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| 1 | Holistic Innovation:An Emerging Innovation Paradigm显示文摘This paper systematically reviews the current typical innovation paradigms worldwide and their shortcomings.Based on eastern wisdom and best innovation practices,this paper introduces a new paradigm of innovation,holistic innovation(HI).It provides a definition and theoretical framework for HI,discusses its connotations,and summarizes the theoretical contribution and policy implications.HI is total and collaborative innovation driven by strategic vision.This new innovation paradigm is a complex of strategic innovation,collaborative innovation,total innovation,and open innovation,which reflects wisdom from the Chinese context and Eastern culture.The four core elements of holistic innovation,“strategic,”“total,”“open,”and“collaborative,”are inter-related with an organic integration with the helix of HI.HI is an original innovation paradigm that conforms to the needs of firms'technological innovation management in the strategic innovation era and supports the implementation of the Innovation-Driven Development Strategy.It also helps China's enterprises build global innovation leadership and improves national innovation ability.Finally,it optimizes the innovation policy design and action mindset to achieve global peace and sustainable development. | Jin Chen Ximing Yin Liang Mei | 2018 | International Journal of Innovation Studies2018，2，1： | 3 |
| 2 | Could more innovation output bring better financial performance?The role of financial constraints显示文摘Innovation scholars highlight the economic benefits to firms,while research findings on the relationship between innovation output and economic returns remain mixed.In this study,we develop the profiting from innovation(PFI)framework and address the crucial role of financial constraints in the relationship between innovation output and financial performance.We argue that the liability of newness differentiates firms’financial performance during the commercialization of innovation,leading to a U-shaped relationship between firms’innovation output and financial performance.We further document the moderating impact of individual financial constraints(IFC)and market-based financial constraints(MFC)on this curvilinear relationship.Empirical tests based on the 142,972 firm-year observations of the multi-source dataset of Chinese manufacturing firms from 1999–2009 support our hypotheses.The additional analysis shows that non-state-owned enterprises and small and medium enterprises benefit more from the synergistic effect of reductions of IFC and MFC than state-owned enterprises and large firms.Our study enriches the literature of the PFI framework by uncovering the mechanism between innovation output and economic returns where financial constraints play an essential role.To the best of our knowledge,we are among the first to investigate the processes and mechanisms between innovation output and financial performance,generating novel insights for business practitioners and policymakers. | Benlu Hai Ximing Yin Jie Xiong Jin Chen | 2022 | Financial Innovation2022，8，1： | 3 |
| 3 | A novel akermanite/poly (lactic-co-glycolic acid) porous composite scaffold fabricated via a solvent casting-particulate leaching method improved by solvent self-proliferating process显示文摘Desirable scaffolds for tissue engineering should be biodegradable carriers to supply suitablemicroenvironments mimicked the extracellular matrices for desired cellular interactions and to providesupports for the formation of new tissues. In this work, a kind of slightly soluble bioactiveceramic akermanite (AKT) powders were aboratively selected and introduced in the PLGA matrix,a novel L-lactide modified AKT/poly (lactic-co-glycolic acid) (m-AKT/PLGA) composite scaffold wasfabricated via a solvent casting-particulate leaching method improved by solvent self-proliferatingprocess. The effects of m-AKT contents on properties of composite scaffolds and on MC3T3-E1 cellularbehaviors in vitro have been primarily investigated. The fabricated scaffolds exhibited threedimensionalporous networks, in which homogenously distributed cavities in size of 300–400 lmwere interconnected by some smaller holes in a size of 100–200 lm. Meanwhile, the mechanicalstructure of scaffolds was reinforced by the introduction of m-AKT. Moreover, alkaline ionic productsreleased by m-AKT could neutralize the acidic degradation products of PLGA, and the apatitemineralizationability of scaffolds could be largely improved. More valuably, significant promotionson adhesion, proliferation, and differentiation of MC3T3-E1 have been observed, which implied thecalcium, magnesium and especially silidous ions released sustainably from composite scaffoldscould regulate the behaviors of osteogenesis-related cells. | Yao Deng Mengjiao Zhang Xianchun Chen Ximing Pu Xiaoming Liao Zhongbing Huang Guangfu Yin | 2017 | Regenerative Biomaterials2017，4，4： | 3 |
| 4 | Thermal conductivity of diamond/copper composites with a bimodal distribution of diamond particle sizes prepared by pressure infiltration method显示文摘The thermal conductivity of diamond/copper composites with bimodal particle sizes was studied.The composites were prepared through pressure infiltration of liquid copper into diamond preforms with a mixture of 40 and 100 μm-size diamonds.The permeability of the preforms with different coarse-to-fine volume ratios of diamonds was investigated.The thermal conductivity of the diamond/copper composites with bimodal size distribution was compared to the theoretical value derived from an analytical model developed by Chu.It is predicted that the diamond/copper composites could reach a higher thermal conductivity and their surface roughness could be improved by applying bimodal diamond particle sizes. | CHEN Chao GUO Hong CHU Ke YIN Fazhang ZHANG Ximing HAN Yuanyuan FAN Yeming | 2011 | Rare Metals2011，30，4： | 2 |
| 5 | Localized delivery of growth factors for angiogenesis and bone formation in tissue engineering显示文摘 | Yan Bai Guangfu Yin Zhongbing Huang Xiaoming Liao Xianchun Chen Yadong Yao Ximing Pu | 2013 | International Immunopharmacology2013，，2： | 1 |
| 6 | Fabrication of extracellular matrix-coated conductive polypyrrolepoly(L-lactide)fiber-films and their synergistic effect with(nerve growth factor)/(epidermal growth factor) on neurites growth显示文摘Non-nerve cell-derived extracellular matrix(ECM)wa s coated on the aligned porous polypyrrole-poly(Llactide)(PPy-PLLA)fiber-films with the conductivity of^12 mS/m via L929 cells culture and lysing,resulting in^10%increase of PC12 cells attachment and^26μm increase of neurites length.The neurite length of^149μm in EGF/NGF group(optimal concentration radio of 12.5/50(ng/mL))on aligned and ECM-conjugated fiber-films was significantly larger than^94μm in only NGF group(50 ng/mL),confirming the synergy of EGF,NGF and aligned ECM-conjuaged PPy-PLLA fibers.When differentiated PC12 cells were exerted electrical stimulation(ES)of 100 mV/cm for 4 h/day in 2 day through ECM-PPyPLLA fiber-films,their neurite length reached to^251μm,significantly larger than^149μm of group without ES,due to the higer expression of related neural proteins in ES group.A simple mechanism was proposed to analyze synergistical effect of ECM,EGF,NGF on axons adhesion and elongation along the aligned ECM-coated fibers under ES condition. | Ximing Pu Xingxing Zhou Zhongbing Huang Guangfu Yin Xianchun Chen | 2020 | Chinese Chemical Letters2020，31，5： | 1 |
| 7 | Spin filtering in transition-metal phthalocyanine molecules from first principles显示文摘用第一原则的计算,基于密度,功能的理论和 nonequilibrium 草地工作形式主义,我们通过金属酞毒学习了旋转运输(MPc, M=Ni, Fe,公司, Mn, Cr ) 分子与金 nanowire 电极连接了。我们发现 MnPc, FePc,和 CrPc 分子的设备展出与 CoPc 和 NiPc 相比过滤效果的完美的旋转。而且,否定微分抵抗出现在 FePc 分子的设备。在不同偏爱电压的传播系数进一步被介绍理解这现象。这些结果将在为未来纳米技术设计设备是有用的。 | Li Niu Huan Wang Lina Bai Ximing Rong Xiaojie Liu Hua Li Haitao Yin | 2017 | Frontiers of physics2017，12，4： | 1 |
| 8 | Firm innovation system: Paths for enhancing corporate indigenous innovation capability显示文摘To obtain a sustainable competitive advantage and achieve global innovation leadership,firms in China and other emerging economies must develop strong indigenous innovation capabilities through the coevolution of strategy,organization,resources,and culture.Drawing on current innovation management theories and practices,this study proposes four systematic paths for improving firm innovation systems(FISs),namely,the R&D-based internal collaborative FIS,the strategic vision-driven FIS,the open and user-driven FIS,and the holistic ecosystemdriven FIS.This study contributes to the systematic approach for enhancing corporate indigenous innovation capability based on FISs.Moreover,this study provides theoretical and practical insights for China as well as other developing countries to cultivate world-class enterprises and build an innovative nation. | Jin CHEN Ximing YIN Jizhen LI | 2020 | Frontiers of Engineering Management2020，7，3： | 1 |
| 9 | Effects of combinations of BMP-2 with FGF-2 and/or VEGF on HUVECs angiogenesis in vitro and CAM angiogenesis in vivo显示文摘 | Yan Bai Yue Leng Guangfu Yin Ximing Pu Zhongbing Huang Xiaoming Liao Xianchun Chen Yadong Yao | 2014 | Cell and Tissue Research2014，，1： | 1 |
| 10 | MBG/PGA-PCL composite scaffolds provide highly tunable degradation and osteogenic features显示文摘It remains a challenge to achieve satisfactory balance between biodegradability and osteogenic capacity in biosynthetic bone grafts.In this study,we aimed to address this challenge by incorporating mesoporous bioactive glass(MBG)into poly(caprolactone-co-glycolide)(PGA-PCL)at gradient ratios.MBG/PGA-PCL(PGC/M)scaffolds with MBG incorporation ratio at 0,10%,25%and 40%(PGC/M0-40)were synthesized using a modified solvent casting-particulate leaching method,and their physiochemical and biological properties were comprehensively evaluated.PGC/M scaffolds exhibited highly perforated porous structure with a large-pore size of 300-450μm,with ordered MBGs of around 6.0 nm mesopores size uniformly dispersed.The increase in MBG incorporation ratio significantly improved the scaffold surface hydrophilicity,apatite-formation ability and pH stability,increased the weight loss rate while insignificantly influenced the molecular chains degradation of PGA-PCL component,and facilitated the attachment,spreading,viability and proliferation of rat bone marrow stromal cells(rBMSCs)on scaffolds.Moreover,rBMSCs cultured on PGC/M10-40 scaffolds demonstrated enhanced ALP activity and osteogenesis-related gene expression in a MBG dose-dependent manner as compared with those cultured on PGC/M0 scaffolds.When implanted to the rat cranial bone defect,PGC/M25 and PGC/M40 scaffolds induced significantly better bone repair as compared to PGC/M0 and PGC/M10 scaffolds.Besides,the biodegradability of PGC/M scaffolds correlated with the MBG incorporation ratio.These data suggested this novel PGC/M scaffolds as promising bone repair biomaterial with highly tunable hydrophilicity,bioactivity,cytocompatibility,osteogenic activity as well as biodegradability. | Jiangfeng Li Chunyi Wang Guoxing Gao Xing Yin Ximing Pu Bing Shi Yang Liu Zhongbing Huang Juan Wang Jingtao Li Guangfu Yin | 2022 | Bioactive Materials2022，7，9： | 0 |
| 11 | Fabrication of carboxylic graphene oxide-composited polypyrrole film for neurite growth under electrical stimulation显示文摘An aligned composite film was fabricated via the deposition of carboxylic graphe ne oxide(C-GO)and polypyrrole(PPy)nano particles on alig ned poly(L-lactic acid)(PLLA)fiber-films(named as C-GO/PPy/PLLA),which has the core(PLLA)-sheath(C-GO/PPy)structure,and the composition of C-GO(~4.8 wt.%of PPy sheath)significantly enhanced the tensile strength and the conductivity of the PPy/PLLA film?Especially,after 4 weeks of immersion in the PBS solution,the conductivity and the tensile strength of CGO/PPy/PLLA films still remained-6.10 S/cm and 28.9 MPa,respectively,which could meet the need of the sustained electrical stimulation(ES)therapy for nerve repair.Moreover,the neurite length and the neurite alignment were significantly in creased through exerting ES on C-GO/PPy/PLLA films due to their sustained conductivity in the fluid of cell culture.These results indicated that C-GO/PPy/PLLA with sustained conductivity and mechanical property possessed great potential of nerve repair by exerting lasting-ES. | Chaoyuan LIU Zhongbing HUANG Ximing PU Lei SHANG Guangfu YIN Xianchun CHEN Shuang CHENG | 2019 | Frontiers of Materials Science2019，13，3： | 0 |
| 12 | Manipulating electromagnetic radiation of one-way edge states by magnetic plasmonic gradient metasurfaces显示文摘We theoretically and experimentally demonstrate that magnetic plasmonic gradient metasurfaces(GMSs) can convert a spatially propagating wave to a one-way edge state or vice versa with high efficiency. Consisting of an array of ferrite rods with a rotation gradient introduced to the rod dimers in the unit cell, GMSs can covert an incident wave beam to a one-way edge state with efficiency over 77%, and almost fully radiate into free space from the one-way edge state. The phenomenon arises from the unidirectional coupling of the spatial electromagnetic wave with magnetic plasmonic GMSs, which is evidenced from the photonic band diagrams of the edge state.The one-way edge state can radiate to or be excited from air with different angles by either engineering the gradient of the GMSs or tuning the bias magnetic field. By designing magnetic plasmonic GMSs with more exquisite configurations, we can expect many more nonreciprocal properties, adding additional freedom in manipulating electromagnetic waves. | Huabing Wu Xiang Xi Ximing Li Yin Poo Shiyang Liu Rui-Xin Wu | 2022 | Photonics Research2022，10，2： | 0 |
| 13 | China's Scientific and Technological Innovation Strategy under the New Pattern of Development显示文摘Innovation is the driver and accelerator for high-quality economic development and the transformation and upgrading of enterprises.At present,the world is undergoing significant changes unseen over the last century.Faced with the new world economic pattern and the new international relations in the postpandemic era,China should systematically clarify the prominent problems with the current scientific and technological(S&T)system,and establish new technological innovation strategies in the new era and new economic landscape,which are of great significance.Especially in the context of the new pattern of development,it is greatly highlighted how to systematically lower over-dependence on core technologies and resolve bottleneck problems with core technology arising from excessive attention to the international economic flows.Based on the medium-and long-term strategic background of the current new pattern of development,this paper explores the prominent problems of the S&T innovation system under the background of the new pattern of development from the perspectives of innovation policy system,regional innovation system,and enterprise innovation mode.Meanwhile,the paper believes that the innovation guidance system under the new pattern of development needs to be realized based on the guidance of the new innovation strategy of'opening thinking based on bottom lines and comprehensive indigenous innovation,'and also the three leading paths of holistic innovation guided by the new pattern of the whole national institutional system,the future industry,and the world-class enterprises.Only in this way can China become a power in terms of S&T innovation in the world. | CHEN Jin YANG Zhen YIN Ximing | 2022 | China Economic Transition2022，5，3： | 0 |
| 14 | Fabrication of doxorubicin and chlorotoxin-linked Eu-Gd2O3 nanorods with dual-model imaging and targeted therapy of brain tumor显示文摘It is urgent to find a technology accurately to better diagnose and treat to brain tumor.Eu-doped Gd2 O3 nanorods(Eu-Gd2 O3 NRs)with paramagnetic and fluorescent properties were conjugated with doxorubicin(Dox)and chlorotoxin(CTX)via PEGylation,hydrazone bond and sulfur bond(named as CTXNRs-Dox),and these NRs could release more Dox in lower pH environment.The results of cell experiments indicated that CTX-NRs-Dox had obvious targeting and toxic effects on U251 cells,as well as good fluorescence imaging behavior.The orthotopic glioma-transplanted mice models were constructed via the intracranial injection of glioma cells(U87 MG).The result of experiments after the tail-vein injection of the prepared NRs suggested that CTX-NRs-Dox could target to brain tumors via the long-time blood circulation,leading to their obvious contrast enhancement of MR imaging of the intracranial tumor and their significant inhibitory effect on the growth and metastasis of brain tumors.A mechanism of synergistic effect of CTX-NRs-Dox on targeting and inhabiting the brain tumor was proposed.Our research suggested that CTX-NRs-Dox had potential application prospect in the detection and treatment of glioma. | Weina Zhang Zhongbing Huang Ximing Pua Xianchun Chen Guangfu Yin Lei Wang Fei Zhang Fabao Gao | 2020 | Chinese Chemical Letters2020，31，1： | 0 |
| 15 | Systematic Transformations of Entrepreneurship in the New Era: The Commitment to Benefit Corporation Entrepreneurship显示文摘Since the 18th National Congress of the Communist Party of China(CPC)was held in 2012,China has comprehensively started shifting economic and social development from the traditional way of extensive growth,driven by labor,land,and capital,to innovation-driven high-quality development.During the transformation process,intricate economic and social contradictions have arisen one after another. | CHEN Jin YANG Zhen YIN Ximing | 2022 | Frontiers of Business Research in China2022，16，3： | 0 |
| 16 | Preparation,properties and biomedical applications progress of 1D magnetic nanomaterials with iron显示文摘1D magnetic nanomaterials with iron,with the special physical properties and biological behaviour,have been found to possess the great promising applications in many fields.In this review,the components,structure,physicochemical properties,biocompatibility and in vitro and in vivo biomedical functions of magnetic nanowires(MNWs),nanorods(MNRs)with iron are summarised,especially their anisotropy shape and magnetism result in their many applications in biodetections and medical treatment fields.The potential future functions of these 1D magnetic nanomaterials compared to magnetic nanoparticles also is discussed by highlighting the possibility of integration with other metal-compositions or bio-compositions and with existing biotechnology as well as by point-ing out their specific properties.Current limitations in the property improvement and issues related with the outcome of the MNRs in the body are also summarised in order to address the remaining challenge for the extended biomedical functions of MNRs in the clinical application field. | Zhongbing Huang Juan Wang Ximing Pu Guangfu Yin | 2023 | Biosurface and Biotribology2023，9，4： | 0 |
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