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| 1 | High energy soliton pulse generation by a magnetron-sputtering-deposition-grown MoTe_2 saturable absorber显示文摘The pulse energy in the ultrafast soliton fiber laser oscillators is usually limited by the well-known wave-breaking phenomenon owing to the absence of a desirable real saturable absorber(SA) with high power tolerance and large modulation depth. Here, we report a type of microfiber-based MoTe_2 SA fabricated by the magnetron-sputtering deposition(MSD) method. High-energy wave-breaking free soliton pulses were generated with pulse duration/pulse energy/average output power of 229 fs/2.14 nJ/57 mW in the 1.5 μm regime and 1.3 ps/13.8 nJ/212 mW in the 2 μm regime, respectively. To our knowledge, the generated soliton pulses at 1.5 μm had the shortest pulse duration and the highest output power among the reported erbium-doped fiber lasers mode locked by transition metal dichalcogenides. Moreover, this was the first demonstration of a MoTe_2-based SA in fiber lasers in the 2 μm regime, and the pulse energy/output power are the highest in the reported thulium-doped fiber lasers mode locked by two-dimensional materials. Our results suggest that a microfiber-based MoTe_2 SA could be used as an excellent photonic device for ultrafast pulse generation, and the MSD technique opens a promising route to produce a high-performance SA with high power tolerance and large modulation depth, which are beneficial for high-energy wave-breaking free pulse generation. | JINTAO WANG ZIKE JIANG HAO CHEN JIARONG LI JINDE YIN JINZHANG WANG TINGCHAO HE PEIGUANG YAN SHUANGCHEN RUAN | 2018 | Photonics Research2018，6，6： | 14 |
| 2 | Thermally Conductive Poly(lactic acid) Composites with Superior Electromagnetic Shielding Performances via 3D Printing Technology显示文摘This work proposes a facile fabrication strategy for thermally conductive graphite nanosheets/poly(lactic acid) sheets with ordered GNPs(o-GNPs/PLA) via fused deposition modeling(FDM) 3 D printing technology.Further combinations of o-GNPs/PLA with Ti_(3) C_(2) T_(x) films prepared by vacuum-assisted filtration were carried out by 'layer-by-layer stacking-hot pressing' to be the thermally conductive Ti_(3) C_(2) T_(x)/(oGNPs/PLA) composites with superior electromagnetic interference shielding effectiveness(EMI SE).When the content of GNPs was 18.60 wt%and 4 layers of Ti_(3) C_(2) T_(x)(6.98 wt%) films were embedded,the in-plane thermal conductivity coefficient(λ_(Ⅱ)) and EMI SE(EMI SE_(Ⅱ)) values of the thermally conductive Ti_(3) C_(2) T_(x)/(o-GNPs/P LA) composites significantly increa sed to 3.44 W·m^(-1)·K^(-1) and 65 d B(3.00 mm),increased by 1223.1% and2066.7%,respectively,compared with λ_(Ⅱ)(0.26 W·m^(-1)·K^(-1)) and EMI SE_(Ⅱ)(3 d B) of neat PLA matrix.This work offers a novel and easily route for designing and manufacturing highly thermally conductive polymer composites with superior EMI SE for broader application. | Teng-Bo Ma Hao Ma Kun-Peng Ruan Xue-Tao Shi Hua Qiu Sheng-Yuan Gao Jun-Wei Gu | 2022 | Chinese Journal of Polymer Science2022，40，3： | 13 |
| 3 | Changing Proportions of HIV-1 Subtypes and Transmitted Drug Resistance Among Newly Diagnosed HIV/AIDS Individuals—China,2015 and 2018显示文摘Introduction:With the expansion of human immunodeficiency virus(HIV)antiretroviral therapy(ART),HIV drug resistance is becoming more and more serious.This study describes the changing prevalence of HIV-1 subtypes and transmitted drug resistance(TDR)among newly diagnosed individuals in China,2015 and 2018.Methods:A total of 8,980 individuals in 2015 and 2018 from 31 provincial-level administrative divisions(PLADs)were enrolled in this study.Viral RNAs were amplified and sequenced using an in-house polymerase chain reaction(PCR)protocol.The Stanford HIV Drug Resistance Database(HIVdb)was used to predict susceptibility to 12 antiretroviral drugs.Results:The prevalence of TDR was not significantly increased over time.The prevalence of TDR was 3.8%and 4.4%in 2015 and 2018,respectively(P=0.13).The prevalence of CRF55_01B increased from 2.3%in 2015 to 3.9%in 2018(P<0.001).The drug resistance prevalence of nonnucleoside reverse transcriptase inhibitors(NNRTI)increased from 2.4%in 2015 to 3.3%in 2018(P<0.01).The prevalence of E138(P<0.001),H221(P=0.03),and V179(P<0.001)mutations increased from 0.30%,0.09%,and 0.70%in 2015 to 1.10%,0.30%,and 1.70%in 2018,respectively.Conclusions:HIV drug resistance affects the effect of antiretroviral treatment,so the monitoring of HIV TDR should be strengthened to control the transmission of HIV drug resistance. | Jingjing Hao Shan Zheng Mengze Gan Aobo Dong Ruihua Kang Miaomiao Li Shuai Zhao Jing Hu Chang Song Lingjie Liao Yi Feng Yiming Shao Yuhua Ruan Hui Xing | 2021 | China CDC weekly2021，3，53： | 13 |
| 4 | Findings of non-pathologic perfusion defects by CT arterial portography and non-pathologic enhancement of CT hepatic arteriography显示文摘INTRODUCTIONCTarterialportography(CTAP)andCThepaticarteriography(CTHA)arethemostsensitivemethodsofdetectinghepatocelularcarci... | LI Li, WU Pei Hong, LIN Hao Gao, LI Jin Qing, MO Yun Xian, ZHENG Lie, LU Li Xia, RUAN Chao Mei and CHEN Lin | 1998 | World Journal of Gastroenterology1998，4，6： | 11 |
| 5 | The transcription factor OpWRKY2 positively regulates the biosynthesis of the anticancer drug camptothecin in Ophiorrhiza pumila显示文摘The limited bioavailability of plant-derived natural products with anticancer activity poses major challenges to the pharmaceutical industry.An example of this is camptothecin,a monoterpene indole alkaloid with potent anticancer activity that is extracted at very low concentrations from woody plants.Recently,camptothecin biosynthesis has been shown to become biotechnologically amenable in hairy-root systems of the natural producer Ophiorrhiza pumila.Here,time-course expression and metabolite analyses were performed to identify novel transcriptional regulators of camptothecin biosynthesis in O.pumila.It is shown here that camptothecin production increased over cultivation time and that the expression pattern of the WRKY transcription factor encoding gene OpWRKY2 is closely correlated with camptothecin accumulation.Overexpression of OpWRKY2 led to a more than three-fold increase in camptothecin levels.Accordingly,silencing of OpWRKY2 correlated with decreased camptothecin levels in the plant.Further detailed molecular characterization by electrophoretic mobility shift,yeast one-hybrid and dual-luciferase assays showed that OpWRKY2 directly binds and activates the central camptothecin pathway gene OpTDC.Taken together,the results of this study demonstrate that OpWRKY2 acts as a direct positive regulator of camptothecin biosynthesis.As such,a feasible strategy for the over-accumulation of camptothecin in a biotechnologically amenable system is presented. | Xiaolong Hao Chenhong Xie Qingyan Ruan Xichen Zhang Chao Wu Bing Han Jun Qian Wei Zhou Hans-Wilhelm Nutzmann Guoyin Kai | 2021 | Horticulture Research2021，8，1： | 7 |
| 6 | Comparison of diagnostic efficacy between transrectal and transperineal prostate biopsy:a propensity score-matched study显示文摘This study compared the diagnostic efficacy of transrectal ultrasound(TRUS)-guided prostate biopsy(TRBx)and transperineal prostate biopsy(TPBx)in patients with suspected prostate cancer(PCa).We enrolled 2962 men who underwent transrectal(n=1216)or transperineal(n=1746)systematic 12-core prostate biopsy.Clinical data including age,prostate-specific antigen(PSA)level,and prostate volume(PV)were recorded.To minimize confounding,we performed propensity score-matching analysis?We measured and compared PCa detection rates between TRBx and TPBx,which were stratified by clinical characteristics and Gleason scores.The effects of clinical characteristics on PCa detection rate were assessed by logistic regression.For all patients,TPBx detected a higher proportion of clinically significant PCa(P<0.001).Logistic regression analyses illustrated that PV had a smaller impact on PCa detection rate of TPBx compared with TRBx.Propensity score-matching analysis showed that the detection rates in TRBx were higher than those in TPBx for patients aged≥80 years(80.4%vs 56.5%,P=0.004)and with PSA level 20.1-100.0 ng ml^-1(80.8%vs 69.1%,P=0.040).In conclusion,TPBx was associated with a higher detection rate of clinically significant PCa than TRBx was;however,because of the high detection rate at certain ages and PSA levels,biopsy approaches should be optimized according to patents'clinical characteristics. | Chen-Yi Jiang Peng-Fei Shen Cheng Wang Hao-Jun Gui Yuan Ruan Hao Zeng Shu-Jie Xia Qiang Wei Fu-Jun Zhao | 2019 | Asian Journal of Andrology2019，21，6： | 6 |
| 7 | The expression of oxidative stress genes related to myocardial ischemia reperfusion injury in patients with ST-elevation myocardial infarction显示文摘BACKGROUND:We aimed to investigate the gene expression of myocardial ischemia/reperfusion injury(MIRI)in patients with acute ST-elevation myocardial infarction(STEMI)using stress and toxicity pathway gene chip technology and try to determine the underlying mechanism.METHODS:The mononuclear cells were separated by ficoll centrifugation,and plasma total antioxidant capacity(T-AOC)was determined by the ferric reducing ability of plasma(FRAP)assay.The expression of toxic oxidative stress genes was determined and verified by oligo gene chip and quantitative real-time polymerase chain reaction(qRT-PCR).Additionally,gene ontology(GO)enrichment analysis was performed on DAVID website to analyze the potential mechanism further.RESULTS:The total numbers of white blood cells(WBC)and neutrophils(N)in the peripheral blood of STEMI patients(the AMI group)were significantly higher than those in the control group(WBC:11.67±4.85×10^(9)/L vs.6.41±0.72×10^(9)/L,P<0.05;N:9.27±4.75×10^(9)/L vs.3.89±0.81×10^(9)/L,P<0.05),and WBCs were significantly associated with creatine kinase-myocardial band(CK-MB)on the first day(Y=8.945+0.018X,P<0.05).In addition,the T-AOC was significantly lower in the AMI group comparing to the control group(12.80±1.79 U/mL vs.20.48±2.55 U/mL,P<0.05).According to the gene analysis,eight up-regulated differentially expressed genes(DEGs)included GADD45A,PRDX2,HSPD1,DNAJB1,DNAJB2,RAD50,TNFSF6,and TRADD.Four down-regulated DEGs contained CCNG1,CAT,CYP1A1,and ATM.TNFSF6 and CYP1A1 were detected by polymerase chain reaction(PCR)to verify the expression at different time points,and the results showed that TNFSF6 was up-regulated and CYP1A1 was down-regulated as the total expression.GO and kyoto encyclopedia of genes and genomes(KEGG)enrichment analysis suggested that the oxidative stress genes mediate MIRI via various ways such as unfolded protein response(UPR)and apoptosis.CONCLUSIONS:WBCs,especially neutrophils,were the critical cells that mediating reperfusion injury.MIRI was regulated by various genes,including oxidative metabolic stress,heat shock,DNA damage and repair,and apoptosis-related genes.The underlying pathway may be associated with UPR and apoptosis,which may be the novel therapeutic target. | Qian-lin Gu Peng Jiang Hui-fen Ruan Hao Tang Yang-bing Liang Zhong-fu Ma Hong Zhan | 2022 | World Journal of Emergency Medicine2022，13，2： | 5 |
| 8 | Incidence and clinical characteristics of inflammatory bowel disease in a developed region of G uangdong P rovince, C hina: A prospective population‐based study显示文摘 | Zhirong Zeng Zhenhua Zhu Yuyu Yang Weishan Ruan Xiabiao Peng Yuhuan Su Lin Peng Jinquan Chen Quan Yin Chao Zhao Haihua Zhou Shuai Yuan Yuantao Hao Jiaming Qian Siew Chien Ng Minhu Chen Pinjin Hu | 2013 | J Gastroenterol Hepatol2013，，7： | 5 |
| 9 | Theoretical and experimental investigation on novel 2D maglev servo proportional valve显示文摘This paper presents a novel two-dimensional maglev servo proportional cartridge valve(2 D maglev valve),where a contactless maglev coupling is introduced between electro-mechanical converter and valve body to realize functions of force transmission,spool position feedback and linear-rotary motion conversion.Such configuration can effectively reduce cost of both valve manufacturing and electro-mechanical converter,while still maintain features of 2 D valve such as null pilot leakage,high power-to-weight ratio and excellent anti-pollution capacity.Firstly,the characteristic equation of the valve is derived using linear theory,and the stability criterion is established for parameter determination.The influences of crucial structural parameters such as initial height of overlapping area,width of high-pressure and low-pressure holes,acting radius of magnetic force,pitch angle of maglev coupling,length of sensitive chamber and system pressure on the dynamic response are investigated based on AMESim numerical simulation.The prototype valve is then designed and manufactured and a special test rig is built.The no-load flow characteristic,load flow characteristic,leakage characteristic,amplitude and phase frequency characteristics and step response under different system pressures are measured.The experimental results are in a good agreement with the simulated analysis.As an over-damped system,the prototype valve has excellent working stability,which can reach a no-load flow rate of 105.9 L/min with hysteresis of 3.51%,amplitude bandwidth of 28.7 Hz and phase bandwidth of 42.8 Hz under 21 MPa.The research indicates that the 2 D maglev valve can be a potential solution of flow rate control valve for flight control surface system of civil aircraft with high pressure and large flow rate application. | Bin MENG Hao XU Jian RUAN Sheng LI | 2021 | Chinese Journal of Aeronautics2021，34，4： | 5 |
| 10 | Plasma soluble C-type lectin-like receptor-2 is associated with the risk of coronary artery disease显示文摘Accumulating evidence suggests that C-type lectin-like receptor-2(CLEC-2)plays an important role in atherothrombosis.In this case-control study,we investigated the association between CLEC-2 and incidence of coronary artery disease(CAD).A total of 216 patients,including 14 cases of stable angina pectoris(SAP,non-ACS)and 202 cases of acute coronary syndrome(ACS),and 89 non-CAD control subjects were enrolled.Plasma levels of soluble CLEC-2(sCLEC-2)were measured using the enzyme-linked immunosorbent assay(ELISA).Compared with the control group(65.69(55.36–143.22)pg/mL),the plasma levels of sCLEC-2 were significantly increased in patients with CAD(133.67(88.76–220.09)pg/mL)and ACS(134.16(88.88–225.81)pg/mL).The multivariate adjusted odds ratios(95%confidence interval)of CAD reached 2.01(1.52–2.66)(Ptrend<0.001)for each 1-quartile increase in sCLEC-2.Restricted cubic splines showed a positive dose-response association between sCLEC2 and CAD incidence(Plinearity<0.001).The addition of sCLEC-2 to conventional risk factors improved the C statistic(0.821 vs.0.761,P=0.004)and reclassification ability(net reclassification improvement:57.45%,P<0.001;integrated discrimination improvement:8.27%,P<0.001)for CAD.In conclusion,high plasma sCLEC-2 is independently associated with CAD risk,and the prognostic value of sCLEC-2 may be evaluated in future prospective studies. | Min Fei Li Xiang Xichen Chai Jingchun Jin Tao You Yiming Zhao Changgeng Ruan Yiwen Hao Li Zhu | 2020 | Frontiers of Medicine2020，14，1： | 5 |
| 11 | Molecular characterization of transformation and halogenation of natural organic matter during the UV/chlorine AOP using FT-ICR mass spectrometry显示文摘UV/chlorine process,as an emerging advanced oxidation process(AOP),was effective for removing micro-pollutants via various reactive radicals,but it also led to the changes of natural organic matter(NOM)and formation of disinfection byproducts(DBPs).By using negative ion electrospray ionization coupled with Fourier transform ion cyclotron resonance mass spectrometry(ESI FT-ICR MS),the transformation of Suwannee River NOM(SRNOM)and the formation of chlorinated DBPs(Cl-DBPs)in the UV/chlorine AOP and subsequent post-chlorination were tracked and compared with dark chlorination.In comparison to dark chlorination,the involvement of Cl O·,Cl·,and HO·in the UV/chlorine AOP promoted the transformation of NOM by removing the compounds owning higher aromaticity(AI mod)value and DBE(double-bond equivalence)/C ratio and causing the decrease in the proportion of aromatic compounds.Meanwhile,more compounds which contained only C,H,O,N atoms(CHON)were observed after the UV/chlorine AOP compared with dark chlorination via photolysis of organic chloramines or radical reactions.A total of 833 compounds contained C,H,O,Cl atoms(CHOCl)were observed after the UV/chlorine AOP,higher than 789 CHOCl compounds in dark chlorination,and one-chlorine-containing components were the dominant species.The different products from chlorine substitution reactions(SR)and addition reactions(AR)suggested that SR often occurred in the precursors owning higher H/C ratio and AR often occurred in the precursors owning higher aromaticity.Post-chlorination further caused the cleavages of NOM structures into small molecular weight compounds,removed CHON compounds and enhanced the formation of Cl-DBPs.The results provide information about NOM transformation and Cl-DBPs formation at molecular levels in the UV/chlorine AOP. | Xiaoxue Ruan Yingying Xiang Chii Shang Shuangshuang Cheng Jingfu Liu Zhineng Hao Xin Yang | 2021 | Journal of Environmental Sciences2021，33，4： | 5 |
| 12 | Microsurgical transverse 2-suture intussusception vasoepididymostomy: effectiveness and rationality显示文摘 | ZHANG Hao HUANG Wen-tao RUAN Xing-xing LI Liao-yuan DI Jin-ming LIUXiao-peng XIAO Heng-jun GAO Xin ZHANG Yan | 2013 | Chinese Medical Journal2013，，24： | 5 |
| 13 | IL-15 increases the frequency of effectormemory CD8^(+) T cells in rhesus monkeys immunized with HIV vaccine显示文摘Several studies have suggested that interleukin(IL)-15 is a promising adjuvant that promotes cellular immunity when administered with human immunodeficiency virus(HIV)vaccine.Here we evaluated the effect of IL-15 plasmid on HIV-specific immune responses,especially cellular immunity,in eight rhesus monkeys.These monkeys were immunized three times with HIV DNA vaccine with or without IL-15 plasmid and boosted with recombinant Tiantan strain vaccinia virus-based HIV vaccine(rTV)22 weeks after the first immunization.Although we did not detect any significant differences in the HIV-specific CD81 T-cell response between monkeys with IL-15 coimmunization and monkeys with HIV vaccine alone,our results showed that the frequency of effector CD8^(+) memory T cells in the peripheral blood was significantly higher in monkeys with IL-15 coimmunization than those with HIV vaccine alone at almost all of the time points examined.Furthermore,the titers of anti-HIV antibodies were higher in Group T than those in Group C after rTV boosting.These findings in rhesus monkeys suggest that IL-15 may be useful as a cytokine adjuvant for HIV vaccine. | Shirui Li Xiangrong Qi Yingying Gao Yanling Hao Lianxian Cui Li Ruan Wei He | 2010 | Cellular & Molecular Immunology2010，7，6： | 5 |
| 14 | Adiponectin receptor 1 and small ubiquitin-like modifier 4 polymorphisms are associated with risk of coronary artery disease without diabetes显示文摘编码 adiponectin 受体 1 的基因( ADIPOR1 )和小象ubiquitin一样修饰词( SUMO4 ) 4 被连接了到 anti-atherogenic 效果,但是很少对是否被知道在二基因的多型性,独立行动或交往,没有 diabetes.MethodsWe genotyped ,影响冠的动脉疾病( CAD )的风险没有糖尿病的 200 个 CAD 病人和没有 CAD 的 200 控制,它被选择基于前一个没有 diabetes.ResultsRisk 等位基因,协会也是的潜力在 ADIPOR1 (rs7539542-G, rs7514221-C 和 rs3737884-G ) 在三 SNP 在这些 SNP 和 CAD 的临床的特征之间探索了,没有糖尿病,在在 SUMO4 的 SNP rs237025 的 G 等位基因显著地增加了 CAD 的风险,与从 1.79 ~ 4.44 的 ORs。任何这四风险等位基因的搬运人出现了类似不利 ? 临床的特征。与有 CC 或 GC 遗传型的个人相比,有在 rs3737884 的 GG 遗传型的那些在影响了左前面的下降冠的动脉的 CAD 的显著地更高的风险(或:6.77, P = 0.009 ) ,恰好冠的动脉(或:4.81, P = 0.028 ) 或容器的一个相对大的数字(P = 0.04 ) 。没有糖尿病,在 SUMO4 在 SNP 象风险等位基因一样在 ADIPOR1 在三 SNP 中的至少一个带风险等位基因的个人比不带任何风险等位基因的个人在 CAD 的显著地更高的风险(或:5.82, 95% CI:1.2327.7, P = 0.013 ) 没有糖尿病,在 ADIPOR1 和 SUMO4 的 .ConclusionsSNPs 与 CAD 的提高的风险被联系,并且在二基因的 SNP 可以交往联合影响疾病风险。 | Hong LI Ze YANG Lian-Mei PU Xiang LI Yang RUAN Fan YANG Shuai MENG Duo YANG Wei YAO Hao FU Feng ZHANG Ze-Ning JIN | 2016 | Journal of Geriatric Cardiology2016，13，9： | 4 |
| 15 | Diosmetin has therapeutic efficacy in colitis regulating gut microbiota, inflammation, and oxidative stress via the circ-Sirt1/Sirt1 axis显示文摘Diosmetin (3',5,7 -trihydroxy-4'-methoxy flavone) is a natural flavonoid compound in the citrus species, it exhibits a variety of pharmacological activities, but little is known of its effects on colitis. In this study we evaluated the therapeutic effects of diosmetin on mouse models of chronic and acute colitis. Chronic colitis was induced in mice by drinking water containing 3% dextran sulfate sodium (DSS) from D0 to D8, followed by administration of diosmetin (25, 50 mg · kg−1 · d−1) for another 8 days. Acute colitis was induced by drinking water containing 5% DSS from D0 to D7, the mice concomitantly received diosmetin (25, 50 mg · kg−1 · d−1) from D1 to D7. During the experiments, body weight and disease activity index (DAI) were assessed daily. After the mice were sacrificed, colon tissue and feces samples were collected, and colon length was measured. We showed that in both models, diosmetin administration significantly decreased DAI score and ameliorated microscopic colon tissue damage;increased the expression of tight junction proteins (occludin, claudin-1, and zonula occludens-1), and reduced the secretion of proinflammatory cytokines IL-1β, IL-6, TNF-α, and Cox-2 in colon tissue. We found that diosmetin administration remarkably inhibited colon oxidative damage by adjusting the levels of intracellular and mitochondrial reactive oxygen species, GSH-Px, SOD, MDA and GSH in colon tissue. The protection of diosmetin against intestinal epithelial barrier damage and oxidative stress were also observed in LPS-treated Caco-2 and IEC-6 cells in vitro. Furthermore, we demonstrated that diosmetin markedly increased the expression of Nrf2 and HO-1 and reduced the ratio of acetylated NF-κB and NF-κB by activating the circ-Sirt1/Sirt1 axis, which inhibited oxidative stress and inflammation in vivo and in vitro. Diosmetin reversed the effects of si-circSirt1 and si-Sirt1 in LPS-treated Caco-2 and IEC-6 cells. When the gut microbiota was analyzed in the mouse model of colitis, we found that diosmetin administration modulated the abundance of Bacteroidetes, Actinobacteria, Cyanobacteria and Firmicutes, which were crucial for inflammatory bowel disease. Our results have linked colitis to the circ-Sirt1/Sirt1 signaling pathway, which is activated by diosmetin. The results imply that diosmetin may be a novel candidate to alleviate DSS-induced colitis and can be a lead compound for future optimization and modification. | Hai-long Li Yi-ying Wei Xiao-he Li Shan-shan Zhang Ruo-tong Zhang Jin-he Li Bo-wei Ma Shuai-bo Shao Zi-wei Lv Hao Ruan Hong-gang Zhou Cheng Yang | 2022 | Acta Pharmacologica Sinica2022，43，4： | 4 |
| 16 | Inhibition of the lncRNA DANCR attenuates cardiomyocyte injury induced by oxygen-glucose deprivation via the miR-19a-3p/MAPK1 axis显示文摘Long noncoding RNAs(lncRNAs)have been considered as crucial regulators of acute myocardial infarction(AMI).In this study,to analyze the effect of differentiation antagonizing nonprotein coding RNA(DANCR)of lncRNA on cardiomyocyte damage in AMI,cardiomyocyte injury was induced by oxygen-glucose deprivation(OGD).Cell counting kit-8(CCK-8)assay and flow cytometry were used to assess cell viability and apoptosis,respectively.Quantitative real-time PCR was used to measure the expression levels of DANCR and miR-19a-3p.Bioinformatics analysis and luciferase gene reporter assay were utilized to explore the relationship among DANCR,miR-19a-3p,and mitogen-activated protein kinase 1(MAPK1).CCK-8 and TUNEL assays were used to explore the effects of DANCR alone or plus miR-19a-3p on the viability and apoptosis of OGD/R-exposed HL-1 cells.Western blot analysis was used to detect changes in the MAPK1/ERK1/2 pathway in HL-1 cells.We found that DANCR expression and miR-19a-3p level are negatively correlated as DANCR expression is increased,while miR-19a-3p level is decreased in AMI patients’serum and OGD/R-exposed HL-1 cells.DANCR knockdown increased miR-19a-3p level,and miR-19a-3p inhibition increased DANCR expression.Moreover,DANCR directly binds to miR-19a-3p.DANCR knockdown reduced viability but induced apoptosis in OGD/R-exposed HL-1 cells,while miR-19a-3p inhibition weakens these effects.Furthermore,MAPK1 is a target of miR-19a-3p.miR-19a-3p overexpression decreases MAPK1 and ERK1/2 in HL-1 cells,while miR-19a-3p inhibition increases MAPK1 and ERK1/2 in HL-1 cells.Moreover,DANCR knockdown reduces myocardium apoptosis in mice with the left anterior descending artery ligated.DANCR knockdown effectively restores myocardial cell apoptosis by regulating the miR-19a-3p/MAPK1/ERK1/2 axis. | Yang Ruan Hong Li Xiaojing Cao Shuai Meng Ruofei Jia Lianmei Pu Hao Fu Zening Jin | 2021 | Acta Biochimica et Biophysica Sinica2021，53，10： | 4 |
| 17 | Dual-polarization programmable metasurface modulator for near-field information encoding and transmission显示文摘Controlling the polarization state of electromagnetic waves is an important topic in microwaves due to the enormous application potential in radar technology and mobile communications. Here, we propose a programmable metasurface based on single-pole double-throw switches to realize multifunctional polarization conversions.A structure of the double-sided metallic pattern is adopted in the metasurface, in which a novel double-pole double-throw hub is achieved to guide the energy direction. Such a mechanism successfully induces multiple transmission channels into the metasurface structure for functional design. By controlling the states of the switches with a field programmable gate array, the x-and y-polarizations of the incident waves can be efficiently modulated into linear co-and cross-polarizations of transmitted waves, suggesting a higher degree of freedom on wave manipulations. The proposed metasurface can be developed as a near-field information encoder to transmit binary coding sequence according to the energy distribution. Character transmissions are realized by programming binary ASCII codes on the transmitted fields. Nine supercells on the metasurface can encode 9-bit binary information in one frame of near-field imaging, which can be switched in real time with high speed. We envision that this work will develop digital coding applications to control the polarization information. | LEI CHEN QIAN MA QIAN FAN NIE QIAO RU HONG HAO YANG CUI YING RUAN TIE JUN CUI | 2021 | Photonics Research2021，9，2： | 4 |
| 18 | First experimental constraints on WIMP couplings in the effective field theory framework from CDEX显示文摘We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region. | Yi Wang Zhi Zeng Qian Yue LiTao Yang KeJun Kang YuanJing Li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan Dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He Li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia LiPing Jia Xi Jiang HauBin Li JianMin Li Jin Li MingXuan Li RenMingJie Li Xia Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu Yu Liu YuanYuan Liu ZhongZhi Liu Hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang Li Wang Qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，8： | 3 |
| 19 | Low serum testosterone predicts upgrading and upstaging of prostate cancer after radical prostatectomy显示文摘经常,病理学的格利森分数(GS ) 和前列腺癌症(PCa ) 的舞台与活体检视 GS 和临床的舞台不一致。然而,没有预言升级的广泛地接受的方法和 upstaging PCa。在我们的学习,我们调查了在浆液睾丸激素之间的协会并且升级或在激进的前列腺切除术(RP ) 以后的 PCa 的 upstaging。我们与活体检视 GS ≤ 与 PCa 注册了 167 个病人; 6,临床的阶段 ≤ T2c,和前列腺特定的抗原(PSA )<从 2009 年 4 月的 10 ng ml −1 到 2015 年 4 月。数据包括年龄,身体团索引,外科手术前的 PSA 水平, comorbidity,临床的演讲,和外科手术前的浆液总计睾丸激素水平被收集。升级发生在 62 (37.1%) 病人,和 upstaging 发生在 73 (43.7%) 病人。外科手术前的睾丸激素在比 nonupgrading 组升级是更低的(3.72 对 4.56, P<0.01 ) 。在有的 upstaging 组的病人在 nonupstaging 组比那些降低外科手术前的睾丸激素(3.84 对 4.57, P= 0.01 ) 。在 multivariate 逻辑回归分析作为连续、范畴的变量,低浆液睾丸激素被证实是病理学的升级的一个独立预言者(P = 0.01 并且 P= 0.01 ) 并且 upstaging (P = 0.01 并且 P = 0.02 ) 在 RP 以后。我们建议那低浆液睾丸激素(< 3 ng ml −1) 与在 RP 以后升级和 upstaging 的高率被联系。外科医生近保证,并且在当与低浆液睾丸激素为病人选择 RP 治疗时,执行扩大淋巴节点解剖热心更好 PSA 层次和成像检查监视是否选择 non-RP 治疗,到在继续神经圆材外科小心。 | Yuan Gao Chen-Yi Jiang Shi-Kui Mao Di Cui Kui-Yuan Hao Wei Zhao Qi Jiang Yuan Ruan Shu-Jie Xia Bang-Min Han | 2016 | Asian Journal of Andrology2016，18，4： | 3 |
| 20 | Homologous Strategy to Construct High‑Performance Coupling Electrodes for Advanced Potassium‑Ion Hybrid Capacitors显示文摘Potassium-ion hybrid capacitors(PIHCs)have been considered as promising potentials in mid-to large-scale storage system applications owing to their high energy and power density.However,the process involving the intercalation of K+into the carbonaceous anode is a sluggish reaction,while the adsorption of anions onto the cathode surface is relatively faster,resulting in an inability to exploit the advantage of high energy.To achieve a high-performance PIHC,it is critical to promote the K^+insertion/desertion in anodic materials and design suitable cathodic materials matching the anodes.In this study,we propose a facile“homologous strategy”to construct suitable anode and cathode for high-performance PIHCs,that is,unique multichannel carbon fiber(MCCF)-based anode and cathode materials are firstly prepared by electrospinning,and then followed by sulfur doping and KOH activation treatment,respectively.Owing to a multichannel structure with a large interlayer spacing for introducing S in the sulfur-doped multichannel carbon fiber(S-MCCF)composite,it presents high capacity,super rate capability,and long cycle stability as an anode in potassium-ion cells.The cathode composite of activated multichannel carbon fiber(aMCCF)has a considerably high specific surface area of 1445 m^2 g^−1 and exhibits outstanding capacitive performance.In particular,benefiting from advantages of the fabricated S-MCCF anode and aMCCF cathode by homologous strategy,PIHCs assembled with the unique MCCF-based anode and cathode show outstanding electrochemical performance,which can deliver high energy and power densities(100 Wh kg^−1 at 200 W kg^−1,and 58.3 Wh kg^−1 at 10,000 W kg^−1)and simultaneously exhibit superior cycling stability(90%capacity retention over 7000 cycles at 1.0 A g^−1).The excellent electrochemical performance of the MCCF-based composites for PIHC electrodes combined with their simple construction renders such materials attractive for further in-depth investigations of alkali-ion battery and capacitor applications. | Ying Xu Jiafeng Ruan Yuepeng Pang Hao Sun Chu Liang Haiwen Li Junhe Yang Shiyou Zheng | 2021 | Nano-Micro Letters2021，13，1： | 3 |
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