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13篇 您的检索式:作者名="Xiaochen Cai"
    题名 作者 年代 出处 被引量
1Major advances in studies of the physical geography and living environment of China during the past 70 years and future prospects显示文摘The natural environment provides material essentials for human survival and development. The characteristics,processes, regional differentiation and forcing mechanisms of the elements of the natural environment(e.g. geomorphology,climate, hydrology, soil, etc.) are the main objects of research in physical geography. China has a complex natural environment and huge regional differentiation and therefore it provides outstanding reserach opportunities in physical geography. This review summarizes the most important developments and the main contributions of research in the physical geography and human living environment in China during the past 70 years. The major topics addressed are the uplift of the Tibetan Plateau and the evolution of its cryosphere, the development of fluvial systems, the acidification of the vast arid region of the Asian interior, variations in the monsoon and westerly climate systems on multiple timescales, the development of lakes and wetlands, the watershed system model, soil erosion, past human-environment interactions, biogeography, and physical geographic zonality. After briefly introducing international research developments, we review the history of research in physical geography in China, focusing on the major achievements and major academic debates, and finally we summarize the status of current research and the future prospects. We propose that in the context of the national demand for the construction of an ecological civilization, we should make full use of the research findings of physical geography, and determine the patterns and mechanisms of natural environmental processes in order to continue to promote the continued contribution of physical geography to national development strategies, and to further contribute to the theory of physical geography from a global perspective.Fahu CHEN Bojie FU Jun XIA Duo WU Shaohong WU Yili ZHANG Hang SUN Yu LIU Xiaomin FANG Boqiang QIN Xin LI Tingjun ZHANG Baoyuan LIU Zhibao DONG Shugui HOU Lide TIAN Baiqing XU Guanghui DONG Jingyun ZHENG Wei YANG Xin WANG Zaijun LI Fei Wang Zhenbo HU Jie WANG Jianbao LIU Jianhui CHEN Wei HUANG Juzhi HOU Qiufang CAI Hao LONG Ming JIANG Yaxian HU Xiaoming FENG Xingguo MO Xiaoyan YANG Dongju ZHANG Xiuhong WANG Yunhe YIN Xiaochen LIU 2019Science China Earth Sciences2019,62,11:11
2Neglected Rural Public Health Issue:The Case of Intestinal Roundworms显示文摘Despite increasing institutional and financial support,certain public health issues are still neglected by the Chinese Government.The present paper examines the soil-transmitted helminth(STH)infection and reinfection rates by conducting a survey on 1724 children in Guizhou Province,China.Our results indicate that 37.5 percent of children had been infected with one or more of the three types of tested STH.However,only 50.4 percent of children reported having taken deworming medicine during the 18-month period before the survey.Of those who reported being dewormed,34.6 percent tested positive for STH infections.Poverty and number of siblings are significantly and positively correlated with infection and reinfection,and parental education is significantly and negatively correlated with infection and reinfection.Given the ineffectiveness of treatment in these areas to date,for anthelmintic campaigns to actually succeed,China must pay more attention to locallevel incentives to improve children's health.Linxiu Zhang Yingping Cai Xiaobing Wang Xiaochen Ma Alexis Medina D.Scott Smith Scott Rozelle 2013China & World Economy2013,21,3:2
3High-throughput sequencing reveals the disruption of methylation of imprinted gene in induced pluripotent stem cells显示文摘在导致的 pluripotent 干细胞(iPSCs ) 积累的反常 epigenetic 修正是否能最终影响 iPSC pluripotency,仍然保持争论。为了探查这个问题,有一样的基因背景的 iPSC 线和 proviral 集成地点,被建立,并且每根 iPSC 线的 pluripotency 状态用 tetraploid (4N ) 被描绘互补试金。随后,基因表示和 “ 的全球 epigenetic 修正; 4N-ON ”并且相应 “ 4N-OFF ”iPSC 线通过深定序 mRNA 表示,小 RNA 侧面, histone 修正(H3K27me3, H3K4me3,和 H3K4me2 ) ,和 DNA methylation 的分析被比较。我们发现了印的基因的那 methylation, Zrsr1,一致地与减少的 pluripotency 在 iPSC 线被破坏。而且,破坏 methylation 不能被改进文化条件或 iPSCs 的 subcloning 救。而且,在 iPSCs 的 Zrsr1 和 pluripotency 状态的 hypomethylation 之间的关系进一步在线从另外的 reprogramming 系统导出的独立 iPSC 被验证。Gang Chang Shuai Gao Xinfeng Hou Zijian Xu Yanfeng Liu Lan Kang Yu Tao Wenqiang Liu Bo Huang Xiaochen Kou Jiayu Chen Lei An Kai Miao Keqian Di Zhilong Wang Kun Tan Tao Cheng Tao Cai Shaorong Gao Jianhui Tian 2014Cell Research2014,24,3:2
4Point Cloud Classification and Accuracy Analysis Based on Feature Fusion显示文摘A method for land-cover classification was proposed based on the fusion of features generated from waveform data and point cloud respectively.It aims to partially overcome the ineffectiveness of many traditional classifiers caused by the fact that point cloud is lacking spectral information.The whole flowchart of the method is as follows:Firstly,Gaussian decomposition was applied to fit an echo full-waveform.The parameters associated with the Gaussian function were optimized by LM(Levenberg-Marquard)algorithm.Six and thirteen features were generated to describe the waveform characteristics and the local geometry of point cloud,respectively.Secondly,a random forest was selected as the classifier to which the generated features were input.Relief-F was used to rank the weights of all the features generated.Finally,features were input to the classifier one by one according to the weights calculated from feature ranking,where classification accuracies were evaluated.The experimental results show that the effectiveness of the fusion of features generated from waveform and point cloud for LiDAR data classification,with 95.4%overall accuracy,0.90 kappa coefficient,which outperform the results obtained by a single class of features,no matter whether they were generated from point cloud or waveform data.Xiaochen WANG Hongchao MA Liang ZHANG Zhan CAI Haichi MA 2021Journal of Geodesy and Geoinformation Science2021,4,3:2
5Replacement of Oct4 by Tet1 during iPSC Induction Reveals an Important Role of DNA Methylation/Hydroxymethylation in Reprogramming显示文摘Yawei Gao Jiayu Chen Ke Li Tong Wu Bo Huang Wenqiang Liu Xiaochen Kou Yu Zhang Hua Huang Yonghua Jiang Chao Yao Xiaolei Liu Zhiwei Lu Zijian Xu Lan Kang Jun Chen Hailin Wang Tao Cai Shaorong Gao 2013Cell Stem Cell2013,,:1
6Small-molecule diketopyrrolopyrrole-based therapeutic nanoparticles for photoacoustic imaging-guided photothermal therapy显示文摘治疗学的 nanoparticles (NP ) 基于 donor-acceptor-donor,结构化的小器官的分子 diketopyrrolopyrrole (SDPP ) 用一条简单降水途径被准备。这些在红外线附近的吸收放射的 NP 有高 photothermal 变换效率并且能有选择地通过提高的渗透和保留效果指向癌症纸巾。得益于这些优点, SDPP NP 能用作一个优秀治疗学的代理人为高度有效并且 noninvasive photoacoustic 指导成像的 photothermal 治疗。用老鼠肿瘤模型的实验证明 SDPP NP 在激光照耀下面展出了非凡的肿瘤脱离能力(660 nm, 1.0 W ? 敳獮瑩癩? 慮潮戭潩椠瑮牥慦散漠 ? 桴獩 ?? 楨牥牡档捩污祬猠牴 ' 壮肭?業牣景畬摩捩搠癥捩 ? 眠楨档猠潨敷 ? 楨桧攠晦捩敩据 ? 景 ?? 挠灡畴敲吗?Yu Cai Weili Si Qianyun Tang Pingping Liang Chengwu Zhang Peng Chen QiZhang Wei Huang Xiaochen Dong 2017Nano Research2017,10,3:1
7Eddy current loss analysis and frequency optimization design of double-sided LCC-IPT system in seawater environment显示文摘Inductive power transfer system can generate eddy current when operating in seawater medium. On the one hand, it can cause eddy current loss, and reduce operating efficiency of the system. On the other hand, it can change parameters of the system and increase difficulty of system design. To grasp the influence mechanism of seawater on the inductive power transfer system,firstly, an equivalent circuit model of double-sided inductor-capacitor-capacitor(LCC) inductive power transfer system in seawater environment was established based on loosely-coupled transformer model of eddy current. Then, based on Maxwell’s equations, the distribution function of the magnetic field and electric current density along radium direction of the coupling coils in seawater medium was obtained by analytical calculation. Besides, in combination with Biot-Savart law, expression of the eddy current loss in transfer direction was derived, and based on which expression of the equivalent of the eddy current loss on the coupling coils was got. Thus the equivalent resistance of the eddy current on the coupling coils in a seawater environment could be predicated, and the optimal operating frequency of the inductive power transfer system could be further optimized. Finally, a prototype of inductive power transfer system was established, which gave the experimental results, and verified the correctness of theoretical analysis, and the experiments showed that: in air medium, the transfer distance was 100 mm, the transfer power was 3.3 k W, and the transfer efficiency was 92.6%;while, in seawater medium, the transfer efficiency was 87%. Eddy current losses mainly caused the reduction in efficiency, and the experimental results of eddy current loss were consistent with the simulation results.SUN Pan WU XuSheng CAI Jin WANG XiaoNa ZHANG XiaoChen LIANG Yan XIONG Qiao RONG EnGuo 2022Science China(Technological Sciences)2022,65,2:1
8Polycyclic naphthalenediimide-based nanoparticles for NIR-Ⅱ fluorescence imaging guided phototherapy显示文摘Optical imaging and phototherapy in the second near-infrared window(NIR-Ⅱ, 900–1700 nm) can reduce tissue auto-fluorescence and photon scattering, which facilitates higher spatial resolution and deeper tissue penetration depth for solid tumor theranostics. Herein, a polycyclic naphthalenediimide(NDI) based chromophore 13-amino-4,5-dibromo-2,7-di(dodecan-6-yl)-1 H-isoquinolino[4,5,6-fgh]naphtho[1,8-bc][1,9]phenanthroline-1,3,6,8(2H,7H,9H)-tetraone(NDI-NA) was designed and synthesized. With large polycyclic π-systems, NDI-NA molecule possesses broad near-infrared(NIR) absorption(maximum at777 nm) and emission(maximum at 921 nm). By nanoprecipitation, NDI-NA nanoparticles(NPs) were formed in aqueous solution with J-aggregative state, which showed huge red-shift in both absorption spectrum(maximum at 904 nm) and emission spectrum(maximum at 1,020 nm), endowing NDI-NA NPs efficient NIR-Ⅱ fluorescence imaging capability. Besides, the NPs present effective tumor-targeting capability in vivo based on the enhanced permeation and retention(EPR) effect. More importantly, NDI-NA NPs simultaneously have high photothermal conversion efficiency(30.8%) and efficient reactive oxygen species generation ability, making them remarkably phototoxic to cancer cells. The polycyclic chromophore based multifunctional NDI-NA NPs as NIR-Ⅱ phototheranostic agents possess bright future for clinical NIR-Ⅱ imaging-guided cancer phototherapy.Chuanchao Tang Chuanhui Song Zheng Wei Chen Liang Jianchuan Ran Yu Cai Xiaochen Dong Wei Han 2020Science China Chemistry2020,63,7:1
9Replacement of Oct4 by Tet1 during iPSC Induction Reveals an Important Role of DNA Methylation/Hydroxymethylation in Reprogramming显示文摘Yawei Gao Jiayu Chen Ke Li Tong Wu Bo Huang Wenqiang Liu Xiaochen Kou Yu Zhang Hua Huang Yonghua Jiang Chao Yao Xiaolei Liu Zhiwei Lu Zijian Xu Lan Kang Jun Chen Hailin Wang Tao Cai Shaorong Gao 2013Cell Stem Cell2013,,:1
10The effect of human capital on energy consumption:Evidence from an extended version of STIRPAT framework显示文摘Human capital is an important aspect of energy consumption,exerting crucial effects on economic growth,technological progress,and economic restructuring.This paper presents an in-depth investigation of the effect of human capital on energy consumption using an extended version of the Stochastic Impacts by Regression on Population,Affluence,and Technology framework.The estimated results using a panel dataset covering China’s 30 provincial regions during the period 1997-2018 and applying fixed effects with instrumental variables and the generalized method of moments indicated that an increase in human capital significantly drove energy consumption.A 1%increase in human capital increased energy consumption by approximately 0.3%.A two-step channel analysis to test scale,technical,and structural effects revealed that the positive effect of human capital on energy consumption is based primarily on the scale effect.However,highly educated human capital alleviates the energy pressure of this effect.In contrast to the scale effect,both the technical and structural effects of human capital reduced energy consumption,and this reduction is primarily correlated with enterprises’utility-oriented technological progress.Finally,we present strategic energy control policy implications related to human capital.Yajun Wang Junbing Huang Xiaochen Cai 2022Chinese Journal of Population,Resources and Environment2022,20,2:0
11Conserved gene arrangement in the mitochondrial genomes of barklouse families Stenopsocidae and Psocidae显示文摘Substantial variation in gene organization and arrangement has been reported for sequenced mitochondrial(mt) genomes from the suborders of the insect order Psocoptera. In this study we sequenced the complete mt genome of Stenopsocus immaculatus, the first representative of the family Stenopsocidae from the suborder Psocomorpha. Relative to the ancestral pattern, rearrangements of a protein-coding gene(nad3) and five t RNA genes(trnQ, trnC, trnN, trnS1, trnE) were found. This pattern was similar to that of two barklice from the family Psocidae, with the exception of the translocation of trnS1,trnE and trnI. Based on comparisons of pairwise breakpoint distances of gene rearrangements, gene number and chromosome number, it was concluded that mt genomes of Stenopsocidae and Psocidae share a relatively conserved pattern of gene rearrangements; mt genomes within the Psocomorpha have been generally stable over long evolutionary history; and mt gene rearrangement has been substantially faster in the booklice(suborder Troctomorpha) than in the barklice(suborders Trogiomorpha and Psocomorpha). It is speculated that the change of life history and persistence of unusual reproductive systems with maternal inheritance contributed to the contrasting rates in mt genome evolution between the barklice and booklice.Xiaochen LIU Hu LI Yao CAI Fan SONG John-James WILSON Wanzhi CAI 2017Frontiers of Agricultural Science and Engineering2017,4,3:0
12Selection of different endothelialization modes and different seed cells for tissue-engineered vascular graft显示文摘Tissue-engineered vascular grafts(TEVGs)have enormous potential for vascular replacement therapy.However,thrombosis and intimal hyperplasia are important problems associated with TEVGs especially small diameter TEVGs(<6 mm)after transplantation.Endothelialization of TEVGs is a key point to prevent thrombosis.Here,we discuss different types of endothelialization and different seed cells of tissue-engineered vascular grafts.Meanwhile,endothelial heterogeneity is also discussed.Based on it,we provide a new perspective for selecting suitable types of endothelialization and suitable seed cells to improve the long-term patency rate of tissue-engineered vascular grafts with different diameters and lengths.Qingjin Cai Wanshan Liao Fangchao Xue Xiaochen Wang Weiming Zhou Yanzhao Li Wen Zeng 2021Bioactive Materials2021,6,8:0
13Light-responsive organic artificial enzymes:Material designs and bio-applications显示文摘As significant biocatalysts,natural enzymes have exhibited a vast range of applications in biocatalytic reactions.However,the“always-on”natural enzyme activity is not beneficial for the regulation of catalytic processes,which limits their bio-applications.Recently,it has been extensively reported that various organic artificial enzymes exhibit prominent absorption and controlled activity under illumination,which not only creates a series of light-responsive catalytic platforms but also plays a key role in biosensing and biomedical research.To provide novel ideas for the design of artificial enzymes,we conduct this review to highlight the recent progress of light-responsive organic artificial enzymes(LOA-Enz).The specific photoresponse mechanism and various bio-applications of LOA-Enz are also presented in detail.Furthermore,the remaining challenges and future perspectives in this field are discussed.Weili Wang Qing Shen Hao Cai Leichen Wang Jinjun Shao Wenjun Wang Xiaochen Dong 2023Nano Research2023,16,1:0
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