differ from non-avian theropods in their limb proportions. In particular, avians have proportionally longer and more robust forelimbs that are capable of supporting a large aerodynamic surface. Here we report on a new maniraptoran dinosaur, Anchiornis huxleyi gen. et sp. nov., based on a specimen collected from lacustrine deposits of uncertain age in western Liaoning, China. With an estimated mass of 110 grams, Anchiornis is the smallest known non-avian theropod dinosaur. It exhibits some wrist features indicative of high mobility, presaging the wing-folding mechanisms seen in more derived birds and suggesting rapid evolution of the carpus. Otherwise, Anchiornis is intermediate in general morphology between non-avian and avian dinosaurs, particularly with regard to relative forelimb length and thickness, and represents a transitional step toward the avian condition. In contrast with some recent comprehensive phylogenetic analyses, our phylogenetic analysis incorporates subtle morphological variations and recovers a conventional result supporting the monophyly of Avialae. | XU Xing ZHAO Qi NORELL Mark SULLIVAN Corwin HONE David ERICKSON Gregory WANG XiaoLin HAN FengLu GUO Yu | 2009 | Chinese Science Bulletin2009，54，3： | 15 |
| 6 | The recognition of adakite-type gneisses in the North Dabie Mountain and its implication to ultrahigh pressure metamorphic geology显示文摘Adakite is an igneous rock generated by the partial melting of subducting ocean slab in an island arc setting. Meanwhile, residuals of the slab-melting are transformed to eclogite or garnet-amphibolite during a slab subduction process. This note reports the adakite-type grey gneisses discovered in the North Dabie Mountain. These adakitic rocks are characterized by high AI2O3(14.97%-17.56%), Sr (545-941 μg/g), Sr/Y (44.71-218.98), La/Yb (16.70-97.50), and low Y (3.32-12.19μg/g), Yb (0.31-1.34 μg/g), Sc (0.92-4.2μg/g), as well as positive Sr anomaly but absent or positive Eu anomaly. They are different from the low aluminum grey gneisses with low AI2O3 (13.73%-14.38%), Sr (262-409 μg/g), Sr/Y (6.46-15.97) and La/Yb (1.90-22.60), high Y(21.79-36.24 μg/g), Yb (2.00-5.59 μg/g) , Sc (8.30%-12.70%), and negative Sr, Eu anomaly in the North Dabie Mountain. The adakite-type grey gneisses in the North Dabie Mountain were most probably formed by the partial melting of subducting ocean slab before the | WANG Qiang XU Jifeng WANG Jianxin ZHAO Zhenhua WANG Renjing QIU Jiaxiang XIONG Xiaolin SANG Longkang PENG Lianhong | 2000 | Chinese Science Bulletin2000，45，21： | 12 |
| 7 | First mass measurement of short-lived nuclides at HIRFL-CSR显示文摘Recent commissioning of the HIRFL-CSR has demonstrated its ability to perform direct mass measurement for short-lived nuclides. Projectile fragments produced by the 78Kr ions at 481.88 MeV/u were separated with the new radioactive beam line in Lanzhou (RIBLL2), and injected into and stored in the experimental storage ring (CSRe). By operating the CSRe as an isochronous mass spectrometry, a typical mass resolution around 2.0×10?5 has been achieved. The masses for 63Ge, 65As and 67Se were measured for the first time. The measured masses are compared with theoretical predictions and the location of the proton drip-line for As isotopes is discussed. The implication of the 65As mass in the astrophysical rapid proton capture process has also been addressed. | XU HuShan TU XiaoLin YUAN YouJin XIA JiaWen ZANG YongDong WANG Meng MAO RuiShi HU ZhengGuo MEI Bo SHUAI Peng ZHU ZhiChao TANG ShuWen GENG Peng LIU Yong ZHAO TieCheng ZHANG XueYing YANG JianCheng MAO LiJun ZHANG YuHu ZHOU XiaoHong HUANG WenXue XIAO GuoQing ZHAO HongWei ZHAN WenLong | 2009 | Chinese Science Bulletin2009，54，24： | 11 |
| 8 | Retrospective study of Traditional Chinese Medicine treatment of type 2 diabetes mellitus显示文摘OBJECTIVE: To provide clinical evidence in support of Dahuang Huanglian Xiexin decoction(DHXD) to treat type 2 diabetes mellitus(T2DM) and to introduce a new treatment option for clinicians.METHODS: Retrospective analysis was used to evaluate DHXD for the treatment of T2DM by analyzing clinical records of 183 cases. Patients with T2DM who met the inclusion criteria between January 1,2013 and January 1, 2014 were enrolled. The effects of the treatment were evaluated by the changes in fasting blood-glucose(FBG), postprandial blood sugar(PBG), hemoglobin A1c(Hb Alc), blood lipid profiles and body mass index(BMI) at 1, 2, 3 and 6 months. The changes in main symptoms were alsoevaluated. The dosage of Huanglian(Rhizoma Coptidis) and related factors were analyzed.RESULTS: There was a significant improvement in mean Hb A1C at 3 and 6 months after DHXD treatment compared with the baseline level(P < 0.01).There were also significant improvements in FBG,PBG, blood lipid series and BMI. DHXD also improved the main symptoms of stomach and intestine excessive heat syndrome in patients with obese T2DM. Huanglian(Rhizoma Coptidis) was the most frequently used in 678 clinical visits, the dosage of Huanglian(Rhizoma Coptidis) was related to age, BMI, DM duration, the level of blood glucose,and use of Western hypoglycemic drugs.CONCLUSION: This study suggests that DHXD could decrease blood glucose and improve T2DM symptoms and reduce body weight. The use of DHXD may indicate a new optional treatment for T2 DM. | Pang Bing Guo Jing Zhao Linhua Zhao Xiyan Zhou Qiang Tong Xiaolin | 2016 | Journal of Traditional Chinese Medicine2016，36，3： | 11 |
| 9 | The role played by traditional Chinese medicine in preventing and treating COVID-19 in China显示文摘Traditional Chinese medicine(TCM),an ancient system of alternative medicine,played an active role in the prevention and control of COVID-19 in China.It improved the clinical symptoms of patients,reduced the mortality rate,improved the recovery rate,and effectively relieved the operating pressure on the national medical system during critical conditions.In light of the current global pandemic,TCM-related measures might open up a new channel in the control of COVID-19 in other countries and regions.Here,we summarize the TCM-related measures that were widely used in China,including TCM guidelines,the Wuchang pattern,mobile cabin hospitals,integrated treatment of TCM and modern medicine for critical patients,and non-medicine therapy for convalescent patients,and describe how TCM effectively treated patients afflicted with the COVID-19.Effective TCM therapies could,therefore,be recommended and practiced based on the existing medical evidence from increased scientific studies. | Qingwei Li Han Wang Xiuyang Li Yujiao Zheng Yu Wei Pei Zhang Qiyou Ding Jiaran Lin Shuang Tang Yikun Zhao Linhua Zhao Xiaolin Tong | 2020 | Frontiers of Medicine2020，14，5： | 10 |
| 10 | Temperature-induced deformation of CRTS II slab track and its effect on track dynamical properties显示文摘Two finite-element models of the CRTS II slab track are presented to simulate temperature-induced deformations of the concrete track slab with no deterioration or with a deteriorated cement asphalt mortar(CAM).One model,which considers the fully bonding interface between the slab and the CAM layer,could applied to a track that is in good condition;the other model uses cohesive zone elements to simulate the deteriorated CAM with some possible interfacial separation and slip.Utilizing both of the models,temperature-induced warp deformations of track under various temperature loads are investigated.The influence of temperature deformation on the dynamic properties of the track is analyzed based on the train-track coupled dynamics.Numerical results show that the deteriorated CAM layer can significantly increase temperature deformations of a CRTS II track slab,which would produce tiny rail irregularities.There are clear differences between the deformation shapes of the track slabs that have an inseparable mortar layer and those have a separable mortar layer.The track slab with a deteriorated mortar layer showed more open curl distortion than the track slab in good condition.The dynamical response index of the slab track is intensified to a certain level due to the temperature deformation;with an increase of the train speed,the track dynamical responses increased linearly.However,rail irregularities due to the temperature deformations are very tiny.Even if a track is exposed to extreme temperature loads and the mortar layer is deteriorated,temperature deformation can have a negligible effect on the track’s dynamical properties. | SONG XiaoLin ZHAO ChunFa ZHU XiaoJia | 2014 | Science China(Technological Sciences)2014，57，10： | 8 |
| 11 | Efficacy of Shenzhuo formula on diabetic kidney disease:a retrospective study显示文摘OBJECTIVE:To observe the efficacy of a traditional Chinese medicine,Shenzhuo formula,on patients with diabetic kidney disease(DKD).METHODS:Eighty-eight outpatients with DKD were enrolled.Changes in estimated glomerular filtration rate(eGFR),creatinine clearance,serum creatinine,blood-urea-nitrogen,albuminuria,glycosylated hemoglobin(Hb_(A1C)),blood pressure,and lipid profile were measured and analyzed before and after intervention with Shenzhuo formula for 1,3,6,9,12,and 18 months.RESULTS:Compared with the baseline amounts,serum creatinine decreased,and eGFR and creatinine clearance increased,significantly after intervention for 1,3,6,9,12,and 18 months(all P < 0.05).Mean eGFR increased by 2.11 mL/min per 1.73 m7 y after18-month treatment.Urinary protein at 24 h decreased significantly after 1,3,9,and 12 months(P < 0.05).Hb_(A1C) decreased significantly(P < 0.05) after 3,6,9,12,and 18 months,and systolic blood pressure decreased significantly(P < 0.05) after 1,3,and 6 months.Total cholesterol decreased significantly(P < 0.05) after 1,3,6,and 18 months.Triglyceride and low-density lipoprotein-cholesterol decreased significantly(P < 0.05) after 1 and 3 months.CONCLUSION:Shenzhuo formula can improve eGFR and possibly slow DKD progression.Shenzhuo formula can also lower Hb_(A1C),lipid levels and blood pressure. | Tian Jiaxing Zhao Linhua Zhou Qiang Liu Wenke Chen Xinyan Lian Fengmei Tong Xiaolin | 2015 | Journal of Traditional Chinese Medicine2015，35，5： | 8 |
| 12 | Adsorption-energy-based activity descriptors for electrocatalysts in energy storage applications显示文摘Energy storage technologies, such as fuel cells, ammonia production and lithium–air batteries, are important strategies for addressing the global challenge of energy crisis and environmental pollution.Taking overpotential as a direct criterion, we illustrate in theory and experiment that the adsorption energies of charged species such as Li^++e^-and H^++e^-are a central parameter to describe catalytic activities related to electricity-in/electricity-out efficiencies. The essence of catalytic activity is revealed to relate with electronic coupling between catalysts and charged species. Based on adsorption energy, some activity descriptors such as d-band center, e_g-electron number and charge-transfer capacity are further defined by electronic properties of catalysts that directly affect interaction between catalysts and charged species. The present review is helpful for understanding the catalytic mechanisms of these electrocatalytic reactions and developing accurate catalytic descriptors, which can be employed to screen high-activity catalysts in future high-throughput calculations and experiments. | Youwei Wang Wujie Qiu Erhong Song Feng Gu Zhihui Zheng Xiaolin Zhao Yingqin Zhao Jianjun Liu Wenqing Zhang | 2018 | National Science Review2018，5，3： | 8 |
| 13 | Hepatocyte growth factor improves right ventricular remodeling in pulmonary arterial hypertensive rats via decreasing neurohormonal activation and inhibiting apoptosis显示文摘 | Wang Xiaolin Wang Yongjin Rong Shuling Ma Hongbiao Ma Qing Zhao Junqing | 2014 | Chinese Medical Journal2014，，10： | 7 |
| 14 | Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Rheumatoid arthritis(RA)is an aggressive autoimmune arthritis,and current therapies remain unsatisfactory due to low remission rate and substantially adverse effects.Low-dose interleukin-2(Ld-IL2)is potentially a therapeutic approach to further improve the disease.This randomized,double-blind,placebo-controlled trial was undertaken to evaluate the efficacy and safety of Ld-IL2 in patients with active RA.Patients were randomly assigned(1:1)to receive Ld-IL2,defined as a dose of 1 million IU,or placebo in a 12-week trial with a 12-week follow-up.Three cycles of Ld-IL2 or placebo were administered subcutaneously every other day for 2 weeks(a total of 7 doses),followed by a 2-week break.All patients received a stable dose of methotrexate(MTX).The primary outcomes were the proportion of patients achieving the ACR20,DAS28-ESR<2.6,and the change from baseline in CDAI or SDAI at week 24.Secondary endpoints included other clinical responses and safety.The primary outcomes were achieved in the perprotocol population.The improvements from baseline in CDAI and SDAI were significantly greater across time points for the LdIL2+MTX group(n=17)than for the placebo+MTX group(n=23)(P=0.018 and P=0.015,respectively).More patients achieved ACR20 response in the Ld-IL2+MTX group than those in the placebo+MTX group at week 12(70.6%vs 43.5%)and at week 24(76.5%vs 56.5%)(P=0.014).In addition,low Treg and high IL-21 were associated with good responses to Ld-IL2.Ld-IL-2 treatment was well-tolerated in this study.These results suggested that Ld-IL2 was effective and safe in RA.ClinicalTrials.gov number:NCT 02467504. | Xiaoying Zhang Miao Miao Ruijun Zhang Xu Liu Xiaozhen Zhao Miao Shao Tian Liu Yuebo Jin Jiali Chen Huixin Liu Xia Zhang Yun Li Yunshan Zhou Yue Yang Ru Li Haihong Yao Yanying Liu Chun Li Yuhui Li Limin Ren Yin Su Xiaolin Sun Jing He Zhanguo Li | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 7 |
| 15 | Effects and safety of aspirin use in patients after cerebrovascular bypass procedures显示文摘Object Superficial temporal artery to middle cerebral artery(STA-MCA)bypass is the most effective treatment for Moyamoya disease(MMD).In this study,we aimed to assess whether aspirin improves STA-MCA bypass patency and is safe in patients with MMD.Methods We performed a retrospective medical record review of patients with ischaemic-onset MMD who had undergone STA-MCA bypass at two hospitals between January 2011 and August 2018,to clarify the effects and safety of aspirin following STA-MCA bypass.The neurological status at the last follow-up(FU)was compared between patients with FU bypass patency and occlusion.Results Among 217 identified patients(238 hemispheres),the mean age was 41.4±10.2 years,and 51.8%were male;the indications for STA-MCA bypass were stroke(48.2%),followed by a transient ischaemic attack(44.0%).Immediate bypass patency was confirmed in all cases.During the FU period(1.5±1.5 y),15 cases were occluded at FU imaging,resulting in an overall cumulative patency rate of 94%.The patency rates were 93%and 94%in the short-term FU group(n=131,mean FU time 0.5±0.2 years)and long-term FU group(n=107,mean FU time 4.1±3.5 years),respectively.The STA-MCA bypass patency rate in the aspirin group was higher than that in the non-aspirin group(98.7%vs 89.7%;HR 1.57;95%CI 1.106 to 2.235;p=0.012).No significant difference in the FU haemorrhagic events was observed between the aspirin and non-aspirin groups.Conclusions Among adult patients with ischaemic-onset MMD undergoing STA-MCA bypass procedures,aspirin might increase the bypass patency rate,without increasing the bleeding risk.FU bypass patency may be associated with a better outcome.Additional studies,especially carefully designed prospective studies,are needed to address the role of aspirin after bypass procedures. | Junlin Lu Guangchao Shi Yuanli Zhao Rong Wang Dong Zhang Xiaolin Chen Hao Wang Ji Zong Zhao | 2021 | Stroke & Vascular Neurology2021，6，4： | 7 |
| 16 | Study on Surface and Bulk Properties of Ce-5 % Lanthanum Alloy显示文摘The surface and bulk properties of Ce-5% La were studied with X-ray photoelectron spectroscopy (XPS)and X-ray diffraction (XRD), respectively.The XRD analysis shows that cerium in bulk is in γ-phase, and its lattice parameter is 0.516 nm.And we also find Ce2O3 in the bulk from the XRD figure but no existence of metal lanthanum because of its small quantity.The XPS analysis shows that there are always oxides existing in the surface.The O1s peak always exists at the binding energy of 530.3 eV, which may be attributed to Ce2O3 and La2O3, but no evidence was found for the existence of CeO2.It is concluded that there is a thick layer of Ce2O3 on the sample surface.And the Ce3d peak show multi-split in the figure, in which there are two peaks in each region, 3d5/2 and 3d3/2, and the binding energy of these peaks are 882.86, 887.70 eV for 3d5/2, and 901.44, 905.93 eV for 3d3/2.The special phenomena can be attributed to the changes of 4f electronic configuration, and the cerium in the sample exhibits properties similar to Ce2O3.But the influence of the addition of lanthanum to cerium is not visible, and further investigations are expected. | Luo Lizhu Wang Xiaolin Fu Xiaoguo Zhang Yanzhi Zhao Zhengping Liu Chunrong | 2004 | Journal of Rare Earths2004，22，z1： | 7 |
| 17 | Effects of Brassinosteroid Associated with Auxin and Gibberellin on Apple Tree Growth and Gene Expression Patterns显示文摘Brassinosteroid is an important hormone that interacts with auxin and gibberellin to regulate plant growth and development. However,there is currently a relative lack of information regarding brassinosteroid in apple. Previous study confirmed that exogenous brassinosteroid treatments increased growth and endogenous brassinosteroid, auxin, as well as gibberellin levels of apple nursery trees. Here we succeeded to find that exogenous brassinosteroid treatments upregulated the transcript expression of auxin biosynthesis, transport, and positive signal transduction genes as well as gibberellin biosynthesis genes. In contrast, the application of exogenous brassinosteroid downregulated the expression of genes encoding negative regulators of auxin and gibberellin signal transductions. Rapid responses of several brassinosteroid-,auxin-, and gibberellin-related genes to the brassinosteroid and brassinazole treatments inferred the crosstalk of BR and IAA or GA. Furthermore,the expression levels of cell growth-related genes were also enhanced by exogenous brassinosteroid. Auxin and gibberellin treatments also influenced growth of apple tree and enhanced the expression of brassinosteroid-and cell growth-related genes. These results indicate that the growth of apple tree is regulated by the interaction between brassinosteroid, auxin, and gibberellin. Our work opened new avenues for deep portfolio of apple tree growth and laid the foundation for future studies aimed at elucidating the mechanisms regulating hormone interactionsmediated growth in apple trees. | Liwei Zheng Cai Gao Caide Zhao Lizhi Zhang Mingyu Han Na An Xiaolin Ren | 2019 | Horticultural Plant Journal2019，5，3： | 7 |
| 18 | 钻石鸟嘴式方管T形节点热点应力集中系数分析显示文摘钻石鸟嘴式节点是桁架式方管结构中一种新的焊接节点型式,本文基于疲劳性能研究的需要,应用有限元方法,分别分析了在支管受轴力和平面弯矩作用下这种T形节点的热点应力集中系数SCF,考察了节点无量纲几何参数β,2γ,τ对SCF的影响效应,并将这种新型节点的SCF与传统方管节点的SCF进行了比较。分析表明钻石鸟嘴式节点在支管轴力作用下,支管和主管的热点应力位置都出现在鞍点;在支管平面弯矩作用下,支管和主管的热点应力位置都出现在冠点;钻石鸟嘴式节点的热点应力集中系数显著低于传统方管节点,意味着前者比后者具有更好的疲劳强度。 | 刘永强 童乐为 ZHAO Xiaolin | 2009 | 结构工程师2009，25，2： | 6 |
| 19 | A new oofamily of dinosaur egg from the Upper Cretaceous of Tiantai Basin,Zhejiang Province,and its mechanism of eggshell formation显示文摘Here we describe new types of dinosaur eggs found from the Late Cretaceous Chichengshan Formation in the Tiantai Basin,Zhejiang Province.On the basis of such characters as small spheroid or near-spheroid,columnar layer composed of three zones,the outer zone consisted of stalagmite-like or coralliform secondary shell units,we established two new oogenera,one new and one combination oospecies:Stalicoolithus shifengensis oogen.et oosp.nov.and Coralloidoolithus shizuiwanensis oogen.et comb.nov.In addition,re-examination of the holotype of Shixingoolithus erbeni from the Upper Cretaceous Pingling Formation,Guangdong Province reveals that it was erroneously attributed to Spheroolithidae,and should be transferred to stalicoolithid.Consequently,we established a new oofamily:Stalicoolithidae oofam.nov.Stalicoolthids represents a new model of dinosaur eggshell and thus sheds new light on the formation and evolution of amniotic eggshells. | WANG Qiang WANG XiaoLin ZHAO ZiKui JIANG YanGen | 2012 | Chinese Science Bulletin2012，57，28： | 6 |
| 20 | The relations among the three kinds of conditional risk measures显示文摘Let(Ω,E,P)be a probability space,F a sub-σ-algebra of E,Lp(E)(1 p+∞)the classical function space and Lp F(E)the L0(F)-module generated by Lp(E),which can be made into a random normed module in a natural way.Up to the present time,there are three kinds of conditional risk measures,whose model spaces are L∞(E),Lp(E)(1 p<+∞)and Lp F(E)(1 p+∞)respectively,and a conditional convex dual representation theorem has been established for each kind.The purpose of this paper is to study the relations among the three kinds of conditional risk measures together with their representation theorems.We first establish the relation between Lp(E)and Lp F(E),namely Lp F(E)=Hcc(Lp(E)),which shows that Lp F(E)is exactly the countable concatenation hull of Lp(E).Based on the precise relation,we then prove that every L0(F)-convex Lp(E)-conditional risk measure(1 p+∞)can be uniquely extended to an L0(F)-convex Lp F(E)-conditional risk measure and that the dual representation theorem of the former can also be regarded as a special case of that of the latter,which shows that the study of Lp-conditional risk measures can be incorporated into that of Lp F(E)-conditional risk measures.In particular,in the process we find that combining the countable concatenation hull of a set and the local property of conditional risk measures is a very useful analytic skill that may considerably simplify and improve the study of L0-convex conditional risk measures. | GUO TieXin ZHAO ShiEn ZENG XiaoLin | 2014 | Science China Mathematics2014，57，8： | 6 |
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