|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Prediction of pathological nodal stage of locally advanced rectal cancer by collective features of multiple lymph nodes in magnetic resonance images before and after neoadjuvant chemoradiotherapy显示文摘Objective:To predict pathological nodal stage of locally advanced rectal cancer by a radiomic method that uses collective features of multiple lymph nodes(LNs)in magnetic resonance images before and after neoadjuvant chemoradiotherapy(NCRT).Methods:A total of 215 patients were included in this study and chronologically divided into the discovery cohort(n=143)and validation cohort(n=72).In total,2,931 pre-NCRT LNs and 1,520 post-NCRT LNs were delineated from all visible rectal LNs in magnetic resonance images.Geometric,first-order and texture features were extracted from each LN before and after NCRT.Collective features are defined as the maximum,minimum,mean,median value and standard deviation of each feature from all delineated LNs of each participant.LN-model is constructed from collective LN features by logistic regression model with L1 regularization to predict pathological nodal stage(ypN0 or ypN+).Tumor-model is constructed from tumor features for comparison by using DeLong test.Results:The LN-model selects 7 features from 412 LN features,and the tumor-model selects 7 features from 82 tumor features.The area under the receiver operating characteristic curve(AUC)of LN-model in the discovery cohort is 0.818[95%confidence interval(95%CI):0.745-0.878],significantly(Z=2.09,P=0.037)larger than 0.685(95%CI:0.602-0.760)of the tumor-model.The AUC of LN-model in validation cohort is 0.812(95%CI:0.703-0.895),significantly(Z=3.106,P=0.002)larger than 0.517(95%CI:0.396-0.636)of the tumor-model.Conclusions:The usage of collective features from all visible rectal LNs performs better than the usage of tumor features for the prediction of pathological nodal stage of locally advanced rectal cancer. | Haitao Zhu Xiaoyan Zhang Xiaoting Li Yanjie Shi Huici Zhu Yingshi Sun | 2019 | Chinese Journal of Cancer Research2019，31，6： | 13 |
| 2 | Prognostic factors for transarterial chemoembolization combined with sustained oxaliplatin-based hepatic arterial infusion chemotherapy of colorectal cancer liver metastasis显示文摘Objective: To investigate the prognostic factors in chemorefractory colorectal cancer liver metastasis(CRCLM)patients treated by transarterial chemoembolization(TACE) and sustained hepatic arterial infusion chemotherapy(HAIC).Methods: Between 2006 and 2015, 162 patients who underwent 763 TACE and HAIC in total were enrolled in this retrospective study, including 110 males and 52 females, with a median age of 60(range, 26–83) years.Prognostic factors were assessed with Log-rank test, Cox univariate and multivariate analyses.Results: The median survival time(MST) and median progression-free survival(PFS) of the 162 patients from first TACE/HAIC were 15.6 months and 5.5 months respectively. Normal serum carbohydrate antigen 19-9(CA19-9, <37 U/m L)(P<0.001) and carbohydrate antigen 72-4(CA72-4, <6.7 U/m L)(P=0.026), combination with other local treatment(liver radiotherapy or liver radiofrequency ablation)(P=0.034) and response to TACE/HAIC(P<0.001) were significant factors related to survival after TACE/HAIC in univariate analysis. A multivariate analysis revealed that normal serum CA19-9(P<0.001), response to TACE/HAIC(P<0.001) and combination with other local treatment(P=0.001) were independent factors among them.Conclusions: Our findings indicate that serum CA19-9 <37 U/m L and response to TACE/HAIC are significant prognostic indicators for this combined treatment, and treated with other local treatment could reach a considerable survival benefit for CRCLM. This could be useful for making decisions regarding the treatment of CRCLM. | Hangyu Zhang Jianhai Guo Song Gao Pengjun Zhang Hui Chen Xiaodong Wang Xiaoting Li Xu Zhu | 2017 | Chinese Journal of Cancer Research2017，29，1： | 12 |
| 3 | Geological and geochemical characteristics of Middle Jurassic granites in Bengbu uplift, Southeast of North China craton显示文摘1 Introduction The early formation and evolution of the North China craton has been widely concerned by scientists.The Bengbu uplift belt is located in the southeast of the craton,theresearch degree of the belt is relatively low and received increasing attention from many scholars in recent years.Through the author’s practical work and combined | Kang Congxuan Yang Xianzhong Cai Yitao Zong Wen Zhu Xiaoting | 2017 | Acta Geologica Sinica(English Edition)2017，91，S1： | 5 |
| 4 | Glycyrrhetinic acid-modified nanoparticles for drug delivery: Preparation and characterization显示文摘In this work, glycyrrhetinic acid-modified chitosan (mGA-suc-CTS) used as liver targeted carrier for drug delivery, was prepared via hemisuccinate as a bridged group. The structure of the product was confirmed by IR and NMR methods and the degree of substitution (DS) of glycyrrhetinic acid groups was estimated via elemental analysis. Nanoparticles were formed by ionic gelation methold. The drug-loading and release behavior of the nanoparticles were investigated using BSA as the model drug. The results indicated that the carrier with a highest DS of 5.19% could be got and the DS was controlled by changing reaction temperature or feed ratio. BSA could be entrapped into the nanoparticles with the drug-loading ratio of 26.3% and the encapsulation efficiency of 81.5%. A sustained release over an 11-day period was observed in pH 7.4 in vitro. | TIAN Qin WANG Wei HE XiaoTing ZHU XiaoCui HUANG Wei ZHANG ChuangNian YUAN Zhi CHEN XueSi | 2009 | Chinese Science Bulletin2009，54，18： | 4 |
| 5 | Understanding pitting corrosion behavior of AZ91 alloy and its MAO coating in 3.5%NaCl solution by cyclic potentiodynamic polarization显示文摘The pitting corrosion behavior of AZ91 alloy before and after micro-oxidation treatment in 3.5%Na Cl solution was investigated by cyclic potentiodynamic polarization(CPDP)and optical and SEM observations of corroded surfaces at different polarization potentials.The CPDP results show that both the alloy and the MAO-coated alloy suffer from pitting corrosion and it is difficult for pits to stop growth once the pits initiates.It is revealed that the air-formed Mg O film on AZ91 alloy,the MAO coating along with corrosion products(mainly Mg(OH))formed during CPDP can significantly influence the kinetics of the redox reactions of Mg,and further influence the propagation behavior of pitting corrosion.The optical and SEM images show that the corrosion products on AZ91 alloy are dense and protective but on the MAO-coated corrosion products are very loose.Such observations support the analyses of CPDP results that pits on AZ91 alloy spread to the width whereas pits on MAO-coated alloy propagate to the depth.Overall,pitting corrosion on the MAO-coated alloy can be very severe once the coating ruptures and post-treatments are necessary to provide a promising corrosion protection for the Mg alloys. | Yuxiang Liu Zhu Liu Anyang Xu Xiaoting Liu | 2022 | Journal of Magnesium and Alloys2022，10，5： | 3 |
| 6 | Rapid, automated, and reliable antimicrobial susceptibility test from positive blood culture by CAST‐R显示文摘Antimicrobial susceptibility tests(ASTs)are pivotal in combating multidrug resistant pathogens,yet they can be time‐consuming,labor‐intensive,and unstable.Using the AST of tigecycline for sepsis as the main model,here we establish an automated system of Clinical Antimicrobials Susceptibility Test Ramanometry(CAST‐R),based on D2O‐probed Raman microspectroscopy.Featuring a liquid robot for sample pretreatment and a machine learning‐based control scheme for data acquisition and quality control,the 3‐h,automated CAST‐R process accelerates AST by>10‐fold,processes 96 paralleled antibiotic‐exposure reactions,and produces high‐quality Raman spectra.The Expedited Minimal Inhibitory Concentration via Metabolic Activity is proposed as a quantitative and broadly applicable parameter for metabolism‐based AST,which shows 99%essential agreement and 93%categorical agreement with the broth microdilution method(BMD)when tested on 100 Acinetobacter baumannii isolates.Further tests on 26 clinically positive blood samples for eight antimicrobials,including tigecycline,meropenem,ceftazidime,ampicillin/sulbactam,oxacillin,clindamycin,vancomycin,and levofloxacin reveal 93%categorical agreement with BMD‐based results.The automation,speed,reliability,and general applicability of CAST‐R suggest its potential utility for guiding the clinical administration of antimicrobials. | Pengfei Zhu Lihui Ren Ying Zhu Jing Dai Huijie Liu Yuli Mao Yuandong Li Yuehui He Xiaoshan Zheng Rongze Chen Xiaoting Fu Lili Zhang Lijun Sun Yuanqi Zhu Yuetong Ji Bo Ma Yingchun Xu Jian Xu Qiwen Yang | 2022 | mLife2022，1，3： | 3 |
| 7 | Re-recognition of Tieshan “Syenite” and its Geological Significance in Zhenghe, Fujian Province显示文摘1 Introduction Tieshan Syenite crosses between Dongfeng and Zhangyuan’an in Zhenghe of Fujian province,occurs in the direction of 42°,Total length 8500m,width 600-800m and its Area of about 39km2.Outcrops of the mass | CHEN Shizhong XING Guangfu LI Yanan XI Wanwan ZHU Xiaoting ZHANG Xiaodong | 2017 | Acta Geologica Sinica(English Edition)2017，91，S1： | 3 |
| 8 | Auditory characteristics of noise-exposed memberscrossing age-related groups显示文摘Objective: To report audiological characteristics in a group of noise-exposed crew members on board ships.Methods and materials: Clinical and audiological measurements including pure-tone thresholds, acoustic immittance results and tinnitus questionnaires were collected from both the ship crew members(study subjects) and their land based colleagues(controls).Results: 1) Noise exposed crew members showed not only high frequency, but also low frequency hearing loss; 2) Hearing impairment increased with age, with 65.5% of crew members younger than 50 years showing normal hearing while only 14.9% of those older than 50 years had normal hearing; 3)hearing loss gradually increased with the extension of on board career time; and 4) Most study subjects reported high pitch tinnitus, significantly more than the control group although not significantly different among different age groups.Conclusion: Noise induced hearing impairment from working on board ships shows specific frequency and age characteristics. Understanding these characteristics is important for advancing relevant studies and for effective prevention of noise-induced hearing loss in ship crew members. | Liu Chenqing Ding Daxiong Zhu Yuhua Wang Hongyang Cheng Xiaoting Zhao Zhenhua Cao Juyang Zhai Suoqiang Yu Ning | 2018 | Journal of Otology2018，13，2： | 3 |
| 9 | Accelerated regeneration of the skeletal muscle in RNF13-knockout mice is mediated by macrophage-secreted IL-4/IL-6显示文摘(RNF13 ) 戒指手指蛋白质 13 是报导在癌症开发,肌肉房间生长,和 neuronal 开发的规定机能上地重要的最新识别的 E3 ligase。在这研究,在导致 cardiotoxin 的骨胳的肌肉新生的 RNF13 的功能用 RNF13 大美人老鼠被调查。RNF13 -/- 老鼠带着野类型的老鼠由加速的卫星房间 proliferationcompared 展出了提高的肌肉 regenerationcharacterized。RNF13 的表达式显著地在肌肉损坏的早阶段在巨噬细胞而非在野类型的鼠标的卫星房间被导致。这结果显示煽动性的房间在调停 RNF13 的卫星房间功能是重要的。在骨胳的肌肉的 cytokine 层次进一步被分析并且证明 RNF13 -/- 老鼠比野类型的老鼠生产了各种各样的 cytokines 的更大的数量。在这些之中, IL-4 和 IL-6 层次显著地在 RNF13 -/- 老鼠增加了。加速的肌肉新生显型被与堵住抗体在 RNF13 -/- 老鼠禁止 IL-4/IL-6 行动废除。这些结果显示那 RNF13 缺乏在卫星房间壁龛上经由效果支持骨胳的肌肉新生由 IL-4 和 IL-6 调停了。 | Jiao Meng Xiaoting Zou Rimao Wu Ran Zhong Dahai Zhu Yong Zhang | 2014 | Protein & Cell2014，5，3： | 2 |
| 10 | Understanding the phase separation characteristics of nucleocapsid protein provides a new therapeutic opportunity against SARS-CoV-2显示文摘Dear Editor To date,tens of millions of people have been infected with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),causing the outbreak of the respiratory disease named the coronavirus disease 2019(COVID-19).As a newly emerged member of the coronavirus family,SARS-CoV-2 is an enveloped positive-strand RNA virus,which has probably the largest genome(approximately 30 kb)among all RNA viruses.The nucleocapsid(N)protein of SARS-CoV-2 is mainly responsible for recognizing and wrapping viral RNA into helically symmetric structures(Malik,2020). | Dan Zhao Weifan Xu Xiaofan Zhang Xiaoting Wang Yiyue Ge Enming Yuan Yuanpeng Xiong Shenyang Wu Shuya Li Nian Wu Tingzhong Tian Xiaolong Feng Hantao Shu Peng Lang Jingxin Li Fengcai Zhu Xiaokun Shen Haitao Li Pilong Li Jianyang Zeng | 2021 | Protein & Cell2021，12，9： | 1 |
| 11 | Structure influence of alkyl chains of thienothiophene-porphyrins on the performance of organic solar cells显示文摘Two new A-D-A porphyrin derivatives,denoted as XLP-I and XLP-II,were prepared through extending theπ-conjugation of thienothiophene-porphyrin center with phenylethynyl bridges and electron-deficient ethylrhodanine terminal units,and varying the structures of alkyl chain(linear vs branched)on peripheral thienothiophene substitutions of porphyrin rings.Both molecules show strong absorption in UV–visible–near-infrared region,good thermal stability,suitable energy levels,and ordered molecular packing in solid state.In organic solar cells,PC71BM was used as electron acceptor,and porphyrin small molecules were used as electron donors.The device based on XLP-I exhibits a power conversion efficiency(PCE)of 8.30%,an open circuit voltage(Voc)of 0.894 eV,and a fill factor(FF)of 62.1%.In contrast,the device based on XLP-II presents an inferior performance with a PCE of 3.14%,a Voc of 0.847 eV,and a FF of 49.3%.The better performance of XLP-I based device is mainly attributed to its optimized film morphology,excellent absorption,and well-balanced charge transport properties. | Liuping Xie Zhixin Liu Wei Tang Xiaote He Fengbing Zhai Zihao Yuan Song Chen Xuan Zhou Lei Yan Xunjin Zhu Xingzhu Wang | 2021 | Materials Reports(Energy)2021，1，4： | 1 |
| 12 | Attitude control without angular velocity measurement for flexible satellites显示文摘In this paper, by using quaternion models, the problem of attitude control is investigated for a class of flexible satellites. Two control laws are presented for the considered flexible satellite models to guarantee convergence of the closed-loop systems without using angular velocity measurement. One is in the form of a partial state feedback for the case where the modal variable is available, and the other is in the form of an observer-based partial state feedback for the case where the modal variable cannot be measured. Finally, an example is employed to illustrate the effectiveness of the proposed control laws. | Qinghua ZHU Guangfu MA Xiaoting WANG Aiguo WU | 2018 | Chinese Journal of Aeronautics2018，31，6： | 1 |
| 13 | Catalytic ozonation of basic yellow 87 with a reusable catalyst chip 显示文摘 | Shi-Ni Zhu K N Hui Xiaoting Hong | 2014 | Chemical Engi- neering Journal2014，242，： | 1 |
| 14 | Triptolide-loaded microemulsion-based hydrogels: physical properties and percutaneous permeability显示文摘Triptolide is a diterpenoid compound that inhibits the inflammation of rheumatoid arthritis(RA).However,the use of triptolide is limited due to its strong gastrointestinal toxicity.The purpose of this work was to develop a transdermal delivery system for triptolide to reduce this toxicity.A microemulsion-based hydrogel(MBH)was prepared from the combination of Gemseal 40-oleic acid as oil phase,Tween 80-labrasol as surfactant,anhydrous ethanol as co-surfactant,water as aqueous phase and Poloxamer 407 as hydrogel matrix.Rheological measurements,environmental scanning electron microscopy(ESEM)and transdermal experiments in vitro were used to characterize triptolide-loaded and blank MBH preparations.The effects of Poloxamer 407 and triptolide on the rheological properties and microstructures of the MBH were determined.Transparent and homogeneous MBH could only be formed when the concentration of Poloxamer 407 in the selected O/W microemulsion was in the range of 14.0–16.0%(w/w).When the concentration of Poloxamer 407 increased,the rheological properties such as the yield stresses(sy),storage and loss moduli(G′,G″)of the formulations increased,and the network structures became more compact.The addition of triptolide did not change the interconnected network structures of the MBH preparations.MBH preparations afford a better sustained release profile when compared to microemulsions,a finding confirmed by an in vitro permeation test in mice.MBH appears to be a promising vehicle for transdermal delivery of triptolide. | Lihua Chen Xiaoting Zhao Jia Cai Yongmei Guan Sen Wang Hongning Liu Weifeng Zhu Junsong Li | 2013 | Acta Pharmaceutica Sinica B2013，3，3： | 1 |
| 15 | Allogeneic gene-edited HIV-specific CAR-T cells secreting PD-1 blocking scFv enhance specific cytotoxic activity against HIV Envt cells in vivo显示文摘HIV-specific chimeric antigen receptor(CAR)T-cells have been developed to target HIV-1 infected CD4t T-cells that express HIV Env proteins.However,T cell exhaustion and the patient-specific autologous paradigm of CAR-T cell hurdled clinical applications.Here,we created HIV-specific CAR-T cells using human peripheral blood mononuclear cells and a 3BNC117-E27(3BE)CAR construct that enabled the expression of programmed cell death protein(PD-1)-blocking scFv E27 and the single-chain variable fragment of the HIV-1-specific broadly neutralizing antibody 3BNC117 to target native HIV Env.Compared with T cells expressing 3BNC117-CAR alone,3BE CAR-T cells showed greater cytotoxic activity against HIV Envt cells with stronger proliferation capability,higher killing efficiency,and enhanced cytokine secretion in the presence of HIV Env-expressing cells.Furthermore,we manufactured TCR-deficient 3BE CAR-T cells through gene editing and demonstrated that these CAR-T cells could effectively kill HIV Env^(+) cells in vivo without the occurrence of severe graft-versus-host disease(GvHD)in NSG mice.These data suggest that we have provided a feasible approach to the generation of“off-theshelf”anti-HIV CAR-T cells in combination with PD-1 checkpoint blockade immunotherapy,which can be a powerful therapeutic candidate for the functional cure of HIV. | Hanyu Pan Xinyi Yang Jing Wang Huitong Liang Zhengtao Jiang Lin Zhao Yanan Wang Zhiming Liang Xiaoting Shen Qinru Lin Yue Liang Jinglong Yang Panpan Lu Yuqi Zhu Min Li Pengfei Wang Jianqing Xu Hongzhou Lu Huanzhang Zhu | 2023 | Virologica Sinica2023，38，2： | 0 |
| 16 | Recent advances in the catalytic production of bio-based diol 2,5-bis(hydroxymethyl)furan显示文摘Biomass-derived 2,5-bis(hydroxymethyl)furan(BHMF)has received great attention and interest due to its broad application prospects in polyesters and medicine.Over the past decades,the catalytic systems including thermocatalytic,biocatalytic,electrocatalytic,and photocatalytic hydrogenation of 5-hydroxymethylfurfural(HMF)into BHMF have been developed to a great extent.To understand the present status and challenges of BHMF production,this review systematically evaluates recent findings and developments of HMF hydrogenation through various reaction systems,with an emphasis on catalyst screening,synthesis processes,and reaction mechanism.Furthermore,a few potential research trends are also proposed,in order to provide innovative ideas for further exploration of BHMF synthesis in a simpler,efficient,and economical way. | Wenguang Zhao Feng Wang Kangyu Zhao Xianxiang Liu Xiaoting Zhu Le Yan Yuan Yin Qiong Xu Dulin Yin | 2023 | Carbon Resources Conversion2023，6，2： | 0 |
| 17 | Review of deep learning-based weed identification in crop fields显示文摘Automatic weed identification and detection are crucial for precision weeding operations.In recent years,deep learning(DL)has gained widespread attention for its potential in crop weed identification.This paper provides a review of the current research status and development trends of weed identification in crop fields based on DL.Through an analysis of relevant literature from both within and outside of China,the author summarizes the development history,research progress,and identification and detection methods of DL-based weed identification technology.Emphasis is placed on data sources and DL models applied to different technical tasks.Additionally,the paper discusses the challenges of time-consuming and laborious dataset preparation,poor generality,unbalanced data categories,and low accuracy of field identification in DL for weed identification.Corresponding solutions are proposed to provide a reference for future research directions in weed identification. | Wenze Hu Samuel Oliver Wane Junke Zhu Dongsheng Li Qing Zhang Xiaoting Bie Yubin Lan | 2023 | International Journal of Agricultural and Biological Engineering2023，16，4： | 0 |
| 18 | Role of daily anal stimulation for intractable functional constipation in infants显示文摘Objective Functional constipation is one of the most common problems in pediatric gastroenterology.The aim of the present study was to evaluate the effectiveness of daily anal stimulation in infants with intractable functional constipation(IFC).Our evaluation was based on clinical improvement and on changes in manometric parameters through time.Methods Infants with IFC treated between January 2018 and December 2019 were included in this retrospective study.Treatment processing included daily anal stimulation for infants and psychological counseling for parents.All cases underwent a complete intervention program and were evaluated for improvement in symptoms and for changes in anorectal manometry within 1 year of follow-up.results A total of 161 patients were included in this study.Positive response was achieved in all patients.Frequency of defecation,change in stool form and decrease in the defecatory pain were significantly relieved in all infants after intervention.On anorectal manometry,no significant difference was found in the peristaltic frequency of distal rectum before and after treatment.There was a significant increase in the mean amplitude of peristalsis and improvement in the rhythm after intervention.In the 1 year of follow-up,three patients had recurrence of constipation requiring colectomy.Conclusion In terms of the high clinical efficacy and limited side effects,daily anal stimulation may be included in the initial part of an intervention program for IFC in infants. | Tianqi Zhu Xiaoyi Sun Dan Zhu Qian You Xiaoting Wan Xinyao Meng Jiexiong Feng | 2020 | World Journal of Pediatric Surgery2020，3，2： | 0 |
| 19 | Invisible vapor catalysis in graphene growth by chemical vapor deposition显示文摘Vapor catalysis was recently found to play a crucial role in superclean graphene growth via chemical vapor decomposition(CVD).However,knowledge of vapor-phase catalysis is scarce,and several fundamental issues,including vapor compositions and their impact on graphene growth,are ambiguous.Here,by combining density functional theory(DFT)calculations,an ideal gas model,and a designed experiment,we found that the vapor was mainly composed of Cui clusters with tens of atoms.The vapor pressure was estimated to be~10^(-12)-10^(-1)1 bar under normal low-pressure CVD system(LPCVD)conditions for graphene growth,and the exposed surface area of Cui clusters in the vapor was 22-269 times that of the Cu substrate surface,highlighting the importance of vapor catalysis.DFT calculations show Cu clusters,represented by Cu17,have strong capabilities for adsorption,dehydrogenation,and decomposition of hydrocarbons.They exhibit an adsorption lifetime and reaction flux six orders of magnitude higher than those on the Cu surface,thus providing a sufficient supply of active C atoms for rapid graphene growth and improving the surface cleanliness of the synthesized graphene.Further experimental validation showed that increasing the amount of Cu vapor improved the as-synthesized graphene growth rate and surface cleanliness.This study provides a comprehensive understanding of vapor catalysis and the fundamental basis of vapor control for superclean graphene rapid growth. | Xiucai Sun Xiaoting Liu Zhongti Sun Xintong Zhang Yuzhu Wu Yeshu Zhu Yuqing Song Kaicheng Jia Jincan Zhang Luzhao Sun Wan-Jian Yin Zhongfan Liu | 2024 | Nano Research2024，17，5： | 0 |
| 20 | B-lymphoid tyrosine kinase-mediated FAM83A phosphorylation elevates pancreatic tumorigenesis through interacting with β-catenin显示文摘Abnormal activation of Wnt/β-catenin-mediated transcription is closely associated with the malignancy of pancreatic cancer.Family with sequence similarity 83 member A(FAM83A)was shown recently to have oncogenic effects in a variety of cancer types,but the biological roles and molecular mechanisms of FAM83A in pancreatic cancer need further investigation.Here,we newly discovered that FAM83A binds directly toβ-catenin and inhibits the assembly of the cytoplasmic destruction complex thus inhibiting the subsequent phosphorylation and degradation.FAM83A is mainly phosphorylated by the SRC non-receptor kinase family member BLK(B-lymphoid tyrosine kinase)at tyrosine 138 residue within the DUF1669 domain that mediates the FAM83A-β-catenin interaction.Moreover,FAM83A tyrosine 138 phosphorylation enhances oncogenic Wnt/β-catenin-mediated transcription through promotingβ-catenin-TCF4 interaction and showed an elevated nucleus translocation,which inhibits the recruitment of histone deacetylases by TCF4.We also showed that FAM83A is a direct downstream target of Wnt/β-catenin signaling and correlates with the levels of Wnt target genes in human clinical pancreatic cancer tissues.Notably,the inhibitory peptides that target the FAM83A-β-catenin interaction significantly suppressed pancreatic cancer growth and metastasis in vitro and in vivo.Our results revealed that blocking the FAM83A cascade signaling defines a therapeutic target in human pancreatic cancer. | Cefan Zhou Xiaoting Zhu Nanxi Liu Xueying Dong Xuewen Zhang Huili Huang Yu Tang Shicheng Liu Mengyu Hu Ming Wang Xiaoling Deng Shi Li Rui Zhang Yuan Huang Hao Lyu Shuai Xiao Sang Luo Declan William Ali Marek Michalak Xing-Zhen Chen Zhentian Wang Jingfeng Tang | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员