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| 1 | Static aeroelastic analysis of very flexible wings based on non-planar vortex lattice method显示文摘A rapid and efficient method for static aeroelastic analysis of a flexible slender wing when considering the structural geometric nonlinearity has been developed in this paper. A non-planar vortex lattice method herein is used to compute the non-planar aerodynamics of flexible wings with large deformation. The finite element method is introduced for structural nonlinear statics analysis. The surface spline method is used for structure/aerodynamics coupling. The static aeroelastic characteristics of the wind tunnel model of a flexible wing are studied by the nonlinear method presented, and the nonlinear method is also evaluated by comparing the results with those obtained from two other methods and the wind tunnel test. The results indicate that the traditional linear method of static aeroelastic analysis is not applicable for cases with large deformation because it produces results that are not realistic. However, the nonlinear methodology, which involves combining the structure finite element method with the non-planar vortex lattice method, could be used to solve the aeroelastic deformation with considerable accuracy, which is in fair agreement with the test results. Moreover, the nonlinear finite element method could consider complex structures. The non-planar vortex lattice method has advantages in both the computational accuracy and efficiency. Consequently, the nonlinear method presented is suitable for the rapid and efficient analysis requirements of engineering practice. It could be used in the preliminary stage and also in the detailed stage of aircraft design. | Xie Changchuan Wang Libo Yang Chao Liu Yi | 2013 | Chinese Journal of Aeronautics2013，26，3： | 13 |
| 2 | Aeroelastic trim and flight loads analysis of flexible aircraft with large deformations显示文摘A method for static aeroelastic trim analysis and flight loads computation of a flexible aircraft with large deformations has been presented in this paper,which considers the geometric nonlinearity of the structure and the nonplanar effects of aerodynamics.A nonplanar vortex lattice method is used to compute the nonplanar aerodynamics.The nonlinear finite element method is introduced to consider the structural geometric nonlinearity.Moreover,the surface spline method is used for structure/aerodynamics coupling.Finally,by combining the equilibrium equations of rigid motions of the deformed aircraft,the nonlinear trim problem of the flexible aircraft is solved by iterative method.For instance,the longitudinal trim analysis of a flexible aircraft with large-aspect-ratio wings is carried out by both the nonlinear method presented and the linear method of MSC Flightloads.Results obtained by these two methods are compared,and it is indicated that the results agree with each other when the deformation is small.However,because the linear method of static aeroelastic analysis does not consider the nonplanar aerodynamic effects or structural geometric nonlinearity,it is not applicable as the deformations increase.Whereas the nonlinear method presented could solve the trim problem accurately,even the deformations are large,which makes the nonlinear method suitable for rapid and efficient analysis in engineering practice.It could be used not only in the preliminary stage but also in the detail stage of aircraft design. | YANG Chao WANG LiBo XIE ChangChuan LIU Yi | 2012 | Science China(Technological Sciences)2012，55，10： | 10 |
| 3 | Chemical compound cinobufotalin potently induces FOXO1-stimulated cisplatin sensitivity by antagonizing its binding partner MYH9显示文摘In this study,we present novel molecular mechanisms by which FOXO1 functions as a tumor suppressor to prevent the pathogenesis of nasopharyngeal carcinoma(NPC).First,we observed that FOXO1 not only controlled tumor stemness and metastasis,but also sensitized NPC cells to cisplatin(DDP)in vitro and in vivo.Mechanistic studies demonstrated that FOXO1-induced miR-200b expression through the GSK3β/β-catenin/TCF4 network-mediated stimulation of ZEB1,which reduced tumor stemness and the epithelial–mesenchymal transition(EMT)signal.Furthermore,we observed FOXO1 interaction with MYH9 and suppression of MYH9 expression by modulating the PI3K/AKT/c-Myc/P53/miR-133a-3p pathway.Decreased MYH9 expression not only reduced its interactions with GSK3β,but also attenuated TRAF6 expression,which then decreased the ubiquitin-mediated degradation of GSK3βprotein.Increased GSK3βexpression stimulated theβ-catenin/TCF4/ZEB1/miR-200b network,which increased the downstream tumor stemness and EMT signals.Subsequently,we observed that chemically synthesized cinobufotalin(CB)strongly increased FOXO1-induced DDP chemosensitivity by reducing MYH9 expression,and the reduction in MYH9 modulated GSK3β/β-catenin and its downstream tumor stemness and EMT signal in NPC.In clinical samples,the combination of low FOXO1 expression and high MYH9 expression indicated the worst overall survival rates.Our studies demonstrated that CB potently induced FOXO1-mediated DDP sensitivity by antagonizing its binding partner MYH9 to modulate tumor stemness in NPC. | YongHao Li Xiong Liu Xian Lin Menyang Zhao Yanyi Xiao Chen Liu Zixi Liang Zelong Lin Renhui Yi Zibo Tang Jiahao Liu Xin Li Qingping Jiang Libo Li Yinyin Xie Zhen Liu Weiyi Fang | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 6 |
| 4 | Reduced dose of Bacillus Calmette-Guérin versus full dose of Bacillus Calmette-Guérin for non-muscle-invasive bladder cancer after transurethral resection bladder tumor: a meta-analysis of randomized controlled trials显示文摘 | Qin Xin Wu Keming Xie Libo Zhao Sixiu Lu Yiping | 2014 | Chinese Medical Journal2014，，22： | 4 |
| 5 | Nickel Complexes Based on Salicylaldehyde-imine Ligands: Synthesis, Characterization and Catalytic Oligomerization of Ethylene显示文摘 | CHEN Liduo HUO Hongliang WANG Libo MA Lili JIANG Yan XIE Junyi WANG Jun | 2018 | Chemical Research in Chinese Universities2018，34，6： | 3 |
| 6 | Clinical features and risk factors for post-partum depression in a large cohort of Chinese women with recurrent major depressive disorder显示文摘 | Tian Tian Yihan Li Dong Xie Yifeng Shen Jianer Ren Wenyuan Wu Chengbin Guan Zhen Zhang Danning Zhang Chengge Gao Xiaoming Zhang Jinbo Wu Hong Deng Gang Wang Yunshu Zhang Yun Shao Han Rong Zhaoyu Gan Yan Sun Bin Hu Jiyang Pan Yi Li Shufan Sun Libo Song Xue | 2011 | Journal of Affective Disorders2011，，3： | 1 |
| 7 | Performance comparison of two different filter design approaches for torsional vibration damping in a doubly fed induction generator-based wind turbine显示文摘 | LIU Libo XIE Da | 2015 | The Journal of Engineering2015，1，1： | 1 |
| 8 | Retrospective study of photodynamic therapy vs photodynamic therapy com- bined with chemotherapy and chemotherapy alone on advanced esophageal cancer显示文摘 | LI Libo XIE Jianming ZHANG Xiaona | 2010 | Photodiagnosis and Photodynamic Ther- apy2010，7，： | 1 |
| 9 | Phenomena of Periodic Precipitaion in Rare Earth-Cholate Diffusion Systems显示文摘Theuseofrareearthcompoundsonfertilizerhasbeenincreasedrapidlyduringrecentdecades,sotheposibilityofrareearthionsgettingintot... | Xie Datao, Wang Libo, Wu Jinguang, Xu Guangxian (State Key Laboratory of Rare Earth Materials Chemistry and Applications, Peking University, Beijing 100871, China) | 1999 | Journal of Rare Earths1999，17，2： | 1 |
| 10 | Mesenchymal stem cells ameliorate renal fibrosis by Galectin-3/Akt/GSK3β/Snail signaling pathway in adenine-induced nephropathy rat显示文摘Tubulointerstitial fibrosis(TIF)is one of the main pathological features of various progressive renal damages and chronic kidney diseases.Mesenchymal stromal cells(MSCs)have been verified with significant improvement i the therapy of fibrosis diseases,but the mechanism is still unclear.We attempted to explore the new mechanism and therapeutic target of MSCs against renal fibrosis based on renal proteomics.TIF model was induced by adenine gavage.Bone marrow derived MSCs was injected by tail vein after modeling. | Tang Huajun Zeng Lianlin Zhang Peiyue Zhao Yu Xie Libo Chen Bo | 2021 | 解剖学杂志2021，44，S01： | 1 |
| 11 | Targeted Sub-Attomole Cancer Biomarker Detection Based on Phase Singularity 2D Nanomaterial-Enhanced Plasmonic Biosensor显示文摘Detection of small cancer biomarkers with low molecular weight and a low concentration range has always been challenging yet urgent in many clinical applications such as diagnosing early-stage cancer,monitoring treatment and detecting relapse.Here,a highly enhanced plasmonic biosensor that can overcome this challenge is developed using atomically thin two-dimensional phase change nanomaterial.By precisely engineering the configuration with atomically thin materials,the phase singularity has been successfully achieved with a significantly enhanced lateral position shift effect.Based on our knowledge,it is the first experimental demonstration of a lateral position signal change>340μm at a sensing interface from all optical techniques.With this enhanced plasmonic effect,the detection limit has been experimentally demonstrated to be 10^(-15) mol L^(−1) for TNF-α cancer marker,which has been found in various human diseases including inflammatory diseases and different kinds of cancer.The as-reported novel integration of atomically thin Ge_(2)Sb_(2)Te_(5) with plasmonic substrate, which results in a phase singularity and thus a giant lateral position shift, enables the detection of cancer markers with low molecular weight at femtomolar level. These results will definitely hold promising potential in biomedical application and clinical diagnostics. | Yuye Wang Shuwen Zeng Aurelian Crunteanu Zhenming Xie Georges Humbert Libo Ma Yuanyuan Wei Aude Brunel Barbara Bessette Jean-Christophe Orlianges Fabrice Lalloué Oliver GSchmidt Nanfang Yu Ho-Pui Ho | 2021 | Nano-Micro Letters2021，13，6： | 1 |
| 12 | CFD simulation of solids residence time distribution in a multi-compartment fluidized bed显示文摘The present work focuses on a numerical investigation of the solids residence time distribution(RTD) and the fluidized structure of a multi-compartment fluidized bed, in which the flow pattern is proved to be close to plug flow by using computational fluid dynamics(CFD) simulations. With the fluidizing gas velocity or the bed outlet height rising, the solids flow out of bed more quickly with a wider spread of residence time and a larger RTD variance(σ2). It is just the heterogeneous fluidized structure that being more prominent with the bed height increasing induces the widely non-uniform RTD. The division of the individual internal circulation into double ones improves the flow pattern to be close to plug flow. | Zheng Zou Yunlong Zhao Hu Zhao Libo Zhang Zhaohui Xie Hongzhong Li Qingshan Zhu | 2017 | Chinese Journal of Chemical Engineering2017，25，12： | 1 |
| 13 | 古风·知足常乐显示文摘赫然禹迹印,脚踏遍神州。
治水丰功建,云根一足留。 | 杨栋 Xie Libo | 2017 | 宝藏2017，0，1： | 0 |
| 14 | Large-scale inverted-V channels of upflowing oxygen ions pumped by Alfvén waves显示文摘Large-scale inverted-V channels of upflowing oxygen ions are frequently identified in data collected by Cluster,at all local times,near the open-closed field line boundary over Earth’s high-latitude ionosphere-occur with downward propagating MHD Alfvén waves which have cascaded into kinetic regimes of plasma.The transverse acceleration of the oxygen ions in the center of these structures is interpreted as the integrated energization by these waves along the channels.Also observed within the channels are upward parallel electric fields,a key characteristic of kinetic Alfvén waves,which may contribute not only to lifting the ions but also to precipitating aurora electrons that might initiate ion upflow in the ionosphere below.Statistics on five-year observations of Cluster show that the channels typically form during geomagnetic perturbations,particularly when solar-wind dynamic pressure is high or highly fluctuated.Near the open-closed field line boundary,the stronger the wave power,the higher the upward oxygen flux and the higher the beam energy,indicating that these waves provide a simple but efficient way to drive oxygen upflows. | Hui Zhang Jun Zhong SuiYan Fu ZuYin Pu Yong Wei Lun Xie LiBo Liu QiAn Chen | 2023 | Earth and Planetary Physics2023，7，6： | 0 |
| 15 | Combining Transcriptomics and Metabolomics to Uncover the Effects of High-Energy Lithium-Ion Beam Irradiation on Capsicum annuum L.显示文摘Hot pepper(Capsicum annuum L.)is consumed as one of the oldest domesticated crops all over the world.Although mutation breeding using radiation has been performed in hot peppers,little is known about the comparative analysis of mutagenic effects at the molecular level by ion beam irradiation.To comprehend the response mechanism of hot pepper to the ion beam,we used a mutant with favorable economic characteristics induced by lithium-ion beam irradiation to investigate the biological effects.The results indicated that the lithium-ion beam had a positive effect on important agronomic traits,particularly yield unit,but had a negligible effect on the photosynthetic rate of hot pepper,with a specific influence on chlorophyll b rather than chlorophyll a.By RNA-Seq analysis,671 up-regulated and 376 down-regulated genes were identified as differentially expressed genes(DEGs)between irradiated and unirradiated hot pepper.Based on GO and KEGG network analysis,the auxin metabolic process was the common pathway in these two networks.A total of 118 potential reactive oxygen species(ROS)scavenging genes and 262 signal transduction genes were identified,suggesting a balance between antioxidant enzymes and enhanced ROS transduction.The amounts of 15 metabolite,involved in GABA pathways,secondary metabolism,carbohydrate metabolism,shikimate pathways,TCA cycles,nitrogen metabolism,glycerol metabolism and acetate pathways,were significantly changed in the ion beam irradiated sample.These results highlighted that the enriched pathways could play important roles in response to ion beam irradiation in hot pepper plants.In summary,these data provide valuable information for future research on ion beam irradiation and genomic studies in hot pepper. | Libo Xie Xue Wang Luxiang Liu Chunmei Xu Yongdun Xie Hongchun Xiong Xinchun Han Mu Guo | 2023 | Phyton-International Journal of Experimental Botany2023，92，11： | 0 |
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