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| 1 | Isolation and characterization of H7N9 viruses from live poultry markets--Implication of the source of current H7N9 infection in humans显示文摘On March 31, 2013, the National Health and Family Planning Commission announced that human infections with a previously undescribed influenza A (H7N9) virus had occurred in Shanghai and Anhui Province, China. To investigate the possible origins of the H7N9 viruses causing these human infections, we collected 970 samples, including drinking water, soil, and cloacal and tracheal swabs of poultry from live poultry markets and poultry farms in Shanghai and Anhui Province. Twenty samples were positive for the H7N9 influenza virus. Notably, all 20 viruses were isolated from samples collected from live poultry markets in Shanghai. Phylogenetic analyses showed that the six internal genes of these novel human H7N9 viruses were derived from avian H9N2 viruses, but the ancestor of their HA and NA genes is uncertain. When we examined the phylogenetic relationship between the H7N9 isolates from live poultry markets and the viruses that caused the human infections, we found that they shared high homology across all eight gene segments. We thus identified the direct avian origin of the H7N9 influenza viruses that caused the human infections. Importantly, we observed that the H7N9 viruses isolated from humans had acquired critical mutations that made them more 'human-like'. It is therefore imperative to take strong measures to control the spread of H7N9 viruses in birds and humans to prevent further threats to human health. | SHI JianZhong DENG GuoHua LIU PeiHong ZHOU JinPing GUAN LiZheng LI WenHui LI XuYong GUO Jing WANG GuoJun FAN Jun WANG JinLiang LI YuanYuan JIANG YongPing LIU LiLing TIAN GuoBin LI ChengJun CHEN HuaLan | 2013 | Chinese Science Bulletin2013，58，16： | 85 |
| 2 | Stage-progressive distribution pattern of the Lungmachi black graptolitic shales from Guizhou to Chongqing, Central China显示文摘The Lungmachi Formation is widely distributed in Guizhou, Chongqing and the adjacent area. It is important for the study of Silurian biostratigraphy and shale-gas investigation. Based on those biostratigraphically well-studied sections from Guiyang to Huayingshan, we reveal the stage-progressive distribution pattern of the Lungmachi black shales. The distribution of the Lungmachi black shales in the studying area can be subdivided into four geographic belts from the south to the north,reflecting the joint effect of regional and global environmental changes. The graptolite depth zonation model was adopted herein to infer the water depth of major graptolite assemblages from the black shales. The changes in the water depth indicate two major stages. The first stage is named the transgressive distribution stage which ranged from the Persculptograptus persculptus Biozone(LM1, upper Hirnantian) to the Coronograptus cyphus Biozone(LM5, upper Rhuddanian), an interval mostly controlled by global sea-level rise. The second stage, ranging from the Demirastrites triangulatus Biozone(LM6, lower Aeronian) to the Spirograptus guerichi Biozone(LM9, lower Telychian), is named the regressive shrinking stage, during which the black shales were gradually replaced by mixed-facies or carbonate sediments from the south to the north, representing the effects of the persistent uplifting of the Central Guizhou Oldland. | CHEN Xu FAN JunXuan WANG WenHui WANG HongYan NIE HaiKuan SHI XueWen WEN ZhiDong CHEN DongYang LI WenJie | 2017 | Science China Earth Sciences2017，60，6： | 23 |
| 3 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 4 | Procalcitonin could be a reliable marker in differential diagnosis of post-implantation syndrome and infection after percutaneous endovascular aortic repair显示文摘 | Xue Ling Luo Songyuan Luo Jianfang Liu Zhen Gu Mengnan Kang Huiyuan Yang Fan Nie Bingrong Liu Yuan Huang Wenhui Xie Nianjin He Pengcheng Dong Haojian Ni Zhonghan Fan Ruixin Chen Jiyan | 2014 | Chinese Medical Journal2014，，14： | 8 |
| 5 | Land-cover changes of national nature reserves in China显示文摘为阻止生态系统降级,保护自然产地并且保存在产地以内的生物多样性, 2588 个自然保护区在 2010 的结束在中国被建立了。全部的区域直到 1.4944 亿哈并且盖住超过 15% 汉语陆上的表面。作为生物多样性变化的主要驱动程序,陆地封面变化直接影响生态系统结构和函数。在这篇论文, 180 个国家自然保护区(NNR ) 被选择,他们的全部的区域是 4471 万哈,为在中国的 29.9% 所有 NNR 的财务。以生态系统特征和他们的主要保护的目标,所有选择 NNR 被分类进 7 种类型。陆地封面(PNCIL ) 的一个积极、否定的变化索引被开发从 1980 年代末分析每种 NNR 类型的陆地封面变化到 2005。结果证明除了森林生态系统储备,所有选择 NNR 类型的陆地封面与逐渐地减轻的降级的减少的率,而是率有 degradated 到某个度。在所有核心地区的陆地封面的吝啬的积极、否定的变化率分别地在 0.69% 和 0.16% 减少了。在核心地区的陆地封面的风景模式在缓冲区地区和试验性的地区是比那更稳定的。而且,在选择 NNR 的陆地封面的生态的差异和补丁连接通常增加了。简言之,在中国的 180 选择 NNR 的陆地封面在建立的 NNR 以后有一个有益的变化趋势,特别在 1995 和 2005 之间。 | FAN Zemeng ZHANG Xuan LI Jing YUE Tianxiang LIU Jiyuan XIANG Bao KUANG Wenhui | 2013 | Journal of Geographical Sciences2013，23，2： | 8 |
| 6 | lncRNA NEAT1 promotes the Taxol resistance of breast cancer via sponging the miR-23a-3p-FOXA1 axis显示文摘Breast cancer is the most prevalent malignancy among women worldwide.Paclitaxel(Taxol)is a widely applied chemotherapeutic agent against breast cancer.Although Taxol therapy has achieved improvements recently,development of chemoresistance of breast cancer patients is a major obstacle,leading to therapeutic failure.Long non-coding RNAs(lncRNAs)play pivotal roles in tumorigenesis and progresses of breast cancer.However,the biological roles and molecular targets of lncRNA NEAT1 in Taxol-resistant breast cancer remain unclear.Here,we report that NEAT1 is significantly upregulated in breast tumors and cell lines.In addition,silencing NEAT1 effectively sensitizes breast cancer cells to Taxol.Bioinformatical analysis and luciferase assay demonstrated that miR-23a-3p could be sponged and downregulated by NEAT1.We demonstrated that miR-23a-3p was downregulated and functioned as a tumor suppressor in breast cancer.Furthermore,in the established Taxol-resistant MDA-MB-231 breast cancer cell line,we detected significantly increased NEAT1 expression and downregulated miR-23a-3p expression.Importantly,FOXA1 was identified and validated as a direct target of miR-23a-3p in breast cancer cells.Rescue experiments demonstrated that the restoration of miR-23a-3p in NEAT1-overexpressing Taxol-resistant breast cancer cells successfully overcame the NEAT1-promoted Taxol resistance.Taken together,our results revealed the clinical roles and molecular mechanisms for the NEAT1-mediated chemoresistance,providing new insights into the development of non-coding RNA-based therapeutic strategies for enhancing the anti-cancer effects of traditional chemotherapeutic drugs. | Lin Zhu Fengchun Wang Wenhui Fan Zhi Jin Chao Teng Jianxin Zhang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，9： | 7 |
| 7 | Distributed continuation power flow method for integrated transmission and active distribution network显示文摘As the integration of distributed generations(DGs)transforms the traditional distribution network into the active distribution network,voltage stability assessments(VSA)of transmission grid and distribution grid are not suitable to be studied separately.This paper presents a distributed continuation power flow method for VSA of global transmission and distribution grid.Two different parameterization schemes are adopted to guarantee the coherence of load growth in transmission and distribution grids.In the correction step,the boundary bus voltage,load parameter and equivalent power are communicated between the transmission and distribution control centers to realize the distributed computation of load margin.The optimal multiplier technique is used to improve the convergence of the proposed method.The three-phase unbalanced characteristic of distribution networks and the reactive capability limits of DGs are considered.Simulation results on two integrated transmission and distribution test systems show that the proposed method is effective. | Jinquan ZHAO Xiaolong FAN Changnian LIN Wenhui WEI | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，4： | 7 |
| 8 | Robust Collaborative Optimization Method Based on Dual-response Surface显示文摘A novel method for robust collaborative design of complex products based on dual-response surface (DRS-RCO) is proposed to solve multidisciplinary design optimization (MDO) problems under uncertainty. Collaborative optimization (CO) which decomposes the whole system into a double-level nonlinear optimization problem is widely accepted as an efficient method to solve MDO problems. In order to improve the quality of complex product in design process, robust collaborative optimization (RCO) is developed to solve those problems under uncertain conditions. RCO does optimization on the linear sum of mean and standard deviation of objective function and gets an optimal solution with high robustness. Response surfaces method is an important way to do approximation in robust design. DRS-RCO is an improved RCO method in which dual-response surface replaces system uncertainty analysis module of CO. The dual-response surface is the approximate model of mean and standard deviation of objective function respectively. In DRS-RCO, All the information of subsystems is included in dual-response surfaces. As an additional item, the standard deviation of objective function is added to the subsystem optimization. This item guarantee both the mean and standard deviation of this subsystem is reaching the minima at the same time. Finally, a test problem with two coupled subsystems is conducted to verify the feasibility and effectiveness of DRS-RCO. | WANG Wei FAN Wenhui CHANG Tianqing YUAN Yuming | 2009 | Chinese Journal of Mechanical Engineering2009，22，2： | 5 |
| 9 | Fine-Mapping of qTGW1.2a, a Quantitative Trait Locus for 1000-Grain Weight in Rice显示文摘Thousand-grain weight (TGW) is a key component of grain yield in rice. This study was conducted to validate and fine-map qTGW1.2a, a quantitative trait locus for grain weight and grain size previously located in a 933.6-kb region on the long arm of rice chromosome 1. Firstly, three residual heterozygotes (RHs) were selected from a BC2F11 population of the indica rice cross Zhenshan 97 (ZS97)///ZS97//ZS97/Milyang 46. The heterozygous segments in these RHs were arranged successively in physical positions, forming one set of sequential residual heterozygotes (SeqRHs). In each of the populations derived, non-recombinant homozygotes were identified to produce near isogenic lines (NILs) comprising the two homozygous genotypes. The NILs were tested for grain weight, grain length and grain width. QTL analyses for the three traits were performed. Then, the updated QTL location was followed for a new run of SeqRHs identification-NIL development-QTL mapping. Altogether, 11 NIL populations derived from four sets of SeqRHs were developed and used. qTGW1.2a was finally delimitated into a 77.5-kb region containing 13 annotated genes. In the six populations segregating this QTL, which were in four generations and were tested across four years, the allelic direction of qTGW1.2a remained consistent and the genetic effects were stable. For TGW, the additive effects ranged from 0.23 to 0.38 g and the proportions of phenotypic variance explained ranged from 26.15% to 41.65%. These results provide a good foundation for the cloning and functional analysis of qTGW1.2a. | WANG Wenhui WANG Linlin ZHU Yujun FAN Yeyang ZHUANG Jieyun | 2019 | Rice science2019，26，4： | 4 |
| 10 | Novel Models and Algorithms of Load Balancing for Variable-structured Collaborative Simulation under HLA/RTI显示文摘High level architecture(HLA) is the open standard in the collaborative simulation field. Scholars have been paying close attention to theoretical research on and engineering applications of collaborative simulation based on HLA/RTI, which extends HLA in various aspects like functionality and efficiency. However, related study on the load balancing problem of HLA collaborative simulation is insufficient. Without load balancing, collaborative simulation under HLA/RTI may encounter performance reduction or even fatal errors. In this paper, load balancing is further divided into static problems and dynamic problems. A multi-objective model is established and the randomness of model parameters is taken into consideration for static load balancing, which makes the model more credible. The Monte Carlo based optimization algorithm(MCOA) is excogitated to gain static load balance. For dynamic load balancing, a new type of dynamic load balancing problem is put forward with regards to the variable-structured collaborative simulation under HLA/RTI. In order to minimize the influence against the running collaborative simulation, the ordinal optimization based algorithm(OOA) is devised to shorten the optimization time. Furthermore, the two algorithms are adopted in simulation experiments of different scenarios, which demonstrate their effectiveness and efficiency. An engineering experiment about collaborative simulation under HLA/RTI of high speed electricity multiple units(EMU) is also conducted to indentify credibility of the proposed models and supportive utility of MCOA and OOA to practical engineering systems. The proposed research ensures compatibility of traditional HLA, enhances the ability for assigning simulation loads onto computing units both statically and dynamically, improves the performance of collaborative simulation system and makes full use of the hardware resources. | YUE Yingchao FAN Wenhui XIAO Tianyuan MA Cheng | 2013 | Chinese Journal of Mechanical Engineering2013，26，4： | 4 |
| 11 | GREEDY NON-DOMINATED SORTING IN GENETIC ALGORITHM-ⅡFOR VEHICLE ROUTING PROBLEM IN DISTRIBUTION显示文摘Vehicle routing problem in distribution (VRPD) is a widely used type of vehicle routing problem (VRP),which has been proved as NP-Hard,and it is usually modeled as single objective optimization problem when modeling.For multi-objective optimization model,most researches consider two objectives.A multi-objective mathematical model for VRP is proposed,which considers the number of vehicles used,the length of route and the time arrived at each client.Genetic algorithm is one of the most widely used algorithms to solve VRP.As a type of genetic algorithm (GA), non-dominated sorting in genetic algorithm-Ⅱ(NSGA-Ⅱ) also suffers from premature convergence and enclosure competition.In order to avoid these kinds of shortage,a greedy NSGA-Ⅱ(GNSGA-Ⅱ) is proposed for VRP problem.Greedy algorithm is implemented in generating the initial population, cross-over and mutation.All these procedures ensure that NSGA-Ⅱis prevented from premature convergence and refine the performance of NSGA-Ⅱat each step.In the distribution problem of a distribution center in Michigan,US,the GNSGA-Ⅱis compared with NSGA-Ⅱ.As a result,the GNSGA-Ⅱis the most efficient one and can get the most optimized solution to VRP problem.Also,in GNSGA-Ⅱ,premature convergence is better avoided and search efficiency has been improved sharply. | WEI Tian FAN Wenhui XU Huayu | 2008 | Chinese Journal of Mechanical Engineering2008，21，6： | 4 |
| 12 | Platinum-group element geochemistry of Cenozoic basalts from the North China Craton: Implications for mantle heterogeneity显示文摘42 新生代(主要中新世) 从北方中国 Craton 的 Jining, Chifeng, Fansi, Xiyang,和 Zuoquan 区域的暗岩样品(NCC 暗岩此后) 为铂组元素(PGE,包括的 O,红外, Ru, Rh,磅,和 Pd ) 被分析。他们中的大多数是碱的暗岩和 tholeiites,所有几乎不他们显示很少外壳的污染。NCC 暗岩的全部的 PGE 内容从 0.1 ~ 0.9 ppb 变化,原始披风的比那些低的大部分 23.5 珍视 ppb。这些暗岩的原始使披风正常化的 PGE 模式定义积极斜坡和 Pd/Ir 比率从 1.2 ~ 25 变化。以 PGE 内容和 Pd/Ir 比率,他们相当类似于海中央山脉暗岩。在 PGE 之间没有明显的否定关联,显示在 magmatic 期间的橄榄石,辉石,或硫化物的部分结晶化处理对在 NCC 暗岩的 MgO, Ni,和 Cu 不能是为观察 PGE 变化的控制因素。NCC 暗岩的观察 Pd/Ir 变化要求异构的披风采购的 non-chondritic 的参与。基于 Sr-Nd-Pb-Hf 同位素的 systematics 和不兼容元素的签名,一混合部分在岩流圈的顶从 asthenospheric 橄榄岩和围住的披风 eclogites 融化为这些 NCC 暗岩的起源被建议。eclogites 的透镜从再循环的大陆人外壳的 upwelling 被导出在期间向西从 600 km 断绝地区的和平的板的 subduction。这些暗岩的 PGE 地球化学提供独立证据支持这个结论和观察 Pd/Ir 变化可以在拍的 peridotitic 的比例反映变化, eclogitic 融化。 | ZHANG WenHui ZHANG HongFu SUN YaLi FAN WeiMing HAN BaoFu TANG YanJie | 2015 | Science China Earth Sciences2015，58，6： | 4 |
| 13 | A Projection Pursuit Dynamic Cluster Model Based on a Memetic Algorithm显示文摘A Projection Pursuit Dynamic Cluster(PPDC) model optimized by Memetic Algorithm(MA) was proposed to solve the practical problems of nonlinearity and high dimensions of sample data, which appear in the context of evaluation or prediction in complex systems. Projection pursuit theory was used to determine the optimal projection direction; then dynamic clusters and minimal total distance within clusters(min TDc) were used to build a PPDC model. 17 agronomic traits of 19 tomato varieties were evaluated by a PPDC model. The projection direction was optimized by Simulated Annealing(SA) algorithm, Particle Swarm Optimization(PSO), and MA. A PPDC model,based on an MA, avoids the problem of parameter calibration in Projection Pursuit Cluster(PPC) models. Its final results can be output directly, making the cluster results objective and definite. The calculation results show that a PPDC model based on an MA can solve the practical difficulties of nonlinearity and high dimensionality of sample data. | Hongli Zhang Cong Wang Wenhui Fan | 2015 | Tsinghua Science and Technology2015，20，6： | 3 |
| 14 | Interferon as a Mucosal Adjuvant for an Influenza Vaccine in Pigs显示文摘Interferon,a natural protein that is produced by a variety of cells during viral infection,activates the transcription of multiple functional genes in cells,regulates synergy among various signaling pathways,and mediates many biological functions such as antiviral activity,immune regulation,and cell growth.However,clinical research on interferon in livestock is lacking.In this study,recombinant porcine interferon(PoIFNα)was used as an adjuvant,in combination with inactivated influenza virus,to vaccinate 6-week-old pigs via nasal infusion.The transcription of target genes was then monitored and the functions of PoIFNαwere determined with respect to the activation of mucosal immunity.We found that a combination of low-dose PoIFNαand in activated influenza virus could significantly up-regulate the expression of immunoregulatory cytokines such as IL-2,IL-1β,IFN-γ,IL-6,and IL-10 by real-time PCR,suggesting the induction of a strong mucosal innate immune response after administration.In addition,low-dose PoIFNαcan significant enhancing the transcription of genes encoding homing factors including CCR9 and CCR10(P<0.001),thereby resulting in the induction of higher levels of HA-specific antibodies(P<0.05),which can be determined by ELISA and IFA.Post-immunization challenges with H1N1 virus demonstrated that PoIFNot,combined with inactivated influenza virus,could alleviate clinical signs in pigs during the early stages of viral infection.These studies reveal low-dose PoIFNαas a potential mucosal adjuvant for influenza virus in pigs. | Lirong Liu Wenhui Fan He Zhang Shuang Zhang Liang Cui Meng Wang Xiaoyuan Bai Wenxian Yang Lei Sun Limin Yang Wenjun Liu Jing Li | 2019 | Virologica Sinica2019，34，3： | 3 |
| 15 | A recombinant receptor-binding domain in trimeric form generates protective immunity against SARSCoV-2 infection in nonhuman primates显示文摘A safe and effective vaccine is critical to combat the COVID-19 pandemic.Here,we developed a trimeric SARS-CoV-2 receptor-binding domain(RBD)subunit vaccine candidate that simulates the natural structure of the spike(S)trimer glycoprotein.Immunization with the RBD trimer-induced robust humoral and cellular immune responses,and a high level of neutralizing antibodies was maintained for at least 4.5 months.Moreover,the antibodies that were produced in response to the vaccine effectively cross-neutralized the SARS-CoV-2501Y.V2 variant(B.1.351).Of note,when the vaccine-induced antibodies dropped to a sufficiently low level,only one boost quickly activated the anamnestic immune response,conferring full protection against a SARSCoV-2 challenge in rhesus macaques without typical histopathological changes in the lung tissues.These results demonstrated that the SARS-CoV-2 RBD trimer vaccine candidate is highly immunogenic and safe,providing long-lasting,broad,and significant immunity protection in nonhuman primates,thereby offering an optimal vaccination strategy against COVID-19. | Limin Yang Deyu Tian Jian-bao Han Wenhui Fan Yuan Zhang Yunlong Li Wenqiang Sun Yanqiu Wei Xiaodong Tian Dan-dan Yu Xiao-li Feng Gong Cheng Yuhai Bi Yong-tang Zheng Wenjun Liu | 2021 | The Innovation2021，2，3： | 3 |
| 16 | CypA Regulates AIP4-Mediated M1 Ubiquitination of Influenza A Virus显示文摘Cyclophilin A (CypA) is a peptidyl-prolyl cis/trans isomerase that interacts with the matrix protein (M1) of influenza A virus (IAV) and restricts virus replication by regulating the ubiquitin–proteasome-mediated degradation of M1. However,the mechanism by which CypA regulates M1 ubiquitination remains unknown. In this study, we reported that E3 ubiquitin ligase AIP4 promoted K48-linked ubiquitination of M1 at K102 and K104, and accelerated ubiquitin–proteasome-mediated degradation of M1. The recombinant IAV with mutant M1 (K102 R/K104 R) could not be rescued, suggesting that the ubiquitination of M1 at K102/K104 was essential for IAV replication. Furthermore, CypA inhibited AIP4-mediated M1 ubiquitination by impairing the interaction between AIP4 and M1. More importantly, both the mutations of M1 (K102 R/K104 R) and CypA inhibited the nuclear export of M1, indicating that CypA regulates the cellular localization of M1 via inhibition of AIP4-mediated M1 ubiquitination at K102 and K104, which results in the reduced replication of IAV.Collectively, our findings reveal a novel ubiquitination-based mechanism by which CypA regulates the replication of IAV. | Madina Mahesutihan Weinan Zheng Liang Cui Yun Li Pengtao Jiao Wenxian Yang Wei Liu Jing Li Wenhui Fan Limin Yang Wenjun Liu Lei Sun | 2018 | Virologica Sinica2018，33，5： | 3 |
| 17 | A New Filter Collaborative State Transition Algorithm for Two-Objective Dynamic Reactive Power Optimization显示文摘Dynamic Reactive Power Optimization(DRPO) is a large-scale, multi-period, and strongly coupled nonlinear mixed-integer programming problem that is difficult to solve directly. First, to handle discrete variables and switching operation constraints, DRPO is formulated as a nonlinear constrained two-objective optimization problem in this paper. The first objective is to minimize the real power loss and the Total Voltage Deviations(TVDs), and the second objective is to minimize incremental system loss. Then a Filter Collaborative State Transition Algorithm(FCSTA) is presented for solving DRPO problems. Two populations corresponding to two different objectives are employed. Moreover, the filter technique is utilized to deal with constraints. Finally, the effectiveness of the proposed method is demonstrated through the results obtained for a 24-hour test on Ward & Hale 6 bus, IEEE 14 bus, and IEEE 30 bus test power systems. To substantiate the effectiveness of the proposed algorithms, the obtained results are compared with different approaches in the literature. | Hongli Zhang Cong Wang Wenhui Fan | 2019 | Tsinghua Science and Technology2019，24，1： | 3 |
| 18 | The self-assembled nanoparticle-based trimeric RBD mRNA vaccine elicits robust and durable protective immunity against SARS-CoV-2 in mice显示文摘As COVID-19 continues to spread rapidly worldwide and variants continue to emerge,the development and deployment of safe and effective vaccines are urgently needed.Here,we developed an mRNA vaccine based on the trimeric receptor-binding domain(RBD)of the SARS-CoV-2 spike(S)protein fused to ferritin-formed nanoparticles(TF-RBD).Compared to the trimeric form of the RBD mRNA vaccine(T-RBD),TF-RBD delivered intramuscularly elicited robust and durable humoral immunity as well as a Th 1-biased cellular response.After further challenge with live SARS-CoV-2,immunization with a two-shot low-dose regimen of TF-RBD provided adequate protection in hACE2-transduced mice.In addition,the mRNA template of TF-RBD was easily and quickly engineered into a variant vaccine to address SARS-CoV-2 mutations.The TF-RBD multivalent vaccine produced broad-spectrum neutralizing antibodies against Alpha(B.1.1.7)and Beta(B.1.351)variants.This mRNA vaccine based on the encoded self-assembled nanoparticle-based trimer RBD provides a referenee for the design of mRNA vaccines targeting SARS-CoV-2. | Wenqiang Sun Lihong He He Zhang Xiaodong Tian Zhihua Bai Lei Sun Limin Yang Xiaojuan Jia Yuhai Bi Tingrong Luo Gong Cheng Wenhui Fan Wenjun Liu Jing Li | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 3 |
| 19 | New Way of Predicting Production State by Carbon Isotope Fractionation in the Fuling Shale Gas Field,Southeast Sichuan Basin显示文摘Objective With the discovery of the Fuling shale gas field and the realization of commercial exploitation, the prediction of shale gas well production state has attracted wide attention of scholars at home and abroad. | LUO Houyong LIU Wenhui FAN Ming TAO Cheng WANG Xiaofeng ZHANG Dongdong HAN Yuanhong | 2019 | Acta Geologica Sinica(English Edition)2019，93，2： | 2 |
| 20 | Multi-Agent Modeling and Simulation in the AI Age显示文摘With the rapid development of artificial intelligence(AI)technology and its successful application in various fields,modeling and simulation technology,especially multi-agent modeling and simulation(MAMS),of complex systems has rapidly advanced.In this study,we first describe the concept,technical advantages,research steps,and research status of MAMS.Then we review the development status of the hybrid modeling and simulation combining multi-agent and system dynamics,the modeling and simulation of multi-agent reinforcement learning,and the modeling and simulation of large-scale multi-agent.Lastly,we introduce existing MAMS platforms and their comparative studies.This work summarizes the current research situation of MAMS,thus helping scholars understand the systematic technology development of MAMS in the AI era.It also paves the way for further research on MAMS technology. | Wenhui Fan Peiyu Chen Daiming Shi Xudong Guo Li Kou | 2021 | Tsinghua Science and Technology2021，26，5： | 2 |
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