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| 1 | Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility显示文摘Premature ovarian failure(POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study,umbilical cord mesenchymal stem cells on a collagen scaffold(collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3 a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles. Successful clinical pregnancy was achieved in women with POF after transplantation of collagen/UC-MSCs or UC-MSCs. In summary, collagen/UC-MSC transplantation may provide an effective treatment for POF. | Lijun Ding Guijun Yan Bin Wang Lu Xu Yan Gu Tong Ru Xiaoying Cui Lei Lei Jingyu Liu Xiaoqiang Sheng Bin Wang Chunxue Zhang Yanjun Yang Ruiwei Jiang Jianjun Zhou Na Kong Feifei Lu Huaijun Zhou Yannan Zhao Bing Chen Yali Hu Jianwu Dai Haixiang Sun | 2018 | Science China(Life Sciences)2018，61，12： | 43 |
| 2 | Overexpression of a dominant-negative mutant of SIRT1 in mouse heart causes cardiomyocyte apoptosis and early-onset heart failure显示文摘SIRT1,a mammalian ortholog of yeast silent information regulator 2(Sir2),is an NAD+-dependent protein deacetylase that plays a critical role in the regulation of vascular function.The current study aims to investigate the functional significance of deacetylase activity of SIRT1 in heart.Here we show that the early postnatal hearts expressed the highest level of SIRT1deacetylase activity compared to adult and aged hearts.We generated transgenic mice with cardiac-specific expression of a dominant-negative form of the human SIRT1(SIRT1H363Y),which represses endogenous SIRT1 activity.The transgenic mice displayed dilated atrial and ventricular chambers,and died early in the postnatal period.Pathological,echocardiographic and molecular phenotype confirmed the presence of dilated cardiomyopathy.Terminal deoxynucleotidyl transferase-mediated dUTP nick-end-labeling analysis revealed a greater abundance of apoptotic nuclei in the hearts of transgenic mice.Furthermore,we show that cardiomyocyte apoptosis caused by suppression of SIRT1 activity is,at least in part,due to increased p53acetylation and upregulated Bax expression.These results indicate that dominant negative form of SIRT1(SIRT1H363Y)overexpression in mouse hearts causes cardiomyocyte apoptosis and early-onset heart failure,suggesting a critical role of SIRT1 in preserving normal cardiac development during the early postnatal period. | MU WenLi ZHANG QingJun TANG XiaoQiang FU WenYan ZHENG Wei LU YunBiao LI HongLiang WEI YuSheng LI Li SHE ZhiGang CHEN HouZao LIU DePei | 2014 | Science China(Life Sciences)2014，57，9： | 12 |
| 3 | New inverter topology for ground current suppression in transformerless photovoltaic system application显示文摘An interesting inverter topology is proposed in this paper.It is similar to the typical three-phase full bridge inverter from the topology point of view,but smartly designed for the ground current reduction in single-phase photovoltaic(PV)inverter applications.Theoretical analysis is conducted to clarify the operation mechanism of the proposed topology.Performance evaluation is carried out to verify the effectiveness of the proposed topology for the ground current suppression. | Xiaoqiang GUO Huaibao WANG Zhigang LU Baocheng WANG | 2014 | Journal of Modern Power Systems and Clean Energy2014，2，2： | 9 |
| 4 | Discrete element modeling of the effect of particle size distribution on the small strain stiffness of granular soils显示文摘 | Xiaoqiang Gu Lutong Lu Jiangu Qian | 2017 | Particuology2017，15，3： | 6 |
| 5 | Ascorbate antagonizes nickel ion to regulate JMJD1A expression in kidney cancer cells显示文摘histone demethylase Jumonji 包含域的蛋白质 1A (JMJD1A ) 的反常表示与许多种癌症被联系。JMJD1A 也是 hypoxic 反应基因,它的表示被组织缺氧可诱导的 factor-1 (HIF-1 ) 调整。在这研究,我们在开发和组织缺氧小径决定了 JMJD1A 的角色。我们也测量了 JMJD1A 和二组织缺氧因素葡萄糖 transporter 的表示 1 ( GLUT1 )并且在 786-0 和 HEK293 细胞的脉管的 endothelial 生长因素( VEGF )为 24 h 与 NiCl2 ( 2.5100 M )的不同集中对待,并且发现 JMJD1A mRNA 和蛋白质与 NiCl2 的增加的集中是起来调整的。我们然后观察到 ascorbate 能延迟以通过减少的一种剂量依赖者方式的导致 NiCl2 的 JMJD1A 表示的起来调整的效果 HIF-1 的稳定性蛋白质。Immunohistochemical 分析进一步证明 ascorbate 在 786-0, HEK293,和 OS-RC-2 房间反对了 JMJD1A 表示的导致 Ni2+ 的起来规定。这些调查结果建议 Ni2+ 和 ascorbate 能调整 histone demethylase JMJD1A 的表示,它为癌症开发或抑制是重要的。 | Xiaoqiang Guo Jingxiao Lu Yuejia Wang Yaoting Gui Xianglin Duan Zhiming Cai | 2012 | Acta Biochimica et Biophysica Sinica2012，44，4： | 5 |
| 6 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 7 | n-Hexadecane and pyrene biodegradation and metabolization by Rhodococcus sp. T1 isolated from oil contaminated soil显示文摘The high-molecular weight polycyclic aromatic hydrocarbons(PAHs) pyrene and typical long chain alkane nhexadecane are both difficult to degrade. In this study, n-hexadecane and pyrene degrading strain Rhodococcus sp. T1 was isolated from oil contaminated soil. Strain T1 could remove 90.81% n-hexadecane(2 vol%) and 42.79% pyrene(200 mg·L^(-1)) as a single carbon within 5 days, respectively. Comparatively, the degradation of pyrene increased to 60.63%, but the degradation of n-hexadecane decreased to 87.55% when these compounds were mixed. Additionally, identification and analysis of degradation metabolites of Rhodococcus sp. T1 in the above experiments showed that there were significant changes in alanine, methylamine, citric acid and heptadecanoic acid between sole and dual substrate degradation. The optimal conditions for degradation were then determined based on analysis of the pH, salinity, additional nutrient sources and liquid surface activity.Under the optimal conditions of pH 7.0, 35 °C, 0.5% NaCl, 5 mg·L^(-1) of yeast extract and 90 mg·L^(-1) of surfactant,the degradation increased in single or dual carbon sources. To our knowledge, this is the first study to discuss metabolite changes in Rhodococcus sp. T1 using sole substrate and dual substrate to enhance the long-chain alkanes and PAHs degradation potential. | Xiaoqiang Jia Yun He Lei Huang Dawei Jiang Wenyu Lu | 2019 | Chinese Journal of Chemical Engineering2019，27，2： | 5 |
| 8 | Characterization and analysis of petrochemical wastewater through particle size distribution, biodegradability, and chemical composition显示文摘The centralized treatment method is a widely used form of wastewater treatment that tends to be less effective at removing toxic substances. Therefore, a detailed analysis of the composition of wastewater can provide important information for the design of an effective wastewater treatment process. The objective of this paper was to investigate particle size distribution(PSD), biodegradability, and the chemical composition of the petrochemical wastewater discharges. For this purpose, this project selected the petrochemical wastewater and treated wastewater of China National Offshore Oil Corporation Zhongjie Petrochemical Co, Ltd. as the analysis objects.The step-by-step filtration method, along with a molecular weight classification method, was selected to build the chemical oxygen demand(COD) and biochemical oxygen demand(BOD) fingerprints of petrochemical wastewater and treated wastewater. The results showed that the main pollutants were settleable particles in petrochemical wastewater, which contributed to over 54.85% of the total COD. The colloidal particles with particle sizes in the range of 450–1000 nm had the highest COD value in the treated wastewater, which contributed34.17% of the total COD of treated wastewater. The results of the BOD analysis showed that the soluble fractions were the main reason that treated wastewaters did not meet the treatment standards. Tests on the organic compounds in petrochemical wastewater found that there were mainly linear paraffins, branched paraffins, benzene series compounds, and some plasticizers in the influent of the petrochemical wastewater. The most abundant pollutants in treated petrochemical wastewater were the adjacent diisobutyl phthalate and the linear alkanes.Fourier transform infrared(FTIR) transmission spectroscopy analysis showed that the settleable particles of petrochemical wastewater and membrane bioreactor(MBR)-treated wastewater contained multiple types of organic substances. The results also indicated that removing the oil-settleable substances, the colloidal particles(450–1000 nm), and the soluble organics will be necessary for the treatment of petrochemical wastewater. | Xiaoqiang Jia Dayao Jin Chen Li Wenyu Lu | 2019 | Chinese Journal of Chemical Engineering2019，27，2： | 4 |
| 9 | Isolation of Secondary Metabolites with Antimicrobial Activities from Bacillus amyloliquefaciens LWYZ003显示文摘The strain LWYZ003, which can restrain multiple pathogens, was screened from the sediment of the ocean and identified as Bacillus amyloliquefaciens. Large-scale fermentation and modern chromatographic separation technologies(macroporous resin column chromatography, silica gel column chromatography, thin-layer chromatography and high-performance liquid chromatography) were used to separate antimicrobial products from the fermentation broth of marine-derived Bacillus amyloliquefaciens LWYZ003. Bioactive-guided separation was used in the term of seeking antimicrobial products from the secondary metabolites of Bacillus amyloliquefaciens LWYZ003. As a result, two natural products cycloheximide( 1) and trehalose( 2) were obtained. Their structures were elucidated by Fourier transform infrared spectroscopy, high-resolution mass spectrometry, ~1 H and ^(13) C nuclear magnetic resonance analysis. In the cylinder plate method, compound 1 exhibited stronger antimicrobial activities than compound 2 against Micrococcus luteus, and also exhibited wider antimicrobial spectrum than compound 2. In conclusion, isolation of bioactive secondary metabolites from marine Bacillus sp. has enormous potentials in finding suitable antibiotics to inhibit multiple pathogens. | Zhen Liu Yiting Wang Xiaoqiang Jia Wenyu Lu | 2019 | Transactions of Tianjin University2019，25，1： | 3 |
| 10 | Manifold Regularized Sparse NMF for Hyperspectral Unmixing 显示文摘 | LU Xiaoqiang WU Hao YUAN Yuan | 2013 | IEEETrans Geo RemoteSe2013，51，5： | 1 |
| 11 | Synthesis, photostability and bioactivity of 2,3-cyclopropanated abscisic acid显示文摘 | Liu Wenjian Han Xiaoqiang Xiao Yumei Fan Jinlong Zhang Yuanzhi Lu Huizhe Wang Mingan Qin Zhaohai | 2013 | Phytochemistry2013，，： | 1 |
| 12 | The structure-directing effect of n-propylamine in the crystallization of open-framework aluminophosphates显示文摘Using n-propylamine as a template,deioned water and secondary-butanol(butan-2-ol)as solvents,a three-dimensional(3D)open-framework aluminophosphate[C3NH10]·[HAl3P3O13](1)and a two-dimensional layered aluminophosphate[C3NH10]3·[Al3P4O16](2)were crystallized from the initial mixtures with compositions of Al2O3:2.4 P2O5:5.0 n-propylamine:100 H2O/butan-2-ol,respectively.They are characterized by X-ray powder diffraction(XRD),thermogravimetric(TG),and elemental(CHN)analyses and structurally determined by single-crystal X-ray diffraction analysis.Compound 1 crystallizes in the monoclinic space group P21/c with a=0.85831(13)nm,b=1.7677(3)nm,c=1.04353(12)nm,=123.887(9)°,and V=1.3143(3)nm3.Compound 2 crystallizes in the monoclinic space group P21/c with a=1.1313(2)nm,b=1.4874(3)nm,c=1.8020(6)nm,=125.07(2)°,and V=2.4817(11)nm3.The results show that the properties of solvent have a significant influence on the structure-directing effect of n-propylamine in the crystallization of the open-framework aluminophosphates. | LU HuiYing YAN Yan TONG XiaoQiang YAN WenFu YU JiHong XU RuRen | 2014 | Science China Chemistry2014，57，1： | 1 |
| 13 | Amelioration of high fat diet induced liver lipogenesis and hepatic steatosis by interleukin-22显示文摘 | Ling Yang Yixuan Zhang Lingdi Wang Fengjuan Fan Lu Zhu Zhigang Li Xiangbo Ruan Heng Huang Zhenzhen Wang Zhihua Huang Yuliang Huang Xiaoqiang Yan Yan Chen | 2010 | Journal of Hepatology2010，，2： | 1 |
| 14 | Stability and dynamical property for two-species ultracold atoms in double wells显示文摘 | Xu Xiaoqiang Lu Lihua Li Youquan | | 0，，04： | 1 |
| 15 | Manifold regularized sparse NMF for hyperspectral unmixing显示文摘 | LU Xiaoqiang WU Hao YUAN Yuan | 2013 | IEEE Transactions on Geomscience and Remote Sensing2013，51，5： | 1 |
| 16 | Computational fluid dynamics simulation of a novel bioreactor forsophorolipid production显示文摘This paper describes three-dimensional computational fluid dynamics(CFD) simulations of gas–liquid flow in a novel laboratory-scale bioreactor contained dual ventilation-pipe and double sieve-plate bioreactor(DVDSB)used for sophorolipid(SL) production. To evaluate the role of hydrodynamics in reactor design, the comparisons between conventional fed-batch fermenter and DVDSB on the hydrodynamic behavior are predicted by the CFD methods. Important hydrodynamic parameters of the gas–liquid two-phase system such as the liquid phase velocity field, turbulent kinetic energy and volume-averaged overall and time-averaged local gas holdups were simulated and analyzed in detail. The numerical results were also validated by experimental measurements of overall gas holdups. The yield of sophorolipids was significantly improved to 484 g·L^(-1)with a 320 h fermentation period in the new reactor. | Xiaoqiang Jia Lin Qi Yaguang Zhang Xue Yang Hongna Wang Fanglong Zhao Wenyu Lu | 2017 | Chinese Journal of Chemical Engineering2017，25，6： | 1 |
| 17 | Molecular engineering of microporous crystals: (VI) Structure-directing effect in the crystallization process of layered aluminophosphates显示文摘 | Xiaoqiang Tong Jun Xu Liang Xin Pai Huang Huiying Lu Chao Wang Wenfu Yan Jihong Yu Feng Deng Huai Sun Ruren Xu | 2012 | Microporous and Mesoporous Materials2012，，： | 1 |
| 18 | Molecular engineering of microporous crystals: (V) Investigation of the structure-directing ability of piperazine in forming two layered aluminophosphates显示文摘 | Xiaoqiang Tong Jun Xu Chao Wang Huiying Lu Pai Huang Wenfu Yan Jihong Yu Feng Deng Ruren Xu | 2012 | Microporous and Mesoporous Materials2012，，： | 1 |
| 19 | Distribution of Bacterial Communities in Petroleum-Contaminated Soils from the Dagang Oilfield, China显示文摘Diversity in bacterial communities was investigated along a petroleum hydrocarbon content gradient(0-0.4043 g/g)in surface(5-10 cm)and subsurface(35-40 cm)petroleum-contaminated soil samples from the Dagang Oilfield,China.Using 16S rRNA Illumina high-throughput sequencing technology and several statistical methods,the bacterial diversity of the soil was studied.Subsequently,the environmental parameters were measured to analyze its relationship with the community variation.Nonmetric multidimensional scaling and analysis of similarities indicated a significant difference in the structure of the bacterial community between the nonpetroleum-contaminated surface and subsurface soils,but no differences were observed in different depths of petroleum-contaminated soil.Meanwhile,many significant correlations were obtained between diversity in soil bacterial community and physicochemical properties.Total petroleum hydrocarbon,total organic carbon,and total nitrogen were the three important factors that had the greatest impacts on the bacterial community distribution in the long-term petroleum-contaminated soils.Our research has provided references for the bacterial community distribution along a petroleum gradient in both surface and subsurface petroleum-contaminated soils of oilfield areas. | Xueke Feng Zhen Liu Xiaoqiang Jia Wenyu Lu | 2020 | Transactions of Tianjin University2020，26，1： | 1 |
| 20 | Amelioration of high fat diet induced liver lipogenesis and hepatic steatosis by interleukin-22显示文摘 | Ling Yang Yixuan Zhang Lingdi Wang Fengjuan Fan Lu Zhu Zhigang Li Xiangbo Ruan Heng Huang Zhenzhen Wang Zhihua Huang Yuliang Huang Xiaoqiang Yan Yan Chen | 2010 | Journal of Hepatology2010，，2： | 1 |
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