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| 1 | Apoptosis and its relationship with cell proliferation,p53,Waf1p21,bcl-2 and c-mycin esophageal carcinogenesis studied with a high-risk population in northern China显示文摘Apoptosisanditsrelationshipwithcelproliferation,p53,Waf1p21,bcl2andcmycinesophagealcarcinogenesisstudiedwithahighriskpopul... | WANG LiDong1, ZHOU Qi1, WEI JunPing1, YANG WanCai1, ZHAO Xin1, WANG LiXia1, ZOU Jian Xiang1, GAO ShanShan1, LI YongXin1 and YANG C.S.2Keywords esophageal neoplasms apoptosis precancerous lesions Waf1 p21 gene p53 | 1998 | World Journal of Gastroenterology1998，4，4： | 295 |
| 2 | Ferroptosis is an autophagic cell death process显示文摘Ferroptosis 是调整坏死的一种铁依赖者形式。它在各种各样的人的疾病被含有,包括 ischemic 机关损坏和癌症。这里,我们报导 autophagy 的关键角色,特别地细胞的铁存储蛋白质(作为 ferritinophagy 知道的一个过程) 的 autophagic 降级,在 ferroptosis。用 RNAi,屏蔽结合了随后的基因分析,我们作为 ferroptosis 的积极管理者识别了多重 autophagy 相关的基因。Ferroptosis 正式就职导致了 autophagy 激活和 ferritin 和 ferritinophagy 货物受体 NCOA4 的作为结果的降级。一致地,由 autophagy 的阻塞的 ferritinophagy 的抑制或废除的 NCOA4 击倒联系 ferroptosis 的细胞的易变的铁的累积和反应的氧种类,以及最终的 ferroptotic 细胞死亡。因此, ferroptosis 是一个 autophagic 房间死亡过程,并且调停 NCOA4 的 ferritinophagy 由控制细胞的铁动态平衡支持 ferroptosis。 | Minghui Gao Prashant Monian Qiuhui Pan Wei Zhang Jenny Xiang Xuejun Jiang | 2016 | Cell Research2016，26，9： | 138 |
| 3 | Identification of a novel coronavirus causing severe pneumonia in human:a descriptive study显示文摘Background:Human infections with zoonotic coronaviruses(CoVs),including severe acute respiratory syndrome(SARS)-CoV and Middle East respiratory syndrome(MERS)-CoV,have raised great public health concern globally.Here,we report a novel batorigin CoV causing severe and fatal pneumonia in humans.Methods:We collected clinical data and bronchoalveolar lavage(BAL)specimens from five patients with severe pneumonia from Wuhan Jinyintan Hospital,Hubei province,China.Nucleic acids of the BAL were extracted and subjected to next-generation sequencing.Virus isolation was carried out,and maximum-likelihood phylogenetic trees were constructed.Results:Five patients hospitalized from December 18 to December 29,2019 presented with fever,cough,and dyspnea accompanied by complications of acute respiratory distress syndrome.Chest radiography revealed diffuse opacities and consolidation.One of these patients died.Sequence results revealed the presence of a previously unknownβ-CoV strain in all five patients,with 99.8%to 99.9%nucleotide identities among the isolates.These isolates showed 79.0%nucleotide identity with the sequence of SARS-CoV(GenBank NC_004718)and 51.8%identity with the sequence of MERS-CoV(GenBank NC_019843).The virus is phylogenetically closest to a bat SARS-like CoV(SL-ZC45,GenBank MG772933)with 87.6%to 87.7%nucleotide identity,but is in a separate clade.Moreover,these viruses have a single intact open reading frame gene 8,as a further indicator of bat-origin CoVs.However,the amino acid sequence of the tentative receptor-binding domain resembles that of SARS-CoV,indicating that these viruses might use the same receptor.Conclusion:A novel bat-borne CoV was identified that is associated with severe and fatal respiratory disease in humans. | Li-Li Ren Ye-Ming Wang Zhi-Qiang Wu Zi-Chun Xiang Li Guo Teng Xu Yong-Zhong Jiang Yan Xiong Yong-Jun Li Xing-Wang Li Hui Li Guo-Hui Fan Xiao-Ying Gu Yan Xiao Hong Gao Jiu-Yang Xu Fan Yang Xin-Ming Wang Chao Wu Lan Chen Yi-Wei Liu Bo Liu Jian Yang Xiao-Rui Wang Jie Dong Li Li Chao-Lin Huang Jian-Ping Zhao Yi Hu Zhen-Shun Cheng Un-Lin Liu Zhao-Hui Qian Chuan Qin Qi Jin Bin Cao Jian-Wei Wang | 2020 | Chinese Medical Journal2020，，9： | 99 |
| 4 | Rupture segmentation and slip partitioning of the mid-eastern part of the Kunlun Fault,north Tibetan Plateau显示文摘The Kunlun Fault,an active fault on the border between the Bayan Har and Kunlun-Qaidam blocks,is one of the major left lateral strike-slip faults in the Tibetan Plateau.Previous research has not reached a consensus on agreeable slip rates along much of its length and the slip rate gradient along the eastern part,both of which play critical roles in a range of models for the eastward extrusion and thickened crust of the Tibetan Plateau.New slip rates have been determined at sites along the eastern part of the Kunlun Fault by dating deposits and measuring atop displaced fluvial terrace risers.Field investigations and interpretation of satellite images reveal geometrical features of the fault and the late Quaternary offset,new earthquake ruptures and surface-rupturing segmentation,from which long-term slip rates and earthquake recurrence intervals on the fault are estimated.The tectonic geomorphology method has determined that the long-term horizontal slip rates on the Tuosuohu,Maqin and Maqu segments from west to east are 11.2±1,9.3±2,and 4.9±1.3 mm/a while their vertical slip rates are 1.2±0.2,0.7±0.1,and 0.3 mm/a in the late Quaternary.Results indicate that the slip rates regularly decrease along the eastern ~300 km of the fault from >10 to <5 mm/a.This is consistent with the decrease in the gradient such that at the slip rate break point is at the triple point intersection with the transverse fault,which in turn is transformed to the Awancang Fault.The vector decomposition for this tectonic transformation shows that the western and eastern branches of the Awancang Fault fit the slip-partitioning mode.The slip rate of the southwestern wall is 4.6 mm/a relative to the northeastern wall and the slip direction is 112.1°.The mid-eastern part of the Kunlun Fault can be divided into three independent segments by the A'nyêmaqên double restraining bend and the Xigongzhou intersection zone,which compose the surface rupture segmentation indicators for themselves as well as the ending point of the 1937 M7.5 Tuosuohu earthquake.The average recurrence interval of the characteristic earthquakes are estimated to be 500-1000 a,respectively.The latest earthquake ruptures occurred in AD 1937 on the western Tuosuohu segment,as compared to ~514-534 a BP on the Maqin segment,and ~1055 to 1524 a BP on the Maqu segment.This may indicate a unidirectional migration for surface rupturing earthquakes along the mid-eastern Kunlun Fault related to stress triggered between these segments.Meanwhile,the long-term slip rate is obtained through the single event offset and the recurrence interval,which turn out to be the same results as those determined by the offset tectonic geomorphology method,i.e.,the decreasing gradient corresponds to the geometrical bending and the fault's intersection with the transverse fault.Therefore,the falling slip rate gradient of the mid-eastern Kunlun Fault is mainly caused by eastward extension of the fault and its intersection with the transverse fault. | LI ChenXia XU XiWei WEN XueZe ZHENG RongZhang CHEN GuiHua YANG Hu AN YanFen GAO Xiang | 2011 | Science China Earth Sciences2011，54，11： | 33 |
| 5 | Diver CE versus Guardwire Plus for thrombectomy in patients with inferior myocardial infarction:a trial of aspiration of thrombus during primary angioplasty for inferior myocardial infarction显示文摘背景不同可行、安全的 thrombectomy 和远侧的保护设备用 Diver CE 设备在临床的 practice.The 效率和附属物 thrombectomy 的安全被使用了( Invatec ,意大利 )对 Guardwire 正设备( Medtronic ,美国)在经皮的冠的干预(一种总线标准)与尖锐劣等的 ST-segment-elevation 心肌的梗塞( STEMI )在病人被作比较不到 12 个小时以前,在心肌的梗塞( TIMI )的 thrombolysis 流动分级 0~1 ,并且总计吸藏第二等的结束点被让结束心脏舒张的体积( LVEDV )室,左室喷射部分( LVEF )和包括死亡的主要不利心脏的事件(权标),心肌的梗塞,在 122 个病人的 30 days.Results A 总数的目标容器 revascularization 和击同等地被划分成 Diver CE 组和 Guardwire 正组,它到年龄是可比较的(( 60 ?????????汣灯摩杯敲????朠潲灵?潃据畬楳湯??湡獵? | YAN Hong-bing WANG Jian LI Nan ZHU Xiao-ling GAO Hai AI Hui LI Xiang YE Ming CHI Yun-peng ZHANG Hong | 2007 | Chinese Medical Journal2007，，7： | 29 |
| 6 | Relationship between Cognition Function and Hippocampus Structure after Long-term Microwave Exposure显示文摘Objective To analyze the effects of long-term microwave exposure on hippocampal structure and function in the rat.Methods Experiments were performed on 184 male Wistar rats(three exposure groups and a sham group).Microwaves were applied daily for 6 min over 1 month at average power densities of 2.5,5,and 10 mW/cm2.Learning and memory abilities were assessed by Morris water maze.High performance liquid chromatography was used to detect neurotransmitter concentrations in the hippocampus.Hippocampal structures were observed by histopathological analysis.Results Following long-term microwave exposure there was a significant decrease in learning and memory activity in the 7 d,14 d,and 1 m in all three microwave exposure groups.Neurotransmitter concentrations of four amino acids(glutamate,aspartic acid,glycine,and gamma-aminobutyric acid) in hippocampus were increased in the 2.5 and 5 mW/cm2 groups and decreased in the 10 mW/cm2 group.There was evidence of neuronal degeneration and enlarged perivascular spaces in the hippocampus in the microwave exposure groups.Further,mitochondria became swollen and cristae were disordered.The rough endoplasmic reticulum exhibited sacculated distension and there was a decrease in the quantity of synaptic vesicles.Conclusion These data suggest that the hippocampus can be injured by long-term microwave exposure,which might result in impairment of cognitive function due to neurotransmitter disruption. | ZHAO Li PENG Rui Yun WANG Shui Ming WANG Li Feng GAO Ya Bing DONG Ji LI Xiang SU Zhen Tao | 2012 | Biomedical and Environmental Sciences2012，25，2： | 27 |
| 7 | Advances on strategies for searching for next generation thermal barrier coating materials显示文摘Thermal barrier coating(TBC) materials play important roles in gas turbine engines to protect the Nibased super-alloys from the high temperature airflow damage. High melting point, ultra-low thermal conductivity, large thermal expansion coefficient, excellent damage tolerance and moderate mechanical properties are the main requirements of promising TBC materials. In order to improve the efficiency of jet and/or gas turbine engines, which is the key of improved thrust-to-weight ratios and the energysaving, significant efforts have been made on searching for enhanced TBC materials. Theoretically, density functional theory has been successfully used in scanning the structure and properties of materials, and at the same time predicting the mechanical and thermal properties of promising TBC materials for high and ultrahigh temperature applications, which are validated by subsequent experiments. Experimentally,doping and/or alloying are also widely applied to further decrease their thermal conductivities. Now, the strategy through combining theoretical calculations and experiments on searching for next generation thermal insulator materials is widely adopted. In this review, the common used techniques and the recent advantages on searching for promising TBC materials in both theory and experiments are summarized. | Bin Liu Yuchen Liu Changhua Zhu Huimin Xiang Hongfei Chen Luchao Sun Yanfeng Gao Yanchun Zhou | 2019 | Journal of Materials Science & Technology2019，35，5： | 24 |
| 8 | Simultaneous oxidation of NO,SO_2 and Hg^0 from flue gas by pulsed corona discharge显示文摘A process capable of simultaneously oxidizing NO,SO2,and Hg0 was proposed,using a high-voltage and short-duration positive pulsed corona discharge.By focusing on NO,SO2,and Hg0 oxidation effciencies,the influences of pulse peak voltage,pulse frequency,initial concentration,electrode number,residence time and water vapor addition were investigated.The results indicate that NO,SO2 and Hg0 oxidation effciencies depend primarily on the radicals(OH,HO2,O) and the active species(O3,H2O2,etc.) produced by the pulsed corona discharge.The NO,SO2 and Hg0 oxidation effciencies could be improved as pulse peak voltage,pulse frequency,electrode number and residence time increased,but they were reduced with increasing initial concentrations.By adding water vapor,the SO2 oxidation effciency was improved remarkably,while the NO oxidation effciency decreased slightly.In our experiments,the simultaneous NO,SO2,and Hg0 oxidation effciencies reached to 40%,98%,and 55% with the initial concentrations 479 mg/m3,1040 mg/m3,and 15.0 μg/m3,respectively. | XU Fei,LUO Zhongyang,CAO Wei,WANG Peng,WEI Bo,GAO Xiang,FANG Mengxiang,CEN Kefa State key Laboratory of Clean Energy Utilization,Zhejiang University,Hangzhou 310027,China. | 2009 | Journal of Environmental Sciences2009，21，3： | 22 |
| 9 | GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity显示文摘Gasdermin B (GSDMB) has been reported to be associated with immune diseases in humans, but the detailed molecular mechanisms remain unsolved. The N-terminus of GSDMB by itself, unlike other gasdermin family proteins, does not induce cell death. Here, we show that GSDMB is highly expressed in the leukocytes of septic shock patients, which is associated with increased release of the gasdermin D (GSDMD) N-terminus. GSDMB expression and the accumulation of the N-terminal fragment of GSDMD are induced by the activation of the non-canonical pyroptosis pathway in a human monocyte cell line. The downregulation of GSDMB alleviates the cleavage of GSDMD and cell death. Consistently, the overexpression of GSDMB promotes GSDMD cleavage, accompanied by increased LDH release. We further found that GSDMB promotes caspase-4 activity, which is required for the cleavage of GSDMD in non-canonical pyroptosis, by directly binding to the CARD domain of caspase-4. Our study reveals a GSDMB-mediated novel regulatory mechanism for non-canonical pyroptosis and suggests a potential new strategy for the treatment of inflammatory diseases. | Qin Chen Peiliang Shi Yufang Wang Dayuan Zou Xiuwen Wu Dingyu Wang Qiongyuan Hu Yujie Zou Zan Huang Jianan Ren Zhaoyu Lin Xiang Gao | 2019 | Journal of Molecular Cell Biology2019，11，6： | 22 |
| 10 | Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation显示文摘Disrupted mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) generation are often associated with macrophage pyroptosis. It remains unclear how these forms of mitochondrial dysfunction relate to inflammasome activation and gasdermin-D (Gsdmd) cleavage, two central steps of the pyroptotic process. Here, we also found MMP collapse and ROS generation induced by Nlrp3 inflammasome activation as previous studies reported. The elimination of ROS alleviated the cleavage of Gsdmd, suggesting that Gsdmd cleavage occurs downstream of ROS release. Consistent with this result, hydrogen peroxide treatment augmented the cleavage of Gsdmd by caspase-1. Indeed, four amino acid residues of Gsdmd were oxidized under oxidative stress in macrophages. The efficiency of Gsdmd cleavage by inflammatory caspase-1 was dramatically reduced when oxidative modification was blocked by mutation of these amino acid residues. These results demonstrate that Gsdmd oxidation serves as a de novo mechanism by which mitochondrial ROS promote Nlrp3 inflammasome-dependent pyroptotic cell death. | Yufang Wang Peiliang Shi Qin Chen Zan Huang Dayuan Zou Jingzi Zhang Xiang Gao Zhaoyu Lin | 2019 | Journal of Molecular Cell Biology2019，11，12： | 23 |
| 11 | Age-related rhesus macaque models of COVID-19显示文摘Background:Since December 2019,an outbreak of the Corona Virus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus(SARS-CoV-2)in Wuhan,China,has become a public health emergency of international concern.The high fatality of aged cases caused by SARS-CoV-2 was a need to explore the possible age-related phenomena with non-human primate models.Methods:Three 3-5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS-CoV-2,and then analyzed by clinical signs,viral replication,chest X-ray,histopathological changes and immune response.Results:Viral replication of nasopharyngeal swabs,anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS-CoV-2 challenge.Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema,notably,old monkeys exhibited diffuse severe interstitial pneumonia.Viral antigens were detected mainly in alveolar epithelial cells and macrophages.Conclusion:SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys.Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection. | Pin Yu Feifei Qi Yanfeng Xu Fengdi Li Peipei Liu Jiayi Liu Linlin Bao Wei Deng Hong Gao Zhiguang Xiang Chong Xiao Qi Lv Shuran Gong Jiangning Liu Zhiqi Song Yajin Qu Jing Xue Qiang Wei Mingya Liu Guanpeng Wang Shunyi Wang Haisheng Yu Xing Liu Baoying Huang Wenling Wang Li Zhao Huijuan Wang Fei Ye Weimin Zhou Wei Zhen Jun Han Guizhen Wu Qi Jin Jianwei Wang Wenjie Tan Chuan Qin | 2020 | Animal Models and Experimental Medicine2020，3，1： | 22 |
| 12 | Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1显示文摘Ferroptosis is a non-apoptotic regulated cell death caused by iron accumulation and subsequent lipid peroxidation.Currently,the therapeutic role of ferroptosis on cancer is gaining increasing interest.Baicalin an active component in Scutellaria baicalensis Georgi with anticancer potential various cancer types;however,the effects of baicalein on bladder cancer and the underlying molecular mechanisms remain largely unknown.In the study,we investigated the effect of baicalin on bladder cancer cells5637 and KU-19-19.As a result,we show baicalin exerted its anticancer activity by inducing apoptosis and cell death in bladder cancer cells.Subsequently,we for the first time demonstrate baicalin-induced ferroptotic cell death in vitro and in vivo,accompanied by reactive oxygen species(ROS) accumulation and intracellular chelate iron enrichment.The ferroptosis inhibitor deferoxamine but not necrostatin-1,chloroquine(CQ),N-acetyl-L-cysteine,L-glutathione reduced,or carbobenzoxy-valyl-alanyl-aspartyl-[O-methyl]-fluoromethylketone(Z-VAD-FMK) rescued baicalin-induced cell death,indicating ferroptosis contributed to baicalin-induced cell death.Mechanistically,we show that ferritin heavy chain1(FTH1) was a key determinant for baicalin-induced ferroptosis.Overexpression of FTH1 abrogated the anticancer effects of baicalin in both 5637 and KU19-19 cells.Taken together,our data for the first time suggest that the natural product baicalin exerts its anticancer activity by inducing FTH1-dependent ferroptosis,which will hopefully provide a prospective compound for bladder cancer treatment. | Na Kong Xiaying Chen Jiao Feng Ting Duan Shuiping Liu Xueni Sun Peng Chen Ting Pan Lili Yan Ting Jin Yu Xiang Quan Gao Chengyong Wen Weirui Ma Wencheng Liu Mingming Zhang Zuyi Yang Wengang Wang Ruonan Zhang Bi Chen Tian Xie Xinbing Sui Wei Tao | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 23 |
| 13 | Insult of gastroesophageal reflux on airway: clinical significance of pharyngeal nozzle显示文摘在到最糟的最高的注意在航线上吸烟以及薄雾侮辱的全球付钱的时间,所有人知道两个外长、显著。然而,包括许多医药人员,人们主要不知道 gastroesophageal 倒流(GER ) 怎么糟糕在我们的自己的航线上侮辱。GER 的症状通常被看作心痛和流回,它能主要被容忍。不管多么起来在它出现的地方,去的胃的内容相对地传递食管然后远侧的咽象苛评一样的鸟喙,用作一张嘴,以便生产众多微粒子并且到达oro鼻的洞并且另外引起的航线过敏鼻炎和气喘的攻击,甚至肺的实质损害。它将减少生活质量或甚至使受危险生活。内长的侮辱在呼吸系统出现,但是从消化的道发源的点不是众所周知的并且经常 undiagnosed 并且不正确地对待。导致的航线挑战是的 GER 一个可对待、预防的实体一旦诊断被做,好消除能通过 radiofrequency 或 fundoplication 借助于张开的贲门的生活方式调整,药,或固定被期望。作者王忠高博士承受了它为长并且症状在反倒流外科以后消失了 8 年。这是王忠高博士和他的队工作的一个演讲并且将引起注意到公众以便认出作为吸烟或薄雾从人的本身,然而并非从外面的环境发生的一个可对待的条件做的这个相对未知的实体。 | Zhonggao Wang Zhiwei Hu Jimin Wu Feng Ji Hongtao Wang Yungang Lai Xiang Gao Yachan Ning Chengchao Zhang Zhitong Li Weitao Liang Jianjun Liu | 2015 | Frontiers of Medicine2015，9，1： | 21 |
| 14 | OCTN and CARD15 gene polymorphism in Chinese patients with inflammatory bowel disease显示文摘AIM: To investigate the single nucleotide polymorphism (SNPs) distribution of NOD2/CARD15 (R702W, G908R), OCTN1 1672C/T and OCTN2-207G/C in Chinese patients with inflammatory bowel disease (IBD). METHODS: A total of 61 patients with Crohn’s disease (CD), 151 patients with ulcerative colitis (UC), and 200 unrelated healthy controls were genotyped. Genotyping was performed by sequence specif ic primer polymerase chain reaction (PCR-SSP) or by restriction fragment length polymorphism (PCR-RFLP) analysis. RESULTS: Among the subjects in our study groups, including patients with CD, UC and healthy controls, none had OCTN and CARD15 variants and very rare IBD family history was found in our patients with the percentage of 0 (0/61 with CD) and 1.3% (2/151 with UC). CONCLUSION: Our results indicate that although OCTN or CARD15 variation is associated with susceptibility to IBD in Western populations, these might be rare and may not be associated with susceptibility to IBD in Chinese patients. | Mei Li Xiang Gao Chang-Cun Guo Kai-Chun Wu Xin Zhang Pin-Jin Hu | 2008 | World Journal of Gastroenterology2008，14，31： | 20 |
| 15 | Research on Key Technologies of Precise InSAR Surveying and Mapping Applications Using Automatic SAR Imaging显示文摘Precise interferometric synthetic aperture radar (InSAR) is a new intelligent photogrammetric technology that uses automatic imaging and processing means. Precise InSAR has become the most efficient satellite surveying and mapping (SASM) method that uses the interferometric phase to create a global digital elevation model (DEM) with high precision. In this paper, we propose the application of systematic InSAR technologies to SASM. Three key technologies are proposed: calibration technology, data processing technology and post-processing technology. First, we need to calibrate the geometric and interferometric parameters including the azimuth time delay, range time delay, and atmospheric delay, as well as baseline errors. Second, we use the calibrated parameters to create a precise DEM. One of the important procedures in data processing is the determination of phase ambiguities. Finally, we improve the DEM quality through the joint use of the block adjustment method, long and short baseline combination method and descending and ascending data merge method. We use 6 sets of TanDEM-X data covering Shanxi to conduct the experiment. The root mean square error of the final DEM is 5.07 m in the mountainous regions. In addition, the low coherence area is 0.8 km 2. The result meets the China domestic SASM accuracy standard at both the 1∶50 000 and 1∶25 000 measurement scales. | Xinming TANG Tao LI Xiaoming GAO Qianfu CHEN Xiang ZHANG | 2019 | Journal of Geodesy and Geoinformation Science2019，2，2： | 20 |
| 16 | Clinical trial with traditional Chinese medicine intervention ''tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'' for chronic hepatitis B-associated liver failure显示文摘AIM:To study the clinical efficacy of traditional Chinese medicine(TCM)intervention'tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'('TTK')for treating liver failure due to chronic hepatitis B.METHODS:We designed the study as a randomized controlled clinical trial.Registration number of Chinese Clinical Trial Registry is Chi CTR-TRC-12002961.A total of 144 patients with liver failure due to infection with chronic hepatitis B virus were enrolled in this randomized controlled clinical study.Participants were randomly assigned to the following three groups:(1)a modern medicine control group(MMC group,36patients);(2)a'tonifying qi and detoxification'('TQD')group(72 patients);and(3)a'tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'('TTK')group(36patients).Patients in the MMC group received general internal medicine treatment;patients in the'TQD'group were given a TCM formula'tonifying qi and detoxification'and general internal medicine treatment;patients in the'TTK'group were given a TCM formula of'TTK'and general internal medicine treatment.All participants were treated for 8 wk and then followed at 48 wk following their final treatment.The primaryefficacy end point was the patient fatality rate in each group.Measurements of various virological and biochemical indicators served as secondary endpoints.The one-way analysis of variance and the t-test were used to compare patient outcomes in the different treatment groups.RESULTS:At the 48-wk post-treatment time point,the patient fatality rates in the MMC,'TQD',and'TTK'groups were 51.61%,35.38%,and 16.67%,respectively,and the differences between groups were statistically significant(P<0.05).However,there were no significant differences in the levels of hepatitis B virus DNA or prothrombin activity among the three groups(P>0.05).Patients in the'TTK'group had significantly higher levels of serum total bilirubin compared to MMC subjects(339.40μmol/L±270.09μmol/L vs 176.13μmol/L±185.70μmol/L,P=0.014).Serum albumin levels were significantly increased in both the'TQD'group and'TTK'group as compared with the MMC group(31.30 g/L±4.77g/L,30.72 g/L±2.89 g/L vs 28.57 g/L±4.56 g/L,P<0.05).There were no significant differences in levels of alanine transaminase among the three groups(P>0.05).Safety data showed that there was one case of stomachache in the'TQD'group and one case of gastrointestinal side effect in the'TTK'group.CONCLUSION:Treatment with'TTK'improved the survival rates of patients with liver failure due to chronic hepatitis B.Additionally,liver tissue was regenerated and liver function was restored. | Han-Min Li Zhi-Hua Ye Jun Zhang Xiang Gao Yan-Ming Chen Xin Yao Jian-Xun Gu Lei Zhan Yang Ji Jian-Liang Xu Ying-He Zeng Fan Yang Lin Xiao Guo-Guang Sheng Wei Xin Qi Long Qing-Jing Zhu Zhao-Hong Shi Lian-Guo Ruan Jia-Yao Yang Chang-Chun Li Hong-Bin Wu Sheng-Duo Chen Xin-La Luo | 2014 | World Journal of Gastroenterology2014，20，48： | 20 |
| 17 | Radiofrequency treatment on respiratory symptoms due to gastroesophageal reflux disease显示文摘为 gastroesophageal 倒流疾病(GERD ) 的呼吸症状(RS ) 的背景诊断和治疗对普通食道的症状比那更困难。这研究的目标是评估 radiofrequency (RF ) 的功效和安全在到有象喘那样的主要呼吸的演讲的 10 月 2008,505 日 GERD 病人的从 2006 年 4 月的初步的 12 月的后续 observation.Methods 的 GERD 的 RS 上的治疗,长期的咳嗽或嘶哑,被内视镜的 RF 对待。一张问询表在治疗前后被完成,用从 0 ~ 5 估计症状严厉和频率的六点的规模。症状分数是频率的和, severity.Results 症状分数显著地在后续经期的结束被改进。吝啬的心痛分数从 5.31 ~ 1.79 减少了。吝啬的流回分数从 5.02 ~ 1.64 减少了;吝啬的咳嗽分数从 6.77 ~ 2.85 减少了;吝啬的喘分数从 7.83 ~ 3.07 减少了;并且吝啬的嘶哑分数从 5.13 ~ 1.81 减少了(P 0.01 ) 。没有主要复杂并发症或死亡发生了。次要的复杂并发症包括了暂时的 procedural 以后 retrosternal 不舒适或疼痛(n=106; 21.0%) ,温和发烧(n=86; 17.0%) ,短暂恶心 / 呕吐(n=97; 19.2%) ,并且短暂咽下困难(n=42; 9.3%) 。35 (6.9%) 病人们有症状的复发。内视镜的 RF 治疗在六个病人被重复,并且 laparoscopic fundoplication 在内视镜的 RF 是的 seven.Conclusion 被执行与 GERD 在病人对待 RS 的一个有效、安全的工具。 | GAO Xiang WANG Zhong-gao WU Ji-min JI Feng ZHANG Cheng-chao NING Ya-chan LI Zhi-tong HU Zhi-wei CHEN Xiu TIAN Shu-rui | 2011 | Chinese Medical Journal2011，，7： | 19 |
| 18 | Process analysis of PM_(2.5) pollution events in a coastal city of China using CMAQ显示文摘US EPA's Community Multiscale Air Quality modeling system(CMAQ) with Process Analysis tool was used to simulate and quantify the contribution of individual atmospheric processes to PM_(2.5) concentration in Qingdao during three representative PM_(2.5) pollution events in the winter of 2015 and 2016. Compared with the observed surface PM_(2.5) concentrations, CMAQ could reasonably reproduce the temporal and spatial variations of PM_(2.5) during these three events. Process analysis results show that primary emissions accounted for 72.7%–93.2% of the accumulation of surface PM_(2.5) before and after the events.When the events occurred, primary emissions were still the major contributor to the increase of PM_(2.5) in Qingdao, however the contribution percentage reduced significantly,which only account for 51.4%–71.8%. Net contribution from horizontal and vertical transport to the accumulation of PM_(2.5) was also positive and its percentage increased when events occurred. Only 1.1%–4.6% of aerosol accumulation was due to PM processes and aqueous chemical processes before and after events. When the events occurred,contribution from PM processes and aqueous chemistry increased to 6.0%–11.8%. Loss of PM_(2.5) was mainly through horizontal transport, vertical transport and dry deposition, no matter during or outside the events. Wet deposition would become the main removal pathway of PM_(2.5), when precipitation occurred. | Qiang Zhang Di Xue Xiaohuan Liu Xiang Gong Huiwang Gao | 2019 | Journal of Environmental Sciences2019，31，5： | 17 |
| 19 | Vision,application scenarios,and key technology trends for 6G mobile communications显示文摘With the global commercialization of the fifth-generation(5G)network,many countries,including China,USA,European countries,Japan,and Korea,have started exploring 6G mobile communication network,following the tradition of“planning the next while commercializing one generation”.Currently,studies on 6G networks are at the infancy stage.Research on the vision and requirements for 6G is still ongoing,and the industry is yet to clarify the key enabling technologies for 6G.However,6G will certainly build on the success of 5G.Therefore,developing high-quality 5G networks and seamlessly integrating 5G with verticals are the priorities before 2030,when 6G is projected to be commercialized.Also,global 5G standards will keep evolving to better support vertical applications.As a milestone,the Third-Generation Partnership Project(3GPP)published Release 16 in July 2020,which continuously enhanced the capabilities of mobile broadband service based on Release 15 and realized the support for low-delay and high-reliability applications,such as Internet of Vehicles and industrial Internet.Currently,3GPP is working on Releases 17 and 18,focusing on meeting the demands of medium-and high-data-rate machine communication with low-cost and high-precision positioning,which will be published in June 2022.Thus,6G networks will further expand the application fields and scope of the Internet of Things to accommodate those services and applications that are beyond the capabilities of 5G networks.Herein,we present our vision,application scenarios,and key technological trends for 6G networks.Furthermore,we propose several future research opportunities in 6G networks with regard to industrialization and standardization. | Zhiqin WANG Ying DU Kejun WEI Kaifeng HAN Xiaoyan XU Guiming WEI Wen TONG Peiying ZHU Jianglei MA Jun WANG Guangjian WANG Xueqiang YAN Jiying XIANG He HUANG Ruyue LI Xinhui WANG Yingmin WANG Shaohui SUN Shiqiang SUO Qiubin GAO Xin SU | 2022 | Science China(Information Sciences)2022，65，5： | 17 |
| 20 | Nutrient Release from Weathering of Purplish Rocks in the Sichuan Basin,China显示文摘Purplish soils having high fertility with mineral nutrients inherited from the parent rock are widely distributed in the hills along the Yangtze River,especially in the Sichuan Basin.Pot and field weathering experiments were conducted to mimic rock weathering and nutrient release processes in order to better understand soil fertility and nutrient compensation. Three types of purplish rock formations formed in the Jurassic period,Shaximiao(J_2s),Suining(J_3s),and Penglaizhen (J_3p),as well as one type formed in the Cretaceous period,the Chengqiangyan group(K_1c),were used in this study. Results showed that the soil formation rate was in the range from 11.2 to 19.6 mm every year,and rock weathering was in the order of J_3s>J_3p>J_2s>K_1c.Because more rock surface was exposed to sunlight and rainfall in field conditions,pot weathering was slower than field weathering.Nutrient release rates increased with rock weathering and was in the order similar to that of rock weathering:J_3p>J_3s>J_2s>K_1c.Potassium release was the most important in all rocks;after 2 years of weathering,19.4% to 46.9% of K was released from the initial parent rocks,which suggested that K release from weathering could meet most of the crop K requirement in purplish soils.Thus,rapid release of nutrients from weathering of purplish rocks was key to nutrient replenishment and fertility of purplish soils. | ZHU Bo WANG Tao YOU Xiang GAO Mei-Rong | 2008 | Pedosphere2008，18，2： | 16 |
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