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| 1 | Ambient volatile organic compounds pollution in China显示文摘Owing to rapid economic and industrial development,China has been suffering from degraded air quality and visibility. Volatile organic compounds(VOCs)are important precursors to the formation of ground-level ozone and hence photochemical smog. Some VOCs adversely affect human health. Therefore,VOCs have recently elicited public concern and given new impetus to scientific interest. China is now implementing a series of polices to control VOCs pollution. The key to formulating policy is understanding the ambient VOCs pollution status. This paper mainly analyzes the species,levels,sources,and spatial distributions of VOCs in ambient air. The results show that the concentrations of ambient VOCs in China are much higher than those of developed countries such as the United States and Japan,especial benzene,which exceeds available standards. At the same time,the ozone formation potential(OFP)and secondary organic aerosol formation potential(SOAFP)of various VOCs are calculated. Aromatics and alkenes have much higher OFPs,while aromatics have higher SOAFP. The OFPs of ambient VOCs in the cities of Beijing,Guangzhou and Changchun are very high,and the SOAFP of ambient VOCs in the cities of Hangzhou,Guangzhou and Changchun are higher. | Xinmin Zhang Zhigang Xue Hong Li Li Yan Yuan Yang Yi Wang Jingchun Duan Lei Li Fahe Chai Miaomiao Cheng Weiqi Zhang | 2017 | Journal of Environmental Sciences2017，29，5： | 34 |
| 2 | Efficacy and safety evaluation of intravenous infusion of cervus and cucumis polypeptides for treatment of avascular necrosis of the femoral head: a randomized clinical trial显示文摘OBJECTIVE: To investigate the efficacy and safety of intravenous cervus and cucumis polypeptides for treating avascular necrosis of the femoral head(ANFH) in regard to pain and hip function in a randomized clinical trial.METHODS: A total of 96 subjects with ANFH who were recruited at the Orthopaedic Hospital Affiliated with Hebei United University and Qian Hai Femoral Head Hospital of Beijing were assigned by lottery to an intervention group(n = 48) or a control group(n = 48). All subjects underwent physical therapy and rehabilitation exercises. In addition,subjects in the intervention group were given intravenous infusions of cervus and cucumis polypeptides. Visual analogue scale(VAS), Harris hip score,and radiography or magnetic resonance imaging were applied to assess all subjects at the beginning of treatment and 3, 6, and 9 months afterward. All the subjects were followed up for 2 years.RESULTS: At the beginning of treatment, there were no statistically significant differences between the two groups in terms of the general condition of patients or the VAS and Harris hip scores(all P > 0.05). At 3, 6, and 9 months after treatment,however, the VAS score decreased and the Harris hip score increased in all patients, with the improvement of intervention group significantly greater than that of the control group(P < 0.05).The total effectiveness rates for the intervention and control groups were 89.58% and 70.83%, respectively, with the difference being statistically significant(P < 0.05). There was no statistically significant difference between the two groups in terms of the safety of the injections(P > 0.05).CONCLUSION: Intravenous infusion of cervus and cucumis polypeptides relieved pain and improved hip function of subjects with ANFH.Thus, the intravenous infusion of cervus and cucumis polypeptides was a safe, effective treatment for ANFH. | Wei Liyou Zhang Hongwei Li Xinmin Yang Chunyan Wang Guoqiang Zhang Lifeng Cui Mingwu Han Lijun | 2016 | Journal of Traditional Chinese Medicine2016，36，1： | 15 |
| 3 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
| 4 | Fabrication and Evaluation of a Bioactive Sr–Ca–P Contained Micro-Arc Oxidation Coating on Magnesium Strontium Alloy for Bone Repair Application显示文摘Considering the compatibility between degradation and bioactivity of magnesium-based implants for bone repair, micro-arc oxidation is used to modify the magnesium alloy surface in aqueous electrolytes,allowing strontium, calcium, and phosphorus to be incorporated into the coating. The thickness, composition, morphology and phase of this Sr–Ca–P containing coating are characterized by scanning electron microscopy equipped with energy dispersive X-ray spectrometer and X-ray diffraction. The in vitro and in vivo degradation of the coating is evaluated by immersion test, electrochemical test and implantation test. Moreover, the cytocompatibility is tested with osteoblast cell according to ISO 10993. The results show that Sr, Ca and P elements are incorporated into the oxide coating, and a refined structure with tiny discharging micro-pores is observed on the surface of the coating. The Sr–Ca–P coating possesses a better corrosion resistance in vitro and retards the degradation in vivo. Such coating is expected to have significant medical applications on orthopedic implants and bone repair materials. | Junjie Han Peng Wan Yu Sun Zongyuan Liu Xinmin Fan Lili Tan Ke Yang | 2016 | Journal of Materials Science & Technology2016，32，3： | 8 |
| 5 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 6 | Efficacy of biofeedback therapy via a mini wireless device on sleep bruxism contrasted with occlusal splint:a pilot study显示文摘The putative causes of bruxism are multifactorial and there are no definite measures for bruxism management.The aim of this study was to evaluate the efficacy of biofeedback therapy on sleep bruxism,compared with occlusal splint.Twenty-four volunteers with sleep bruxism were divided into two groups:the GTB group that were treated with biofeedback therapy(n 512) and the GTO group that were treated with occlusal splint(n 512).A mini pressure sensor integrated with a monitoring circuit by use of a maxillary biofeedback splint was fabricated.To foster the relaxation of the masticatory muscles and the nervous system,the wireless device received signals from bruxism events and vibrations alerted the bruxer when the threshold was exceeded.Total episodes and average duration of bruxism events during8 hours of sleep were analyzed with the monitoring program(TRMY1.0).After 6 and 12 weeks,the episodes(P 50.001) and duration(P,0.05) in the GTB group declined dramatically.In contrast,there were no significant differences in the GTO group after the treatment(P.0.05).Furthermore,the episodes had significant differences between the GTB group and the GTO group after the same period of treatment(P 5 0.000).The results suggest that biofeedback therapy may be an effective and convenient measure for mild bruxers,when compared with occlusal splint therapy.The mini wireless biofeedback method may be of value for the diagnosis and management of bruxism in the future. | WeiPing Gu Jie Yang FeiMin Zhang XinMin Yin XiaoLong Wei Chen Wang | 2015 | The Journal of Biomedical Research2015，29，2： | 4 |
| 7 | Continuous-time System Identification with Nuclear Norm Minimization and GPMF-based Subspace Method显示文摘To improve the accuracy and effectiveness of continuous-time(CT) system identification, this paper introduces a novel method that incorporates the nuclear norm minimization(NNM) with the generalized Poisson moment functional(GPMF)based subspace method. The GPMF algorithm provides a simple linear mapping for subspace identification without the timederivatives of the input and output measurements to avoid amplification of measurement noise, and the NNM is a heuristic convex relaxation of the rank minimization. The Hankel matrix with minimized nuclear norm is used to determine the model order and to avoid the over-parameterization in subspace identification method(SIM). Furthermore, the algorithm to solve the NNM problem in CT case is also deduced with alternating direction methods of multipliers(ADMM). Lastly, two numerical examples are presented to evaluate the performance of the proposed method and to show the advantages of the proposed method over the existing methods. | Mingxiang Dai Ying He Xinmin Yang | 2016 | IEEE/CAA Journal of Automatica Sinica2016，3，2： | 4 |
| 8 | Probing primordial gravitational waves: Ali CMB Polarization Telescope显示文摘In this paper, we will give a general introduction to the Ali CMB Polarization Telescope(Ali CPT) project,which is a Sino–US joint project led by the Institute of High Energy Physics and involves many different institutes in China. It is the first ground-based Cosmic Microwave Background(CMB) polarization experiment in China and an integral part of China's Gravitational-wave Program. The main scientific goal of the Ali CPT project is to probe the primordial gravitational waves(PGWs) originating from the very early Universe. The AliCPT project includes two stages. The first stage, referred to as AliCPT-1, is to build a telescope in the Ali region of Tibet at an altitude of 5250 meters. Once completed, it will be the highest ground-based CMB observatory in the world and will open a new window for probing PGWs in the northern hemisphere. The AliCPT-1 telescope is designed to have about 7000 transition-edge sensor detectors at 95 GHz and 150 GHz. The second stage is to have a more sensitive telescope(Ali CPT-2) with more than 20 000 detectors. Our simulations show that AliCPT will improve the current constraint on the tensor-to-scalar ratio r by one order of magnitude with three years' observation. Besides the PGWs, Ali CPT will also enable a precise measurement of the CMB rotation angle and provide a precise test of the CPT symmetry. We show that three years' observation will improve the current limit by two orders of magnitude. | Hong Li Si-Yu Li Yang Liu Yong-Ping Li Yifu Cai Mingzhe Li Gong-Bo Zhao Cong-Zhan Liu Zheng-Wei Li He Xu Di Wu Yong-Jie Zhang Zu-Hui Fan Yong-Qiang Yao Chao-Lin Kuo Fang-Jun Lu Xinmin Zhang | 2019 | National Science Review2019，6，1： | 4 |
| 9 | Safety and efficacy of Yupingfeng granules in children with recurrent respiratory tract infection:A randomized clinical trial显示文摘Importance:Recurrent respiratory tract infection(RRTI)is common in children.Inappropriate RRTI treatment will lead to asthma and other diseases,thereby seriously affecting the growth and physical health of children.Immune function modulation can prevent and alleviate childhood RRTI.Yupingfeng(YPF),a patented traditional Chinese medicine(TCM),has immunomodulatory effects and is widely used in China to treat children with RRTI.Objective:To evaluate the safety and efficacy of YPF monotherapy in treating children with RRTI.Methods:This multicenter,randomized,double-blind,double-simulation,noninferiority clinical trial was conducted from January 2015 to August 2017,with an 8-week treatment period and 52-week follow-up after the drug withdrawal.Children aged 2–6 years with RRTI meeting the inclusion and exclusion criteria were enrolled in 13 hospitals in China and divided randomly into three groups(2:2:1 ratio)to receive YPF,pidotimod,or placebo.The primary outcome was the proportion of RRTI returning to normal standard level during the follow-up.The secondary outcomes were reduction in the number of RRTI recurrences,effect on clinical symptoms(in accord with TCM practice),effect per symptom,and safety.The trial was registered at the Chinese Clinical Trials Registry(www.chictr.org.cn)under the unique identifier ChiCTR-IPR-15006847.Results:Three hundred and fifty-one children were enrolled and randomly assigned to 3 groups;124,125,and 61 children in the YPF,pidotimod,and placebo groups,respectively,had completed the trial.During the follow-up,the proportion of RRTI returning to normal standard level was 73.13%,67.15%,and 38.81%with YPF,pidotimod,and placebo,respectively(P<0.0001).The proportion of cases who returned to normal standard level in the YPF group was 34.32%higher than that in the placebo group.The safety profile did not significantly differ among the groups.Interpretation:YPF granules were noninferior to the active control drug pidotimod oral solution for the treatment of RRTI in children,and were superior to placebo,with a high safety profile. | Baoping Xu Xinmin Li Siyuan Hu Yixiao Bao Fengmei Chen Zhimin Chen Yonggang Du Enmei Liu Yufeng Liu Qinghui Mou Baoling Su Bo Wang Jianwen Xu Guiping Xu Qiaozhi Yang Liwei Gao Xiaohui Liu Lei Li Rong Ma Kunling Shen | 2022 | Pediatric Investigation2022，6，2： | 3 |
| 10 | Integrated petrophysical log characterization for tight carbonate reservoir effectiveness: A case study from the Longgang area, Sichuan Basin, China显示文摘Ultra-low porosity and permeability, inhomogeneous fracture distribution, and complex storage space together make the effectiveness evaluation of tight carbonate reservoirs difficult. Aiming at the carbonate reservoirs of the Da'anzhai Formation in the Longgang area of the Sichuan Basin, based on petrophysical experiments and logging response characteristics, we investigated the storage properties of matrix pores and the characteristics of fracture development to establish a method for the characterization of effectiveness of tight reservoirs. Mercury injection and nuclear magnetic resonance (NMR) experiments show that the conventional relationship between porosity and permeability cannot fully reflect the fluid flow behavior in tight matrix pores. Under reservoir conditions, the tight reservoirs still possess certain storage space and permeability, which are controlled by the characteristic structures of the matrix porosity. The degree of fracture development is crucial to the productivity and quality of tight reservoirs. By combining the fracture development similarity of the same type of reservoirs and the fracture development heterogeneity in the same block, a three-level classification method of fracture development was established on the basis of fracture porosity distribution and its cumulative features. According to the actual production data, based on the effectiveness analysis of the matrix pores and fast inversion of fracture parameters from dual laterolog data, we divided the effective reservoirs into three classes Class I with developed fractures and pores, and high-intermediate productivity; Class II with moderately developed fractures and pores or of fractured type, and intermediate-low productivity; Class III with poorly developed fractures and matrix pores, and extremely low productivity. Accordingly log classification standards were set up. Production data shows that the classification of effective reservoirs is highly consistent with the reservoir productivity level, providing a new approach for the effectiveness evaluation of tight reservoirs. | Deng Shaogui Wang Yang Hu Yunyun Ge Xinmin He Xuquan | 2013 | Petroleum Science2013，10，3： | 3 |
| 11 | Neutron activation analysis and Mossbauer spectroscopy research on coloring mechanism of Chinese Ru porcelain显示文摘The characteristic spectrum and its main wavelength of Ru porcelain glaze are measured by color difference instrument to determine the relations between glaze color and its main wavelength. The content of the 30 coloring elements in Ru porcelain is determined by neutron activation analysis (NAA), which showed that iron is the major coloring element. Mossbauer spectroscopy analysis shows that the iron element in the glaze exists in the form of structural iron (Fe2+, Fe3+). The quantitative relationship between the main wavelength of glaze in various colors and the relative content of structural iron (Fe2+/Fe3+) is determined. Thus the coloring mechanism of Ru porcelain is investigated entirely. | LI Rongwu YANG Lei LI Guoxia ZHAO Weijuan GAO Zhengyao XIE Jianzhong CHEN Jin ZHANG Bin SUN Xinmin FENG Songlin JIA Xiuqin HAN Song HUANG Zhongxiang | 2002 | Chinese Science Bulletin2002，47，14： | 2 |
| 12 | GENERALIZED SUBCONVEXLIKE FUNCTIONS AND MULTIPLE OBJECTIVE OPTIMIZATION 显示文摘GENERALIZEDSUBCONVEXLIKEFUNCTIONSANDMULTIPLEOBJECTIVEOPTIMIZATION￥YANGXinmin(DepartmentofMathematics,ChongqingNormalUniversit... | YANG Xinmin(Department of Mathematics, Chongqing Normal University, Chongqing 630047,China) | 1995 | Systems Science and Mathematical Sciences1995，8，3： | 2 |
| 13 | Optimal value functions of generalized semi-infinite min-max programming on a noncompact set显示文摘In this paper, we study optimal value functions of generalized semi-infinite min-max programming problems on a noncompact set. Directional derivatives and subdifferential characterizations of optimal value functions are given. Using these properties,we establish first order optimality conditions for unconstrained generalized semi-infinite programming problems. | WANG Changyu, YANG Xiaoqi & YANG Xinmin Institute oi Operations Research, Qufu Normal University, Qufu 273165, China Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, China Department of Applied Mathematics, The Hong Kong Polytechnic University, Hong Kong, China Department of Mathematics, Chongqing Normal University, Chongqing 400047, China | 2005 | Science China Mathematics2005，48，2： | 2 |
| 14 | Lightweight design of automobile component using high strength steel based on dent resistance显示文摘 | ZHANG Yang LAI Xinmin ZHU Ping | 2006 | Materials and Design2006，27，： | 1 |
| 15 | Aproperly on convex fuzzy sets显示文摘 | Yang Xinmin Feng Mei | 2002 | Fuzzy Sets and Systems2002，126，： | 1 |
| 16 | Some properties of convex fuzzy sets显示文摘 | Yang Xinmin | 1995 | Fuzzy Sets and Systems1995，72，： | 1 |
| 17 | Multiple amino acid substitutions are involved in the adaptation of H9N2 avian influenza virus to mice显示文摘 | Rui Wu Hongbo Zhang Keli Yang Wangwang Liang Zhongliang Xiong Zewen Liu Xuehai Yang Huabin Shao Xinmin Zheng Mingxin Chen Diping Xu | 2009 | Veterinary Microbiology2009，，1： | 1 |
| 18 | Convergence properties of nonmonotone spectral projected gradient methods显示文摘 | Changyu Wang Qian Liu Xinmin Yang | 2004 | Journal of Computational and Applied Mathematics2004，，： | 1 |
| 19 | A characterization of convex functions 显示文摘 | YANG XINMIN TEO K L YANG XIAOQI | 2000 | Applied Mathematics Letter2000，13，： | 1 |
| 20 | Technical note on E-Convex sets, E-Cofunctions and E-Convex programming显示文摘 | YANG Xinmin | 2001 | Journal of Optimization Theory and Applications2001，109，3： | 1 |
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