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| 1 | Has split share structure reform improved the efficiency of the Chinese stock market? 显示文摘 | Xindan Li Bing Zhang | 2011 | Applied Economics Letters2011，，： | 1 |
| 2 | Design of Compressor Displacement Testing System for Air-conditioner of Air-conditioned Passenger Train显示文摘 | Li Hua Qi Xindan | 2009 | IEEE Computer Society2009，，47： | 1 |
| 3 | Price discovery for copper futures ininformationally linked markets 显示文摘 | Li Xindan Zhang Bing | 2009 | Applied Economics Let-ters2009，16，15： | 1 |
| 4 | A novel clustered SPIO nanoplatform with enhanced magnetic resonance T2 relaxation rate for micro-tumor detection and photothermal synergistic therapy显示文摘Construction of micro tumor sensitive theranostic nanoagents that can increase the accuracy of imaging diagnosis and boost the therapeutic efficacy has been demonstrated for a promising approach for diagnosis and treatment of cancer.Herein,we reported a novel super-paramagnetic iron oxide(SPIO)based nanoplatform that possess significantly enhanced magnetic resonance property and photothermal effect for tumor theranostic purpose.This polyethylene glycol with four phenylboronic acid(PEG-B4)/CNTs@porphyrin(ph)/SPIO(BCPS)nanoplatform was simply prepared via integrated SPIO,ph,and a novel dendrimer with PEG liner and four PBA groups(PEG-B4)on the surface of carbon nanotubes(CNTs).Subsequently,a significant T2 relaxation rate enhanced can be achieved by the reduced accessibility of water to SPIO clustering.Moreover,the synergetic enhanced photothermal from BCPS nanoplatform contributed to better photothermal effect for cancer therapy.Furthermore,the targeting ability to sialic acid overexpressed tumor was further introduced from phenylboronic acid from PEG-B4.We showed that BCPS nanoplatform could not only selectively identify solid tumors and detect micro-sized metastatic tumor(1 mm)in the liver,but also effectively ablate tumors in a xenograft model,thereby achieving a complete cure rate of 100%at low laser dose.Our results highlight the potential of BCPS nanoplatform for accurate micro-tumor diagnosis and effective tumor therapy. | Hongwei Lu Yongjing Xu Ruirui Qiao Ziwei Lu Pin Wang Xindan Zhang An Chen Liming Zou Zhongling Wang | 2020 | Nano Research2020，13，8： | 1 |
| 5 | Three dimensional nilpotent singularity and Sil' nikov bifurcation显示文摘 | LI Xindan LIU Haifei | 2007 | Chaos Solitons and Fractals2007，31，1： | 1 |
| 6 | A Self‑Powered,Highly Embedded and Sensitive Tribo‑Label‑Sensor for the Fast and Stable Label Printer显示文摘Label-sensor is an essential component of the label printer which is becoming a most significant tool for the development of Internet of Things(IoT).However,some drawbacks of the traditional infrared label-sensor make the printer fail to realize the high-speed recognition of labels as well as stable printing.Herein,we propose a selfpowered and highly sensitive tribo-label-sensor(TLS)for accurate label identification,positioning and counting by embedding triboelectric nanogenerator into the indispensable roller structure of a label printer.The sensing mechanism,device parameters and deep comparison with infrared sensor are systematically studied both in theory and experiment.As the results,TLS delivers 6 times higher signal magnitude than traditional one.Moreover,TLS is immune to label jitter and temperature variation during fast printing and can also be used for transparent label directly and shows long-term robustness.This work may provide an alternative toolkit with outstanding advantages to improve current label printer and further promote the development of IoT. | Xindan Hui Zhongjie Li Lirong Tang Jianfeng Sun Xingzhe Hou Jie Chen Yan Peng Zhiyi Wu Hengyu Guo | 2023 | Nano-Micro Letters2023，15，2： | 1 |
| 7 | Highly selective removal of organic dyes from aqueous solutions with chitin beads entrapping rectorite显示文摘 | Guoxiang Li Daichan Lu Xindan Shi Mingyue Cai | 2014 | J. Appl. Polym. Sci2014，，20： | 1 |
| 8 | Clinical utility of PDX cohorts to reveal biomarkers of intrinsic resistance and clonal architecture changes underlying acquired resistance to cetuximab in HNSCC显示文摘Cetuximab is a widely used drug for treating head and neck squamous cell carcinomas(HNSCCs);however,it provides restricted clinical benefits,and its response duration is limited by drug resistance.Here,we conducted randomized“Phase II-like clinical trials”of 49 HNSCC PDX models and reveal multiple informative biomarkers for intrinsic resistance to cetuximab(e.g.,amplification of ANKH,up-regulation of PARP3).After validating these intrinsic resistance biomarkers in another HNSCC PDX cohort(61 PDX models),we generated acquired cetuximab resistance PDX models and analyzed them to uncover resistance mechanisms.Whole exome sequencing and transcriptome sequencing revealed diverse patterns of clonal selection in acquired resistant PDXs,including the emergence of subclones with strongly activated RAS/MAPK.Extending these insights,we show that a combination of a RAC1/RAC3 dual-target inhibitor and cetuximab could overcome acquired cetuximab resistance in vitro and in vivo.Beyond revealing intrinsic resistance biomarkers,our PDX-based study shows how clonal architecture changes underlying acquired resistance can be targeted to expand the therapeutic utility of this important drug to more HNSCC patients. | Yanli Yao Yujue Wang Lan Chen Zhen Tian Guizhu Yang Rui Wang Chong Wang Qi Wu Yaping Wu Jiamin Gao Xindan Kang Shengzhong Duan Zhiyuan Zhang Shuyang Sun | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 1 |
| 9 | A new reconiigurable modular robotic system with multimode locomotion ability显示文摘 | Zhao Jie Cui Xindan Zhu Yanhe | 2012 | International Journal2012，4，2： | 1 |
| 10 | Optimization of the cylindrical sieves for separating threshed rice mixture using EDEM显示文摘The design of the cylindrical sieve equipment used for the screening and separation of agricultural granular materials is mainly through the experimental method,which has the disadvantages of a long development cycle and high cost.To solve this problem,the discrete element method(DEM)was utilized to accurately build the particle models of threshed rice components(grains,shriveled grains,and short stalks),and simulated the separation of grains from the mixture in a cylindrical sieve.The influences of rotational speed(A),cylindrical sieve diameter(B),cylindrical sieve aperture(C),and inclinational angle(D)on screening cleaning rate,screening loss rate,and screening efficiency were investigated.Meanwhile,the optimal parameters of the cylindrical sieve were obtained using a central composite design(CCD)under response surface methodology(RSM).The results of CCD showed that the quadratic multinomial model is credible and revealed that the cylindrical sieve aperture has a significant impact on the screening characteristics.It is predicted that the optimal values for screening cleaning rate,loss rate,and efficiency were 97.84%,0.27%,and 85.38%,respectively,while A,B,C,and D were 23.6 r/min,297 mm,8.7 mm,and 2°,respectively.The experimental results using a real threshed rice mixture were found to be in good agreement with the optimal simulation results.This study proved a reliable research method and provides a design reference for the cylinder sieving systems for threshed rice or separation of other bulk material. | Jianbo Yuan Jufei Wang Hua Li Xindan Qi Yongjian Wang Chao Li | 2022 | International Journal of Agricultural and Biological Engineering2022，15，2： | 0 |
| 11 | Optimized design of the pneumatic precision seed-metering device for carrots显示文摘The small size, light weight, irregular shape, and impurities that characterize seed groups increase clogging tendencies in the traditional seed-metering device thereby making it difficult to achieve high-speed precision seeding. A pneumatic seed-metering device with good seed-filling performance for carrot was designed in this study. By analyzing the movement state of seeds in the device under the theoretical condition, it was concluded that the minimum critical negative pressure value of air chamber was 0.32 kPa, which provided a theoretical basis for simulation and testing. ANSYS 17.0 Software was used to simulate the shape of the seeding plate hole. By comparing the pressure, air flow stability between the suction surface and the plug removal surface of the convection field, it was concluded that the conical hole was optimal. A bench verification test was conducted on the device. The average qualified rate, missing rate, and replaying rate were 81.48%, 4.07%, and 14.45%, respectively, which provided a strong reference for the design of carrot precision seed-metering device. | Dinghao Feng Xinping Sun Hua Li Xindan Qi Yongjian Wang Samuel Mbugua Nyambura | 2023 | International Journal of Agricultural and Biological Engineering2023，16，6： | 0 |
| 12 | Genome-wide scan for oil quality reveals a coregulation mechanism of tocopherols and fatty acids in soybean seeds显示文摘Tocopherols(vitamin E)play essential roles in human health because of their antioxidant activity,and plantderived oils are the richest sources of tocopherols in the human diet.Although soybean(Glycinemax)is one of themain sources of plant-derived oil and tocopherol in the world,the relationship between tocopherol and oil in soybean seeds remains unclear.Here,we focus on dissecting tocopherol metabolism with the longterm goal of increasing a-tocopherol content and soybean oil quality.We first collected tocopherol and fatty acid profiles in a soybean population(>800 soybean accessions)and found that tocopherol content increased during soybean domestication.A strong positive correlation between tocopherol and oil content was also detected.Five tocopherol pathway–related lociwere identified using a metabolite genome-wide association study strategy.Genetic variations in three tocopherol pathway genes were responsible for total tocopherol content and composition in the soybean population through effects on enzyme activity,mainly caused by non-conserved amino acid substitution or changes in gene transcription level.Moreover,the fatty acid regulatory transcription factor GmZF351 directly activated tocopherol pathway gene expression,increasing both fatty acid and tocopherol contents in soybean seeds.Our study reveals the functional differentiation of tocopherol pathway genes in soybean populations and provides a framework for development of new soybean varieties with high a-tocopherol content and oil quality in seeds. | Danni Chu Zhifang Zhang Yang Hu Chao Fang Xindan Xu Jia Yuan Jinsong Zhang Zhixi Tian Guodong Wang | 2023 | Plant Communications2023，4，5： | 0 |
| 13 | S19W,T27W,and N33OY mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular basis显示文摘SARS-CoV-2 recognizes,via its spike receptor-binding domain(S-RBD),human angiotensin-converting enzyme 2(ACE2)to initiate infection.Ecto-domain protein of ACE2 can therefore function as a decoy.Here we show that mutations of S19W,T27W,and N330Y in ACE2 could individually enhance SARS-CoV-2 S-RBD binding.Y330 could be synergistically combined with either W19 or W27,whereas W19 and W27 are mutually unbeneficial.The structures of SARS-CoV-2S-RBD bound to the ACE2 mutants reveal that the enhan ced binding is mainly con tributed by the van der Waals interactio ns mediated by the aromatic side-chai ns from W19,W27,and Y330.While Y330 and W19/W27 are distantly located and devoid of any steric interference,W19 and W27 are shown to orient their side-chains toward each other and to cause steric conflicts,explai ning their in compatibility.Finally,using pseudotyped SARS-CoV-2 viruses,we dem on strate that these residue substitutions are associated with dramatically improved entry-inhibition efficacy toward both wild-type and antibody-resistant viruses.Taken together,our biochemical and structural data have delineated the basis for the elevated S-RBD binding associated with S19W,T27W,and N330Y mutations in ACE2,paving the way for potential application of these mutants in dinical treatment of COVID-19. | Fei Ye Xi Lin Zimin Che Fanli Yang Sheng Lin Jing Yang Hua Chen Honglu Sun Lingling Wang Ao Wen Xindan Zhang Yushan Dai Yu Cao Jingyun Yang Guobo Shen Li Yang Jiong Li Zhenling Wang Wei Wang Xiawei Wei Guangwen Lu | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 0 |
| 14 | Characterization of SARS-CoV-2 Omicron spike RBD reveals significantly decreased stability, severe evasion of neutralizing- antibody recognition but unaffected engagement by decoy ACE2 modified for enhanced RBD binding显示文摘Dear Editor,The recent-emerging Omicron variant(B.1.1.529 lineage)of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has raised serious public concern because of its rapid regional-and global-transmission.As of 11th January 2022,the Omicron variant has spread to 140 countries,territories or areas through infected air travelers,and the number is continuously increasing. | Sheng Lin Zimin Chen Xindan Zhang Ao Wen Xin Yuan Chongzhang Yu Jing Yang Bin He Yu Cao Guangwen Lu | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 0 |
| 15 | A biomimetic nanoplatform for customized photothermal therapy of HNSCC evaluated on patient-derived xenograft models显示文摘Cancer cell membrane(CCM)derived nanotechnology functionalizes nanoparticles(NPs)to recognize homologous cells,exhibiting translational potential in accurate tumor therapy.However,these nanoplatforms are majorly generated from fixed cell lines and are typically evaluated in cell line-derived subcutaneous-xenografts(CDX),ignoring the tumor heterogeneity and differentiation from inter-and intra-individuals and microenvironments between heterotopic-and orthotopic-tumors,limiting the therapeutic efficiency of such nanoplatforms.Herein,various biomimetic nanoplatforms(CCM-modified gold@Carbon,i.e.,Au@C-CCM)were fabricated by coating CCMs of head and neck squamous cell carcinoma(HNSCC)cell lines and patient-derived cells on the surface of Au@C NP.The generated Au@C-CCMs were evaluated on corresponding CDX,tongue orthotopic xenograft(TOX),immunecompetent primary and distant tumor models,and patient-derived xenograft(PDX)models.The Au@C-CCM generates a photothermal conversion efficiency up to 44.2% for primary HNSCC therapy and induced immunotherapy to inhibit metastasis via photothermal therapy-induced immunogenic cell death.The homologous CCM endowed the nanoplatforms with optimal targeting properties for the highest therapeutic efficiency,far above those with mismatched CCMs,resulting in distinct tumor ablation and tumor growth inhibition in all four models.This work reinforces the feasibility of biomimetic NPs combining modular designed CMs and functional cores for customized treatment of HNSCC,can be further extended to other malignant tumors therapy. | Qi Wu Lan Chen Xiaojuan Huang Jiayi Lin Jiamin Gao Guizhu Yang Yaping Wu Chong Wang Xindan Kang Yanli Yao Yujue Wang Mengzhu Xue Xin Luan Xin Chen Zhiyuan Zhang Shuyang Sun | 2023 | International Journal of Oral Science2023，15，1： | 0 |
| 16 | Robust and Tumor-Environment-Activated DNA Cross-Linker Driving Nanoparticle Accumulation for Enhanced Therapeutics显示文摘Agglomeration of therapeutic nanoparticles in response to tumor microenvironments is a promising approach to enhance drug accumulation and improve therapeutic efficacy.Cytosine-rich DNA sequences show potential as ideal cross-linkers to drive nanoparticle agglomeration because they can sensitively respond to weak acidity and form interchain folding.However,the in vivo application of DNA is generally limited by its poor biostability;as a consequence,modifications with unprotected DNA cross-linkers can enhance the accumulation of nanoparticles twofold at the tumor site.Facing this challenge,we have designed and developed a protection and tumor-environment activation strategy to enable the in vivo application of a DNA cross-linker.Specifically,reactive oxygen species(ROS)-responsive polyethylene glycol(PEG)was modified on the nanoparticle surface together with the DNA crosslinker,which protects DNA from degradation during the blood circulation;meanwhile,when arriving at the tumor site,the nanoparticles shed the PEG shell as a response to ROS to uncover and activate the DNA cross-linkers.Using this strategy,a sevenfold enhancement in tumor accumulation was achieved owing to both superior pH sensitivity and improved stability of DNA cross-linkers.Finally,significantly improved therapeutic efficacy in in vivo anticancer treatment was realized by using this agglomeration strategy driven by protected and stimuli-activated DNA cross-linkers. | Zhicong Chao Hongwei Lu Fan Xiao Chen Shao Zixiang Wei Jiantao Yu Xindan Zhang Li Lin Leilei Tian | 2020 | CCS Chemistry2020，2，5： | 0 |
| 17 | A recently evolved BAHD acetyltransferase,responsible for bitter soyasaponin A production,is indispensable for soybean seed germination显示文摘Soyasaponins are major small molecules that accumulate in soybean(Glycine max)seeds.Among them,type-A soyasaponins,fully acetylated at the terminal sugar of their C22 sugar chain,are responsible for the bitter taste of soybean-derived foods.However,the molecular basis for the acetylation of type-A soyasaponins remains unclear.Here,we identify and characterize Gm SSAc T1,encoding a BADH-type soyasaponin acetyltransferase that catalyzes three or four consecutive acetylations on type-A soyasaponins in vitro and in planta.Phylogenetic analysis and biochemical assays suggest that Gm SSAc T1 likely evolved from acyltransferases present in leguminous plants involved in isoflavonoid acylation.Loss-of-function mutants of Gm SSAc T1 exhibited impaired seed germination,which attribute to the excessive accumulation of null-acetylated type-A soyasaponins.We conclude that Gm SSAc T1 not only functions as a detoxification gene for high accumulation of type-A soyasaponins in soybean seeds but is also a promising target for breeding new soybean varieties with lower bitter soyasaponin content. | Jia Yuan Liya Ma Yan Wang Xindan Xu Rui Zhang Chengyuan Wang Wenxiang Meng Zhixi Tian Yihua Zhou Guodong Wang | 2023 | Journal of Integrative Plant Biology2023，65，11： | 0 |
| 18 | A Perspective:Electrospun Fibers for Repairing Spinal Cord Injury显示文摘Patients with spinal cord injury(SCI)are suffering disability and accompanying complications.Due to the complex biological processes and inhibitory microenvironment after SCI,advances in clinical treatment show obvious limitations for achieving a successful repair.Herein,we summarize recent advances in engineering strategies of using electrospun nanofibers to promote the neural regeneration and functional recovery after SCI.We firstly introduce the pathological mechanism of SCI and thus point out the challenges on the regeneration of the nerve.We then discuss the regenerative approaches by combining electrospun nanofibrous scaffolds with physical cues,biochemical cues(e.g.,cells,growth factors and other biomolecules),external stimuli,and supporting materials filling in the inner lumen of the scaffolds.All these strategies have indicated their potentials to enhance the efficacy of repairing the SCI.At last,we provide a perspective on the future direction for designing the electrospun nanofibrous scaffolds in combination with imaging systems to realize the in-situ monitoring of regeneration progress for further improving the treatment outcome. | ZHANG Xindan GONG Bowen ZHAI Jiliang ZHAO Yu LU Yonglai ZHANG Liqun XUE Jiajia | 2021 | Chemical Research in Chinese Universities2021，37，3： | 0 |
| 19 | High performance wide frequency band triboelectric nanogenerator based on multilayer wave superstructure for harvesting vibration energy显示文摘Efficiently converting the random vibration energy widely existed in human activities and natural environments into electricity is significant to the local power supply of sensor nodes in the internet of things.However,the conversion efficiency of energy harvester is relatively low due to the limitation of device’s intrinsic frequency.In this work,a multi-layered,wavy super-structuredtriboelectric nanogenerator(SS-TENG)is designed,whose output performances can be greatly promoted by combining the charge excitation mechanism.The steel sheet acts not only as an electrode but also as a supporter for the overall frame of SSTENG,which effectively improves the space utilization rate and results in a volume charge density up to 129 mC·m^(−3).In addition,the resonant frequency width of the SS-TENG can be widened by changing the parameters of the superstructure.For demonstration,the SS-TENG can sustainably drive two temperature and humidity sensors in parallel by harvesting vibration energy.This work may provide an effective strategy for harvesting vibration energy and broadening frequency response. | Song Tang Wenxuan Chang Gui Li Jianfeng Sun Yan Du Xindan Hui Qian Tang Zhihao Hu Jiaqi Li Jie Chen Wencong He Hengyu Guo | 2023 | Nano Research2023，16，5： | 0 |
| 20 | Optimization of a three-row air-suction Brassica chinensis precision metering device based on CFD-DEM coupling simulation显示文摘This study aimed to optimize a three-row air-suction Brassica chinensis precision metering device to improve the low seeding performance.ANSYS 17.0 Software was used to analyze the effect of different numbers of suction holes and different suction hole structures on the airflow field.It was found that a suction hole number of 60 was beneficial to the flow field stability and a conical hole structure was beneficial to the adsorption of seeds.Box-Behnken design experiments were carried out with negative pressure,rotational speed,and hole diameter as the experimental factors.The optimal parameter combination was achieved when the negative pressure was 3.96 kPa,the rotational speed of the seeding plate was 1.49 rad/s and the hole diameter was 1.10 mm.The qualification rate of inner,middle,and outer rings were 87.580%,90.548%,and 90.117%,respectively,and the miss seeding rate of inner,middle,and outer rings were 10.915%,7.139%,and 5.920%,respectively. | Xinping Sun Hua Li Xindan Qi Dinghao Feng Jianqi Zhou Yongjian Wang Samuel Mbugua Nyambura Xiaoyu Zhang Xi Chen | 2023 | International Journal of Agricultural and Biological Engineering2023，16，3： | 0 |
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