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| 1 | Development and validation of an endoscopic images-based deep learning model for detection with nasopharyngeal malignancies显示文摘Background:Due to the occult anatomic location of the nasopharynx and frequent presence of adenoid hyperpla-sia,the positive rate for malignancy identification during biopsy is low,thus leading to delayed or missed diagnosis for nasopharyngeal malignancies upon initial attempt.Here,we aimed to develop an artificial intelligence tool to detect nasopharyngeal malignancies under endoscopic examination based on deep learning.Methods:An endoscopic images-based nasopharyngeal malignancy detection model(eNPM-DM)consisting of a fully convolutional network based on the inception architecture was developed and fine-tuned using separate training and validation sets for both classification and segmentation.Briefly,a total of 28,966 qualified images were collected.Among these images,27,536 biopsy-proven images from 7951 individuals obtained from January 1st,2008,to December 31st,2016,were split into the training,validation and test sets at a ratio of 7:1:2 using simple randomiza-tion.Additionally,1430 images obtained from January 1st,2017,to March 31st,2017,were used as a prospective test set to compare the performance of the established model against oncologist evaluation.The dice similarity coef-ficient(DSC)was used to evaluate the efficiency of eNPM-DM in automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images,by comparing automatic segmentation with manual segmenta-tion performed by the experts.Results:All images were histopathologically confirmed,and included 5713(19.7%)normal control,19,107(66.0%)nasopharyngeal carcinoma(NPC),335(1.2%)NPC and 3811(13.2%)benign diseases.The eNPM-DM attained an overall accuracy of 88.7%(95%confidence interval(CI)87.8%-89.5%)in detecting malignancies in the test set.In the prospective comparison phase,eNPM-DM outperformed the experts:the overall accuracy was 88.0%(95%CI 86.1%-89.6%)vs.80.5%(95%CI 77.0%-84.0%).The eNPM-DM required less time(40 s vs.110.0±5.8 min)and exhibited encouraging performance in automatic segmentation of nasopharyngeal malignant area from the background,with an average DSC of 0.78±0.24 and 0.75±0.26 in the test and prospective test sets,respectively.Conclusions:The eNPM-DM outperformed oncologist evaluation in diagnostic classification of nasopharyngeal mass into benign versus malignant,and realized automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images. | Chaofeng Li Bingzhong Jing Liangru Ke Bin Li Weixiong Xia Caisheng He Chaonan Qian Chong Zhao Haiqiang Mai Mingyuan Chen Kajia Cao Haoyuan Mo Ling Guo Qiuyan Chen Linquan Tang Wenze Qiu Yahui Yu Hu Liang Xinjun Huang Guoying Liu Wangzhong Li Lin Wang Rui Sun Xiong Zou Shanshan Guo Peiyu Huang Donghua Luo Fang Qiu Yishan Wu Yijun Hua Kuiyuan Liu Shuhui Lv Jingjing Miao Yanqun Xiang Ying Sun Xiang Guo Xing Lv | 2018 | Cancer Communications2018，38，1： | 9 |
| 2 | 声波激励的超小型纳机电系统磁电天线显示文摘当前的小型天线依赖于电磁波的谐振,因此天线的尺寸与电磁波波长相关。典型的天线尺寸大于波长的1/10,而进一步缩小天线尺寸在近十年来都是一个公开的挑战。介绍一种通过悬浮铁氧/压电薄膜异质结构的声波激励纳机械磁电天线。这种磁电天线通过其在声波谐振频率处的磁电效应接收和发射电磁波。磁电天线中的体声波激发铁磁薄膜的磁化振荡,产生电磁波的辐射;反之,天线感应电磁波的磁场,得到压电电压输出。这种磁电天线(尺寸仅为波长的千分之一)比现有小型天线的尺寸小1到2个数量级,但性能却没有降低,在便携式无线通信系统中具有很大的应用潜力。 | Tianxiang Nan Hwaider Lin Yuan Gao Alexei Matyushov Guoliang Yu Huaihao Chen Neville Sun Shengjun Wei Zhiguang Wang Menghui Li Xinjun Wang Amine Belkessam Rongdi Guo Brian Chen James Zhou Zhenyun Qian Yu Hui Matteo Rinaldi Michael E.McConney BrANDon M.Howe Zhongqiang Hu John G.Jones Gail J.Brown Nian Xiang Sun 张建强(翻译) 陈鼎鼎(审校) | 2017 | 通信对抗2017，36，4： | 8 |
| 3 | Y-chromosome evidence for no independent origin of modern human in China显示文摘East Asia is one of the few regions in the world where a large number of human fossils have been unearthed. The continuity of hominid fossils in East Asia, particularly in China has been presented as strong evidence supporting an independent origin of modern humans in this area. To search for such evidence of a possible independent origin of modern humans in China, a total of 9988 male individuals were sampled across China. Three Y-chromosome biallelic markers (M89, M130 and YAP), which were located at the non-re-combinant region of Y-chromosome, were typed among the samples. Our result showed that all the individuals carry a mutation at one of the three loci. The three mutations (M89T, M130T, YAP+) coalesce to another mutation (M168T), which was originally derived from Africa about 31000 to 79000 years ago. In other words, all Y-chromosome samples from China, with no exception, were originally derived from a lineage of African origin. Hence, we conclude that even a very minor contribution of in situ hominid origin in China cannot be supported by the Y-chromosome evidence. | KE Yuehai SU Bing LI Hongyu CHEN Lifeng QI Chunjian GUO Xinjun HUANG Wei JIN Jianzhong LU Daru JIN Li | 2001 | Chinese Science Bulletin2001，46，11： | 7 |
| 4 | tRNA-derived small RNAs:Mechanisms and potential roles in cancers显示文摘Transfer RNAs(tRNAs)are essential for protein synthesis.Mature or pre-tRNAs may be cleaved to produce tRNA-derived small RNAs(tsRNAs).tsRNAs,divided into tRNA-derived stress-induced RNA(tiRNAs)and tRNA-derived fragments(tRFs),play versatile roles in a number of fundamental biological processes.tsRNAs not only play regulatory roles in gene silencing,RNA stability,reverse transcription,and translation,but are also closely related to cell proliferation,migration,cell cycle,and apoptosis.Their abnormal expression is associated with the occurrence and development of various human diseases,especially cancer.This paper reviews the classification,biogenesis,and mechanism of action of tsRNAs,and the research progress to date on tsRNAs in cancers.These findings provide new opportunities for diagnostic biomarkers and treatment targets of several types of cancers including gastric cancer,colorectal cancer,hepatocellular carcinomas,pancreatic cancer,breast cancer,prostate cancer,renal cell carcinoma,ovarian cancer,lung cancer,bladder cancer,thyroid cancer,oral cancer,and leukemia. | Yao Wang Qiuyan Weng Jiaxin Ge Xinjun Zhang Junming Guo Guoliang Ye | 2022 | Genes & Diseases2022，9，6： | 2 |
| 5 | Detection of circulating tumor cells in peripheral blood from patients with gastric cancer using piRNAs as markers显示文摘 | Long Cui Yanru Lou Xinjun Zhang Hui Zhou Hongxia Deng Haojun Song Xiuchong Yu Bingxiu Xiao Weihua Wang Junming Guo | 2011 | Clinical Biochemistry2011，，13： | 2 |
| 6 | MiR-421 is a functional marker of circulating tumor cells in gastric cancer patients显示文摘 | Hui Zhou Bingxiu Xiao Fei Zhou Hongxia Deng Xinjun Zhang Yanru Lou Zhaohui Gong Caigan Du Junming Guo | 2012 | Biomarkers2012，，2： | 2 |
| 7 | RHOBTB3 promotes proteasomal degradation of HIFa through facilitating hydroxylation and suppresses the Warburg effect显示文摘 | Chen-Song Zhang Qi Liu Mengqi Li Shu-Yong Lin Yongying Peng Di Wu Terytty Yang Li Qiang Fu Weiping Jia Xinjun Wang Teng Ma Yue Zong Jiwen Cui Chengfei Pu Guili Lian Huiling Guo Zhiyun Ye Sheng-Cai Lin | 2015 | Cell Research2015，25，9： | 2 |
| 8 | lncRNA-AC130710 targeting by miR-129-5p is upregulated in gastric cancer and associates with poor prognosis显示文摘 | Chunjing Xu Yongfu Shao Tian Xia Yunben Yang Jiawei Dai Lin Luo Xinjun Zhang Weiliang Sun Haojun Song Bingxiu Xiao Junming Guo | 2014 | Tumor Biology2014，，10： | 1 |
| 9 | Opening the Excavation Chamber of the Large-Diameter Size Slurry' Shieht: A Case Study in Nanjing Yangtze River Tunnel in China 显示文摘 | Fanlu MIN Wei ZHU Cheng L1N Xinjun GUO | 2015 | Tunnelling and Underground Space Technology2015，46，2： | 1 |
| 10 | Opening the Excavation Chamber of the Large-Diameter Size Slurry Shield: A Case Study in Nanjing Yangtze River Tunnel in China显示文摘 | MIN Fanlu ZHU Wei LIN Cheng GUO Xinjun | 2015 | Tunnelling and Underground Space Technology2015，46，2： | 1 |
| 11 | Inulinase overproduction by a mutant of the marine yeast Pichia guilliermondii using surface response methodology and inulin hydrolysis显示文摘 | Xinjun Yu Ning Guo Zhenming Chi Fang Gong Jun Sheng Zhe Chi | 2008 | Biochemical Engineering Journal2008，，3： | 1 |
| 12 | Towards semi-supervised myoelectric finger motion recognition based on spatial motor units activation显示文摘It is vital to recognize the intention of finger motions for human-machine interaction(HMI).The latest research focuses on fine myoelectric control through the decoding of neural motor unit action potential trains(MUAPt) from high-density surface electromyographic(sEMG) signals.However,the existing EMG decoding algorithms rarely obtain the spatial matching relationship between decoded motion units(MU) and designated muscles,and the control interface can only recognize the trained hand gestures.In this study,a semi-supervised HMI based on MU-muscle matching(MMM) is proposed to recognize individual finger motions and even the untrained combined multi-finger actions.Through automatic channel selection from high-density s EMG signals,the optimal spatial positions to monitor the MU activation of finger muscles are determined.Finger tapping experiment is carried out on ten subjects,and the experimental results show that the proposed s EMG decomposition algorithm based on MMM can accurately identify single finger motions with an accuracy of 93.1%±1.4%,which is comparable to that of state-of-the-art pattern recognition methods.Furthermore,the MMM allows unsupervised recognizing the untrained combined multi-finger motions with an accuracy of 73%±3.8%.The outcomes of this study benefit the practical applications of HMI,such as controlling prosthetic hand and virtual keyboard. | GUO WeiChao WANG Mian SHENG XinJun ZHU XiangYang | 2022 | Science China(Technological Sciences)2022，65，6： | 1 |
| 13 | First results of the low energy ion spectrometer onboard a Chinese geosynchronous satellite显示文摘A Chinese geosynchronous satellite was launched on June 23,2020.It carried a plasma detection package to monitor the space environment around the orbit.Here we report the inflight performance of a low energy ion spectrometer(LEIS),one of the primary instruments in the plasma detection package,and its initial observations in flight.Benefiting from the state-of-the-art design of a top-hat electrostatic analyzer cooperated with angular scanning deflectors,three-dimensional measurement of ions in space with a large field of view of 360°×90°and a wide energy range from 50 eV to 25 keV per charge has been achieved.The differential energy flux spectra of ions around the orbit have shown clear signatures of surface charging and storm/substorm ion injections.The occurrence of surface charging could be caused by the lack of photoemission at the Earth's eclipse(near the midnight)or the storm energetic electron injection at the dawn sector.The present results demonstrated a good performance of the LEIS payload in flight for monitoring the space ion environment around the orbit.In situ measurements of the LEIS payload provide us an opportunity to understand the magnetospheric ion dynamics and forecast the associate space weather impacts. | SHAN Xu MIAO Bin CAO Zhe SUN ZhenYu LI YiRen LIU Kai GUO XingYu QU SanBiao SU ZhenPeng SHEN ChengLong PAN ZongHao LI Xin HAO XinJun YANG XiaoPing TIAN Chao JIANG Yu LIU ShuBin AN Qi CHEN XiangJun WANG YuMing | 2023 | Science China(Technological Sciences)2023，66，5： | 0 |
| 14 | In-flight calibration of the magnetometer on the Mars orbiter of Tianwen-1显示文摘Mars orbiter magnetometer(MOMAG)is one of seven science payloads onboard Tianwen-1’s orbiter.Unlike most of the satellites,Tianwen-1’s orbiter is not magnetically cleaned,and the boom where placed the magnetometer’s sensors is not long enough.These pose many challenges to the magnetic field data processing.In this study,we introduce the in-flight calibration process of the Tianwen-1/MOMAG.The magnetic interference including spacecraft generated dynamic field and the slowlychanging zero offsets are cleaned in sequence.Then the calibrated magnetic field data are compared with the data from the Mars atmosphere and volatile Evolutio N(MAVEN).We find that some physical structures in the solar wind are consistent between the two data sets,and the distributions of the magnetic field strength in the solar wind are very similar.These results suggest that the in-flight calibration of the MOMAG is successful and the MOMAG provides reliable data for scientific research. | ZOU ZhuXuan WANG YuMing ZHANG TieLong WANG GuoQiang XIAO SuDong PAN ZongHao ZHANG ZhouBin YAN Wei DU Yang CHI YuTian CHENG Long WU ZhiYong HAO XinJun LI YiRen LIU Kai CHEN ManMing SU ZhenPeng SHEN ChengLong XU MengJiao GUO JingNan | 2023 | Science China(Technological Sciences)2023，66，8： | 0 |
| 15 | Vacuum System in CSRm Commissioning显示文摘 | Yang Xiaotian Zhang Junhui Meng Jun Hu Zhenjun Zhang Xiping Hou Shengjun Guo Dizhou Yang Weishun Wu Huimin Zhang Xinjun | 2006 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2006，，1： | 0 |
| 16 | An optimal medicinal and edible Chinese herbal formula attenuates particulate matter-induced lung injury through its anti-oxidative,anti-inflammatory and anti-apoptosis activities显示文摘Objective:Identifying novel strategies to prevent particulate matter(PM)-induced lung injury is crucial for the reduction of the morbidity of chronic respiratory diseases.The combined intervention represented by herbal formulae for simultaneously targeting multiple pathological processes can provide a more beneficial effect than the single intervention.The aim of this paper is therefore to design a safe and effective medicinal and edible Chinese herbs(MECHs)formula against PM-induced lung injury.Methods:PM-induced oxidative stress,inflammatory response and apoptosis A549 cell model were used to screen anti-oxidant,anti-inflammatory and anti-apoptotic MECHs,respectively.A network pharmacology method was utilized to rationally design a novel herbal formula.Ultra performance liquid chromatography-mass spectrometer was utilized to assess the quality control of MECHs formula.The excretion of magnetic iron oxide nanospheres of the MECHs formula was estimated in zebrafish.The MECH formula against PM-induced lung injury was investigated with mice experiments.Results:Five selected herbs were rationally designed to form a new MECH formula,including Citri Exocarpium Rubrum(Juhong),Lablab Semen Album(Baibiandou),Atractylodis Macrocephalae Rhizoma(Baizhu),Mori Folium(Sangye)and Polygonati Odorati Rhizoma(Yuzhu).The formula effectively promoted the magnetic iron oxide nanospheres excretion in zebrafish.The mid/high dose formula significantly prevented PM-induced lung damage in mice by enhancing the activity of SOD and GSH-Px,reducing the MDA and ROS level and attenuating the upregulation of pro-inflammatory cytokine(IL-6,IL-8,IL-1βand TNFa),down regulating the protein expression of NF-κB,STAT3 and Caspase-3.Conclusion:Our findings suggest that the effective MECHs formula will become a novel strategy for preventing PM-induced lung injury and provide a paradigm for the development of functional foods using MECHs. | Huan Zhang Jun Kang Wuyan Guo Fujie Wang Mengjiao Guo Shanshan Feng Wuai Zhou Jinnan Li Ayesha T.Tahir Shaoshan Wang Xinjun Du Hui Zhao Weihua Wang Hong Zhu Bo Zhang | 2023 | Chinese Herbal Medicines2023，15，3： | 0 |
| 17 | The Mars orbiter magnetometer of Tianwen-1:in-flight performance and first science results显示文摘The Mars Orbiter MAGnetometer(MOMAG)is a scientific instrument onboard the orbiter of China’s first mission for Mars—Tianwen-1.Since November 13,2021,it has been recording magnetic field data from the solar wind to the magnetic pile-up region surrounding Mars.Here we present its in-flight performance and first science results,based on its first one and one-half months’data.Comparing these early MOMAG observations to the magnetic field data in the solar wind from NASA’s Mars Atmosphere and Volatile EvolutioN(MAVEN)mission,we report that the MOMAG magnetic field data are at the same level in magnitude,and describe the same magnetic structures with similar variations in three components.We recognize 158 clear bow shock(BS)crossings in these MOMAG data;their locations match well statistically with the modeled average BS.We also identify and compare five pairs of datasets collected when Tianwen-1’s orbiter and the MAVEN probe made simultaneous BS crossings.These BS crossings confirm the global shape of modeled BS,as well as the south-north asymmetry of the Martian BS.Two cases presented in this paper suggest that the BS is probably more dynamic at flank than near the nose.So far,MOMAG performs well,and provides accurate magnetic field vectors.MOMAG is continuously scanning the magnetic field surrounding Mars.Data from MOMAG’s measurements complement data from MAVEN and will undoubt edly advance our understanding of the plasma environment of Mars. | YuMing Wang TieLong Zhang GuoQiang Wang SuDong Xiao ZhuXuan Zou Long Cheng ZongHao Pan Kai Liu XinJun Hao YiRen Li ManMing Chen ZhouBin Zhang Wei Yan ZhenPeng Su ZhiYong Wu ChengLong Shen YuTian Chi MengJiao Xu JingNan Guo Yang Du | 2023 | Earth and Planetary Physics2023，7，2： | 0 |
| 18 | Progress of HIRFL-CSR Vacuum System显示文摘In 2005, the installation of whole vacuum system of HIRFL-CSR was finished and the ideal pressures have been obtained. During the beam commissioning, the vacuum system of CSRm's injection beam line keeps a good condition in most of the cases. But at one time, the beam bumped against a glass view window in a 60°dipole chamber which was designed for alignment (Fig. 1). The fast valve closed when the pressure rose. Then | Yang Xiaotian,Zhang Junhui, Meng Jun, Zhang Xiping, Hou Shengjun, Hu Zhenjun Guo Dizhou, Zhang Xinjun, Wu Huimin and Hao Bingan | 2005 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2005，，1： | 0 |
| 19 | Gradient defects mediate negative thermal quenching in phosphors显示文摘Luminescent materials often suffer from thermal quenching(TQ),limiting the continuation of their applications under high temperatures up to 473 K.The formation of defect levels could suppress TQ,but rational synthesis and deep understanding of multiple defects-regulated luminescent materials working in such a wide temperature range still remain challenging.Here,we prepare a negative thermal quenching(NTQ)phosphor LiTaO_(3)∶Tb^(3+)by introducing gradient defects V_(Ta)^(5−),Tb_(Li)^(2+),and(V_(Ta)Tb_(Li))^(3−)as identified by advanced experimental and theoretical studies.Its photoluminescence significantly becomes intense with rising temperatures and then slowly increases at 373 to 473 K.The mechanism studies reveal that gradient defects with varied trapping depths could act as energy buffer layers to effectively capture the carriers.Under thermal disturbance,the stored carriers could successively migrate to the activators in consecutive and wide temperature zones,compensating for TQ to enhance luminescence emission.This study initiates the synthesis of multi-defect NTQ phosphors for temperature-dependent applications. | Mingxue Deng Xingzhong Cao Yangmin Tang Zhenzhen Zhou Lijia Liu Xiaofeng Liu Peng Zhang Lo-Yueh Chang Hao Ruan Xinjun Guo Jiacheng Wang Qian Liu | 2023 | Advanced Photonics2023，5，2： | 0 |
| 20 | 基于内镜图像深度学习的鼻咽恶性肿瘤检测模型的建立与验证显示文摘背景与目的由于鼻咽部解剖位置隐匿且腺体增生频发,活检时恶性肿瘤的阳性率较低,从而导致初诊时鼻咽恶性肿瘤确诊延时或漏诊。本文旨在建立一种人工智能工具——基于深度学习的内镜检查,来检测鼻咽恶性肿瘤。方法建立了一种基于内镜图像的鼻咽恶性肿瘤检测模型(endoscopic imagesbased nasopharyngeal malignancies detection model,eNPM-DM),该模型由基于空间结构的全卷积网络构成,采用单独训练集和验证集对分类和分割进行微调。总共收集了28,966张合格图像。其中,自2008年1月1日至2016年12月31日,从7951例个体中获得了27,536张经活检证实的图像,按照7∶1∶2的比例随机分为训练、验证和测试集。此外,将2017年1月1日到2017年3月31日获得的1430张图像纳入预测集,用以对建立模型的性能与肿瘤专家的评价进行比较。以鼻咽镜图像为背景,对自动分割和专家手工分割进行比较,采用dice相似系数(dice similarity coefficient,DSC)评价eNPM-DM从鼻咽部内镜图像的背景中自动分割出恶性肿瘤区域的效率。结果所有图像经过病理组织学验证,包括正常对照5713(19.7%)例、鼻咽癌(nasopharyngeal carcinoma,NPC)19,107(66.0%)例、其他恶性肿瘤335(1.2%)例和3811(13.2%)例良性病变。在测试集中,eNPM-DM检测恶性肿瘤的总准确率达88.7%[95%置信区间(confidence interval,CI):87.8%–89.5%]。在预测比较阶段,eNPM-DM表现优于专家:总准确率分别为88.0%(95%CI:86.1%–89.6%)和80.5%(95%CI:77.0%–84.0%)。eNPM-DM耗时更短(40 s vs. 110.0±5.8 min),且从背景中自动分割出鼻咽恶性肿瘤区域方面表现优秀,测试集和预测集中的平均DSC分别为0.78±0.24和0.75±0.26。结论 eNPM-DM在鼻咽肿块良性/恶性诊断分类方面优于肿瘤学家评估,并且实现了从鼻咽内镜图像背景中对恶性区域自动分割。 | Chaofeng Li Bingzhong Jing Liangru Ke Bin Li Weixiong Xia Caisheng He Chaonan Qian Chong Zhao Haiqiang Mai Mingyuan Chen Kajia Cao Haoyuan Mo Ling Guo Qiuyan Chen Linquan Tang Wenze Qiu Yahui Yu Hu Liang Xinjun Huang Guoying Liu Wangzhong Li Lin Wang Rui Sun Xiong Zou Shanshan Guo Peiyu Huang Donghua Luo Fang Qiu Yishan Wu Yijun Hua Kuiyuan Liu Shuhui Lv Jingjing Miao Yanqun Xiang Ying Sun Xiang Guo Xing Lv | 2019 | 癌症2019，38，7： | 0 |
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