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| 1 | Chinese Atherosclerosis Risk Evaluation(CARE II)study:a novel cross-sectional,multicentre study of the prevalence of high-risk atherosclerotic carotid plaque in Chinese patients with ischaemic cerebrovascular events-design and rationale显示文摘Background:Carotid atherosclerotic plaque is identified as one of the main sources of ischaemic stroke.However,the prevalence of carotid high-risk atherosclerotic plaque in Chinese patients with ischaemic cerebrovascular events has been inconsistently reported and needs to be investigated in a large population.Objectives:The primary objective of CARE II study was to determine the prevalence and characteristics of high-risk features of atherosclerotic plaques in the carotid arteries in Chinese patients with recent ischaemic stroke or transient ischaemia attack(TIA).The relationship between carotid plaque features and cerebral infarcts,the differences of carotid plaque patterns among different regions of China and the gender specific characteristics of carotid plaque will be also determined.Study design:The CARE II study will enrol 1000 patients with recent ischaemic stroke or TIA and carotid plaque from 13 hospitals and medical centres across China.In this cross-sectional,non-randomised,observational,multicentre study,all patients will undergo carotid artery MRI of bilateral carotid arteries and routine brain MRI with standardised protocols.The MRI will be interpreted at core reading centres to evaluate the characteristics of morphology and compositions of carotid plaque.Conclusions:This is a cross-sectional,multicentre study to investigate the prevalence and characteristics of high-risk atherosclerotic carotid plaque in Chinese patients with stroke and TIA by using high-resolution MRI of vessel wall.This trial is sufficiently powered to demonstrate the prevalence of carotid high-risk plaque and to explore regional differences in Chinese patients who suffered stroke. | Xihai Zhao Rui Li Daniel S Hippe Thomas S Hatsukami Chun Yuan CARE-II Investigators | 2017 | Stroke & Vascular Neurology2017，2，1： | 21 |
| 2 | Influence of Long-Term Fertilization on Selenium Accumulation in Soil and Uptake by Crops显示文摘Continuous applications of organic and inorganic fertilizers can affect soil and food quality with respect to selenium(Se) concentrations.A long-term(over 20 years) experimental field study,started in 1989,was conducted to investigate the changes in soil Se fractions and its uptake by crops,as affected by different fertilizer practices,in the North China Plain with an annual crop rotation of winter wheat and summer maize.The long-term experiment was arranged in a complete randomized block design consisting of 4replications with 7 fertilizer treatments:1) organic compost(OC),2) half organic compost plus half N-P-K chemical fertilizers(OC+ NPK),3) N-P-K fertilizers(NPK),4) N-P fertilizers(NP),5) P-K fertilizers(PK),6) N-K fertilizers(NK),and 7) an un-amended control.Soil samples from the surface(20 cm) were collected in 1989,1994,1999,2004 and 2009 to characterize Se and other soil properties.In 2009,the average soil Se concentrations in the treatments(149 ± 8 μg kg^(-1)) were higher than those in the soil samples collected in 1989 at the beginning of the experiment(112 ± 4 μg kg^(-1)),and decreased in the order of OC > OC + NPK > NPK≈NP > PK ≈NK > control.Sequential extraction showed the oxidizable fraction(50.06%± 3.94%) was the dominant form of Se in the soil,followed by the residual fraction(24.12%± 2.89%),exchangeable fraction(15.09%± 4.34%) and Fe-Mn oxides fraction(10.73%± 4.04%).With an increase of soil K,the exchangeable Se concentrations in the soil increased.The Se concentrations in the soil tillage layer(0-20 cm) were mainly related to soil organic carbon(SOC),although different contributions came from atmospheric deposition,irrigation and fertilizers.With the accumulation of SOC,the uptakes of soil Se by two crops were inhibited.For the OC and OC + NPK treatments,Se concentrations in wheat grains were lower than the critical standard of Se in stable food(100 μg kg^(-1)).Additionally,Se concentrations in grains were also decreased by the deficiencies of major soil nutrients,especially P. | WANG Qingyun ZHANG Jiabao ZHAO Bingzi XIN Xiuli DENG Xihai Hailin ZHANG | 2016 | Pedosphere2016，26，1： | 12 |
| 3 | Association between coexisting intracranial artery and extracranial carotid artery atherosclerotic diseases and ipsilateral cerebral infarction: a Chinese Atherosclerosis Risk Evaluation (CARE- II) study显示文摘Background To evaluate the association between coexisting intracranial and extracranial carotid artery atherosclerotic diseases and ipsilateral acute cerebral infarct(ACI)in symptomatic patients by using magnetic resonance(MR)vessel wall imaging.Methods Symptomatic patients were recruited from a cross-sectional,multicentre study of Chinese Atherosclerosis Risk Evaluation(CARE-II).All patients underwent MR imaging for extracranial carotid arterial wall,intracranial artery and brain.Coexisting intracranial stenosis≥50%and extracranial carotid artery mean wall thickness(MWT)≥1 mm and plaque compositions at the same side were evaluated and the ipsilateral ACI was identified.The association between coexisting atherosclerotic diseases and ACI was evaluated using logistic regression.Results 351 patients were recruited.Patients with ipsilateral ACI had significantly greater prevalence of coexisting intracranial stenosis≥50%and carotid MWT≥1 mm(20.5%vs 4.9%,p<0.001),calcification(15.1%vs 4.4%,p=0.001)and lipid-rich necrotic core(LRNC)(19.2%vs 7.8%,p=0.002)compared with those without.Coexisting intracranial artery stenosis≥50%and carotid MWT≥1 mm(OR 5.043,95%CI 2.378 to 10.694;p<0.001),calcification(OR 3.864,95%CI 1.723 to 8.664;p=0.001)and LRNC(OR 2.803,95%CI 1.455 to 5.401;p=0.002)were significantly associated with ipsilateral ACI.After adjusting for confounding factors,the aforementioned associations remained statistically significant(intracranial stenosis≥50%coexisting with carotid MWT≥1 mm:OR 4.313,95%CI 1.937 to 9.601,p<0.001;calcification:OR 3.606,95%CI 1.513 to 8.593,p=0.004;LRNC:OR 2.358,95%CI 1.166 to 4.769,p=0.017).Conclusions Coexistence of intracranial artery severe stenosis and extracranial carotid artery large burden and intraplaque components of calcification and LRNC are independently associated with ipsilateral ACI.Trial registration number http://gffzz1caf53c915c04334sv6n6wncw5bup6cv9.ffgz.tsg.suse.edu.cn/.Unique identifier:NCT02017756. | Chunxiu Jiang Jing Zhang Jianbin Zhu Xianlong Wang Zhibo Wen Xihai Zhao Chun Yuan On behalf of CARE-II Investigators | 2021 | Stroke & Vascular Neurology2021，6，4： | 11 |
| 4 | Simulation of electro-slag re-melting process of 120t large ingot for nuclear power station and its application显示文摘Further research on metallic materials for the super critical rotator and the main pipe line of a nuclear power station is very important for developing the nuclear power industry. In this study, the mathematical model for 120 t large ingot was established, and the computer program ESR3D was developed to simulate the whole electro-slag re-melting (ESR) process. This includes the electrode melting, metallic droplet falling, metal pool forming, metal pool and slag pool rising and moving, installation of top crystallizer, ingot solidifying, etc. The simulated average melting rate of the electrode was in good agreement with that in practical production. The optimized parameters were used to produce 80-120 t large ingots, and the quality of the ingots satisfied the specifications of nuclear power and the super critical generating unit. | Liu Xihai Wang Junqing Jia Weiguo Gao Jianjun Zhao Lin Tang Zuobin | 2011 | China Foundry2011，8，4： | 6 |
| 5 | Effect of Lanthanum Accumulation on Cation Exchange Capacity and Solution Composition of Red Soil显示文摘Pot and adsorption-exchange experiments were carried out by collecting the soil samples from the surface layer(0-15cm) of red soil at the Ecological Experiment Station of Red Soil,the Chinese Academy of Sciences,in Jiangxi Province of CHina.When concentration of the exogenous La^3+ exceeded 400mg kg^-1,there was less non-exchangeable La^3+ than exchangeable La^3+ in the soil.Cation exchagne capacity of the soil changed slightly with increasing concentration of the exogenous La^3+ in both experiments.However,in the adsorption-exchange experiment,when concentration of the exogenous La^3+ was higher than 300mg kg^-1,exchangeable basic cations decreased significantly,while exchangeable hydrogen and exchangeable aluminum increased significantly compared with the control treatments.The amounts of base cations(Ca^2+,Mg^2+,k^+and Na^+)exchanged by La^3+ in the supernatant solution increased with the concentration of the exogenous La^3+,especially when concentration of the exogenous La^3+ was higher than 50mg kg^-1. | XIE ZUBIN ZHU JIANGUO CHU HAIYAN CAO ZHIHONG and DENG XIHAI(Institute of Soil Science, the Chinese Academy of Sciences, P.O. Box 821, Naviing 210008 China) | 2000 | Pedosphere2000，10，2： | 6 |
| 6 | Mitochondrial uncoupler BAM15 inhibits artery constriction and potently activates AMPK in vascular smooth muscle cells显示文摘Our previous studies found that mitochondrial uncouplers CCCP and niclosamide inhibited artery constriction and the mechanism involved AMPK activation in vascular smooth muscle cells. BAM15 is a novel type of mitochondrial uncoupler. The aim of the present study is to identify the vasoactivity of BAM15 and characterize the BAM15-induced AMPK activation in vascular smooth muscle cells(A10 cells). BAM15 relaxed phenylephrine(PE)-induced constricted rat mesenteric arteries with intact and denuded endothelium. Pretreatment with BAM15 inhibited PEinduced constriction of rat mesenteric arteries with intact and denuded endothelium. BAM15, CCCP,and niclosamide had the comparable IC50 value of vasorelaxation in PE-induced constriction of rat mesenteric arteries. BAM15 was less cytotoxic in A10 cells compared with CCCP and niclosamide.BAM15 depolarized mitochondrial membrane potential, induced mitochondrial fission, increased mitochondrial ROS production, and increased mitochondrial oxygen consumption rate in A10 cells.BAM15 potently activated AMPK in A10 cells and the efficacy of BAM15 was stronger than that of CCCP, niclosamide, and AMPK positive activators metformin and AICAR. In conclusion, BAM15 activates AMPK in vascular smooth muscle cells with higher potency than that of CCCP, niclosamide and the known AMPK activators metformin and AICAR. The present work indicates that BAM15 is a potent AMPK activator. | Yu Tai Lanjun Li Xuan Peng Junxue Zhu Xihai Mao Nan Qin Minghui Ma Rong Huo Yunlong Bai Deli Dong | 2018 | Acta Pharmaceutica Sinica B2018，8，6： | 5 |
| 7 | Advances of graphene application in electrode materials for lithium ion batteries显示文摘The demands for better energy storage devices due to fast development of electric vehicles(EVs) have raised increasing attention on lithium ion batteries(LIBs) with high power and energy densities. In this paper, we provide an overview of recent progress in graphene-based electrode materials. Graphene with its great electrical conductivity and mechanical properties have apparently improved the performance of traditional electrode materials. The methods and electrochemical properties of advanced graphene composite as cathode and anode for LIBs are reviewed. Two novel kinds of graphene hybrid materials are specially highlighted: three-dimensional porous and flexible binder-free graphene-based materials. Challenges for LIBs and future research trend in the development of high-performance electrode materials are further discussed. | LU XiaoYu JIN XiHai SUN Jing | 2015 | Science China(Technological Sciences)2015，58，11： | 5 |
| 8 | Comprehensive evaluation of heavy metal contamination of sediment in Lake Dianchi by using modified AHP method and ^(137)Cs dating显示文摘Through the use of general sampling and measurement by ^(137)Cs dating,problems regarding the absence of monitoring data can easily be resolved.Further,weighted values need to be determined while Environment Quality Comprehensive Index(EQCI)is commonly used as applied in environmental quality comprehensive evaluation.In order to overcome the subjectivity in determining weights,the modified Analytical Hierarchy Process(AHP)method was designed.The modified AHP method involved the following key procedures:First,the parameters y_(i1) and y_(i2) were calculated based on the monitoring data;second,the factors were put in order according to the symbol and value of y_(i1) and y_(i2);third,the continuous odd integers,which represented the importance of factors,were given to factors according to their seating order;and,fourth,the factor weights were determined from the pair-wise comparison matrix calculated by the ratio of the given odd integers.Therefore,the weights were completely based on the monitoring data.In the present study,the comprehensive quality of sediments in five sections of Lake Dianchi were evaluated and the results indicated that the current contamination of sediments in each lake section is much more serious than at any other time in history. | Yan ZHANG Xiang GAO Zhenyu ZHONG Xihai DENG Buzhuo PENG | 2008 | Frontiers of Environmental Science & Engineering2008，2，3： | 4 |
| 9 | Differences in atheroma between Caucasian and Asian subjects with anterior stroke:A vessel wall MRI study显示文摘Background and purpose While extracranial carotid artery stenosis is more common among Caucasians and intracranial artery stenosis is more common among Asians,the differences in atherosclerotic plaque characteristics have not yet been extensively examined.We sought to investigate plaque location and characteristics within extracranial carotid and intracranial arteries in symptomatic Caucasians and Chinese using vessel wall MRI.Methods Subjects with recent anterior circulation ischaemic stroke were recruited and imaged at two sites in the USA and China using similar protocols.Both extracranial carotid and intracranial arteries were reviewed to determine plaque location and characteristics.Results The prevalence of extracranial carotid plaque in Caucasians and Chinese was 73.1%and 49.1%,respectively(p=0.055).Prevalence of intracranial plaque was 38.5%and 69.1%in Caucasians and Chinese,respectively(p=0.02).Furthermore,42% of Caucasians and 16%of Chinese had high-risk plaque(HRP)features(intraplaque haemorrhage,luminal surface disruption)in the extracranial carotid artery(p=0.03).The prevalence of HRP features in intracranial arteries was not significantly different between the two cohorts(4%vs 11%;p=0.42).Conclusions Differences in the location and characteristics of cerebrovascular atherosclerosis were identified by vessel wall MRI in US Caucasian and Chinese subjects with recent anterior circulation ischaemic stroke.Extracranial carotid plaques with HRP features were more common in Caucasians.Intracranial plaques were more common in Chinese subjects,but no significant difference between the two cohorts in intracranial HRP prevalence was found.Larger studies using vessel wall imaging to investigate racial differences in cerebrovascular disease may inform underlying mechanisms of HRP development and may ultimately help guide appropriate therapy. | Hiroko Watase Mi Shen Binbin Sui Peiyi Gao Dong Zhang Jie Sun Niranjan Balu Daniel S Hippe Gail P Jarvik Xihai Zhao Rui Li Shuo Chen Chun Yuan Thomas S Hatsukami | 2021 | Stroke & Vascular Neurology2021，6，1： | 4 |
| 10 | Association between fluid-attenuated inversion recovery vascular hyperintensity and outcome varies with different lesion patterns in patients with intravenous thrombolysis显示文摘Background and purpose To evaluate relationship between fluid-attenuated inversion recovery vascular hyperintensity(FVH)after intravenous thrombolysis and outcomes in different lesion patterns on diffusion-weighted imaging(DWI).Methods Patients with severe internal carotid or intracranial artery stenosis who received intravenous thrombolysis from March 2012 to April 2019 were analysed.They were divided into four groups by DWI lesion patterns:border-zone infarct(BZ group),multiple lesions infarct(ML group),large territory infarct(LT group),and single cortical or subcortical lesion infarct(SL group).Logistic regression was performed to identify risk factors for outcome(unfavourable outcome,modified Rankin Scale(mRS)≥2;poor outcome,mRS≥3).Results Finally,203 participants(63.3±10.2 years old;BZ group,n=72;ML group,n=64;LT group,n=37;SL group,n=30)from 1190 patient cohorts were analysed.After adjusting for confounding factors,FVH(+)was associated with unfavourable outcome in total group(OR 3.02;95%CI 1.49 to 6.13;p=0.002),BZ group(OR 4.22;95%CI 1.25 to 14.25;p=0.021)and ML group(OR 5.44;95%CI 1.41 to 20.92;p=0.014)patients.FVH(+)was associated with poor outcome in total group(OR 2.25;95%CI 1.01 to 4.97;p=0.046),BZ group(OR 5.52;95%CI 0.98 to 31.07;p=0.053)and ML group(OR 4.09;95%CI 1.04 to 16.16;p=0.045)patients,which was marginal significance.FVH(+)was not associated with unfavourable or poor outcome in LT and SL groups.Conclusion This study suggests that association between FVH and outcome varies with different lesion patterns on DWI.The presence of FVH after intravenous thrombolysis may help to identify patients who require close observations in the hospitalisation in patients with border-zone and multiple lesion infarcts. | Erling Wang Chuanjie Wu Dandan Yang Xihai Zhao Jie Zhao Hong Chang Qi Yang | 2021 | Stroke & Vascular Neurology2021，6，3： | 3 |
| 11 | A novel and smart automatic light-seeking flowerpot for monitoring flower growth environment显示文摘Although the flowerpot is widely used for indoor flowers,it cannot meet the needs of intelligent management during the uncared-for period.The objective of this study was to design a new microcontroller-based smart flowerpot.Its overall system was composed of three parts:information collection layer,automatic control layer and data transmission layer.Firstly,in the process of collecting information,the Laiyite criterion and the normalized weighted average algorithm were adopted to improve the accuracy of information collection.Secondly,for making precise control decisions,the fuzzy control was used to achieve automatic on-demand watering.Finally,the method for comparative analysis of regional light intensity was utilized to achieve light-seeking and light-supplementing.Experimental results showed that the smart flowerpot had strong anti-jamming performance for information collection,the relative soil moisture of flowers could be stably maintained near the optimum humidity(65%),and the light was well-distributed on the flower with the error angle of light-supplementing ranged from-3°to 3°. | Xihai Zhang Dong Liu Chengguo Fan Jiali Du Fanfeng Meng Junlong Fang | 2018 | International Journal of Agricultural and Biological Engineering2018，11，2： | 2 |
| 12 | Photoelectrocatalytic degradation of oxalic acid in aqueous phase with a novel three- dimensional electrode-hollow quartz tube photoelectrocatalytic reactor 显示文摘 | An Taicheng Li Guiying Zhu Xihai | 2005 | Applied Catalysis A : General2005，279，12： | 1 |
| 13 | Anisotropic grain growth of Bi4Ti3O12 in molten salt fluxes显示文摘 | KANA Yanmei JINA Xihai WANG Peiling | 2003 | Mater Res Bull2003，38，： | 1 |
| 14 | Reinforcement of alumina matrix with multi -walled carbon nanotubes 显示文摘 | Jing Sun Lian Gao Xihai Jin | 2005 | Ceramics International2005，31，： | 1 |
| 15 | Microstruc- ture and Mechanical Properties of SiC- mullite Nanocomposite Prepared by Spark Plasma Sintering 显示文摘 | Gao Lian Jin Xihai Kawaoka H | 2002 | Material Science and Engineering A2002，334，12： | 1 |
| 16 | BN/Si3N4 nanocomposite with high strength and good machinability显示文摘 | Gao Lian Jin Xihai Li Jingguo | 2006 | Materials Science and Engineering A2006，，415： | 1 |
| 17 | Photoelectrocatalytic degradation of oxalic acid in aqueous phase with a novel three-dimensional electrode-hollowquartz tube photoelectrocatalytic reactor显示文摘 | An Taicheng Li Guiying Zhu Xihai | 2005 | Applied Catalysis A:General2005，279，12： | 1 |
| 18 | Photoelectrocatalytic degradation of oxalic acid in aqueous phase with a novel three - dimensional electrode - hollow quartz tube photoelectroeatalytie reactor 显示文摘 | Taicheng An Guiying Li Xihai Zhu | 2005 | Applied Catalysis A: General2005，279，12： | 1 |
| 19 | Comparison of carotid atherosclerotic plaques between subjects in Northern and Southern China: a Chinese atherosclerosis risk evaluation study显示文摘Background and purpose To investigate differences in the characteristics of carotid atherosclerotic plaques of symptomatic subjects in northern and southern China using MRI.Methods Sixty-three subjects in northern China(mean age:59.1±8.6 years,45 men)and 56 subjects in southern China(mean age:60.4±8.6 years,38 men)were included.All subjects underwent carotid artery multicontrast vessel wall MRI.Plaque morphology,calcification,lipid-rich necrotic core,intraplaque haemorrhage,luminal surface disruption and high-risk plaque were measured and identified.All plaque characteristics were compared between subjects in northern and southern China using Mann-Whitney U test or χ^(2) test.results Compared with subjects in southern China,those in northern China had significantly greater areas for lumen(57.7±14.9 mm^(2) vs 50.4±18.3 mm^(2),p=0.009),wall(38.4±13.1 mm^(2) vs 31.9±11.7 mm^(2),p<0.001)and total vessel(96.1±20.2 mm^(2) vs 82.4±22.7 mm^(2),p=0.001)and mean wall thickness(1.25±0.43 mm vs 1.13±0.40 mm,p=0.019).χ^(2) analysis showed that subjects in northern China tended to have a higher prevalence of intraplaque haemorrhage(14.3%vs 5.4%,p=0.106)and high-risk plaque(20.6%vs 10.7%,p=0.140)than those in southern China,although these differences were not statistically significant(all p>0.05).Conclusion Subjects in northern China have significantly larger vessel size and may have a higher prevalence of vulnerable plaques than those in southern China.Our findings provide additional perspective to optimise the management of cerebrovascular disease in individuals in different regions in China. | Dandan Yang Yang Ji Dan Wang Hiroko Watase Daniel S Hippe Xihai Zhao Chun Yuan | 2020 | Stroke & Vascular Neurology2020，5，2： | 1 |
| 20 | Feasibility study of photoelectrochemical degradation of methylene blue aqueous solutions with three dimensional electrodes-photocatalytic reactor显示文摘 | An Taicheng Zhu Xihai Xiong Ya | 2002 | Chemosphere2002，46，6： | 1 |
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