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| 1 | Pluripotent stem cells induced from mouse neural stem cells and small intestinal epithelial cells by small molecule compounds显示文摘最近,我们报导了一条化学途径从老鼠成纤维细胞产生 pluripotent 干细胞。然而,是否化学上导致了 pluripotent 干细胞(CiPSCs ) ,能从要示威的另外的房间类型遗体被导出。用系跟踪,这里,我们首先从成纤维细胞验证 CiPSCs 的产生。下次,我们证明从外胚层的神经干细胞(NSC ) 和从内胚叶的小肠的上皮的房间(IEC ) 能是化学上 reprogrammed 进 pluripotent 干细胞。CiPSCs 源于 NSC 和 IEC 类似于老鼠处于增长率,全球基因表示侧面, epigenetic 地位,自强和区别能力的胚胎的干细胞,和 germline 传播才能。有趣地, pluripotency 基因 Sall4 从不同房间类型,和一样的核心在化学 reprogramming 过程在起始的阶段被表示小分子为 reprogramming 被要求,在从这些多样的房间类型位于化学 reprogramming 下面的分子的机制建议保存。我们的分析也证明这些小分子的使用应该被调整从不同房间类型满足 reprogramming 的要求。一起,这些调查结果证明那条完整的化学 reprogramming 途径能在不同织物起源的房间被使用并且建议化学 reprogramming 是有要延长到更起始的类型的潜力的有希望的策略。 | Junqing Ye Jian Ge Xu Zhang Lin Cheng Zhengyuan Zhang Shan He Yuping Wang Hua Lin Weifeng Yang Junfang Liu Yang Zhao Hongkui Deng | 2016 | Cell Research2016，26，1： | 19 |
| 2 | Scaling all-fiber mid-infrared supercontinuum up to 10 W-level based on thermal-spliced silica fiber and ZBLAN fiber显示文摘We demonstrate an integrated all-fiber mid-infrared(mid-IR)supercontinuum(SC)source generated by a 1.95μm master oscillator power amplifier system and a single-mode ZBLAN(ZrF_4–BaF_2–LaF_3–AlF_3–NaF)fiber.The maximum average output power is 10.67 W with spectral bandwidth covering from~1.9 to 4.1μm.The single-mode ZBLAN fiber and silica fiber are thermal-spliced to enhance the robustness and practicability of the system.It is,to the best of our knowledge,the first high-power integrated compacted all-fiber mid-IR SC source based on thermal-spliced silica fiber and ZBLAN fiber. | Zhijian Zheng Deqin Ouyang Junqing Zhao Minqiu Liu Shuangchen Ruan Peiguang Yan Jinzhang Wang | 2016 | Photonics Research2016，4，4： | 13 |
| 3 | A unified model for the formation and distribution of both conventional and unconventional hydrocarbon reservoirs显示文摘The discovery and large-scale exploration of unconventional oil/gas resources since 1980s have been considered as the most important advancement in the history of petroleum geology;that has not only changed the balance of supply and demand in the global energy market,but also improved our understanding of the formation mechanisms and distribution characteristics of oil/gas reservoirs.However,what is the difference of conventional and unconventional resources and why they always related to each other in petroliferous basins is not clear.As the differences and correlations between unconventional and conventional resources are complex challenging issues and very critical for resources assessment and hydrocarbon exploration,this paper focused on studying the relationship of formations and distributions among different oil/gas reservoirs.Drilling results of 12,237 exploratory wells in 6 representative petroliferous basins of China and distribution characteristics for 52,926 oil/gas accumulations over the world were applied to clarify the formation conditions and genetic relations of different oil/gas reservoirs in a petroliferous basin,and then to establish a unified model to address the differences and correlations of conventional and unconventional reservoirs.In this model,conventional reservoirs formed in free hydrocarbon dynamic field with high porosity and permeability located above the boundary of hydrocarbon buoyancy-driven accumulation depth limit.Unconventional tight reservoirs formed in confined hydrocarbon dynamic field with low porosity and permeability located between hydrocarbon buoyancy-driven accumulation depth limit and hydrocarbon accumulation depth limit.Shale oil/gas reservoirs formed in the bound hydrocarbon dynamic field with low porosity and ultra-low permeability within the source rock layers.More than 75%of proved reserves around the world are discovered in the free hydrocarbon dynamic field,which is estimated to contain only 10%of originally generated hydrocarbons.Most of undiscovered resources distributed in the confined hydrocarbon dynamic field and the bound hydrocarbon dynamic field,which contains 90%of original generated hydrocarbons,implying a reasonable and promising area for future hydrocarbon explorations.The buried depths of hydrocarbon dynamic fields become shallow with the increase of heat flow,and the remaining oil/gas resources mainly exist in the deep area of“cold basin”with low geothermal gradient.Lithology changing in the hydrocarbon dynamic field causes local anomalies in the oil/gas dynamic mechanism,leading to the local formation of unconventional hydrocarbon reservoirs in the free hydrocarbon dynamic field or the occurrence of oil/gas enrichment sweet points with high porosity and permeability in the confined hydrocarbon dynamic field.The tectonic movements destroy the medium conditions and oil/gas components,which leads to the transformation of conventional oil/gas reservoirs formed in free hydrocarbon dynamic field to unconventional ones or unconventional ones formed in confined and bound hydrocarbon dynamic fields to conventional ones. | Xiongqi Pang Chengzao Jia Junqing Chen Maowen Li Wenyang Wang Qinhong Hu Yingchun Guo Zhangxin Chen Junwen Peng Keyu Liu Keliu Wu | 2021 | Geoscience Frontiers2021，12，2： | 8 |
| 4 | Hepatocyte growth factor improves right ventricular remodeling in pulmonary arterial hypertensive rats via decreasing neurohormonal activation and inhibiting apoptosis显示文摘 | Wang Xiaolin Wang Yongjin Rong Shuling Ma Hongbiao Ma Qing Zhao Junqing | 2014 | Chinese Medical Journal2014，，10： | 7 |
| 5 | Simulation of electro-slag re-melting process of 120t large ingot for nuclear power station and its application显示文摘Further research on metallic materials for the super critical rotator and the main pipe line of a nuclear power station is very important for developing the nuclear power industry. In this study, the mathematical model for 120 t large ingot was established, and the computer program ESR3D was developed to simulate the whole electro-slag re-melting (ESR) process. This includes the electrode melting, metallic droplet falling, metal pool forming, metal pool and slag pool rising and moving, installation of top crystallizer, ingot solidifying, etc. The simulated average melting rate of the electrode was in good agreement with that in practical production. The optimized parameters were used to produce 80-120 t large ingots, and the quality of the ingots satisfied the specifications of nuclear power and the super critical generating unit. | Liu Xihai Wang Junqing Jia Weiguo Gao Jianjun Zhao Lin Tang Zuobin | 2011 | China Foundry2011，8，4： | 6 |
| 6 | In vitro testicular organogenesis from human fetal gonads produces fertilization-competent spermatids显示文摘Unlike most organs that mature during the fetal period,the male reproductive system reaches maturity only at puberty with the commencement of spermatogenesis.Robust modelling of human testicular organogenesis in vitro would facilitate research into mechanisms of and factors affecting human spermatogenic failure and male fertility preservation in prepubertal tumor patients.Here,we report successful recapitulation of human testicular organogenesis in vitro from fetal gonadal ridge.Our model displayed the formation of mature seminiferous epithelium and self-renewing spermatogonia.Remarkably,in vitro-derived haploid spermatids have undergone meiotic recombination,and showed increased genetic diversity as indicated by genetic analysis.Moreover,these spermatids were able to fertilize oocytes and support subsequent blastocyst formation.The in vitro testicular organogenesis system described here will play an important role in elucidating the regulation of human testis development and maintaining male fertility in prepubertal cancer patients. | Yan Yuan Laihua Li Qing Cheng Feiyang Diao Qiao Zeng Xiaoyu Yang Yibo Wu Hao Zhang Mingqian Huang Junqing Chen Quan Zhou Yunfei Zhu Rong Hua Jianyu Tian Xin Wang Zuomin Zhou Jie Hao Jinjin Yu Dong Hua Jiayin Liu Xuejiang Guo Qi Zhou Jiahao Sha | 2020 | Cell Research2020，30，3： | 6 |
| 7 | Numerical simulation and processoptimization for producing large-sized castings显示文摘3-Dvelocity and temperature fields of mold filling and solidification processes of large-sized castingswere calculated,and the efficiency and accuracy of numerical calculation were studied.The mold filling andsolidification processes of large-sized stainless steel,iron and aluminum alloy castings were simulated by using ofnew scheme;their casting processes were optimized,and then applied to produce castings. | Wang Junqing Sun Xun Guan Yang Wang Penghua Li Hailan Bai Limei Sun Xinzhi | 2008 | China Foundry2008，5，3： | 6 |
| 8 | Metal-organic frameworks nanoswitch:Toward photo-controllable endo/lysosomal rupture and release for enhanced cancer RNA interference显示文摘Endo/lysosomal escape and gene release are two critical bottlenecks in gene delivery.Herein,a novel photo-controllable metal-organic frameworks(MOFs)nanoswitch is rationally designed for enhancing small interfering RNA(siRNA)delivery.One single laser triggers the“off-to-on”switching of MOFs nanocomplexes,inducing significant siRNA release accompanied by rapid MOFs dissociation into protonatable 2-methylimidazalo and osmotic rupturing Zn2+ions,which cooperatively contribute to remarkable endo/lysosomal rupture(∼90%).The simultaneous endo/lysosomal rupture and release enable a high spatio-temporal control on RNA interference for effective cancer therapy.Notably,the“off-to-on”switching also activates fluorescence recovery for real-time monitoring siRNA delivery.The nanoswitch could easily be extended to deliver other therapeutic agents(e.g.,DNA,protein,anticancer drug)for overcoming endo/lysosomal entrapment. | Gan Lin Yang Zhang Long Zhang Junqing Wang Ye Tian Wen Cai Shangui Tang Chengchao Chu JiaJing Zhou Peng Mi Xiaoyuan Chen Gang Liu | 2020 | Nano Research2020，13，1： | 5 |
| 9 | Intrinsically Stretchable Organic-Tribotronic-Transistor for Tactile Sensing显示文摘Stretchable electronics are of great significance for the development of the next-generation smart interactive systems.Here,we propose an intrinsically stretchable organic tribotronic transistor(SOTT)without a top gate electrode,which is composed of a stretchable substrate,silver nanowire electrodes,semiconductor blends,and a nonpolar elastomer dielectric.The drain-source current of the SOTT can be modulated by external contact electrification with the dielectric layer.Under 0-50%stretching both parallel and perpendicular to the channel directions,the SOTT retains great output performance.After being stretched to 50%for thousands of cycles,the SOTT can survive with excellent stability.Moreover,the SOTT can be conformably attached to the human hand,which can be used for tactile signal perception in human-machine interaction and for controlling smart home devices and robots.This work has realized a stretchable tribotronic transistor as the tactile sensor for smart interaction,which has extended the application of tribotronics in the human-machine interface,wearable electronics,and robotics. | Junqing Zhao Tianzhao Bu Xiaohan Zhang Yaokun Pang Wenjian Li Zhi Zhang Guoxu Liu Zhong Lin Wang Chi Zhang | 2020 | Research2020，，1： | 4 |
| 10 | Surface disorder engineering in ZnCdS for cocatalyst free visible light driven hydrogen production显示文摘Metal chalcogenide solid solution,especially ZnCdS,has been intensively investigated in photocatalytic H_(2) generation due to their cost-effective synthetic procedure and adjustable band structures.In this work,we report on the defect engineering of ZnCdS with surface disorder layer by simple room temperature Li-ethylenediamine(Li-EDA)treatment.Experimental results confirm the formation of unusual Zn and S dual vacancies,where rich S vacancies(Vs)served as electron trapping sites,meanwhile Zn vacancies(Vzn)served as hole trapping sites.The refined structure significantly facilitates the photo charge carrier transfer and improves photocatalytic properties of ZnCdS.The disordered ZnCdS shows a highest photocatalytic H_(2) production rate of 33.6 mmol·g^(-1)·h^(-1) under visible light with superior photocatalytic stabilities,which is 7.3 times higher than pristine ZnCdS and 7 times of Pt(1 wt.%)loaded ZnCdS. | Enna Ha Shuhong Ruan Danyang Li Yuanmin Zhu Yanping Chen Jiangyuan Qiu Zhaohui Chen Tingting Xu Jingyun Su Luyang Wang Junqing Hu | 2022 | Nano Research2022，15，2： | 3 |
| 11 | Biomimetic synthesis of nanovesicles for targeted drug delivery显示文摘Targeted drug delivery to the site of disease is of both fundamental and practical importance in the development of personalized and precision nanomedicine.How to design a drug carrier that can specifically deliver drugs to tumors and other cell populations has long been a formidable challenge in clinical practice.With the development of nanotechnology,increasing effort has been dedicated to exploring the application of many nanoformulations in biology and medical science,such as nanoparticles, | Zhao Lei Junqing Wang Peng Lv Gang Liu | 2018 | Science Bulletin2018，63，11： | 3 |
| 12 | Comprehensive test stand for high-intensity cyclotron development显示文摘A comprehensive test stand for high-intensity cyclotron development,a 10 MeV 430 μA cyclotron,has been successfully constructed at China Institute of Atomic Energy (CIAE) for the experimental verification of the viability of a 100 MeV high-intensity cyclotron (CYCIAE-100) being constructed at CIAE.The verification includes the overall design technology,detail design and engineering technology for the crucial parts of the machine,e.g.main magnet and beam diagnostics.It will also pave the way for future enhancement of the beam intensity.The test stand consists of a H-ion source,axial injection system,central region,main magnet and coil,RF resonator,stripping extraction,and auxiliary systems,which include the RF power amplifier,high voltage and DC power supplies,electric apparatus,beam diagnostics,control,vacuum,water cooling,pneumatic system,and safety interlock.This paper presents the work regarding the design and sub-system development of the test sand,and the results of the beam commissioning of the machine. | ZHANG TianJue LI ZhenGuo CHU ChengJie XING JianSheng GUAN FengPing ZHONG JunQing JI Bin GE Tao YIN ZhiGuo HOU ShiGang PAN GaoFeng YAO HongJuan LU YinLong WANG ZhenHui WU LongCheng LIN Jun JIA XianLu WEI SuMin WEN LiPeng WANG Feng XIA Le CAI HongRu XIE HuaiDong CHEN RongFan ZHANG Yan ZHANG SuPing LIU GengShou ZOU Jian AN ShiZhong YANG JianJun BI YuanJie YANG Fang | 2011 | Chinese Science Bulletin2011，56，3： | 3 |
| 13 | Advanced noble-metal-free bifunctional electrocatalysts for metal-air batteries显示文摘The sluggish reaction kinetics at the oxygen cathode is one of the important issues hindering the commercialization of the metal-air batteries.Although the noble metal can be used as the high-efficiency electrocatalyst to solve the problems to some extent,the high cost and scarcity of these noble-metal catalysts have limited their application in electrocatalysis.In this review,we discussed the mecha-nisms of the ORR and OER,and proposed the principles for the bifunctional electrocatalysts firstly,and then the state-of-the-art bifunctional catalysts,including carbon-based materials and transition-metal-based materials.On the basis of that,the self-supporting 3D noble-metal-free bifunctional ORR/OER catalysts were also discussed.Finally,the perspectives for the bifunctional electrocatalysts were discussed. | Wenhao Tang Boya Li Kewei Teng Xiaodong Wang Ruiping Liu Mengwei Wu Lei Zhang Pengfei Ren Junqing Zhang Ming Feng | 2022 | Journal of Materiomics2022，8，2： | 2 |
| 14 | Manufacturing-oriented BOM Reconfiguration Method显示文摘Bill of material (BOM) structures describe the component structure of a product.It is used and processed in the whole product lifecycle,and is the bridge for the product data integration among enterprise application.In the process of product development,product model is evolving and BOM is also changed.To keep the data among BOM views integrate,accurate and consistent,a general model of weighted diagraph of product BOM is developed.By establishing BOM structure model and defining the mapping rules of Virtual Component,Successive Component,Middle Component and Collaborative Component,an algorithm for BOM structure mapping is proposed based on single source of product data (SSPD).According to BOM multi-view mapping and SSPD,an integration model and application framework of the product design and the manufacturing process is given.Final- ly,a BOM management system named BomMan is provided,which indicates the validity and feasibility of this method.Thus, the reconfiguration from EBOM to MBOM could be realized. | YAN Hui WANG Zhongqi HAO Guangke YIN Junqing (Institute of Mechanical Engineering,Northwestern Polytechnical University,Xi’an 710072,China | 2006 | 武汉理工大学学报2006，28，S2： | 2 |
| 15 | Alteration of sperm protein profile induced by cigarette smoking显示文摘香烟吸烟与更低的精液质量被联系,但是香烟吸烟怎么改变精液质量,仍然保持不清楚。这研究的目的是屏蔽在有到香烟的每日的暴露的老鼠的精子的表示蛋白质吸的差别。2D 胶化电气泳动(2DE ) 和集体 spectrometry (MS ) 分析显示出的结果老鼠精子蛋白质侧面被香烟吸烟改变。并且对应于表示的差别的 22 最丰富的蛋白质在精子的 2DE 胶化看到样品被识别。这些蛋白质基于他们的功能被分类进不同的组,例如精力新陈代谢,复制,和结构的分子。而且,五蛋白质(Aldoa, ATP5a1, Gpx4, C,和 Spatc1 ) 的 2DE 和 MS 结果被西方的污点分析和反向的 transcriptase 聚合酶链反应验证。结果证明除了 Spatc1,另外的四蛋白质显示出在吸烟的组和控制组之间的统计上重要的不同蛋白质层次(P < 0.05 ) 。三基因(Aldoa, Gpx4,和 Spatc1 ) 的表达式是显著地不同的(P < 0.05 ) 在在吸烟的组和控制组之间的抄写水平。另外,在从 30 个男吸烟者和 30 个不抽烟的人的人的精子样品的五蛋白质(Aldoa, ATP5a1, Spatc1, C,和 Gpx4 ) 被西方的污点分析检测。与精力生产被联系的二蛋白质(Aldoa 和 C ) 被发现显著地被改变,建议这些蛋白质可以是为吸在精子的风险的评估的潜在的诊断标记。这些蛋白质的进一步的学习可以提供卓见进在吸人位于不孕下面的病原的机制。 | Xiaohui Chen Wangjie Xu Maohua Miao Zijue Zhu Jingbo Dai Zhong Chen Peng Fang Junqing Wu Dongsheng Nie Lianyun Wang Zhaoxia Wang Zhongdong Qiao Huijuan Shi | 2015 | Acta Biochimica et Biophysica Sinica2015，47，7： | 2 |
| 16 | Modeling and Energy Efficiency Analysis of Thermal Power Plant with High Temperature Thermal Energy Storage(HTTES)显示文摘This paper presents the recent research on the study of the strategies for the flexible operation of the thermal power plant to meet the requirement of load balance. The study aimed to investigate the feasibility of bringing the High Temperature Thermal Energy Storage(HTTES) to the thermal power plant steam-water cycle, to identify the suitable HTTES in the cold(hot) section of the reheating pipeline and to test the efficiency of the HTTES integration to increase the flexibility of peak shaving and energy efficiency via thermal power plant with HTTTES modelling and simulation. Thermoflex was adopted to perform the simulation and a 300 MW subcritical coal-fired power plant model was implemented onto the software platform. The simulation results show that it is feasible to extract steam from the steam turbine to charge the HTTES, and to discharge the stored thermal energy back to the power generation process, and to analyse the improved capability of the plant flexible operation with HTTES. Then the study was extended to analyse the effect of thermal energy temperature, the opening of the regulating valve, and the pipeline pressure loss aspects on thermal efficiency of the whole plant. The study is beneficial to achieve more economic operation of the thermal power plant with HTTES integration. It is concluded that the introduction of the HTTES can improve the consumption of wind power, and these ideas and methods for solving the energy consumption of the renewable energy and reducing the peak energy consumption are provided. | ZHANG Hongwei LIANG Wenbin LIU Junqing WANG Jie | 2020 | Journal of Thermal Science2020，29，4： | 2 |
| 17 | Treatment of Unresectable Advanced Gastric Cancer Using lodine-125 Brachytherapy显示文摘OBJECTIVE The purpose of the study was to examine the efficacy of treating patients with advanced gastric cancer using iodine -125 (125I) brachytherapy. METHODS Ten patients with unresectable advanced gastric cancer were selected based on their pattern of CT scans. We utilized a brachytherapy planning system to determine the distribution of the 125I seeds, their activity and quantity. The matched peripheral dose (MPD) was 110-135 Gy. 125I seeds were implanted in a single plane or biplane by an intraoperative small incision or percutaneous puncture. The post- operative hemogram, CT, KPS, pain-relieving period and survival period were recorded. RESULTS One patient developed a complete response (CR), 4 patients a partial response (PR), 3 patients showed no change (NC) and 2 pa- tients developed progressive disease (PD). The overall response rate (CR+PR) was 50% (5/10). The pain-relieving rate was 89% (8/9). The pa- tients’ appetite and KPS were improved. The longest survival period was 10 months and median life span was 4 months. There were 8 patients whose seeds fell off resulting in an expulsion rate of 3.8% (26/692). The patients showed 0-1 degree acute radio-therapeutic side-effects without other symptoms such as abdominal pain, vomitus cruentes or intestinal obstruction etc. CONCLUSION Applying 125I implantation to treat advanced gastric can- cer with a reasonable seed distribution can significantly improve clinical symptoms and their quality of life. The radioactive damage is mild. This method can be used as an important supplementary treatment for unre- sectable advanced gastric cancer. | Juan Wang Aixia Sui Yitao Jia Binjian Xu Liang Wei Junqing Chen Wenjiang Shen | 2006 | Chinese Journal of Clinical Oncology2006，3，3： | 2 |
| 18 | Prognostic significance of subclassification of pT2 gastric cancer: A retrospective study of 847 patients显示文摘 | Yang Lu Caigang Liu Ruishan Zhang Hua Li Ping Lu Feng Jin Huimian Xu Shubao Wang Junqing Chen | 2008 | Surgical Oncology2008，，4： | 1 |
| 19 | A specific genomic organization and a novel promoter sequence for both ZP2 and ZP3 gene expressions in the Pingxiang red transparent crucian carp, Carassius auratus var. pingxiangnensis显示文摘 | Jianwu Shi Kou Peng Junqing Sheng Junhua Wang Weijia Yi Haijun Wu Qing Gu Yijiang Hong | 2013 | Comparative Biochemistry and Physiology - Part D:2013，，4： | 1 |
| 20 | Nano silver oxide (AGO) as a super high charge/discharge rate cathode material for rechargeable alkaline batteries 显示文摘 | Junqing Pan Yanzh Zihao Wang | 2007 | Journal of Materials Chem- istry2007，17，： | 1 |
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