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| 1 | From concept to reality-A review to the primary test stand and its preliminary application in high energy density physics显示文摘Pulsed power technology,whereas the electrical energy stored in a relative long period is released in much shorter timescale,is an efficient method to create high energy density physics(HEDP)conditions in laboratory.Around the beginning of this century,China Academy of Engineering Physics(CAEP)began to build some experimental facilities for HEDP investigations,among which the Primary Test Stand(PTS),a multi-module pulsed power facility with a nominal current of 10 MA and a current rising time~90 ns,is an important achievement on the roadmap of the electro-magnetically driven inertial confinement fusion(ICF)researches.PTS is the first pulsed power facility beyond 10 TW in China.Therefore,all the technologies have to be demonstrated,and all the engineering issues have to be overcome.In this article,the research outline,key technologies and the preliminary HEDP experiments are reviewed.Prospects on HEDP research on PTS and pulsed power development for the next step are also discussed. | Jianjun Deng Weiping Xie Shuping Feng Meng Wang Hongtao Li Shengyi Song Minghe Xia Ji Ce An He Qing Tian Yuanchao Gu Yongchao Guan Bin Wei Xianbin Huang Xiaodong Ren Jiakun Dan Jing Li Shaotong Zhou Hongchun Cai Siqun Zhang Kunlun Wang Qiang Xu Yujuan Wang Zhaohui Zhang Guilin Wang Shuai Guo Yi He Yiwei Zhou Zhanji Zhang Libing Yang Wenkang Zou | 2016 | Matter and Radiation at Extremes2016，1，1： | 19 |
| 2 | Modeling the climate effects of different subregional uplifts within the Himalaya-Tibetan Plateau on Asian summer monsoon evolution显示文摘Considering the different uplifting time of different subregions of the Himalaya-Tibetan Plateau(TP),a series of numerical simulations have been conducted with the Community Atmosphere Model(CAM4) developed at the National Center for Atmospheric Research to explore the effects of the phased tectonic uplift of the Himalaya-TP on the evolution of Asian summer monsoons.The results show that the uplifts of the Himalaya and northern TP significantly affect the evolutions of South Asian summer monsoon and northern East Asian summer monsoon respectively.That is,the tectonic uplift of the Himalaya intensifies the South Asian summer monsoon circulation and increases the precipitation in South Asia,whereas the uplift of the northern TP intensifies the northern East Asian summer monsoon circulation and increases the precipitation in northern East Asia.Compared with previous simulations,current comparative analyses of modeling results for different subregional uplifts within the Himalaya-TP help deepen our understanding of the evolutionary history of Asian monsoons. | ZHANG Ran 1,JIANG DaBang 1,2,3,LIU XiaoDong 4 & TIAN ZhiPing 2,5 1 Climate Change Research Center,Chinese Academy of Sciences,Beijing 100029,China 2 Nansen-Zhu International Research Centre,Institute of Atmospheric Physics,Chinese Academy of Sciences,Beijing 100029,China 3 Key Laboratory of Regional Climate-Environment Research for Temperate East Asia,Chinese Academy of Sciences,Beijing 100029,China 4 State Key Laboratory of Loess and Quaternary Geology,Institute of Earth Environment,Chinese Academy of Sciences,Xi’an 710075,China 5 Graduate University of Chinese Academy of Sciences,Beijing 100049,China | 2012 | Chinese Science Bulletin2012，57，35： | 14 |
| 3 | Mooring observations of internal solitary waves in the deep basin west of Luzon Strait显示文摘A total of 137 internal solitary waves(ISWs) are captured during a field experiment conducted in the deep basin west of the Luzon Strait(LS) from March to August, 2010. Mooring observations reveal that a fully developed ISW owns a maximum westward velocity of more than 1.8 m/s and an amplitude of about 200 m. The ISWs in the South China Sea(SCS) are most active in July, which may be due to the strong stratification in summer. Most of the ISW episodes are detected around and after the 1st or 15th lunar day, indicating that the ISW in the SCS is triggered by astronomic tides. Half part of the observed ISWs were detected around 19:00 local time, which can be explained by the fact that type-a ISWs emerged in the evening at roughly the same time each day. The propagation direction of the ISWs and the astronomic tides in the LS show that the area south of the Batan Island is probably the main source region of the type-a ISWs, while the area south of Itbayat Island and south of the Batan Island is likely the main source region of the type-b ISWs observed at the mooring. Moreover, for the resonance of semidiurnal internal tides emitting from the double ridges in the LS, the underwater ridge south of the Itbayat Island and south of the Batan Island is believed to favor the generation of the energetic ISWs. | HUANG Xiaodong ZHAO Wei TIAN Jiwei YANG Qingxuan | 2014 | Acta Oceanologica Sinica2014，33，3： | 13 |
| 4 | Design and development of an oral remdesivir derivative W116 against SARS-CoV-2显示文摘Dear Editor,Since the declaration of COVID-19 as a global pandemic on March 11,2020,this pandemic has been circulating for 17 months throughout the world,leading to more than 200 million infections and nearly 4.4 million deaths as of August 15,2021.The pathogen of COVID-19 is a novel coronavirus named SARS-CoV-2,which shares-79%genome sequence identity with SARS-CoV.1 At the early stage of the COVID-19 outbreak,5ARS-CoV-2 caused great panic in the hardest-hit areas due to its high transmissibility and pathogenicity.To fight the COVID-19 crisis,drug repurposing was immediately pursued in order to find potential therapeutics. | Yuanchao Xie Wanchao Yin Yumin Zhang Weijuan Shang Zhen Wang Xiaodong Luan Guanghui Tian Haji A.Aisa Yechun Xu Gengfu Xiao Jia Li Hualiang Jiang Shuyang Zhanq Leike Zhang H.Eric Xu Jingshan Shen | 2021 | Cell Research2021，31，11： | 12 |
| 5 | Corrosion mechanism investigation of TiN/Ti coating and TC4 alloy for aircraft compressor application显示文摘It is imperative to develop multifunctional erosion and corrosion resistant coatings for compressor blades of aircraft engines in harsh environment.PVD(Physical Vapor Deposition)technology has the advances in processing erosion-resistant coatings;however,the performance of PVD coatings to combat corrosion depends on various coating defects.Determining and comparing the corrosion performances of PVD TiN/Ti coating and uncoated TC4 alloy was the main objective of present work.The 960 h salt spray corrosion and 116 h hot corrosion tests were conducted to simulate the grounding and working environments of the aircraft compressors.The corrosion mechanisms due to the coating defects such as pinhole,columnar boundary and large grain were analyzed based on the OM,Confocal microscope,electrochemical measurements,SEM,XRD and EDS results.Owing to the disordered state associated with the columnar boundary and the coating defect,nitrogen could be easily replaced by oxygen in the hot corrosion process,these structures were channels for fast diffusion of oxygen.Moreover,the Gibbs energy changes of Ti oxidation and TiN oxidation were thermodynamically calculated according to the working condition of aircraft compressors,and considerable research effort was focused on mapping out the phase diagram of Ti,TiN and high pressure gases.The findings of this research can provide insights into developing multifunctional coatings for future aircraft engines. | Zhiping SUN Guangyu HE Qingjie MENG Yuqin LI Xiaodong TIAN | 2020 | Chinese Journal of Aeronautics2020，33，6： | 11 |
| 6 | Research of Compound Controller for Flight Simulator with Disturbance Observer显示文摘A compound controller is proposed to alleviate the considerable chattering in output of zero phase error tracking controller (ZPETC), when the flight simulator losses command data of simulation signal. Besides, the shortcomings, caused by conventional differential methods in retrieving velocity and acceleration signals, are avoided to a certain extent. The compound controller based on disturbance observer (DOB) is composed of a feed-forward controller and a feedback controller. It estimates velocity and acceleration of unknown tracking signal, and also velocity response with an approximate method for differential. The experiments on a single-axis flight simulator show that the proposed method has strong robustness against parameter perturbations and external disturbances, owing to the introduced DOB. Compared with the scheme with ZPETC, the proposed scheme possesses more simple design and better tracking performance. Moreover, it is less sensitive to position command distortion of flight simulator. | WU Yunjie LIU Xiaodong TIAN Dapeng | 2011 | Chinese Journal of Aeronautics2011，24，5： | 10 |
| 7 | Self-aggregation of vapor-liquid phase transition显示文摘The concept of the molecular free path is introduced to derive a criterion distinguishing active molecules from inactive molecules in liquid phase. Based on molecular self-aggregation theory a concept of the critical aggregation concentration (CAC) of active molecules is proposed to describe the physical configuration before the formation of the nuclei in the process of vapor-liquid phase transition. All active molecules exist in the form of the monomer when the concentration of active molecules is lower than CAC, while the active molecules will generate aggregation once the concentration of the active molecules reaches CAC. However, these aggregates with the aggregation number N smaller than 5 can steadily exist in bulk phase. The other excess active molecules can only produce infinite aggregation and form a critical nucleus of vapor-liquid phase transition. Without outer perturbation the state point of CAC corresponds to the critical superheated or supercooled state in the process of vapor-liquid phase transition. With the aggregate property, the interfacial tension between the bulk phase and the tiny new phase is predicted and a correction is made for the classical nucleation rate in a quite good agreement with experimental results. | WANG Xiaodong, TIAN Yong and PENG Xiaofeng(Department of Thermal Engineering, Tsinghua University, Beijing 100084, China) | 2003 | Progress in Natural Science:Materials International2003，13，6： | 9 |
| 8 | Flexible design of gradient multilayer nanofilms coated on carbon nanofibers by atomic layer deposition for enhanced microwave absorption performance显示文摘阻抗匹配为完成高效率的微波吸收器是重要的。象纯金属和碳 nanomaterials 那样的绝缘的损失材料的高传导性通常由于在吸收器和表情之间匹配的低阻抗导致差的吸收。因为他们的吸引人的特征,碳 nanostructures 很包括低密度,高表面区域,和好稳定性为高效率的吸收正在答应候选人。此处,新策略被建议改进作为一个例子用 electrospun 碳 nanofibers 绝缘的损失材料匹配的阻抗。碳 nanofibers 与明确地设计的坡度是涂的有逐渐地增加 electroconductibility 的多层的 nanofilms 由与不同艾尔 2 O 3 内容(偶氮) 旁边原子层免职。也就是,坡度 nanofilms 由绝缘的电影的五层组成纯艾尔 2 O 3, 偶氮(5:1,到艾尔 2 O 3), 纯 ZnO,偶氮(10:1 ) ,并且偶氮(20:1 ) 。万用的坡度电影用作中间的层调节在空气和碳 nanofiber 表面之间匹配的阻抗。因此,与讲道理地选择的厚度的电影显著地展出的坡度涂的碳 nanofibers 提高了微波吸收性能,和最佳的思考损失活动范围在有仅仅 1.8 公里的厚度的 16.2 GHz 的 58.5 dB。这个工作能进一步帮助理解阻抗匹配到微波吸收的贡献。我们的策略是一般的并且能被使用在新窗户中在另外的 fields.Open | Shichao Zhao Lili Yan Xiaodong Tian Yequn Liu Chaoqiu Chen Yunqin Li Jiankang Zhang Yan Song Yong Qin | 2018 | Nano Research2018，11，1： | 8 |
| 9 | Diode-pumped power scalable Kerr-lens mode-locked Yb:CYA laser显示文摘Stable 68 fs pulses with the average power of 1.5 W is directly generated from a multimode diode-pumped Kerr-lens mode-locked Yb:CYA laser by separating the gain medium and Kerr medium. The repetition rate is about 50 MHz, resulting in a single pulse energy of 30 n J and a peak power of 0.44 MW. To the best of our knowledge, this is the highest single pulse energy ever produced from a mode-locked Yb:CYA oscillator. Our experimental results show that Yb:CYA crystal is an excellent candidate for multiwatt, sub-100 fs pulse generation in diode-pumped all-solid-state lasers. It is believed that the output power can be scalable to multi-W while the pulse duration is maintained with this simple method. | WENLONG TIAN YINGNAN PENG ZIYUE ZHANG ZIJIAO YU JIANGFENG ZHU XIAODONG XU ZHIYI WEI | 2018 | Photonics Research2018，6，2： | 8 |
| 10 | Characteristics of dissolved organic matter in lakes with different eutrophic levels in southeastern Hubei Province,China显示文摘Dissolved organic matter(DOM)plays a crucial role in both the carbon cycle and geochemical cycles of other nutrient elements,which is of importance to the management and protection of the aquatic environments.To achieve a more comprehensive understanding the characteristics of DOM in the Changjiang(Yangtze)River basin,water samples from four natural lakes(Xiandao,Baoan,Daye,and Qingshan)in southeastern Hubei Province in China with different eutrophication levels were collected and analyzed.The optical characteristics were analyzed using ultraviolet-visible spectrophotometry and excitation-emission matrix spectroscopy coupled with parallel factor analysis.The results show that:(1)two humic-like components(C1 and C2)and two protein-like substances(C3 and C4)of DOM were identified in all waterbodies;(2)C3 originated primarily from the degradation of microalgae and contributed substantially to humic-like components during transformation.C4 was widely present in the Changjiang River basin and its formation was related to microbial activity,rather than algal blooms or seasons.Influenced by the water mixing,the protein-like components were more likely to be transformed by microorganism,whereas humic-like components were more easily to be photobleached;(3)the concentration of DOM and the fluorescence intensity of humic-like components gradually increased with rising lake eutrophication levels.With respect to protein-like components,only C3 showed changes along the eutrophication gradients;(4)DOM showed a high affinity with permanganate index(COD Mn)and chlorophyll a(chl a)while the relationship was variable with phosphorus.This study helps us systematically understand the DOM characteristics,microbial activities,and pollutant transformation in the Changjiang River basin and provides reference to the ecological restoration of aquatic environments. | Weixiang REN Xiaodong WU Xuguang GE Guiying LIN Mengdie ZHOU Zijie LONG Xinhui YU Wei TIAN | 2021 | Journal of Oceanology and Limnology2021，39，4： | 8 |
| 11 | Coefficient of earth pressure at rest for normal,consolidated soils显示文摘In this study consecutive consolidated isotropically drained triaxial tests for the coefficient of earth pressure at rest(K_0) were carried out to investigate its rules of evolution as well as its strength characteristics for normal,consolidated saturated silt under high pressure.The tests results indicate that:1) for normal,consolidated saturated silt,K_0 values increase as the consolidation stress increases at high pressure levels,while the nonlinear characteristics of K_0 are inconspicuous compared to cohesive soils;2) the Jaky and Roscoe equations,used to calculate K_0,are only suitable for certain soils,but cannot represent these values for normal, consolidated saturated silt due to the variation in bilinear strength at high pressure;and 3) there are close relations between the nonlinear characteristics of K_0 and the void ratio,measured in the tests.Both share the same functional form while under pressure. Based on our experimental results,we developed an empirical linear model to interpret the rules of nonlinear variation for the coefficient of earth pressure at rest. | ZHAO Xiaodong ZHOU Guoqing TIAN Qiuhong KUANG Lianfei | 2010 | Mining Science and Technology2010，20，3： | 7 |
| 12 | Holistic Service-Based Architecture for Space-Air-Ground Integrated Network for 5G-Advanced and Beyond显示文摘The Service-based Architecture(SBA) is one of the key innovations of 5G architecture that leverage modularized, self-contained and independent services to provide flexible and cloud-native 5G network. In this paper, SBA for Space-Air-Ground Integrated Network(SAGIN) is investigated to enable the 5G integration deployment. This paper proposes a novel Holistic Service-based Architecture(H-SBA)for SAGIN of 5G-Advanced and beyond, i.e., 6G. The H-SBA introduces the concept of end-to-end servicebased architecture design. The 'Network Function Service', introduced in 5G SBA, is extended from Control Plane to User Plane, from core network to access network. Based on H-SBA, the new generation of protocol design is proposed, which proposes to use IETF QUIC and SRv6 to substitute 5G HTTP/2.0 and GTP-U. Testing results show that new protocols can achieve low latency and high throughput, making them promising candidate for H-SBA. | Xiaoyun Wang Tao Sun Xiaodong Duan Dan Wang Yongjing Li Ming Zhao Zhigang Tian | 2022 | China Communications2022，19，1： | 6 |
| 13 | A theranostic agent for cancer therapy and imaging in the second nearinfrared window显示文摘Thera no stic nano particles are integrated systems useful for simulta neous diag nosis and imaging guided delivery of therapeutic drugs, with wide ranging pote ntial applicati ons in the clinic. Here we developed a thera no stic nan oparticle (~24 nm size by dynamic light scatteri ng) p-FE-PTX-FA based on polymeric micelle encapsulating an organic dye (FE) fluorescing in the 1,000-1,700 nm second near-infrared (NIR-Ⅱ) window and an an ti-ca ncer drug paclitaxel. Folic acid (FA) was conjugated to the nan oparticles to afford specific binding to molecular folate receptors on muri ne breast can cer 4T1 tumor cells. In vivo, the nan oparticles accumulated in 4T1 tumor through both passive and active targeting effect. Under an 808 nm laser excitation, fluorescence detection above 1,300 nm afforded a large Stokes shift, allowing targeted molecular imaging tumor with high signal to background ratios, reaching a high tumor to normal tissue signal ratio (T/NT) of (20.0±2.3). Further, 4T1 tumors on mice were completed eradicated by paclitaxel released from p-FE-PTA-FA within 20 days of the first injection. Pharmacokinetics and histology studies indicated p-FE-PTX-FA had no obvious toxic side effects to major organs. This represented the first NIR-Ⅱ theranostic age nt developed. | Zhuoran Ma Hao Wan Weizhi Wang Xiaodong Zhang Takaaki Uno Qianglai Yang Jingying Yue Hongpeng Gao Yeteng Zhong Ye Tian Qinchao Sun Yongye Liang Hongjie Dai | 2019 | Nano Research2019，12，2： | 4 |
| 14 | Recombinant Expression of a Novel Human Transcriptional Repressor HMBOX1 and Preparation of Anti-HMBOX1 Monoclonal Antibody显示文摘HMBOX1 是可能在胰的功能和 NK 房间的 cytotoxicity 包含的一个新奇抄写因素。为功能决心, recombinant 人 HMBOX1 蛋白质被获得并且净化,并且对 HMBOX1 的 monoclonal 抗体被准备。编码 HMBOX1 的全身的 cDNA 碎片从 NK-92 房间被放大并且插入了到原核生物的表示向量 pET22b。pET22b-HMBOX1-6his 向量然后被转变成 E。coli 罗塞达碑(DE3 ) 并且在 37oC 为 4 h 由 1 公里 IPTG 导致了。熔化 HMBOX1 蛋白质主要在包括身体被表示,它被净化并且 refolded 使用 Ni2+ 亲密关系层析。与是的净化的熔化 HMBOX1 蛋白质抗原,对 HMBOX1 的 monoclonal 抗体被产生,在 HMBOX1 为进一步的学习提供一个潜在地有用的工具工作。用这些 anti-HMBOX1 mAbs,我们鉴别 HMBOX1 位于细胞质和原子核并且能在 10 人的正常纸巾被检测,包括大脑,胰,肾和肝纸巾。而且,在肝的癌的表示在邻近的纸巾是比那显著地低的。 | Jun Dai Longyan Wu Cai Zhang Xiaodong Zheng Zhigang Tian Jian Zhang | 2009 | Cellular & Molecular Immunology2009，6，4： | 4 |
| 15 | Comparison of three remotely sensed drought indices for assessing the impact of drought on winter wheat yield显示文摘Agricultural drought threatens food security.Numerous remote-sensing drought indices have been developed,but their different principles,assumptions and physical quantities make it necessary to compare their suitability for drought monitoring over large areas.Here,we analyzed the performance of three typical remote sensing-based drought indices for monitoring agricultural drought in two major agricultural production regions in Shaanxi and Henan provinces,northern China(predominantly rain-fed and irrigated agriculture,respectively):vegetation health index(VHI),temperature vegetation dryness index(TVDI)and drought severity index(DSI).We compared the agreement between these indices and the standardized precipitation index(SPI),soil moisture,winter wheat yield and National Meteorological Drought Monitoring(NMDM)maps.On average,DSI outperformed the other indices,with stronger correlations with SPI and soil moisture.DSI also corresponded better with soil moisture and NMDM maps.The jointing and grain-filling stages of winter wheat are more sensitive to water stress,indicating that winter wheat required more water during these stages.Moreover,the correlations between the drought indices and SPI,soil moisture,and winter wheat yield were generally stronger in Shaanxi province than in Henan province,suggesting that remote-sensing drought indices provide more accurate predictions of the impacts of drought in predominantly rain-fed agricultural areas. | Jianxi Huang Wen Zhuo Ying Li Ran Huang Fernando Sedano Wei Su Jinwei Dong Liyan Tian Yanbo Huang Dehai Zhu Xiaodong Zhang | 2020 | International Journal of Digital Earth2020，13，4： | 4 |
| 16 | Re-isolation of Wuxiang Virus from Wild Sandflies Collected from Yangquan County, China显示文摘We previously isolated a new species of the genus Phlebovirus from wild sandflies collected from Wuxiang County in central China,which named the Wuxiang virus(WUXV).In this study,we re-isolated the WUXV from wild sandflies collected from two villages in Yangquan County,China in 2019.Four virus isolates that caused cytopathic effects in BHK-21 cells were successfully isolated from sandfly specimens collected from chicken pens and sheep pens.Phylogenetic analyses of the L,M and S gene segments of the viruses revealed that the four virus strains represented the previously isolated WUXV.The minimum infection rate(MIR)of the virus isolated from the sheep pen was 3.21,and the MIR of the virus isolated from the chicken pen was 3.45.The positive rates of Wuxiang virus neutralizing antibodies in serum samples of local healthy people and domestic chickens were 8.7%(4/46)and 100%(4/4),respectively,suggesting that Wuxiang virus can infect human and animal.In view of the fact that Wuxiang virus is infectious to humans and animals and has a relatively wide geographical distribution in China,it is of great public health significance to strengthen the investigation and study on the infection status of Wuxiang virus in humans and animals. | Qinyan Wang Shihong Fu Jingxia Cheng Xiuyan Xu Jing Wang Bin Wu Xiaodong Tian Yan Li Ying He Fan Li Kai Nie Songtao Xu Bin Wang Huanyu Wang Xiaoqing Lu Guodong Liang | 2021 | Virologica Sinica2021，36，5： | 4 |
| 17 | A recombinant receptor-binding domain in trimeric form generates protective immunity against SARSCoV-2 infection in nonhuman primates显示文摘A safe and effective vaccine is critical to combat the COVID-19 pandemic.Here,we developed a trimeric SARS-CoV-2 receptor-binding domain(RBD)subunit vaccine candidate that simulates the natural structure of the spike(S)trimer glycoprotein.Immunization with the RBD trimer-induced robust humoral and cellular immune responses,and a high level of neutralizing antibodies was maintained for at least 4.5 months.Moreover,the antibodies that were produced in response to the vaccine effectively cross-neutralized the SARS-CoV-2501Y.V2 variant(B.1.351).Of note,when the vaccine-induced antibodies dropped to a sufficiently low level,only one boost quickly activated the anamnestic immune response,conferring full protection against a SARSCoV-2 challenge in rhesus macaques without typical histopathological changes in the lung tissues.These results demonstrated that the SARS-CoV-2 RBD trimer vaccine candidate is highly immunogenic and safe,providing long-lasting,broad,and significant immunity protection in nonhuman primates,thereby offering an optimal vaccination strategy against COVID-19. | Limin Yang Deyu Tian Jian-bao Han Wenhui Fan Yuan Zhang Yunlong Li Wenqiang Sun Yanqiu Wei Xiaodong Tian Dan-dan Yu Xiao-li Feng Gong Cheng Yuhai Bi Yong-tang Zheng Wenjun Liu | 2021 | The Innovation2021，2，3： | 3 |
| 18 | Moment magnitudes of two large Turkish earthquakes on February 6,2023 from long-period coda显示文摘Two large earthquakes(an earthquake doublet)occurred in south-central Turkey on February 6,2023,causing massive damages and casualties.The magnitudes and the relative sizes of the two mainshocks are essential information for scientific research and public awareness.There are obvious discrepancies among the results that have been reported so far,which may be revised and updated later.Here we applied a novel and reliable long-period coda moment magnitude method to the two large earthquakes.The moment magnitudes(with one standard error)are 7.95±0.013 and 7.86±0.012,respectively,which are larger than all the previous reports.The first mainshock,which matches the largest recorded earthquakes in the Turkish history,is slightly larger than the second one by 0.11±0.035 in magnitude or by 0.04 to 0.18 at 95%confidence level. | Xinyu Jiang Xiaodong Song Tian Li Kaixin Wu | 2023 | Earthquake Science2023，36，2： | 3 |
| 19 | Molecular characterization of circulating tumor cells in pancreatic ductal adenocarcinoma:potential diagnostic and prognostic significance in clinical practice显示文摘Background:The clinical value of heterogeneous sub-populations of circulating tumor cells(CTCs)in pancreatic ductal adenocarcinoma(PDAC)remains unclear.Methods:Peripheral blood samples were obtained from 67 PDAC patients.CTCs were isolated by employing CD45 negative enrichment technique and further characterized for epithelial to mesenchymal transition(EMT)or human equilibrative nucleoside transporter-1(hENT-1).The relationships between CTCs sub-phenotypes with clinicopathological factors or post-operative recurrence in PDAC patients were analyzed.Results:EMT related CTCs could be isolated and identified from the 81%of patients(54/67),and both the total count(median:5 vs.17/mL,P<0.0001)and M-CTC percentage(median:0.2 vs.0.345,P=0.0244)of CTCs could differentiate local/regional with metastatic disease.Multivariate analysis showed that both AJCC stage(P=0.025)and M-CTC percentage(P=0.001)were independent prognostic indicators of recurrence free survival(RFS)in resected patients.Moreover,Kaplan-Meier survival analysis showed that M-CTC after 2 courses of chemotherapy was significantly associated with inferior RFS(49.5 weeks vs.undefined,P=0.0288).No significant correlation in hENT-1 expression was found between CTCs and matched tumor tissues,and further multivariate analysis suggested hENT-1 expression in CTCs as independent prognostic factor for RFS(P=0.016).Patients with low hENT-1 expression in CTCs had decreased RFS(32 weeks vs.undefined,P=0.0337).Conclusions:CTCs could be the promising diagnostic biomarkers in PDAC patients,and phenotypic profiling of CTCs based on EMT or hENT-1 could help establish novel prognostic biomarkers in resected patients undergoing adjuvant gemcitabine-based chemotherapy. | Xudong Zhao Yongsu Ma Xiu Dong Zhengkui Zhang Xiaodong Tian Xiaohang Zhao Yinmo Yang | 2021 | Hepatobiliary Surgery and Nutrition2021，10，6： | 3 |
| 20 | Shoaling of the internal solitary waves over the continental shelf of the northern South China Sea显示文摘The activities of internal solitary waves(ISWs) over the continental shelf of the northern South China Sea(SCS)are of high complexity. In this study, we investigated the spatial-temporal characteristics of the shoaling ISWs over the northern SCS continental shelf using the satellite images and the results of numerical simulation. The examination of the ISW signals in the satellite optical images revealed the existence of three types of ISWs in the region north to the Dongsha Island, namely, mode-1 depression ISW, mode-1 elevation ISW, and mode-2 convex ISW. The geographical distributions of these ISWs were derived from the satellite images. Numerical results exhibited the process of polarity conversion of ISWs, by which mode-1 elevation waves were transformed from the shoaling mode-1 depression waves. The mode-2 convex ISWs generally followed the mode-1 depression ISWs.The numerical results suggested that the interaction of the mode-1 depression ISWs with the up-slope topography locally generated mode-2 ISWs, and such waves of high vertical mode dissipated rapidly during the inshore propagation. | QIAN Hongbao HUANG Xiaodong TIAN Jiwei ZHAO Wei | 2015 | Acta Oceanologica Sinica2015，34，9： | 3 |
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