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| 1 | Agriculture Green Development: a model for China and the world显示文摘Realizing sustainable development has become a global priority.This holds,in particular,for agriculture.Recently,the United Nations launched the Sustainable Development Goals(SDGs),and the Nineteenth National People’s Congress has delivered a national strategy for sustainable development in China—realizing green development.The overall objective of Agriculture Green Development(AGD)is to coordinate'green'with'development'to realize the transformation of current agriculture with high resource consumption and high environmental costs into a green agriculture and countryside with high productivity,high resource use efficiency and low environmental impact.This is a formidable task,requiring joint efforts of government,farmers,industry,educators and researchers.The innovative concept for AGD will focus on reconstructing the whole crop-animal production and food production-consumption system,with the emphasis on high thresholds for environmental standards and food quality as well as enhanced human well-being.This paper addresses the significance,challenges,framework,pathways and potential solutions for realizing AGD in China,and highlights the potential changes that will lead to a more sustainable agriculture in the future.Proposals include interdisciplinary innovations,whole food chain improvement and regional solutions.The implementation of AGD in China will provide important implications for the countries in developmental transition,and contribute to global sustainable development. | Jianbo SHEN Qichao ZHU Xiaoqiang JIAO Hao YING Hongliang WANG Xin WEN Wen XU Tingyu LI Wenfeng CONG Xuejun LIU Yong HOU Zhenling CUI Oene OENEMA William JDAVIES Fusuo ZHANG | 2020 | Frontiers of Agricultural Science and Engineering2020，7，1： | 18 |
| 2 | The cross talk between long, non-coding RNAs and microRNAs in gastric cancer显示文摘胃的癌症是最普通的恶意的疾病之一并且仍然是世界范围的癌症相关的死亡的第二个领先的原因。尽管大努力在过去的十年期间被作了便于胃的癌症的早察觉和治疗,预后是还没令人满意的,胃的癌症致病的内在的分子的机制充分没被理解。同时,非编码的 RNA 在调整各种各样的生物、病理学的过程作为关键播放器被建立了,例如房间周期前进,改变的染色质,基因抄写,并且 posttranscriptional 处理。而且,众多的研究也在非编码的 RNA 的不同种类之中揭示了复杂相互影响;因此,在长非编码的 RNA (lncRNAs ) 和 microRNAs (miRNAs ) 之间跨规定开始出现了。这次 lncRNAmiRNA 十字谈话,在最近的年里吸引了增加的注意,包括胃的癌症涉及很多人的疾病。在这评论,我们总结在 lncRNAs 和 miRNAs 之间的相互作用的最近的研究进步,加亮他们对提供为癌症诊断和治疗的新奇途径的胃的癌症的发展和前进的影响。 | Kaiyuan Deng Hao Wang Xiaoqiang Guo Jiazeng Xia | 2016 | Acta Biochimica et Biophysica Sinica2016，48，2： | 16 |
| 3 | A new bone repair scaffold combined with chitosan/ hydroxyapatite and sustained releasing icariin显示文摘Icariin, a plant-derived flavonol glycoside, has been proved as an osteoinductive agent for bone tissue engineering. A new bone repair scaffold was generated by thorough mixing of icariin and chitosan/ hydroxyapatite (icariin-CS/HA) using freeze-drying technigue. Characteristics of morphology, mechanical properties, biocompatibility, drug release behavior and bone repair abilities in vivo were evaluated. The results show that drug loading process of icariin did not affect physical structure of CS/HA composite significantly but decreased mechanical properies of CS/HA composite, which happened with a high dosage; icariin-CS/HA had favorable cell compatibility and promoted osteogenic differentiation of hBMSCs; the controlled release of icariin was satisfactory and the release retained after 90 d in vitro. In addition, icariin-CS/HA scaffolds had favorable osteoconduction and osteoinduction in vivo, and could fill bone defect sites and stimulate newborn bone tissues formation at early stage. On the basis of these data, icariin-CS/HA is believed to be an optical bone repair scaffold for tissue engineering. | WU Tao NAN KaiHui CHEN JingDi JIN Dan JIANG Shan ZHAO PeiRan XU JunChang DU Hao ZHANG XiaoQiang LI JianWei PEI GuoXian | 2009 | Chinese Science Bulletin2009，54，17： | 14 |
| 4 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 5 | Improving the lubrication and anti-corrosion performance of polyurea grease via ingredient optimization显示文摘Thickener formulation plays a significant role in the performance characteristics of grease.The polyurea greases(PUGs)were synthesized using mineral oil(500SN)as the base oil,and by regulating the reaction of diphenylmethane diisocyanate(MDI)and different organic amines.The as‐prepared PUGs from the reaction of MDI and cyclohexylamine/p‐toluidine exhibit the optimum physicochemical and friction‐wear properties,confirming that the regulation of thickener formulation can improve the performance characteristics of grease,including friction reduction,wear,corrosion resistance,and load‐carrying capacity.The anticorrosion and lubrication properties of as‐prepared PUGs depend on good sealing functions and a boundary lubrication film(synergy of grease‐film and tribo‐chemical reaction film),as well as their chemical components and structure. | Guanlin REN Xiaowen SUN Wen LI Hao LI Lin ZHANG Xiaoqiang FAN Dongshan LI Minhao ZHU | 2021 | Friction2021，9，5： | 4 |
| 6 | Effect of the benzene ring of the dispersant on the rheological characteristics of coal-water slurry:Experiments and theoretical calculations显示文摘In this study,low-rank coal-water slurry(LCWS)was prepared using polyoxyethylene dodecylphenol ether(PDPE)and polyoxyethylene lauryl ether(PLE),respectively.A combination of experiments and simulations was used to investigate the pulping properties and microscopic mechanism of the LCWS samples prepared using the two agents,so as to explore the influence of benzene ring on the performance of dispersant.The results of the LCWS preparation experiments revealed that the pulp-forming performance of PDPE exceeded that of PLE.When LCWS concentration is 62%,64%,and 66%,the apparent viscosity corresponding to PDPE is 247.80,504.17,and 653.10 mPa·s,and the apparent viscosity corresponding to PLE is 548.10,1470.61,and 1549.98 mPa·s,respectively.The C_(1000)(When the apparent viscosity is 1000 mPa·s,the corresponding concentration of LCWS is defined as C_(1000))values of PDPE and PLE are 67.60%and 62.95%,respectively.In addition to the van der Waals forces and hydrogen bonds between the PDPE and/or PLE molecules and coal,the benzene rings of PDPE presentπ-πstacking effect with the aromatic rings of coal.That could facilitate and strengthen the adsorption of PDPE on coal,which would be conducive to further improving the dispersion of coal particles.The two dispersants have no significant difference in effect on the pyrolysis of LCWS.The simulation results indicated that the times for PDPE and PLE molecules to reach flat adsorption state on coal are approximately 290 and 565 ps,respectively.The self-diffusion coefficient(D)of the PDPE and PLE on coal is 3.16 x 10^(-6)and6.57×10^(-6)m~2/s,respectively,and their interaction energies with coal are 785.71 and 648.60 kcal/mol,respectively.The results of the simulation calculations demonstrated that PDPE adsorbed on coal easier than PLE,and its binding is more stable than that of PLE owing to theπ-πstacking effect,which is conducive to uniform dispersion of coal in solution.The simulation results confirmed the experimental results. | Lin Li Chuandong Ma Shanpei Hu Meng He Hao Yu Qingbiao Wang Xiaoqiang Cao Xiaofang You | 2021 | International Journal of Mining Science and Technology2021，31，3： | 4 |
| 7 | Design, analysis and application of synthetic microbial consortia显示文摘The rapid development of synthetic biology has conferred almost perfect modification on single cells,and provided methodological support for synthesizing microbial consortia,which have a much wider application potential than synthetic single cells.Co-cultivating multiple cell populations with rational strategies based on interacting relationships within natural microbial consortia provides theoretical as well as experimental support for the successful obtaining of synthetic microbial consortia,promoting it into extensive research on both industrial applications in plenty of areas and also better understanding of natural microbial consortia.According to their composition complexity,synthetic microbial consortia are summarized in three aspects in this reviewand are discussed in principles of design and construction,insights and methods for analysis,and applications in energy,healthcare,etc. | Xiaoqiang Jia Chang Liu Hao Song Mingzhu Ding Jin Du Qian Ma Yingjin Yuan | 2016 | Synthetic and Systems Biotechnology2016，1，2： | 3 |
| 8 | A ratiometric benzothiazole-based fluorescence probe for selectively recognizing HClO and its practical applications显示文摘A ratiometric probe(HBT-HBZ)bearing 2-hydrazino benzothiazole and 3-(benzo[d]thiazol-2-yl)-2-hydroxy-5-methylbenzaldehyde for sensing hypochlorous acid(HClO)with high selectivity and sensitivity is reported in this article.The fluorescence intensity ratios(I470nm/I572nm)of the probe with different concentrations of analyte showed excellent selectivity and a linear response to minor changes in HClO.The detection limit of 24 nmol/L suggests that the sensor is very sensitive to HClO.According to the series of performed experiments,HBT-HBZ has practical applications,such as the detection of HClO residues in tap water,which has been rarely reported.In addition,confocal laser microscopy experiments confirmed that HBT-HBZ can selectively recognize HClO in HeLa cells.A ratiometric probe(HBT-HBZ)for sensing HClO with high selectivity and sensitivity is reported in this article.The probe exhibited high selectivity for HClO among other ROS,RNS and anions.In addition,HBTHBZ has some practical applications such as the analysis of the HClO content in tap water.Furthermore,confocal fluorescence microscopy imaging showed that HBT-HBZ can be applied for detecting HClO in living cells. | Kaijie Wang Dazhou Xi Chuantao Liu Yahui Chen Hao Gu Long Jiang Xiaoqiang Chen Fang Wang | 2020 | Chinese Chemical Letters2020，31，11： | 2 |
| 9 | Comparative Study on the Efficacies of 11 Chemical Agents against Taro Soft Rot Caused by Pectobacterium aroidearum显示文摘[Objective]The paper was to screen the effective agents for effectively controlling the occurrence and prevalence of taro soft rot.[Method]The fungicidal effects of 11 fungicides on taro soft rot were determined by inhibition zone method.[Result]0.3%Tetramycin,25%bromothalonil,3%Zhongshengmycin and 30%zinc thiazole had better antifungal effect on Pectobacterium aroidearum at recommended concentration.The indoor toxicity of four fungicides showed that the EC50 of 0.3%tetramycin AS was the smallest of 0.6μg/mL,indicating that tetramycin had the largest toxicity and the best inhibitory effect against P.aroidearum;followed by 25%bromothalonil EC and 3%Zhongshengmycin WP,with the EC_(50) of 2.57 and 97.72μg/mL,respectively;the inhibitory effect of 30%zinc thiazole SC against P.aroidearum was the poorest.[Conclusion]The study provides a reference for screening out new and efficient chemical agents against taro soft rot. | Dongkun Wang Xiuting Ji Huaixu Zhan Chengpeng Zheng Hao Zong Xiaolei Tan Xiuchun Du Weimin Wang Jingjing Wu Fenglong Wang Xiaoqiang Wang | 2021 | Plant Diseases and Pests2021，12，2： | 2 |
| 10 | Analysis of Protein Moiety of Polysaccharide Conjugates Water-extracted from Low Grade Green Tea显示文摘 | CHEN Xiaoqiang SHAO Shengrong XIE Jianchun YUAN Hao LI Qian WU Long WU Zhengqi YUAN Haibo JIANG Yongwen | 2018 | Chemical Research in Chinese Universities2018，34，4： | 2 |
| 11 | Manifold Regularized Sparse NMF for Hyperspectral Unmixing 显示文摘 | LU Xiaoqiang WU Hao YUAN Yuan | 2013 | IEEETrans Geo RemoteSe2013，51，5： | 1 |
| 12 | Thermal effects on the stability and antioxidant activity of an acid polysaccharide conjugate derived from green tea显示文摘 | CHEN Xiaoqiang YE Yang CHENG Hao | 2009 | Journal of Agricultural and Food Chemistry2009，57，13： | 1 |
| 13 | VEGF-C/VEGFR-3/iNOS Signaling in Osteosarcoma MG63 Cells Mediates Stimulatory Effects on Human Umbilical Vein Endothelial Cell Proliferation显示文摘Objectives To assess the effects of vascular endothelial growth factor-C(VEGF-C)/vascular endothelial growth factor receptor-3(VEGFR-3)signaling on nitric oxide(NO)production and inducible nitric oxide synthase(iNOS)expression in human osteosarcoma MG63 cells and the subsequent impact on the proliferation of human umbilical vein endothelial cells(HUVECs).Methods MG63 cells were treated with VEGF-C alone(VEGF-C group),VEGF-C+iNOS inhibitor aminoguanidine(AG;AG group),and VEGF-C+VEGFR-3 inhibitor MAZ51(MAZ51 group);untreated MG63 cells were used as controls.NO production was evaluated by a colorimetric method involving nitrate reductase.Meanwhile,mRNA and protein levels of iNOS were examined by reverse transcription polymerase chain reaction(RT-PCR)and Western blot.To explore the effect of VEGF-C/VEGFR-3/iNOS signaling of MG63 cells on proliferation of HUVECs,we set up six groups:HUVECs,HUVECs+MG63,HUVECs+VEGF-C,HUVECs+MG63+VEGF-C,HUVECs+MG63+VEGF-C+AG,and HUVECs+MG63+VEGF-C+MAZ51 groups.The proliferation of HUVEC cells was assessed by Cell Counting Kit-8(CCK-8),5-ethynyl-2'-deoxyuridine(EdU)incorporation assay,and proliferating cell nuclear antigen(PCNA)expression quantitation.Results VEGF-C treatment enhanced iNOS expression at both gene and protein levels(mRNA:LSD-t=4.152,P<0.01;protein:LSD-t=3.486,P<0.01)and increased NO release of MG63 cells(LSD-t=3.774,P<0.01);treatment with either AG or MAZ51 decreased these effects(mRNA:LSD-t=9.183,P<0.001;LSD-t=8.639,P<0.001;protein:LSD-t=5.170,P<0.001;LSD-t=7.25S,P<0.001;NO production:LSD-t=10.326,P<0.001;LSD-t=l0.540,P<0.001).Interestingly,co-incubation of HUVECs with MG63 cells and/or VEGF-C significantly promoted HUVEC proliferation(EdU:LSD-t=5.374,P<0.001;LSD-t=2.984,P<0.05;LSD-t=8.526,P<0.001;PCNA:LSD-t=9.267,P<0.001;LSD-t=5.515,P<0.001;LSD-t=14.873,P<0.001).The proliferation effects of HUVEC induced by MG63 cells and VEGF-C attenuated by the treatment of AG(EdU:LSD-t=10.770,P<0.001;PCNA:LSD-t=19.94O,P<0.001)or MAZ51(EdU:LSD-t=6.950,P<0.001;PCNA:LSD-t=14.001,P<0.001).Conclusion In human osteosarcoma MG63 cells,activation of VEGFR-3 by VEGF-C promotes iNOS expression and NO production,which subsequendy induces HUVEC proliferation. | Jie Lv Jie Yuan Chaojian Xu Jiaqi Hao Yichuan Qin Xiaoqiang Wang Yongfeng Wang | 2021 | Chinese Medical Sciences Journal2021，36，1： | 1 |
| 14 | Highly-efficient fabrication of nanoscrolls from functionalized graphene oxide by Langmuir–Blodgett method显示文摘 | Yan Gao Xiaoqiang Chen Hao Xu Yunlong Zou Renpeng Gu Mingsheng Xu Alex K.-Y. Jen Hongzheng Chen | 2010 | Carbon2010，，15： | 1 |
| 15 | Manifold regularized sparse NMF for hyperspectral unmixing显示文摘 | LU Xiaoqiang WU Hao YUAN Yuan | 2013 | IEEE Transactions on Geomscience and Remote Sensing2013，51，5： | 1 |
| 16 | Exosomes derived from human adipose-derived stem cells ameliorate osteoporosis through miR-335-3p/Aplnr axis显示文摘Treatment of osteoporosis is still a challenge in clinic,which leads to an increasing social burden as the aging of population.Exosomes originated from human adipose-derived stem cells(hASCs)hold promise to promote osteogenic differentiation,thus may ameliorate osteoporosis.The main purpose of this study was to investigate the novel usage of hASC-derived exosomes in the treatment of osteoporosis and their underlying mechanism.Two types of exosomes,i.e.,exosomes derived from hASCs cultured in proliferation medium(P-Exos)and osteogenic induction medium(O-Exos),were obtained.As compared with P-Exos,O-Exos could promote the osteogenic differentiation of mouse bone marrow-derived stem cells(mBMSCs)from osteoporotic mice in vitro and ameliorated osteoporosis in vivo.Then,microRNA(miRNA)-335-3p was identified to be the key differentially expressed microRNA between the two exosomes by small RNA sequencing,gene overexpression and knock-down,qRT-PCR,and dual-luciferase reporter assay,and Aplnr was confirmed to be the potential target gene of miRNA-335-3p.In addition,miR335-3p inhibitor-optimized O-Exos were established by transfection of miR-335-3p inhibitor,which significantly enhanced the osteogenic differentiation of mBMSCs in vitro,and bone density and number of trabecular bones in vivo compared with unoptimized O-Exos.Our results indicated that the ASC-exosome-based therapy brings new possibilities for osteoporosis treatment.Besides,engineered exosomes based on transfection of miRNA are a promising strategy to optimize the therapeutic effect of exosomes on osteoporosis. | Chunhui Sheng Xiaodong Guo Zhuqing Wan Xiaoqiang Bai Hao Liu Xiao Zhang Ping Zhang Yunsong Liu Wenyue Li Yongsheng Zhou Longwei Lv | 2022 | Nano Research2022，15，10： | 1 |
| 17 | Manifold regularized spares NMF for hyperspectral unmixing显示文摘 | Lu Xiaoqiang Wu Hao Liu Wei | 2013 | IEEE Trans on Geoscience and Remote Sensing2013，51，5： | 1 |
| 18 | Hierarchical Ti_(3)C_(2)T_(x)@MoS_(2) heterostructures:A first principles calculation and application in corrosion/wear protection显示文摘Surface and interface engineering plays a crucial role in modulating the properties of materials,especially two-dimensional(2D)materials.Hence,a strategy,forming heterostructures with MoS_(2),is proposed to overcome the natural agglomeration of Ti_(3)C_(2)T_(x) MXene nanosheets.Most importantly,the interactions between Ti_(3)C_(2)Tx and MoS_(2) were elaborately investigated by first-principles calculations based on density functional theory(DFT)for the first time.The calculations demonstrate that van der Waals forces dominate the interface interactions of Ti_(3)C_(2)T_(x) and MoS_(2),rendering Ti_(3)C_(2)T_(x)@MoS_(2) heterostructures favorable stability.The Ti_(3)C_(2)T_(x)@MoS_(2) heterostructure composites were synthesized through a facile one-step hydrothermal method and exhibit a 2D hierarchical structure.Furthermore,the corrosion and tribological properties of epoxy composite coatings with varying proportions of Ti_(3)C_(2)T_(x)@MoS_(2) composites were studied in detail.As a result,the epoxy composite coating with 0.1 wt.%Ti_(3)C_(2)T_(x)@MoS_(2) composites(Ti_(3)C_(2)T_(x)@MoS_(2)-0.1)exhibits excellent corrosion protection and antiwear performances.The Ti_(3)C_(2)T_(x)@MoS_(2)-0.1 keeps the largest low-frequency impedance modulus(|Z|_(0.)01 Hz)and coating resistance(R_(c))during the whole immersion period.Its wear rate is 0.09μm^(3)/(Nμm)under the load of 10 N,one half of that of pure epoxy coating(EP).This work further broadens the application of MXene-based heterostructure composites. | Meng Cai Peng Feng Han Yan Yuting Li Shijie Song Wen Li Hao Li Xiaoqiang Fan Minhao Zhu | 2022 | Journal of Materials Science & Technology2022，，21： | 1 |
| 19 | cRGD-functionalized, DOX-conjugated, and 64 Cu-labeled superparamagnetic iron oxide nanoparticles for targeted anticancer drug delivery and PET/MR imaging显示文摘 | Xiaoqiang Yang Hao Hong Jamison J. Grailer Ian J. Rowland Alireza Javadi Samuel A. Hurley Yuling Xiao Yunan Yang Yin Zhang Robert J. Nickles Weibo Cai Douglas A. Steeber Shaoqin Gong | 2011 | Biomaterials2011，，17： | 1 |
| 20 | Study of sodium lignosulfonate prepare low-rank coal-water slurry:Experiments and simulations显示文摘The effect of sodium lignosulfonate(SL)as additive on the preparation of low-rank coal-water slurry(LCWS)was studied by experiments and molecular dynamics(MD)simulation s.The experimental results show that the appropriate amount of additives is beneficial to reduce the viscosity of LCWS and increase the slurry concentration.Adsorption isotherm studies showed that SL conforms to single-layer adsorption on the coal surface,andΔG_(ads)^(0) was negative,proving that the reaction was spontaneous.Zeta potential measurements showed that SL increased the negative charge on coal.FTIR scanning and XPS wide-range scanning were performed on the coal before and after adsorption,and it was found that the content of oxygen functional groups on coal increased after adsorption.Simulation results show that when a large number of SL molecules exist in the solution,some SL molecules will bind to hydrophobic hydrocarbon groups on coal.The rest of the SL molecule s,their hydrophobic alkyl tails,come into contact with each other and aggregate in solution.The agglomeration of SL molecules and the surface of coal with static electricity will also produce electrostatic interaction,which is conducive to the even dispersion of coal particles.The results of mean square displacement(MSD)and self-diffusion coefficient(D)show that the addition of SL reduces the diffusion rate of water molecules.Simulation results correspond to experimental results,indicating that MD simulation is accurate and feasible. | Lin Li Chuandong Ma Mengyu Lin Mingpu Liu Hao Yu QingbiaoWang Xiaoqiang Cao Xiaofang You | 2021 | Chinese Journal of Chemical Engineering2021，34，1： | 1 |
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