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| 1 | Meditation promotes insightful problem-solving by keeping people in amindful and alert conscious state显示文摘Although previous studies have shown that sleep can inspire insight,it is still unclear whether meditation can promote insight.Meditation differs from other types of passive rest such as relaxation and sleep because it requires full consciousness andmindfulness of targets such as one's breathing.Forty-eight university students without meditation experience were recruited to learn a simple meditation technique.They were given a list of 10 insight problems to solve (the pre-test session).In this study,we focused on the unsolved problems and examined if they could be successfully solved after a 20min rest interval with or without meditation.Results showed that relative to the control group that listened to Chinese or English words and made a language judgment,the groups who learned meditation successfully solved significantly more failed problems from the pre-test session,providing direct evidence for the role of meditation in promoting insight.Further analysis showed that maintaining amindful and alert state during meditation (raising a hand to report every 10 deep breaths compared to every 100 deep breaths) resulted in more insight regarding the failed items from the pre-test session.This implies that it was watchfulness in meditation,rather than relaxation,that actually contributed to insight.Consistently,in the meditation session or control task,the percentage of alpha waves—a brain index of mental relaxation—was negatively correlated with insight.These results suggest a meditation-based insight-promoting mechanism different from that involved in passive rest such as relaxation and sleep. | REN Jun HUANG ZhiHui LUO Jing WEI GaoXia YING XiaoPing DING ZhiGuang WU YiBin LUO Fei | 2011 | Science China(Life Sciences)2011，54，10： | 11 |
| 2 | SERK Receptor-like Kinases Control Division Patterns of Vascular Precursors and Ground Tissue Stem Cells during Embryo Development in Arabidopsis显示文摘During embryo development, the vascular precursors and ground tissue stem cells divide to renew them-selves and produce the vascular tissue, endodermal cells, and cortical cells. However, the molecular mech-anisms regulating division of these stem cells have remained largely elusive. In this study, we show that loss of function of SOMATIC EMBRYOGENESIS RECEPTOR-UKE KINASE (SERK) genes results in aberrant em-bryo development. Fewer cortical, endodermal, and vascular cells are generated in the embryos of serk1 serk2bak1 triple mutants. WUSCHEL-RELATED HOMBOBOX5 (WOXS) is ectopically expressed in vascular cells of serkl serk2 bak1 embryos. The first transverse division of vascular precursors in mid-globular em-bryos and second asymmetric division of ground tissue stem cells in early-heart embryos are abnormally altered to a longitudinal division. The embryo defects can be partially rescued by constitutively activated mitogen-activated protein kinase (MAPK) kinase kinase YODA (YDA) and MAPK kinase MKK5. Taken together, our results reveal that SERK-mediated signals regulate division patterns of vascular precursors and ground tissue stem cells, likely via the YDA-MKK4/5 cascade, during embryo development. | Huiqiang Li Zeping Cai Xiaojuan Wang Meizhen Li Yanwei Cui Nan Cui Fei Yang Mingsong Zhu Junxiang Zhao Wenbin Du Kai He Jing Yi Frans E.Tax Suiwen Hou Jia Li Xiaoping Gou | 2019 | Molecular Plant2019，12，7： | 7 |
| 3 | Cross-cultural adaption and psychometric properties of the Chinese version of the Diabetes Behavior Rating Scale: a pilot study显示文摘Self-care behavior plays a major role in diabetic management. However, in China, a satisfactory instrument has not yet been developed to evaluate the compliance of self-care behavior for young patients with type 1 diabetes mellitus(T1 DM). The Diabetes Behavior Rating Scale(DBRS) has a potential to be the first mature instrument. The purpose of this study is to cross-culturally adapt the DBRS, and preliminarily evaluate its psychometric properties. The instrument translation included translation, back translation and culture adaptation. Psychometric properties were assessed in a sample of 116 young patients with T1 DM adapting insulin injection therapy. The Chinese version of the DBRS was divided to four subscales. Cronbach's α for the total scale was 0.92. The mean inter-item and item-total correlations were 0.35 and 0.54 respectively. Test-retest reliability showed good temporal stability(r=0.81, P=0.001). Negative correlations were found between DBRS scores with the Diabetes Distress Scale scores(r=.0.32, P=0.003) and hemoglobin A1 c(HbA1 c) levels(r=.0.36, P=0.002). Higher DBRS scores correlated with better glycemic control. The Chinese insulin injection therapy version of the DBRS is well translated and culturally adapted. It shows good overall reliability and validity and appears to be a valuable tool for assessing the diabetic self-care behaviors for young patients with T1 DM. | Jing Zhu Jingjing Xu Yang Chen Yong Gu Li Ji Yufeng Zhou Min Zhu Hsiang-Ting Hsu Xiaoping Huang Cuiping Yuan Yun Shi Dan Yan Lili Xie Shuang Chen Tao Yang Wei He | 2018 | Science China(Life Sciences)2018，61，3： | 6 |
| 4 | An antiretroviral regimen containing 6 months of stavudine followed by long-term zidovudine for first-fine HIV therapy is optimal in resource-limited settings: a prospective, multicenter study in China显示文摘 | Li Taisheng Guo Fuping Li Yijia Zhang Chengda Han Yang Lye Wei He Yun Lu Hongzhou Xie Jing Huang Aiqiong Li Yanling Tang Xiaoping Wang Hui Zhang Tong Gao Guiju Lei Junkang Zhang Xiaoying Wu Xinhua Sun Yongtao Bai Jinsong Luo Ling Wang Huanlmg | 2014 | Chinese Medical Journal2014，，1： | 6 |
| 5 | Genetic Analysis of Carbon Isotope Discrimination and its Relation to Yield in a Wheat Doubled Haploid Population显示文摘Carbon isotope discrimination(△13C) is considered a useful indicator for indirect selection of grain yield(GY) in cereals.Therefore,it is important to evaluate the genetic variation in △13C and its relationship with GY.A doubled haploid(DH) population derived from a cross of two common wheat varieties,Hanxuan 10(H10) and Lumai 14(L14),was phenotyped for △13C in the flag leaf,GY and yield associated traits in two trials contrasted by water availability,specifically,rain-fed and irrigated.Quantitative trait loci(QTLs) were identified by single locus and two locus QTL analyses.QTLs for △13C were located on chromosomes 1A,2B,3B,5A,7A and 7B,and QTLs for other traits on all chromosomes except 1A,4D,5A,5B and 6D.The population selected for high △13C had an increased frequency of QTL for high △13C,GY and number of spikes per plant(NSP) when grown under rain-fed conditions and only for high △13C and NSP when grown under irrigated conditions,which was consistent with agronomic performance of the corresponding trait values in the high △13C progeny;that is,significantly greater than that in the low △13C.Therefore,selection for △13C was beneficial in increasing grain yield in rain-fed environments. | Xianshan Wu Xiaoping Chang Ruilian Jing | 2011 | Journal of Integrative Plant Biology2011，53，9： | 6 |
| 6 | Rearrangement and expression of the immunoglobulin μ-chain gene in human myeloid cells显示文摘 | Jing Huang Xiaoping Sun Xiaoting Gong Zhiqiao He Lei Chen Xiaoyan Qiu C Cameron Yin | 2014 | Cellular & Molecular Immunology2014，11，1： | 5 |
| 7 | Proteomic analysis of heterosis in the leaves of sorghum-sudangrass hybrids显示文摘 | Pingan Han Xiaoping Lu Fugui Mi Jing Dong Chunlei Xue Jianke Li Bin Han Xiaoyu Zhang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，2： | 5 |
| 8 | MiR-23b-3p induces the proliferation and metastasis of esophageal squamous cell carcinomas cells through the inhibition of EBF3显示文摘 | Jing Zhang Yan Zhang Xiaoping Tan Oing Zhang Chaoyong Liu Yali Zhang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，6： | 4 |
| 9 | Resection of Giant Hepatic Cavernous Hemangiomas after Dissection of the Third Porta Hepatis显示文摘Objective:To estabhsh a novel and safe operation technique for the resection of giant hepatic cavernous hemangiomas involving the retro-hepatic vena cava.Methods:After ligating the hepatic artery of affected lobe, the short hepatic veins at the third porta hepatis were dissected and ligated individually to separate the tumor from the retrohepatic vena cava, followed by the resection of the tumor under intermittent interruption of the porta hepatis.Results:A total of 62 giant hepatic cavernous hemangiomas were successfully resected without hepatic vascular exclusion. Right and caudate lobectomies were done in 27 cases, right hemihepatectornies in 5 cases, right upper segnentectomies in 7 cases, right posterior lobectomies in 7 cases, extended left and caudate lobectomies in 10 cases, and caudate lobectomies in 6 cases. The blood transfusion requirement during operation was 1 400 ml on average. All did well postoperatively during a follow up of 4 - 84 months.Conclusion:It is safe and feasible to resect giant hepatic cavernous hemangioma following dissection of the third porta hepatis. Duringoperation the key step is dissection of the short hepatic veins. | YAO Xiaoping, ZHOU Weiping, WANG Yi, WU Mengchao, JING Liang Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China | 2002 | The Chinese-German Journal of Clinical Oncology2002，1，1： | 4 |
| 10 | Identification of Histoplasma causing an unexplained disease cluster in Matthews Ridge, Guyana显示文摘Here,we report the identification of Histoplasma causing an unexplained disease cluster in Matthews Ridge,Guyana.In March 2019,14 employees of Chongqing Bosai Mining Company,China,working in a manganese mining of Guyana,had unexplained fever,and two of them died.We obtained lung and brain tissues as well as the blood samples from the two deceased cases(patient No.1 and 2),and bronchoscopy lavages and cerebrospinal fluid samples from one severe case(patient No.3),respectively.All samples were tested by pathological examination,high-throughput sequencing,and real-time PCR.Pathological detection showed the presence of spore-like structures in the lung tissue of patient No.1,indicating a fungal infection in this patient.Nanopore sequencing identified the existing of H.capsulatum in the lung tissue sample within 13 h.Next-generation sequencing identified specific fragments of H.capsulatum in all of the samples tested(lung,brain and blood serum from the deceased cases,and plasma from the severe case).Real-time PCR assays did not reveal any viral infection related to transmission from bat feces.We conclude that H.capsulatum was the causative pathogen of this disease cluster based on epidemiologic,clinical,pathological and nucleic acid evidence. | Ji Wang Weimin Zhou Hua Ling Xiaoping Dong Yi Zhang Jiandong Li Yong Zhang Jingdong Song William J.Liu Yang Li Ruiqing Zhang Wei Zhen Kun Cai Shuangli Zhu Dongyan Wang Jinbo Xiao Yigang Tong Wenli Liu Lihua Song Wei Wu Yang Liu Xiang Zhao Ruihuan Wang Sheng Ye Jing Wang Roujian Lu Baoying Huang Fei Ye Wenwen Lei Rongbao Gao Qi Shi Cao Chen Jun Han Wenbo Xu George F.Gao Xuejun Ma Guizhen Wu | 2019 | Biosafety and Health2019，1，3： | 3 |
| 11 | p190A inactivating mutations cause aberrant RhoA activation and promote malignant transformation via the Hippo-YAP pathway in endometrial cancer显示文摘The Rho family of GTPases is strictly regulated by a large family of GTPase-activating proteins(GAPs)that stimulate the relatively weak intrinsic GTP-hydrolyzing activity of Rho GTPases.p190A is a potent and widely expressed GAP that acts on RhoA GTPases.p190A is frequently mutated in endometrial cancer,but the contribution of p190A mutations to endometrial tumorigenesis remains unclear.Here we identified that p190A is an upstream regulator of the Hippo-YAP signaling pathway,which is a critical regulator of cell proliferation,apoptosis,and cell fate.p190A knockout in endometrial cancer cells promoted cell proliferation,migration,and epithelial–mesenchymal transition(EMT),which were partially dependent on YAP activation.Wild-type p190A,but not endometrial cancer-associated mutants,suppressed the nuclear localization,transcriptional activity,and malignant transformation function of YAP.Moreover,the nuclear localization of YAP was enhanced in p190A-mutated endometrial cancer.These findings reveal novel molecular mechanisms underlying Hippo-YAP pathway-driven endometrial tumorigenesis and elucidate the potential for therapy targeting the Hippo-YAP pathway in p190A-mutated endometrial cancer. | Xiaoli Wen Jing Wan Qizhi He Mengfei Wang Shuangdi Li Mei Jiang Zhen Qian Binya Liu Wen Lu Kai Wang Kun Gao Xiaoping Wan | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 3 |
| 12 | The adaptive strategies of yaks to live in the Asian highlands显示文摘The yak(Bos grunniens),an indigenous herbivore raised at altitudes between 3,000 and 5,000 m above sea level,is closely linked to more than 40 ethnic communities and plays a vital role in the ecological stability,livelihood security,socio-economic development,and ethnic cultural traditions in the Asian highlands.They provide the highlanders with meat,milk,fibres,leather and dung(fuel).They are also used as pack animals to transport goods,for travel and ploughing,and are important in many religious and traditional ceremonies.The Asian highlands are known for an extremely,harsh environment,namely low air temperature and oxygen content and high ultraviolet light and winds.Pasture availability fluctuates greatly,with sparse pasture of poor quality over the long seven-month cold winter.After longterm natural and artificial selections,yaks have adapted excellently to the harsh conditions:1)by genomics,with positively selected genes involved in hypoxia response and energy metabolism;2)anatomically,including a short tongue with a weak sense of taste,and large lung and heart;3)physiologically,by insensitivity to hypoxic pulmonary vasoconstriction,maintaining foetal haemoglobin throughout life,and low heart rate and heat production in the cold season;4)behaviourlly,by efficient grazing and selecting forbs with high nutritional contents;5)by low nitrogen and energy requirements for maintenance and low methane emission and nitrogen excretion,namely,‘Low-Carbon’and‘Nitrogen-Saving’traits;6)by harboring unique rumen microbiota with a distinct maturation pattern,that has coevolved with host metabolism.This review aims to provide an overview of the comprehensive adaptive strategies of the yak to the severe conditions of the highlands.A better understanding of these strategies that yaks employ to adapt to the harsh environment could be used in improving their production,breeding and management,and gaining benefits in ecosystem service and a more resilient livelihood to climate change in the Asian highlands. | Xiaoping Jing Luming Ding Jianwei Zhou Xiaodan Huang Allan Degen Ruijun Long | 2022 | Animal Nutrition2022，，2： | 2 |
| 13 | Layered Double Hydroxides Derived ZnO-Al2O3 Supported Pd-Ag Catalysts for Selective Hydrogenation of Acetylene显示文摘ZnO-Al 2 从分层的双氢氧化物(ZnAl-LDH ) 导出的 O 3 成功地被申请为到乙烯和 Pd-Ag/ZnO-Al 2 O 3 催化剂在准备样品之中显示出最好的催化表演。这被发现 ZnO-Al 2 O 3 金属氧化物导出形式 ZnAl-LDH 能显著地压制乙炔的在加氢上获得乙烯的相对更高的选择。因为 oligomerization 反应, Ag 的介绍高效地限制了焦炭的形成,它被热 gravimetric 分析进一步证实。向乙烯的选择在 Pd-Ag/ZnO-Al 2 O 3> Pd/ZnO-Al 2 O 3> Pd-Ag/Al 2 O 3> Pd/Al 2 在高变换水平的 O 3 。作为热 gravimetric 和揭示的微分温度分析(TG-DTA ) , ZnO-Al 2 O 3 支持显示出更少的焦炭形成。 | Xiaoping Gao Yanan Zhou Fangli Jing Jingjie Luo Qingsong Huang Wei Chu | 2017 | Chinese Journal of Chemistry2017，35，6： | 2 |
| 14 | Conserved and differentiated functions of CIK receptor kinases in modulating stem cell signaling in Arabidopsis显示文摘The shoot apical meristem(SAM)and root apical meristem(RAM)act as pools of stem cells that give rise to aboveground and underground tissues and organs in higher plants,respectively.The CLAVATA3(CLV3)-WUSCHEL(WUS)negative-feedback loop acts as a core pathway controlling SAM homeostasis,while CLV3/EMBRYO SURROUNDING REGION(ESR)40(CLE40)and WUSCHEL-RELATED HOMEOBOX5(WOX5),homologs of CLV3 and WUS,direct columella stem cell fate.Moreover,CLV3 INSENSITIVE KINASES(CIKs)have been shown to be essential for maintaining SAM homeostasis,whereas whether they regulate the distal root meristem remains to be elucidated.Here,we report that CIKs are indispensable for transducing the CLE40 signal to maintain homeostasis of the distal root meristem.We found that the cik mutant roots displayed disrupted quiescent center and delayed columella stem cell(CSC)differentiation.Biochemical assays demonstrated that CIKs interact with ARABIDOPSIS CRINKLY4(ACR4)in a ligand-independent manner and can be phosphorylated by ACR4 in vitro.In addition,the phosphorylation of CIKs can be rapidly induced by CLE40,which partially depends on ACR4.Although CIKs act as conserved and redundant regulators in the SAM and RAM,our results demonstrated that they exhibit differentiated functions in these meristems. | Yafen Zhu Chong Hu Yanwei Cui Li Zeng Sunjingnan Li Mingsong Zhu Fanhui Meng Shuting Huang Li Long Jing Yi Jia Li Xiaoping Gou | 2021 | Molecular Plant2021，14，7： | 2 |
| 15 | Accurate reconstruction of soft X-ray energy spectrum in detector response matrix显示文摘In this paper, we report the design of a Monte Carlo simulation for the energy spectrum measurement system based on the ladderabsorption method. Herein, the detector response matrix can be calculated using the detector responses to several monochromatic X-ray beams. A novel soft X-ray spectrum unfolding method based on the two-step reverse iteration(TSRI) algorithm is applied to acquire the primary spectrum. This paper provides examples of the use of TSRI, and the unfolded energy spectra for the soft Xray beams show excellent agreement with the references. The unfolded energy spectra obtained using the TSRI exhibit better accuracy than those obtained from the commonly used unfolding code GRAVEL. | RunLong Gao Yang Liu XiaoPing Ouyang Jing Chen Xiao Ouyang | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，12： | 2 |
| 16 | Reverse Transcription Recombinase Polymerase Amplification Assays for Rapid Detection of Tick-Borne Encephalitis Virus Infection显示文摘Dear Editor,Tick-borne encephalitis virus(TBEV)belongs to the genus Flavivirus within the family Flaviviridae and includes three subtypes:Siberian,European,and Far Eastern.TBEV infects humans via tick bites;indeed,at least 10,000 human cases of encephalitis caused by TBEV are reported annually in Russia,China,and European countries(Banzhoff et al.2008;Carletti et al.2017). | Jia Jia Yuchang Li Xiaoyan Wu Sen Zhang Yi Hu Jing Li Tao Jiang Xiaoping Kang | 2019 | Virologica Sinica2019，34，3： | 1 |
| 17 | Susceptibility of dairy cows to subacute ruminal acidosis is reflected in both prepartum and postpartum bacteria as well as odd-and branched-chain fatty acids in feces显示文摘Background:The transition period is a challenging period for high-producing dairy cattle.Cows in early lactation are considered as a group at risk of subacute ruminal acidosis(SARA).Variability in SARA susceptibility in early lactation is hypothesized to be reflected in fecal characteristics such as fecal pH,dry matter content,volatile and odd-and branched-chain fatty acids(VFA and OBCFA,respectively),as well as fecal microbiota.This was investigated with 38 periparturient dairy cows,which were classified into four groups differing in median and mean time of reticular pH below 6 as well as area under the curve of pH below 6.Furthermore,we investigated whether fecal differences were already obvious during a period prior to the SARA risk(prepartum).Results:Variation in reticular pH during a 3-week postpartum period was not associated with differences in fecal pH and VFA concentration.In the postpartum period,the copy number of fecal bacteria and methanogens of unsusceptible(UN)cows was higher than moderately susceptible(MS)or susceptible(SU)cows,while the genera Ruminococcus and Prevotellacea_UCG-001 were proportionally less abundant in UN compared with SU cows.Nevertheless,only a minor reduction was observed in iso-BCFA proportions in fecal fatty acids of SU cows,particularly iso-C15:0and iso-C16:0,compared with UN cows.Consistent with the bacterial changes postpartum,the lower abundance of Ruminococcus was already observed in the prepartum fecal bacterial communities of UN cows,whereas Lachnospiraceae_UCG-001 was increased.Nevertheless,no differences were observed in the prepartum fecal VFA or OBCFA profiles among the groups.Prepartum fecal bacterial communities of cows were clustered into two distinct clusters with 70%of the SU cows belonging to cluster 1,in which they represented 60%of the animals.Conclusions:Inter-animal variation in postpartum SARA susceptibility was reflected in post-and prepartum fecal bacterial communities.Differences in prepartum fecal bacterial communities could alert for susceptibility to develop SARA postpartum.Our results generated knowledge on the association between fecal bacteria and SARA development which could be further explored in a prevention strategy. | Hong Yang Stijn Heirbaut Xiaoping Jing Nympha De Neve Leen Vandaele Jeyamalar Jeyanathan Veerle Fievez | 2023 | Journal of Animal Science and Biotechnology2023，14，1： | 1 |
| 18 | Single arm external fixator in the treatment of femoral intertmchanteric fracture in the elderly显示文摘 | Liu Xiaoping Wang Kunzheng Wang Jing | 2009 | contemporary medicine2009，33，15： | 1 |
| 19 | Lentiviral vector-mediate ATG3 overexpression inhibits growth and promotes apoptosis of human SKM-1 cells显示文摘 | Lin Wang Jin Song Jing Zhang Chen Zhu Yan Ma Xiaoping Xu | 2014 | Molecular Biology Reports2014，，4： | 1 |
| 20 | Heat transfer enhancement and performance of the molten salt receiver of a solar power tower显示文摘 | Minlin Yang Xiaoxi Yang Xiaoping Yang Jing Ding | 2009 | Applied Energy2009，，9： | 1 |
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