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| 1 | Self-adjusted elastic action and its CBM pool-forming effect of the high rank coal reservoir显示文摘The coal reservoir is a kind of geologic body with considerable elasticity, and its response to stress is more sensitive than the routine ones. In the pool-forming process of the coalbed methane, (CBM) the action of many external geodynamic factors in the coal reservoir is represented by the ability of CBM’s diffusion and migration in the coal reservoir. Therefore, the occurrence of the natural fissures in the coal reservoir becomes a key that determines whether the CBM pool can be formed or not. Based on the principle, the authors have designed a comprehensive method of physical modeling to study the elasticity of the coal matrix block with different coal ranks in the light of the solid to fluid coupling, have established the model of the volume deformation (self-adjusted elastic effect) of the coal reservoir under the condition of the effective stress-adsorption/desorption, and have obtained a correct understanding of the law of the elastic deformation. Afterwards, a new viewpoint, named as the self-closing elastic effect for forming the CBM pool in the high rank reservoir, is put forward, providing an initial point and a scientific basis for a further investigation into its dynamic factors, possible mechanism and role in the CBM energy-balancing system. | QIN Yong FU Xuehai WU Caifang FU Guoyou BU Yingying | 2005 | Chinese Science Bulletin2005，50，S1： | 9 |
| 2 | Targeting slug-mediated non-canonical activation of c-Met to overcome chemo-resistance in metastatic ovarian cancer cells显示文摘Metastasis-associated drug resistance accounts for high mortality in ovarian cancer and remains to be a major barrier for effective treatment. In this study, SKOV3/T4, a metastatic subpopulation of ovarian cancer SKOV3 cells, was enriched to explore potential interventions against metastaticassociated drug resistance. Quantitative genomic and functional analyses were performed and found that slug was significantly increased in the SKOV3/T4 subpopulation and contributed to the high resistance of SKOV3/T4. Further studies showed that slug activated c-Met in a ligand-independent manner due to elevated levels of fibronectin and provoked integrin α V function, which was confirmed by the significant correlation of slug and p-Met levels in 121 ovarian cancer patient samples. Intriguingly,c-Met inhibitor(s) exhibited greatly enhanced anti-cancer effects in slug-positive ovarian cancer models both in vitro and in vivo. Additionally, IHC analyses revealed that slug levels were highly correlated with reduced survival of ovarian cancer patients. Taken together, this study not only uncovers the critical roles of slug in drug resistance in ovarian cancer but also highlights a promising therapeutic strategy by targeting the noncanonical activation of c-Met in slug-positive ovarian cancer patients with poor prognosis. | Linlin Chang Yan Hu Yingying Fu Tianyi Zhou Jun You Jiamin Du Lin Zheng Ji Cao Meidan Ying Xiaoyang Dai Dan Su Qiaojun He Hong Zhu Bo Yang | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 3 |
| 3 | Quercetin promotes human epidermal stem cell proliferation through the estrogen receptor/β-catenin/c-Myc/cyclin A2 signaling pathway显示文摘Skin epidermal stem cells(EpSCs)play an important role in wound healing.Quercetin is a phytoestrogen reported to accelerate skin wound healing,but its effect on EpSCs is unknown.In this study,we investigated the effect of quercetin on human EpSC proliferation and explored the underlying mechanisms.We found that quercetin at 0.1~1μM significantly promoted EpSC proliferation and increased the number of cells in S phase.The pro-proliferative effect of quercetin on EpSCs was confirmed in cultured human skin tissue.Mechanistic studies showed that quercetin significantly upregulated the expressions ofβ-catenin,c-Myc,and cyclins A2 and E1.Inhibitor forβ-catenin or c-Myc significantly inhibited quercetin-induced EpSC proliferation.Theβ-catenin inhibitor XAV-939 suppressed quercetin-induced expressions ofβ-catenin,c-Myc,and cyclins A2 and E1.The c-Myc inhibitor 10058-F4 inhibited the upregulation of c-Myc and cyclin A2 by quercetin.Pretreatment of EpSCs with estrogen receptor(ER)antagonist ICI182780,but not the G protein-coupled ER1 antagonist G15,reversed quercetin-induced cell proliferation and upregulation ofβ-catenin,c-Myc,and cyclin A2.Collectively,these results indicate that quercetin promotes EpSC proliferation through ER-mediated activation ofβ-catenin/c-Myc/cyclinA2 signaling pathway and ER-independent upregulation of cyclin E1 and that quercetin may accelerate skin wound healing through promoting EpSC proliferation.As EpSCs are used not only in clinic to treat skin wounds but also as seed cells in skin tissue engineering,quercetin is a useful reagent to expand EpSCs for basic research,skin wound treatment,and skin tissue engineering. | Zhaodong Wang Guangliang Zhang Yingying Le Jihui Ju Ping Zhang Dapeng Wan Qiang Zhao Guangzhe Jin Hao Su Jinwei Liu Jiaxuan Feng Yi Fu Ruixing Hou | 2020 | Acta Biochimica et Biophysica Sinica2020，52，10： | 3 |
| 4 | Hollow Gradient-Structured Iron-Anchored Carbon Nanospheres for Enhanced Electromagnetic Wave Absorption显示文摘In the present paper,a microwave absorber with nanoscale gradient structure was proposed for enhancing the electromagnetic absorption performance.The inorganic-organic competitive coating strategy was employed,which can effectively adjust the thermodynamic and kinetic reactions of iron ions during the solvothermal process.As a result,Fe nanoparticles can be gradually decreased from the inner side to the surface across the hollow carbon shell.The results reveal that it offers an outstanding reflection loss value in combination with broadband wave absorption and flexible adjustment ability,which is superior to other relative graded distribution structures and satisfied with the requirements of lightweight equipment.In addition,this work elucidates the intrinsic microwave regulation mechanism of the multiscale hybrid electromagnetic wave absorber.The excellent impedance matching and moderate dielectric parameters are exhibited to be the dominative factors for the promotion of microwave absorption performance of the optimized materials.This strategy to prepare gradient-distributed microwave absorbing materials initiates a new way for designing and fabricating wave absorber with excellent impedance matching property in practical applications. | Cao Wu Jing Wang Xiaohang Zhang Lixing Kang Xun Cao Yongyi Zhang Yutao Niu Yingying Yu Huili Fu Zongjie Shen Kunjie Wu Zhenzhong Yong Jingyun Zou Bin Wang Zhou Chen Zhengpeng Yang Qingwen Li | 2023 | Nano-Micro Letters2023，15，1： | 2 |
| 5 | An injectable micelle-hydrogel hybrid for localized and prolonged drug delivery in the management of renal fibrosis显示文摘Localized delivery,comparing to systemic drug administration,offers a unique alternative to enhance efficacy,lower dosage,and minimize systemic tissue toxicity by releasing therapeutics locally and specifically to the site of interests.Herein,a localized drug delivery platform ('plum?pudding'structure) with controlled release and long-acting features is developed through an injectable hydrogel ('pudding') crosslinked via self-assembled triblock polymeric micelles ('plum') to help reduce renal interstitial fibrosis.This strategy achieves controlled and prolonged release of model therapeutics in the kidney for up to three weeks in mice.Following a single injection,local treatments containing either anti-inflammatory small molecule celastrol or anti-TGFb antibody effectively minimize inflammation while alleviating fibrosis via inhibiting NF-k B signaling pathway or neutralizing TGF-b1 locally.Importantly,the micelle-hydrogel hybrid based localized therapy shows enhanced efficacy without local or systemic toxicity,which may represent a clinically relevant delivery platform in the management of renal interstitial fibrosis. | Xianyan Qin Yingying Xu Xu Zhou Tao Gong Zhi-Rong Zhang Yao Fu | 2021 | Acta Pharmaceutica Sinica B2021，11，3： | 2 |
| 6 | VPS4B mutation impairs the osteogenic differentiation of dental follicle cells derived from a patient with dentin dysplasia type I显示文摘A splicing mutation in VPS4B can cause dentin dysplasia type I(DD-I),a hereditary autosomal-dominant disorder characterized by rootless teeth,the etiology of which is genetically heterogeneous.In our study,dental follicle cells(DFCs)were isolated and cultured from a patient with DD-I and compared with those from an age-matched,healthy control.In a previous study,this DD-I patient was confirmed to have a loss-of-function splicing mutation in VPS4B(IVS7+46C>G).The results from this study showed that the isolated DFCs were vimentin-positive and CK14-negative,indicating that the isolated cells were derived from the mesenchyme.DFCs harboring the VPS4B mutation had a significantly higher proliferation rate from day 3 to day 8 than control DFCs,indicating that VPS4B is involved in cell proliferation.The cells were then replenished with osteogenic medium to investigate how the VPS4B mutation affected osteogenic differentiation.Induction of osteogenesis,detected by alizarin red and alkaline phosphatase staining in vitro,was decreased in the DFCs from the DD-I patient compared to the control DFCs.Furthermore,we also found that the VPS4B mutation in the DD-I patient downregulated the expression of osteoblast-related genes,such as ALP,BSP,OCN,RUNX2,and their encoded proteins.These outcomes confirmed that the DD-I-associated VPS4B mutation could decrease the capacity of DFCs to differentiate during the mineralization process and may also impair physiological root formation and bone remodeling.This might provide valuable insights and implications for exploring the pathological mechanisms underlying DD-I root development. | Qiang Li Fangli Lu Tianxuan Chen Ke Zhang Yuping Lu Xiaocong Li Yingying Wang Ling Liu Qing Tian Fu Xiong Dong Chen | 2020 | International Journal of Oral Science2020，12，3： | 2 |
| 7 | Integrated Fertilization Regimes Boost Heavy Metals Accumulation and Biomass of Sedum alfredii Hance显示文摘The hyperaccumulator Sedum alfredii Hance(S.alfredii)may be employed for zinc(Zn)and cadmium(Cd)-polluted soil remediation.However,the low phytoremediation efficiency,related to the low biomass production,limits its use with that purpose.In this experiment,nitrogen(N),phosphorus(P),and potassium(K)fertilizers,and organic manure were applied to investigate the phytoremediation ability of S.alfredii.Hydroponic and pot experiments were conducted using Zn-Cd polluted soil.The hydroponic experiment indicated that appropriate fertilizer application could increase(p<0.05)the amount of accumulated Zn and Cd in S.alfredii.When N supply ranged from 0.5 to 2.5 mmol L^(−1),it could improve growth and accumulation of Zn and Cd in whole plants of S.alfredii.The 1 mmol L^(−1) N was an optimal N dosage for shoot biomass production and Cd accumulation in shoots,while the 2.5 mmol L^(−1) was an optimal N dosage for Zn accumulation in shoots.Both low(<0.05 mmol L^(−1))and high(>0.8 mmol L^(−1))P supply decreased growth,and Zn/Cd accumulation in whole plants of the studied species.The 0.1 mmol L^(−1) P was an optimal dosage for S.alfredii biomass production and Zn/Cd accumulation in shoots.The supply levels within the range from 0.3 to 1 mmol L^(−1) K could significantly improve the biomass production of S.alfredii and its capability to accumulate Zn and Cd in the biomass.The 0.5 mmol L^(−1) K was an optimal dosage for the whole biomass production and Zn accumulation in shoots,while the 1 mmol L^(−1) was an optimal K dosage for Zn accumulation in shoots,which was 17.2%higher than the control.Moreover,the soil pot experiment showed that the combination of organic(fermented manure)and inorganic fertilizers made significant effects on the Zn and Cd-polluted soil remediation by S.alfredii.These effects varied,however,with the application of different proportions of N,P,K and organic matter.The Zn accumulation by S.alfredii reached the highest efficiency ability under the highest fertilizer mixing rate(N:50 mg kg^(−1),P:40 mg kg^(−1),K:100 mg kg^(−1),organic matter:1%).Even more,S.alfredii showed the strongest ability to accumulate Cd with a lower fertilizer mixing rate(N:25mg kg^(−1),P:20mg kg^(−1),K:50 mg kg^(−1),organic matter:0.5%). | Kangning Zhou Yingying Zhang Jiasen Wu Chunying Dou Zihao Ye Zhengqian Ye Weijun Fu | 2021 | Phyton-International Journal of Experimental Botany2021，90，4： | 2 |
| 8 | Effect of tumor necrosis factor inhibitors on rheumatoid arthritis-induced peripheral neuropathy A cohort study显示文摘In this historical cohort study,236 patients with primary rheumatoid arthritis were treated with the tumor necrosis factor inhibitors,etanercept or infliximab(n = 80),or by conventional methods(n = 156).Results revealed that 11 patients developed varying types of peripheral neuropathy at 1-2 years post-treatment(mean 16 months).The incidence of peripheral neuropathy in the tumor necrosis factor inhibitors treatment group was 8.8%(7/80),which was significantly higher than the conventional treatment group(2.6%;4/156).The relative risk of developing peripheral neuropathy in the tumor necrosis factor inhibitors treatment group was 3.41(95% confidence interval:1.03-11.31).Comparison of the tumor necrosis factor inhibitors revealed that etanercept and infliximab had no significant difference in terms of inducing peripheral neuropathy.Experimental findings indicate that tumor necrosis factor inhibitors may increase the risk of peripheral neuropathy. | Naizhi Wang Yingying Guo Lili Yang Wenyi Fu Yanbing Xu Linxin Hou Shuai Zhao Ning Zhang | 2012 | Neural Regeneration Research2012，7，11： | 2 |
| 9 | The effect of variants in the promoter of BMPER on the intramuscular fat deposition in longissimus dorsi muscle of pigs显示文摘 | Zhi Liu Wenxing Sun Yongyan Zhao Chunying Xu Yingying Fu Yan Li Jie Chen | 2014 | Gene2014，，2： | 1 |
| 10 | Smart heightened-containment biological laboratory:Technologies,modules,and aims显示文摘With the rapid development of intelligent technology,the smart heightened-containment biological laboratory(sHCBL)has moved from concept to reality.Experimental activities and laboratory construction,operation,and management will undoubtedly lead to disruptive changes.Conventional laboratories are increasingly being replaced by smart laboratories;however,the key technologies involved in this transition remain at an exploratory stage.It is necessary for HCBLs to absorb the advanced ideas of smart laboratories to guarantee the establishment of biosafety and biosecurity in a more automated way.This study examines in detail sHCBL module structures,the functions of each module,laboratory operation processes,and the advanced nature of smart laboratories.It may provide a theoretical foundation for the future transformation and smart construction of sHCBLs. | Jiaming Li Zhongyi Wang Gang Tao Yingying Fu Yifei Jin Hongliang Cheng Jingjing Li Xinrong Shu Jianjian Yang Jiuxiang Yang Bing Lu | 2022 | Journal of Biosafety and Biosecurity2022，4，2： | 1 |
| 11 | The TNF-alpha -308G/A polymorphism is associated with type 2 diabetes mellitus: an updated meta-analysis显示文摘 | Yuliang Zhao Zheng Li Ling Zhang Yonggang Zhang Yingying Yang Yi Tang Ping Fu | 2014 | Molecular Biology Reports2014，，1： | 1 |
| 12 | Complete synchronization on multi-layer center dynamical networks显示文摘 | LIU Meng SHAO Yingying FU Xinchu | 2009 | Chaos Soliton Fract2009，41，5： | 1 |
| 13 | Yoctonewton force detection based on optically levitated oscillator显示文摘Optically levitated oscillators in high vacuum have excellent environmental isolation and low mass compared with conventional solid-state sensors,which makes them suitable for ultrasensitive force detection.The force resolution usually scales with the measurement bandwidth,which represents the ultimate detection capability of the system under ideal conditions if sufficient time is provided for measurement.However,considering the stability of a real system,a method based on the Allan variance is more reliable to evaluate the actual force detection performance.In this study,a levitated optomechanical system with a force detection sensitivity of 6.33±1.62 zN/Hz^(1/2)was demonstrated.And for the first time,the Allan variance was introduced to evaluate the system stability due to the force sensitivity fluctuations.The force detection resolution of 166.40±55.48 yN was reached at the optimal measurement time of 2751 s.The system demonstrated in this work has the best force detection performance in both sensitivity and resolution that have been reported so far for optically levitated particles.The reported high-sensitivity force detection system is an excellent candidate for the exploration of new physics such as fifth force searching,high-frequency gravitational waves detection,dark matter research and so on. | Tao Liang Shaochong Zhu Peitong He Zhiming Chen Yingying Wang Cuihong Li Zhenhai Fu Xiaowen Gao Xinfan Chen Nan Li Qi Zhu Huizhu Hu | 2023 | Fundamental Research2023，3，1： | 1 |
| 14 | Simultaneous NF‐κB inhibition and E‐cadherin upregulation mediate mutually synergistic anticancer activity of celastrol and SAHA in vitro and in vivo显示文摘 | Lin Zheng Yingying Fu Linhan Zhuang Renhua Gai Jian Ma Jianshu Lou Hong Zhu Qiaojun He Bo Yang | 2014 | Int. J. Cancer2014，，： | 1 |
| 15 | The RIP3-RIP1-NF-κB signaling axis is dispensable for necroptotic cells to elicit cross-priming of CD8^(+) T cells显示文摘Apoptosis and necroptosis are two types of programmed cell death with distinct morphological features.Necroptosis has been assumed to be more inflammatory than apoptosis,but a recent paper1 concluded that necroptotic cells cannot elicit cross-priming of CD8^(+)T cells and that NF-κB activation in necroptotic cells is required for maximal CD8^(+)T-cell cross-priming. | Junming Ren Xian Jia Yihao Zhao Wenke Shi Jiongcong Lu Yingying Zhang Jianfeng Wu Bo Liang Rui Wu Guo Fu Jiahuai Han | 2017 | Cellular & Molecular Immunology2017，14，7： | 1 |
| 16 | Understanding resistant germplasm‐induced virulence variation through analysis of proteomics and suppression subtractive hybridization in a maize pathogen C urvularia lunata显示文摘 | Shigang Gao Tong Liu Yingying Li Qiong Wu Kehe Fu Jie Chen | 2012 | Proteomics . 2012 (23-2)2012，，23： | 1 |
| 17 | Spectroscopic Measurements of Impurity Spectra on the EAST Tokamak显示文摘Ultraviolet (UV) and visible impurity spectra (200~750 nm) are commonly used to study plasma and wall interactions in magnetic fusion plasmas. Two optical multi-channel analysis (OMA) systems have been installed for the UV-visible spectrum measurement on EAST. These two OMA systems are both equipped with the Czerny-Turner (C-T) type spectrometer. The upper vacuum vessel and inner divertor baffle can be viewed simultaneously through two optical lenses. The OMA1 system is mainly used for multi-impurity lines radiation measurement. A 280 nm wavelength range can be covered by a 300 mm focal length spectrometer equipped with a 300 grooves/mm grating. The Dα/Hα line shapes can be resolved by the OMA2 system. The focal length is 750 mm. The spectral resolution can be up to 0.01 nm using a 1800 grooves/mm grating. The impurity behaviour and hydrogen ratio evolution after boroniztion, lithium coating, and siliconization are compared. Lithium coating has shown beneficial effects on the reduction of edge recycling and low Z impurity (C,O) influx. The impurity expelling effect of the divertor configuration is also briefly discussed through multi-channels observation of OMA1 system. | FU Jia LI Yingying SHI Yuejiang WANG Fudi ZHANG Wei LV Bo HUANG Juan WAN Baonian ZHOU Qian | 2012 | Plasma Science and Technology2012，14，12： | 1 |
| 18 | Donor- acceptor conjugates- functionalized zinc phthaloeyanine: Towards broad absorption and application in organic solar cells 显示文摘 | Fushun Liang Fan Shi Yingying Fu | 2010 | Solar Energy Materials & Solar Cells2010，94，： | 1 |
| 19 | Donor-acceptor cojugates-functionalized zinc phthalocyanine: Towards broad absorption and application in organic solar cells显示文摘 | Fushun Liang Fan Shi Yingying Fu | 2010 | Solar Energy Materials Solar Cells2010，94，10： | 1 |
| 20 | Association between TNF-α ?308G/A polymorphism and diabetic nephropathy risk: a meta-analysis显示文摘 | Yuliang Zhao Jiqiao Yang Ling Zhang Zheng Li Yingying Yang Yi Tang Ping Fu | 2013 | International Urology and Nephrology2013，，6： | 1 |
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