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| 1 | Adsorptive desulfurization over hierarchical beta zeolite by alkaline treatment显示文摘Hierarchical beta zeolites with SiO2 /Al2O3 molar ratios of 16 to 25 were obtained by alkaline treatment in NaOH solution. The effects of treatment temperature on crystallinity, textural properties and chemical composites were studied by XRD, N2 sorption, FT-IR and XRF techniques. The desulfurization performance of parent and alkaline-treated beta zeolites was investigated by static absorption in four model fuels, containing four sulfur compounds of different molecular sizes like thiophene (TP), 3-methylthiophene (3-MT), benzothiophene (BT) and dibenzothiophene (DBT), respectively. The crystallinity was observed to be successfully maintained when the treatment temperature was below 50 C. Mesoporosity of beta zeolite was evidently developed with alkaline treatment. The formation of mesopore remarkably improved the desulfurization performance for TP, 3-MT, BT and DBT, especially for DBT with larger molecular diameter. Though the addition of toluene in the model fuels resulted in a significant drop of the desulfurization performance of mesoporous beta zeolite, the introduction of cerium ions to some extent mitigated the effect of toluene, which means that both the adsorbents porous structure and the adsorption mode are responsible for the desulfurization performance. The adsorbent of cerium ion-exchanged mesoporous beta showed about 80% recovery of desulfurization after the first regeneration. | Fuping Tian Xiaojian Yang Yanchun Shi Cuiying Jia Yongying Chen | 2012 | Journal of Natural Gas Chemistry2012，21，6： | 11 |
| 2 | Effects of toluene on thiophene adsorption over NaY and Ce(IV)Y zeolites显示文摘Zeolites NaY and Ce(IV)Y were employed as adsorbents to remove organic sulfur compounds from model gasoline(MG) solutions with and without toluene in static adsorption experiments at room temperature(RT) and atmospheric pressure.The adsorbents were characterized by XRD,XRF and pyridine infrared spectrum(IR).The adsorption experiments show that the desulfurization performance of Ce(IV)Y is much better than that of NaY.The sulfur removal over both NaY and Ce(IV)Y decreases with the increase of toluene concentration in MG,however,the decline tendency on Ce(IV)Y is smooth,and it is steep on NaY.FT-IR spectra of thiophene adsorption indicate that thiophene molecules are mainly adsorbed on NaY via π electron interaction,but on Ce(IV)Y,in addition to the π electron interaction,both Ce4+-S direct interaction and protonation of thiophene also play important roles.Toluene molecules are adsorbed on NaY also via π electron interaction.Although the amount of Brnsted acid sites is increased due to the introduction of Ce4+ ions into NaY zeolite,it is not found to influence the adsorption mode of toluene over Ce(IV)Y.Compared with NaY zeolite,the improved desulfurization performance over Ce(IV)Y for removing organic sulfur compounds from MG solution,especially those containing large amount of aromatics,may be ascribed to the direct Ce(IV)-S interaction,which is much resistant to the influence resulted from toluene adsorption. | Yanchun Shi Xiaojian Yang Fuping Tian Cuiying Jia Yongying Chen | 2012 | Journal of Natural Gas Chemistry2012，21，4： | 9 |
| 3 | Ultrawide-band radar imagery from multiple incoherent frequency subband measurements显示文摘The problem of combined radar imagery from multiple sparse frequency subbands initially incoherent to each other is of practical importance for radar target discrimination.A new coherent processing technique based on probability density analysis of the subband data is proposed,which is applicable for radar imaging from measurements of two or more initially incoherent radar subbands.The coherence parameters for both amplitude and phase are obtained by combining modern spectral analysis with probability density estimation.The major advantage of the proposed technique lies in that it enables much more robust cohering for the sparse subband data of real-world complex targets. | Xiaojian Xu Jia Li | 2011 | Journal of Systems Engineering and Electronics2011，22，3： | 7 |
| 4 | miR-137 and miR-491 Negatively Regulate Dopamine Transporter Expression and Function in Neural Cells显示文摘The dopamine transporter(DAT) is involved in the regulation of extracellular dopamine levels.A 40-bp variable-number tandem repeat(VNTR) polymorphism in the 3'-untranslated region(3'UTR) of the DAT has been reported to be associated with various phenotypes that are involved in the aberrant regulation of dopaminergic neurotransmission.In the present study,we found that miR-137 and miR-491 caused a marked reduction of DAT expression,thereby influencing neuronal dopamine transport.Moreover,the regulation of miR-137 and miR-491 on this transport disappeared after the DAT was silenced.The miR-491 seed region that is located on the VNTR sequence in the 3'UTR of the DAT and the regulatory effect of miR-491 on the DAT depended on the VNTR copy-number.These data indicate that miR-137 and miR-491 regulate DAT expression and dopamine transport at the posttranscriptional level,suggesting that microRNA may be targeted for the treatment of diseases associated with DAT dysfunction. | Xiaojian Jia Feng Wang Ying Han XuewenGeng Minghua Li Yu Shi Lin Lu Yun Chen | 2016 | Neuroscience Bulletin2016，32，6： | 5 |
| 5 | Interaction mechanism between niobium-silicide-based alloy melt and Y_2O_3 refractory crucible in vacuum induction melting process显示文摘Y2O3 坩锅在真空正式就职融化多部件 Nb-16Si-22Ti-2Al-2Hf-17Cr (at.%) 合金作为传统的陶器的一种选择在学习被介绍,到表明在合金之间的可能的相互作用融化并且倔强的坩锅。多重融化时间长度和二冷却计划被设计并且为实验使用了。测试合金和融化坩锅相互作用的化学作文和微观结构被调查并且评估。在实验, Y2O3 坩锅显示好物理化学药品的相容性。结果显示在当演员组铸块锭的 O 元素的增长是 0.03at .%-0.04at.%(72-97 ppm ) , Y 元素的增长是很不足道的。合金的特色融化与 Y2O3 陶艺交往在纸被分析并且得出结论。由于溶解反应 xY2O3 (在熔融的合金)+( 1-x ) HfO2 (杂质) Hf1x Y2x O2x ,一部连续双层固体电影由 HfO2 稳固的答案( 2 下午)组成了,在在坩锅凉下来以后,纯 RfO2 ( 5 下午)在测试铸块锭的表面上被形成。Y2O3 坩锅对真空正式就职适用 NbSi 融化的试验性的结果表演基于合金。 | Gao Ming Jia Lina Tang Xiaoxia Li Xiaojian Cui Renjie Zhang Hu | 2011 | China Foundry2011，8，2： | 4 |
| 6 | Nonlinear relationship between enteric-coated mycophenolate sodium dose and mycophenolic acid exposure in Han kidney transplantation recipients显示文摘The aim of the research was to investigate the pharmacokinetics(PK) of enteric-coated mycophenolate sodium(EC-MPS) by quantification of the active metabolite of mycophenolic acid(MPA)after multiple escalating oral doses in Han kidney transplant recipients. A total of 28 Han postoperative kidney transplant recipients were given a multiple-dose of 540, 720 or 900 mg of EC-MPS two times a day in combination with tacrolimus for 6 days. Blood specimens were collected at each time point from0 to 12 h after EC-MPS administration. MPA plasma concentrations were measured by UPLC–UV. The relationship between the EC-MPS dose and its PK parameters was assessed. In the range from 540 to900 mg, C_(max) and AUC_(0–12h) did not increase with dose escalation. The AUC_(0–12h), C_(max), C_0 and T_(max) for the 540 720 and 900 mg doses were not significantly different, respectively(P 40.05). AUC_0–12 h and C_(max) were increased less than proportionally with increasing EC-MPS dose levels. Inter-individual variability in AUC_(0–12h), C_(max) and C_0 were considerable. Nonlinear PK relationships were found from the doses of 540–900 mg of EC-MPS. | Jun Zhang Mengmeng Jia Lihua Zuo Na Li Yonggang Luo Zhi Sun Xiaojian Zhang Zhenfeng Zhu | 2017 | Acta Pharmaceutica Sinica B2017，7，3： | 3 |
| 7 | Changes in compressed neurons from dogs with acute and severe cauda equina constrictions following intrathecal injection of brain-derived neurotrophic factor-conjugated polymer nanoparticles显示文摘This study established a dog model of acute multiple cauda equina constriction by experimental constriction injury (48 hours) of the lumbosacral central processes in dorsal root ganglia neurons. The repair effect of intrathecal injection of brain-derived neurotrophic factor with 15 mg encapsulated biodegradable poly(lactide-co-glycolide) nanoparticles on this injury was then analyzed. Dorsal root ganglion cells (L7) of all experimental dogs were analyzed using hematoxylin-eosin staining and immunohistochemistry at 1, 2 and 4 weeks following model induction. Intrathecal injection of brain-derived neurotrophic factor can relieve degeneration and inflammation, and elevate the expression of brain-derived neurotrophic factor in sensory neurons of compressed dorsal root ganglion. Simultaneously, intrathecal injection of brain-derived neurotrophic factor obviously improved neurological function in the dog model of acute multiple cauda equina constriction. Results verified that sustained intraspinal delivery of brain-derived neurotrophic factor encapsulated in biodegradable nanoparticles promoted the repair of histomorphology and function of neurons within the dorsal root ganglia in dogs with acute and severe cauda equina syndrome. | Junming Tan Jiangang Shi Guodong Shi Yanling Liu Xiaohong Liu Chaoyang Wang Dechun Chen Shunming Xing Lianbing Shen Lianshun Jia Xiaojian Ye Hailong He Jiashun Li | 2013 | Neural Regeneration Research2013，8，3： | 2 |
| 8 | Drug-drug cocrystals:Opportunities and challenges显示文摘Recently,drug-drug cocrystal attracts more and more attention.It offers a low risk,low-cost but high reward route to new and better medicines and could improve the physiochemical and biopharmaceutical properties of a medicine by addition of a suitable therapeutically effective component without any chemical modification.Having so many advantages,to date,the reported drug-drug cocrystals are rare.Here we review the drug-drug cocrystals that reported in last decade and shed light on the opportunities and challenges for the development of drug-drug cocrystals. | Xiaojuan Wang Shuzhang Du Rui Zhang Xuedong Jia Ting Yang Xiaojian Zhang | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，3： | 2 |
| 9 | Task Autonomy of a Flexible Endoscopic System for Laser-Assisted Surgery显示文摘Laser beam string has ben widely studied forthe automation ofsurgery.Currently fexible instruments for laser surgery areoperated entirely by surgeons,which keeps the automation of endoluminal surgery at the initial level.This paper introducesthe design of a new workflow that enables the task autonomy of laser-assisted surgery in constrained environments such as thegastrointestinal(GI)tract with a flexible continuum robotic system.Unlike current,laser steering systems driven bypiezoelectric require the use of high voltage and are risky.This paper describes a tendon-driven 2mm diameter flexiblemanipulator integrated with an endoscope toster thelaser beamBy separating its motionfrom the total endoscopic systemthe designed flexible manipulator can automatically manipulate the laser beam.After the surgical site is searched by thesurgeon with a master/slave control,a population-based model-free control method is applied for the fexible manipulatortoachieve accurate laser beam steering while overcoming the noise from the visual feedback and disturbances from environmentduring operation.Simulations and experiments are performed with the system and control methods to demonstrate theproposed framework in a simulated constrained environment. | Hangjie Mo Xiaojian Li Bo Ouyang Ge Fang Yuanjun Jia | 2022 | Cyborg and Bionic Systems2022，，1： | 2 |
| 10 | The inhibitor effect of RKIP on inflammasome activation and inflammasome-dependent diseases显示文摘Aberrant inflammasome activation contributes to the pathogenesis of various human diseases,including atherosclerosis,gout,and metabolic disorders.Elucidation of the underlying mechanism involved in the negative regulation of the inflammasome is important for developing new therapeutic targets for these diseases.Here,we showed that Raf kinase inhibitor protein(RKIP)negatively regulates the activation of the NLRP1,NLRP3,and NLRC4 inflammasomes.RKIP deficiency enhanced caspase-1 activation and IL-1P secretion via NLRP1,NLRP3,and NLRC4 Inflammasome activation In primary macrophages.The overexpression of RKIP in THP-1 cells inhibited NLRP1,NLRP3,and NLRC4 inflammasome activation.RKIP-deficient mice showed increased sensitivity to Aluminduced peritonitis and Salmonella typhimurium-induced inflammation,indicating that RKIP inhibits NLRP3 and NLRC4 inflammasome activation in vivo.Mechanistically,RKIP directly binds to apoptosis-associated speck-like protein containing a caspase-recruitment domain(ASC)and competes with NLRP1,NLRP3,or NLRC4 to interact with ASC thus interrupting inflammasome assembly and activation.The depletion of RKIP aggravated inflammasome-related diseases such as monosodium urate(MSU)-induced gouty arthritis and high-fat diet(HFD)-induced metabolic disorders.Furthermore,the expression of RKIP was substantially downregulated in patients with gouty arthritis or type 2 diabetes(T2D)compared to healthy controls.Collectively,our findings suggest that RKIP negatively regulates NLRP1,NLRP3,and NLRC4 inflammasome activation and is a potential therapeutic target for the treatment of inflammasome-related diseases. | Qiang Qin Huan Liu Jia’nan Shou Yu Jiang Hong Yu Xiaojian Wang | 2021 | Cellular & Molecular Immunology2021，18，4： | 2 |
| 11 | 术前低蛋白血症会增加克罗恩病一期肠吻合术后腹腔内感染性并发症的发生风险显示文摘目的:本研究旨在探讨术前低蛋白血症对克罗恩病(CD)患者一期肠吻合术后发生腹腔内感染性并发症(IASCs)的影响。方法:2007-2015年期间所有行肠切除一期肠吻合手术的CD患者纳入研究。采用单因素和多因素分析评估术前低蛋白血症(白蛋白<30 g/L)与术后IASCs发生风险的关系。结果:共计124例患者纳入研究,其中117例(94.4%)可以获得术前白蛋白水平的数据。13例(11.7%)患者术前合并低蛋白血症。相较之下,术前低蛋白血症患者CD诊断至手术的间期更长(P=0.012),术前服用5氨基水杨酸的比例更高(P=0.013),术中发现小肠梗阻的比例更高(P=0.015)。共有24例(19.4%)患者术后出现IASCs。单因素分析显示,术前低蛋白血症患者术后IASCs风险更高(P=0.012)。多因素分析证实,术前低蛋白血症是术后IASCs的独立危险因素(OR=4.67,95%CI:1.28–17.04,P=0.02)。将术前白蛋白水平作为一个连续型变量进行多因素分析,亦可得到相同的结果(P=0.019)。结论:对于行肠切除一期肠吻合的CD患者,术前低蛋白血症提示术后IASCs发生风险增高。改善术前营养状态或可降低术后IASCs的发生风险。 | Xuanhui Liu Xianrui Wu Chi Zhou Tuo Hu Jia Ke Yufeng Chen Xiaosheng He Xiaobin Zheng Xiaowen He Jiancong Hu Min Zhi Xiang Gao Pinjin Hu Xiaojian Wu Ping Lan | 2017 | Gastroenterology Report2017，5，4： | 1 |
| 12 | Syringomyelia after operation:diagnosis and its formational mechanism显示文摘描述 MRI 调查结果并且在脊骨以后在病人讨论 syringomyelia 的致病形成机制的目的外科的操作。完全, 13 个病人在学习被注册的方法。在手术前,任何一个都没与针的绳索 syringomyelia 我们的病人介绍。吝啬的后续持续时间由 MRI 是 6 年(范围 210 月) 。在针的绳索肿瘤以后的 13 个病人中的四个移开操作,在针的损伤操作以后的 3 个病人, 2 个盒子以前有脊柱侧凸, 2 个盒子是颈的 spondylotic myelopathy, 2 个盒子以前拴住绳索症候群操作。操作前的先生特征并且在所有病人上操作以后与外科的结果和临床的症状在对比被学习。辐射学诊断被 3 个不同放射线学者分别地做。长度,宽度,信号,洞的形状以及 subarachnoid 形状的特征上被集中。结果所有病人以前没在 MRI 上有 syringomyelia 手术。7 个病人的针的绳索出现了坚持压缩和 2 个病人以前拴住绳索操作。在在我们的情况中的操作以后的 syringomyelia 的 MRI 特征证明有鸣管液体的纵的洞有脑髓的液体(CSF ) 的 T1 和 T2 关系特征。吝啬的长度是 5.5 针的片断, 13 个病人的 4 绳索介绍了从前面的材料压缩的绳索, 4 发生了对腰部的针的运河和 1 格的针的绳索的背的手术后的粘附依附颈的针的运河的前面墙。在在针的外科的干预以后的病人的 syringomyelia 的机制可以是在操作前的时期的针的绳索的坚持的压缩或意愿的结论或操作以后。浮肿,包囊,针的绳索的 malacia 是最重要的损害,风险因素导致 syringomyelia。 | Shi Jiangang Jia Lianshun Yuan Wen Shi Guodong Wu Jianfeng Ye XiaoJian Ni Bin Xiao Jianru Tan Junming Xu Guohua | 2008 | Journal of Medical Colleges of PLA(China)2008，23，2： | 1 |
| 13 | Development of Steel Slag-Based Solidification/Stabilization Materials for High Moisture Content Soil显示文摘To solve the problems of high moisture content,high viscosity,and poor engineering mechanical properties of soil,this paper using with steel slag(SS)and desulfurization ash(DS)as initial raw materials,realizing the coop-erative treatment of solid waste and solidification of silt soil.The synergistic utilization of SS and DS can reduce the production cost of curing agent and promote its own consumption.According to blended cement of various SS contents and inspected compressive strength performances,the most suitable raw materials ratio was selected.The best formula for this curing agent is cement:steel slag=3:7 with 5%DS,and its 28-day compressive strength can reach 30 MPa.The experiment shows that the effect of DS and Na_(2)SO_(4) reagent with the same quality on early compressive strength improvement of cement and SS system is not much different.In this study,the mineral composition and microstructure of different gel system blocks were characterized by XRD,SEM and EDX,and a large number of webbed structures were found in the SEM test,which was not seen in previous studies.Besides,unconfined compressive strength(UCS),water resistance,and toxic characteristic leaching procedure(TCLP)were used to evaluate silt solidified soil properties.The results demonstrated that the solidified silt could meet not only the standard of general subgrade;but also has a partial stabilization effect of heavy metal ions. | Yu Jia Sudong Hua Liying Qian Xiaojian Ren Jie Zuo Yanfang Zhang | 2022 | Journal of Renewable Materials2022，10，3： | 1 |
| 14 | Experimental investigation on the deformation characteristics of locking-steel-pipe(LSP)pile retaining structure during excavation in sand显示文摘Locking-steel-pipe(LSP)piles connect with adjacent joints to form a pile row enclosure structure.Due to the advantages of quick construction,efficiency in installation,and recycle utilization,the connected LSP piles are frequently used as retaining structure in deep excavation.However,systematic studies of the deformation mechanism of the LSP pile retaining structure are rarely reported,and it still lack of experimental evidence to optimize the design.In this study,a braced supported excavation experimental model test in sand was designed and conducted to investigate the deformation characteristics of LSP pile retaining structure.Three dimensional(3D)printing technique was creatively applied to manufacture LSP model piles.The experimental results show that,a“S”shaped distribution of bending moments is observed along pile shaft when excavation is executed;the deflection of pile shaft develops deep-seated movements toward the excavation side as excavation went deeper,resulting in a“bowl”ground settlement.With the deflection of LSP piles,a rotating trend was occurred between pairs of locking joint,and the severe open deformation of locking joint arose on excavation side.There was a gradual reduction in earth pressure behind the LSP pile retaining wall with excavation depth.The earth pressure between two struts level had no obvious changing,owing to the supported effect of inner struts. | Shi Wei Rongzhu Liang Guoxiong Mei M.Hesham El Naggar Lianwei Sun Jinqing Jia Xiaohua Bao Xiaojian Wu Wenbing Wu | 2022 | Underground Space2022，7，6： | 0 |
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