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| 1 | Why Chinese Exports Face So Many Trade Remedy Actions: An Empirical Study Based on Multi-country and Multi-industry Data显示文摘 | Xiangyu Tian Shenxiang Xie Qi Wang Xiaosong Wang | 2016 | China & World Economy2016，24，6： | 4 |
| 2 | Single-cell atlas reveals a distinct immune profile fostered by T cell-B cell crosstalk in triple negative breast cancer显示文摘Background:Characterizing the unique immune microenvironment of each tumor is of great importance for better predicting prognosis and guiding cancer immunotherapy.However,the unique features of the immune microenvironment of triple negative breast cancer(TNBC)compared with other subtypes of breast cancer remain elusive.Therefore,we aimed to depict and compare the immune landscape among TNBC,human epidermal growth factor receptor 2-positive(HER2^(+))breast cancer,and luminal-like breast cancer.Methods:Single-cell RNA sequencing(scRNA-seq)was performed on CD45^(+)immune cells isolated from human normal breast tissues and primary breast tumors of various subtypes.By analyzing the scRNA-seq data,immune cell clusters were identified and their proportions as well as transcriptome features were compared among TNBC,human HER2^(+)breast cancer,and luminal-like breast cancer.Pseudotime and cell-cell communication analyses were also conducted to characterize the immune microenvironment.Results:ScRNA-seq data of 117,958 immune cells were obtained and 31 immune clusters were identified.A unique immunosuppressive microenvironment in TNBC was decoded as compared to that in HER2^(+)or luminal-like breast cancer,which was characterized by higher proportions of regulatory T cells(Tregs)and exhausted CD8+T cells and accompanied by more abundant plasma cells.Tregs and exhausted CD8+T cells in TNBC exhibited increased immunosuppression signature and dysfunctional scores.Pseudotime analyses showed that B cells tended to differentiate to plasma cells in TNBC.Cell-cell communication analyses indicated that these unique features are fostered by the diversified T cell-B cell crosstalk in TNBC.Based on the T cell-B cell crosstalk,a prognostic signaturewas established that could effectively predict the prognosis status for patients with TNBC.Additionally,it was found that TNBC had a higher proportion of cytotoxic natural killer(NK)cells,whereas HER2^(+)or luminal-like breast cancer lost this feature,suggesting thatHER2^(+)or luminal-like breast cancer,but not TNBC,may benefit from NK-based immunotherapy.Conclusions:This study identified a distinct immune feature fostered by T cell-B cell crosstalk in TNBC,which provides better prognostic information and effective therapeutic targets for breast cancer. | Shuning Ding Niu Qiao Qingchen Zhu Yiwei Tong Shengyue Wang Xiaosong Chen Qiang Tian Yichuan Xiao Kunwei Shen | 2023 | Cancer Communications2023，43，6： | 2 |
| 3 | Photonic engineering of superbroadband near-infrared emission in nanoglass composites containing hybrid metal and dielectric nanocrystals显示文摘Photonic media containing hybrid noble metal-dielectric nanocrystals(NCs)represent a wonderland of nanophotonics,with a myriad of uncharted optical functions yet to be explored.Capitalizing on the unique phase separation and spontaneous formation of Au-metal NCs in a gallosilicate glass,we fabricated Ni^2+-doped transparent nanoglass composites(GCs)containing Au-metal/γ-Ga2O3-dielectric NCs.Compared with GCs free of Au-metal NCs,the super broadband near-infrared emission of Ni^2+with a full width at half-maximum over280 nm is enhanced twice in the Au-metal/γ-Ga2O3 dual-phase GCs.A comparison is given as to the spontaneous emission(SPE)properties of Ni^2+in the dual-phase GCs when pumped resonantly and off-resonantly with the localized surface plasmon resonance band of the Au-metal NCs.The important role of the Au-metal NCs in the SPE enhancement is revealed by theoretical simulation based on the finite-element method.Combining the photonic engineering effect of hybrid Au-metal/γ-Ga2O3 NCs and the sensitization effect of Yb^3+on Ni^2+,a record-high enhancement factor of over 10 of the Ni^2+NIR emission is achieved,and optical gain is demonstrated in the GCs at the fiber communication wavelength. | ZHIGANG GAO HAIBO ZHU BOCHAO SUN YINGKE JI XIAOSONG LU HAO TIAN JING REN SHU GUO JIANZHONG ZHANG JUN YANG XIANGENG MENG KATSUHISA TANAKA | 2020 | Photonics Research2020，8，5： | 2 |
| 4 | miR‐194 is a marker of hepatic epithelial cells and suppresses metastasis of liver cancer cells in mice显示文摘 | Zhipeng Meng Xianghui Fu Xiaosong Chen Samuel Zeng Yan Tian Richard Jove Rongzhen Xu Wendong Huang | 2010 | Hepatology2010，，6： | 1 |
| 5 | High energy and insensitive explosives based on energetic porous aromatic frameworks显示文摘The design and synthesis of energetic materials with a compatibility of high energy and insensitivity have always been the research fronts in military and civilian fields.Considering excellent performances of porous organic frameworks and the lack of research in the field of energetic materials,in this study,a new concept named energetic porous aromatic frameworks(EPAFs)is proposed.The strategy of coating high energy explosives such as 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane(CL-20)and 1,3,5,7-tetranitro-1,3,5,7-tetrazocane(HMX)in the EPAFs by wet-infiltration method has successfully realized the assembly of target energetic composite materials.The results show that the 75 wt.%CL-20@EPAF-1 possesses the safer impact sensitivity of 31.4 J than that of CL-20(4.0 J).Notably,for 75 wt.%CL-20@EPAF-1,in addition to the superior detonation performances of the detonation velocity(8,761 m·s^(-1))and detonation pressure(31.27 GPa),the synergistic effect of the nitrogen-rich EPAFs and the nitramines high energy explosives results in a higher heat of detonation that surpasses the most of pristine high explosives and reported novel energetic materials.In prospect,energetic porous aromatic frameworks could be a promising and inspiring strategy to build high energy insensitive energetic materials. | Jian Song Yansong Shi YaoLu Qinghai Shu Yuyang Tian Fengchao Cui Xiaosong Duli Xijuan Lv Shaohua Jin Guangshan Zhu | 2022 | Nano Research2022，15，2： | 1 |
| 6 | Mantis Shrimp-Inspired Underwater Striking Device Generates Cavitation显示文摘Different from direct impact damage exerted by limbs of most organisms,mantis shrimps’appendages can carry out ultra-fast,powerful underwater strikes with cavitation superimposed damage to harvest hard-shelled prey.The power amplification systems and cavitation generation of mantis shrimp have attracted vast attention of researchers.Much effort has been paid to developing mantis shrimp-inspired striking robots;however,none of them are capable of generating cavitation during impacting hard objects yet.In this paper,an underwater striking robot named Shrimpbot was developed to reproduce the cavitation phenomenon when striking hard objects.Shrimpbot incorporates a Latch-Mediated Spring Actuation(LaMSA)to slowly store energy and release it instantaneously.A Diamond-Shaped Four-bar Linkage(DSFL)stretches springs to more effectively store elastic energy by reducing the maximum torque requirement of the motor.This design promised an average power amplification of over 30 times of the motor.Shape optimization and hydrophobic coating on the hammerhead and hand of Shrimpbot helped to reduce the water drag.The accomplished Shrimpbot reached an impact speed of over 12 m/s,at an acceleration of 2×10^(3) m/s^(2),an impact force of more than 1200 N in water,very close to the performance of mantis shrimp.More importantly,cavitation bubbles accompanied with the impacts were observed for the first time in mantis shrimp-inspired robots.Shrimpbot ingeniously employs only one motor to accomplish the striking automatically and repeatedly for practical purposes.Shrimpbot mimics the cavitation generation skills of mantis shrimp,which could facilitate the understanding of its mechanical principles and fluid dynamics of ultra-fast power-amplified systems of mantis shrimp and even those energy storage mechanisms of jumping robots or exoskeleton robots. | Xinxin Li Xiaosong Li Xin Hou Yuanzhe Li Yonggang Meng Liran Ma Yu Tian | 2022 | Journal of Bionic Engineering2022，19，6： | 1 |
| 7 | Designing energetic covalent organic frameworks for stabilizing high-energy compounds显示文摘As an emerging high-energy compound,3-nitro-1,2,4-triazol-5-one(NTO)is used in military explosives and rocket propellants.However,the strong acidic corrosion of NTO,and the high sensitivity and poor thermostability of its salts,severely restrict their practical applications.Therefore,a novel strategy to design and construct energetic covalent organic frameworks(COFs)is proposed in this study.We have successfully prepared a two-dimensional crystalline energetic COF(named ECOF-1)assembled from triaminoguanidine salt,in which NTO anions are trapped in the porous framework via the ionic interaction and hydrogen bonds.The results show that ECOF-1 exhibits superior thermal stability than energetic salt of NTO.It also exhibits insensitivity and excellent heat of detonation of 7,971.71 kJ·kg−1.ECOF-1 greatly inhibits the corrosiveness of NTO.In prospect,energetic COFs are promising as a functional platform to design high-energy and insensitive energetic materials. | Yansong Shi Jian Song Fengchao Cui Xiaosong Duli Yuyang Tian Shaohua Jin Qinghai Shu Guangshan Zhu | 2023 | Nano Research2023，16，1： | 0 |
| 8 | Robust scalable reversible strong adhesion by gecko-inspired composite design显示文摘Bio-inspired reversible adhesion has significant potential in many fields requiring flexible grasping and manipulation,such as precision manufacturing,flexible electronics,and intelligent robotics.Despite extensive efforts for adhesive synthesis with a high adhesion strength at the interface,an effective strategy to actively tune the adhesion capacity between a strong attachment and an easy detachment spanning a wide range of scales has been lagged.Herein,we report a novel soft-hard-soft sandwiched composite design to achieve a stable,repeatable,and reversible strong adhesion with an easily scalable performance for a large area ranging from~1.5 to 150 cm2 and a high load ranging from~20 to 700 N.Theoretical studies indicate that this design can enhance the uniform loading for attachment by restraining the lateral shrinkage in the natural state,while facilitate a flexible peeling for detachment by causing stress concentration in the bending state,yielding an adhesion switching ratio of~54 and a switching time of less than~0.2 s.This design is further integrated into versatile grippers,climbing robots,and human climbing grippers,demonstrating its robust scalability for a reversible strong adhesion.This biomimetic design bridges microscopic interfacial interactions with macroscopic controllable applications,providing a universal and feasible paradigm for adhesion design and control. | Xiaosong LI Pengpeng BAI Xinxin LI Lvzhou LI Yuanzhe LI Hongyu LU Liran MA Yonggang MENG Yu TIAN | 2022 | Friction2022，10，8： | 0 |
| 9 | The BBC News Hunter:A Novel Crawler for BBC News显示文摘In order to distinguish and extract the topic information from other interferential information on the BBC news website for the study in social computing,the BBC News Hunter was proposed in this paper.The whole system consists of 6 subsystems,respectively named:UI,Control,Download,Analysis,Storage and Log.Numerical experiments show that satisfactory results can be obtained from the BBC news website,whose average accuracy as well as efficiency are acceptable. | Mingxin Wang Ning Wang Boran Wang Can Tian Yanchun Liang Guozhong Zhao Xiaosong Han | 2016 | 国际计算机前沿大会会议论文集2016，，2： | 0 |
| 10 | miRNA sequencing analysis of healthy and atretic follicles of chickens revealed that miR-30a-5p inhibits granulosa cell death via targeting Beclin1显示文摘Background:The egg production performance of chickens is affected by many factors,including genetics,nutrition and environmental conditions.These factors all play a role in egg production by affecting the development of follicles.MicroRNAs(miRNAs)are important non-coding RNAs that regulate biological processes by targeting genes or other non-coding RNAs after transcription.In the animal reproduction process,miRNA is known to affect the development and atresia of follicles by regulating apoptosis and autophagy of granulosa cells(GCs).Results:In this study,we identified potential miRNAs in the atretic follicles of broody chickens and unatretic follicles of healthy chickens.We identified gga-miR-30a-5p in 50 differentially expressed miRNAs and found that gga-miR-30a-5p played a regulatory role in the development of chicken follicles.The function of miR-30a-5p was explored through the transfection test of miR-30a-5p inhibitor and miR-30a-5p mimics.In the study,we used qPCR,western blot and flow cytometry to detect granulosa cell apoptosis,autophagy and steroid hormone synthesis.Confocal microscopy and transmission electron microscopy are used for the observation of autophagolysosomes.The levels of estradiol(E2),progesterone(P4),malondialdehyde(MDA)and superoxide dismutase(SOD)were detected by ELISA.The results showed that miR-30a-5p showed a negative effect on autophagy and apoptosis of granulosa cells,and also contributed in steroid hormones and reactive oxygen species(ROS)production.In addition,the results obtained from the biosynthesis and dual luciferase experiments showed that Beclin1 was the target gene of miR-30a-5p.The rescue experiment conducted further confirmed that Beclin1 belongs to the miR-30a-5p regulatory pathway.Conclusions:In summary,after deep miRNA sequencing on healthy and atretic follicles,the results indicated that miR-30a-5p inhibits granulosa cell death by inhibiting Beclin1. | Haorong He Dongmei Li Yongtong Tian Qinyao Wei Felix Kwame Amevor Congjiao Sun Chunlin Yu Chaowu Yang Huarui Du Xiaosong Jiang Menggen Ma Can Cui Zhichao Zhang Kai Tian Yao Zhang Qing Zhu Huadong Yin | 2022 | Journal of Animal Science and Biotechnology2022，13，5： | 0 |
| 11 | Tissue Engineering and Regulatory Science显示文摘Tissue engineering has successfully evolved from its original concept[1]into medical products with a rapid pace of develop-ment and a multi-billion dollar market[2].Compared with tradi-tional medical products,tissue-engineered medical products(TEMPs)have distinct characteristics that provide unique benefits for the repair and regeneration of damaged or diseased tissues or organs[1,2]. | Peng Zhao Wenbo Liu Jiaxin Tian Xinli Shi Xiaosong Gu Antonios G.Mikos | 2022 | Engineering2022，8，6： | 0 |
| 12 | Role of the rhizosphere of a flooding-tolerant herb in promoting mercury methylation in water-level fluctuation zones显示文摘The water-level fluctuation zone(WLFZ) has been considered as a hotspot for mercury(Hg) methylation. Flooding-tolerant herbs are gradually acclimated to this water-land ecotone, tending to form substantial root systems for improving erosion resistance. Accompanying rhizosphere microzone plays crucial but unclear roles in methylmercury(Me Hg) formation in the WLFZ. Thus, we conducted this study in the WLFZ of the Three Gorges Reservoir, to explore effects of the rhizosphere of a dominant flooding-tolerant herb(bermudagrass) on Me Hg production. The elevated Hg and Me Hg in rhizosphere soils suggest that the rhizosphere environment provides favorable conditions for Hg accumulation and methylation. The increased bioavailable Hg and microbial activity in the rhizosphere probably serve as important factors driving Me Hg formation in the presence of bermudagrass. Simultaneously, the rhizosphere environments changed the richness, diversity, and distribution of hgc A-containing microorganisms. Here, a typical ironreducing bacterium( Geobacteraceae) has been screened, however, the majority of hgc A genes detected in rhizosphere, near-, and non-rhizosphere soils of the WLFZ were unclassified. Collectively, these results provide new insights into the elevated Me Hg production as related to microbial processes in the rhizosphere of perennial herbs in the WLFZ, with general implications for Hg cycling in other ecosystems with water-level fluctuations. | Juan Wang Yuping Xiang Xiaosong Tian Cheng Zhang Guiqing Gong Jinping Xue Tao Jiang Dingyong Wang Yongmin Wang | 2022 | Journal of Environmental Sciences2022，34，9： | 0 |
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