|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Microcalorimetric investigation of the effect of berberine alkaloids from Coptis chinensis Franch on Staphylococcus aureus growth显示文摘The inhibitory effects of three berberine alkaloids (BAs) from rhizome of Coptis chinensis Franch, a traditional Chinese medicinal (TCM) herb, on Staphylococcus aureus growth were investigated by mi- crocalorimetry. The power–time curves of S. aureus with and without BAs were acquired; meanwhile the extent and duration of inhibitory effects on the metabolism were evaluated by studying the growth rate constant (k), half inhibitory ratio (IC50), maximum heat-output power (Pmax), peak time of maximum heat-output power (tp) and total heat production (Qt). The value of k of S. aureus in the presence of the three BAs decreased with the increasing concentrations of BAs. Moreover, Pmax was reduced and the value of tp increased with increasing concentrations of the three drugs. The inhibitory activity varied with different drugs. The values of IC50 of the three BAs are respectively, 101.4 μg/mL for berberine, 241.0 μg/mL for palmatine and 792.3 μg/mL for jateorrhizine. The sequence of antimicrobial activity of the three BAs is: berberine > palmatine > jateorrhizine. It is suggested that the functional group me- thylenedioxy or methoxyl at C2 on the phenyl ring could possibly improve antimicrobial activity more strongly than hydroxyl at C2 on the phenyl ring. | YAN Dan XIAO XiaoHe JIN Cheng DONG XiaoPing | 2008 | Science China Chemistry2008，51，7： | 27 |
| 2 | Guidance for the clinical evaluation of traditional Chinese medicine-induced liver injury Issued by China Food and Drug Administration显示文摘1. Introduction Drug-induced liver injury (DILI), defined as liver injury caused by a drug and/or its metabolites, is a common clinical adverse drug reaction1–4. This type of injury can cause acute liver failure and even death in severe cases5. | Xiaohe Xiao Jianyuan Tang Yimin Mao Xiuhui Li Jiabo Wang Chenghai Liu Kewei Sun Yong’an Ye Zhengsheng Zou Cheng Peng Ling Yang Yuming Guo Zhaofang Bai Tingting He Jing Jing Fengyi Li Na An | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 22 |
| 3 | The action of medicinal animal horns on Escherichia coli growth investigated by microcalorimetry and chemometric analysis显示文摘The action of Cornu Cervi Pantotrichum (CCP), Cornu Cervi (CC) and Cornu Saigae Tataricae (CST) on Escherichia coli growth were investigated using microcalorimetry to find the heat change regularity of microbial growth. The similarity of thermogenic curves and thermodynamics parameters were investigated as evaluation index, such as the growth rate constant in the first expo- nential phase (k1), maximum power in the first exponential phase (P1), maximum power in the secondary exponential phase (P2), peak time in the first exponential phase (T1), peak time in the stationary phase (T2) and the total heat production in stage 1 (Q1), and the total heat production in stage 2 (Q2). Chemometric analysis was used as a reference for the bioactivity evaluation of medicinal animal horns. The results indicated that the similarity between CST and the control was smaller than that between CCP, CC and the control. Both CCP and CC could increase the heat in the microbial growth, whereas CST decreased it. The biotic thermal activity of different medicinal animal horns was objectively, qualitatively, and quantitatively evaluated by the similarity of thermogenic curves and thermodynamics parameters analysis. | YAN Dan HAN YuMei LUO JiaoYang ZHANG Ping TANG HuiYing PENG Cheng XIAO XiaoHe | 2010 | Chinese Science Bulletin2010，55，26： | 6 |
| 4 | The self-regulation process and its mechanism of channels' bed changes in the Changjiang(Yangtze) Estuary in China显示文摘Recent bathymetric changes in the Changjiang Estuary under the influence of artificial regulation engineerings and basin reservoirs have been analyzed based on the maritime charts since 1997 and recent fieldworks. The results indicate a slight erosion of the channels in the upper and middle estuary, continuing deposition and seaward move of the mouth bar crest and intensifying erosion at the nearshore seabed. It is noteworthy that the morphological evolution caused by intensive human activities dominates over the changes from nature process.First, the riverbes are eroded overall in the South Branch(SB), the South Channel(SC) and the upper and middle reaches of the North Channel(NC). The nearshore seabed outside the river mouth is being eroded slightly, which is attributed to the declining sediment supply from the Changjiang Basin due to the construction of the Three Gorges Dam upstream. The sediment above the seabed is very active and coarsened, meanwhile, sand waves are becoming more distinct. Second, a deposition occurs in the North Brach(NB), the mouth of the NC, the mouth bars of the North Passage(NP) and the South Passage(SP) and especially the main channel of the NP, where it shows a massive siltation after the deep waterway project. The reasons for the recent changes are not only the dynamic structure in estuarine mouth bars, but also the supply of sediment resuspension in a local and offshore area. Meanwhile, the severe erosion and siltation in some reaches is related to the construction of estuarine engineerings. It is indicated that the Changjiang Estuary is gradually self-adjusted and adapting to the varying natural factors and intensive human activities. The study on the mechanism of self-regulation of the recent bathymetric changes in the Changjiang Estuary has important and practical significance. | ZHANG Xiaohe LI Jiufa ZHU Wenwu CHENG Heqin CHEN Wei | 2015 | Acta Oceanologica Sinica2015，34，7： | 5 |
| 5 | A quality evaluation strategy for Rhizoma coptidis from a variety of different sources using chromatographic fingerprinting combined with biological fingerprinting显示文摘Most of herbal medicines of different sources are used for the same treatment goal in clinic despite their tremendous differences of the quality.Because the clinical efficacy is closely related to the quality of medicines,the implementation of an effective quality control(QC)process is vital.Chemical methods based on content determination and chromatographic fingerprints(CFs)have been recommended as powerful tools.In spite of advances in QC,it is still difficult to determine that which of the chemical compositions can best reflect the correlation with the desired biological activity.Herein,we have focused on the biological activities of multi-source herbal medicines to establish an analytical method.By looking for correlations between the biological activities and their chemical compositions,the method can identify reasonable chemical indicators or chemical methods with biological activity information.In this study,high-performance liquid chromatography(HPLC)and microcalorimetry are combined as a useful method for evaluating the quality of Rhizoma coptidis from different sources.The results of biological fingerprints(BFs)showed that the antibacterial activity sequence of R.coptidis of different sources was Coptis teeta Wall.(CT)>Coptis chinensis Franch.(CC)>Coptis deltoidea C.Y.Cheng et Hsiao(CD).The'spectrum-activity'relationships between CFs and BFs were investigated using the canonical correlation analysis(CCA).Compared with the CCA result of CFs and BFs,the canonical correlation coefficient r1and r2were 0.9974 and 0.9752,respectively.It revealed that there are a close correlation between the spectrum-activity relationships and several of the major anti-bacterial components in the CFs,including jatrorrhizine,coptisine,palmatine,and berberine.Of course,R.coptidis was only a representative of multisource medical plants.The result of the current study will provide an effective reference for evaluating the quality of multisource herbal medicines. | LI JunXian YAN Dan MA LiNa XIONG Yin YAN ChunXia LI BaoCai PENG Cheng XIAO XiaoHe | 2013 | Chinese Science Bulletin2013，58，33： | 5 |
| 6 | A Wideband E-Plane Crossover Coupler for Terahertz Applications显示文摘In this paper,a new approach to design terahertz(THz)E-plane crossover coupler is reported.By cascading two symmetrical septum polarizers,a simple structure with wide operating bandwidth and high isolation performance is achieved.The working principle is explained by operating waveguide modes.To simplify the optimization process,the scattering matrix(S-matrix)of the crossover is calculated.Two prototypes loaded and unloaded electromagnetic band gap(EBG)are fabricated and measured.The electrical contact problem at assembly plane is eliminated by the prototype loaded EBG.A measured bandwidth of 17.3%from 92.5 to 110 GHz for reflection and isolation coefficients<-15 dB and transmission coefficient>-2 dB is achieved. | Xiaohe Cheng Zhiyan Liu Yuan Yao Junsheng Yu Xiaodong Chen | 2021 | China Communications2021，18，5： | 1 |
| 7 | Transcriptional and Post-transcriptional Modulation of SQU and KEW Activities in the Control of Dorsal-Ventral Asymmetric Flower Development in Lotus japonicus显示文摘在 Papilionoideae 荚,莲花 japonicus,发展背面腹(DV ) 不对称的花被二 TB1/CYCLOIDEA/PCF (TCP ) 基因,摆平的标准(SQU ) 和翻身翅膀主要在莲花(英国伦敦郊外的村名) 控制,它分别地决定背面、侧面的身份。然而,这二高度相应的基因怎么安排他们的多样的功能的分子的基础仍然保持不清楚。这里,我们分析了他们的表示层次,并且调查了 SQU 和英国伦敦郊外的村名的 transcriptional 活动。我们证明 SQU 拥有激活和压抑活动,当英国伦敦郊外的村名仅仅充当使活跃之物时。他们形成人 -- 并且 heterodimers,然后联合地在抄写水平调整他们的表示。而且,我们识别了 post-transcriptional 修正, phosphorylation 和 ATP/GTP 绑定的二种类型,哪个能影响他们的 transcriptional 活动。在 SQU 和英国伦敦郊外的村名的 ATP/GTP 有约束力的主题的变化导致忍受变异的蛋白质显示器有缺陷者 DV 不对称的花开发的 phosphorylation,和转基因的植物的失败,显示二结合修正为他们的多样的函数是必要的。总的来说, SQU 和英国伦敦郊外的村名活动精确在抄写和抄写以后的层次被调制,它可能连接 DV 不对称的花开发到不同生理的地位或发信号的小径。 | Zhiyong xu Kai Cheng Xin Li Jun Yang Shilei Xu Xiangling Cao Xiaohe Hu Wei Xie Ling Yuan Mike Ambrose Genyun Chen Hualing Mi Da Luo | 2016 | Molecular Plant2016，9，5： | 1 |
| 8 | High-Gain Dual Circularly Polarized Antenna for Air-to-Ground Wireless Link显示文摘This paper presents an E-band reflector antenna fed by dual circularly polarized feed system. Axial displaced ellipse reflector is adopted for high gain and low blockage mechanisms. The feed system mainly composed of orthomode transducer, iris polarizer and horn antenna, and possesses dual circular polarization. The orthomode transducer offers high isolation performance in broadband by double symmetry and the iris polarizer achieves phase shift by introducing discontinuities. In addition, the ridge and iris in the feed are optimized to be wide enough to fabricate and maintain good mechanical properties in higher frequency band. The entire antenna is simulated and fabricated. The measured gain of 45 ± 1.2 d Bi corresponds to about 52% efficiency. The measured results of reflection coefficients less than-18 d B, isolation over 27 d B, axial-ratio value less than 2.3 d B are achieved from 71 to 86 GHz. | JIANG Hang YAO Yuan XIU Tao CHENG Xiaohe YU Junsheng CHEN Xiaodong | 2022 | Chinese Journal of Electronics2022，31，3： | 0 |
| 9 | ALIGNING GOALS显示文摘APEC members can do more to promote connectivity agenda By Cheng Xiaohe As another annual APEC Summit drew to a close in Da Nang Viet Nam,the future suddenly became uncertain as the U.S.president lashed out at so-called'chronic trade abuses'and promised to take a bilateral approach to address trade issues.President Donald Trump sent a clear message that his country does not offer | Cheng Xiaohe | 2017 | Beijing Review2017，60，47： | 0 |
| 10 | Honeycomb-like biochar framework coupled with Fe_(3)O_(4)/FeS nanoparticles as efficient heterogeneous Fenton catalyst for phenol degradation显示文摘Achieving an efficient and stable heterogeneous Fenton reaction over a wide pH range is of great significance for wastewater treatment.Here,a pollen-derived biochar catalyst with a unique honeycomb-like structure,coupled with the dispersion of magnetic Fe_(3)O_(4)/FeS(Fe/S)nanoparticles,was synthesized by simple impregnation precursor,followed by pyrolysis.The prepared Fe/S-biochar catalyst demonstrated outstanding phenol degradation efficiency across a wide pH range,with 98%of which eliminated even under neutral conditions(pH 7.0).The high catalytic activity was due to the multilevel porous structure of pollenderived biochar provided enough active sites and allowed for better electron transfer,then increases oxidation ability to promote the reaction.Moreover,the acid microenvironment formed by SO_(4)^(2-)group from Fe/S composite extended the pH range for Fenton reaction,and S^(2-)facilitated the conversion of≡Fe^(3+)to≡Fe^(2+),resulting in remarkable degradation efficiency.Further,biochar can effectively promote cycling stability by limiting Fe leaching.This work may provide a general strategy for designing 3D framework biochar-based Fe/S catalysts with excellent performance for heterogeneous Fenton reactions. | Aihua Cheng Yi He Xiaohe Liu Chi He | 2024 | Journal of Environmental Sciences2024，，2： | 0 |
| 11 | Sanctions Are No Panacea显示文摘The UN Security Council is faced with a tricky North Korea’s ongoing nuclear and ballistic missile programs,and the consequent decision by South Korea to deploy the Terminal High Altitude Area Defense(THAAD)system,have constituted asignifcant challenge to peace and stability in Northeast Asia. | Cheng Xiaohe | 2016 | Beijing Review2016，59，50： | 0 |
| 12 | Vulnerability assessment of coastal wetlands in Minjiang River Estuary based on cloud model under sea level rise显示文摘The change of coastal wetland vulnerability affects the ecological environment and the economic development of the estuary area.In the past,most of the assessment studies on the vulnerability of coastal ecosystems stayed in static qualitative research,lacking predictability,and the qualitative and quantitative relationship was not objective enough.In this study,the“Source-Pathway-Receptor-Consequence”model and the Intergovernmental Panel on Climate Change vulnerability definition were used to analyze the main impact of sea level rise caused by climate change on coastal wetland ecosystem in Minjiang River Estuary.The results show that:(1)With the increase of time and carbon emission,the area of high vulnerability and the higher vulnerability increased continuously,and the area of low vulnerability and the lower vulnerability decreased.(2)The eastern and northeastern part of the Culu Island in the Minjiang River Estuary of Fujian Province and the eastern coastal wetland of Meihua Town in Changle District are areas with high vulnerability risk.The area of high vulnerability area of coastal wetland under high emission scenario is wider than that under low emission scenario.(3)Under different sea level rise scenarios,elevation has the greatest impact on the vulnerability of coastal wetlands,and slope has less impact.The impact of sea level rise caused by climate change on the coastal wetland ecosystem in the Minjiang River Estuary is mainly manifested in the sea level rise,which changes the habitat elevation and daily flooding time of coastal wetlands,and then affects the survival and distribution of coastal wetland ecosystems. | Xiaohe Lai Chuqing Zeng Yan Su Shaoxiang Huang Jianping Jia Cheng Chen Jun Jiang | 2023 | Acta Oceanologica Sinica2023，42，7： | 0 |
| 13 | Geological context and vents morphology in the ultramafic-hosted Tianxiu field, Carlsberg Ridge显示文摘The Tianxiu hydrothermal field(TXHF) located on Carlsberg Ridge is one of the few active ultramafic-hosted venting systems known in the Indian Ocean. Despite numerous investigations, there is limited understanding of its sulfide structure morphology, and the factors controlling the formation of TXHF are poorly understood. In this study, we conducted detailed seafloor mapping using visual data obtained by dives using the human-occupied vehicle(HOV) Jiaolong. The TXHF is found to be an active, off-axis, ultramafic-hosted, high-temperature hydrothermal area in which serpentine peridotite is exposed. Two main hydrothermal sites were identified, i.e., P and Y, both of which feature a complex of chimneys and beehive diffusers constituting a “chimney jungle” and isolated large steep-sided structures developed on flat-lying sulfide mounds. In addition, some sporadic inactive chimneys and outcrops of hydrothermal deposits were noted. The chimneys are rich in Fe and Zn sulfide, and lack the central fluid channel formed by focused high-temperature fluid flow. Hydrothermal venting at TXHF is likely related to low-angle detachment faults that focus and transport hydrothermal fluids away from a heat source along the valley wall. Our results complement and expand upon previous works concerning sulfide chimney morphology and their corresponding mineral paragenesis in ultramafic-hosted hydrothermal systems in the Indian Ocean and further our understanding of modern seafloor hydrothermal systems. | Jin Liang Chunhui Tao Xiangxin Wang Cheng Su Wei Gao Yadong Zhou Weikun Xu Xiaohe Liu Zhongjun Ding | 2023 | Acta Oceanologica Sinica2023，42，9： | 0 |
| 14 | Statistical Analysis of the Relationship between Macroscopic Anomalies and Earthquakes显示文摘Macroscopic anomalies from'Earthquake Cases in China'are statistically analyzed in this paper. The conclusion is as follows: The probability of occurrence of macroscopic anomalies before earthquakes increases with magnitude. The larger the earthquake magnitude, the more macroscopic anomalies appear. The temporal distribution of macroscopic anomalies is as follows: There are few macroscopic anomalies at beginning; as time goes on,the number of macroscopic anomalies increases; the increase of macroscopic anomaly quantity accelerates with the impending earthquake and reaches a climax when the earthquake breaks out. The spatial distribution pattern of macroscopic anomalies is as follows: macroscopic anomalies appear at the epicenter at the beginning,then spread out,and finally arise explosively at the epicenter area. | Lu Shuangling Qu Baoan Cai Yin Zhang Ming Zhao Xiaohe Zhao Rui Yu Cheng Li Bo | 2015 | Earthquake Research in China2015，29，4： | 0 |
| 15 | Reverse spillover of SARS-CoV-2 from human to wild animals显示文摘The heavily transmitted and mutated SARS-CoV-2 has constitutes a sustained threat to global health.A recent article published in Nature,firstly provided solid evidence confirming the cross-species transmission of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)from human to free-ranging white-tailed deer(Hale et al.,2022).More importantly,circulation of SARS-CoV-2 among deer rapidly resulted into new phylogenetic clades of deer-only viruses which were believed linking to the high infection rate of SARS-CoV-2 within white-tailed deer in northeast Ohio,USA(Hale et al.,2022). | Mingyuan Li Xiaohe Cheng Chengfeng Qin | 2022 | Science China(Life Sciences)2022，65，9： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员