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| 1 | Multiple genetic alterations and behavior of cellular biology in gastric cancer and other gastric mucosal lesions:H.pylori infection,histological types and staging显示文摘AIM To investigate the expression of multiplegenes and the behavior of cellular biology ingastric cancer(GC)and other gastric mucosallesions and their relations to Helicobacter pylori(H.pylori)infection,tumor staging andhistological subtypes.METHODS Three hundred and twenty-sevenspecimens of gastric mucosa obtained viaendoscopy or surgical resection,and ABCimmunohistochemical staining were used todetect the expression of p53,p16,Bcl-2 andCOX-2 proteins.H.pylori was determined byrapid urea test combined with pathologicalstaining or14C urea breath test.Cellular image analysis was performed in 66 patients withintestinal metaplasia(IM)and/or dysplasia(Dys).In 30 of them,both cancer and theparacancerous tissues were obtained at the timeof surgery.Histological pattern,tumor staging,lymph node metastasis,grading ofdifferentiation and other clinical data werestudied in the medical records.RESULTS p16 expression of IM or Dys wassignificantly lower in positive H.pylori chronicatrophic gastritis(CAG)than those withnegative H.pylori(CAG:54.8% vs 88.0%,IM:34.4% vs 69.6%,Dys:23.8% vs 53.6%,allP<0.05),Bcl-2 or COX-2 expression of IM orDys in positive H.pylori cases was significantlyhigher than that without H.pylori(Bcl-2:68.8%vs23.9%,90.5% vs 60.7%;COX-2:50.0% vs10.8%,61.8% vs 17.8%;all P<0.05).Themean number of most parameters of cellularimage analysis in positive H.pylori group wassignificantly higher than that in negative H.pylori group(Ellipser:53±14,40±12μm,Area1:748±572,302±202 μm2,Area2:3050±1661,1681±1990 μm2,all P<0.05;Ellipseb:79±23,58±15 μm,Ratio1:22%±5%,13%±4%,Ratio2:79%±17%,53%±20%,all P<0.01).There was significant correlation between Bcl-2and histologic pattern of gastric carcinoma,andbetween COX-2 and tumor staging or lymph nodemetastasis(Bcl-2:75.0% vs 16.7%;COX-2:76.0% vs 20.0%,79.2% vs 16.7%;allP<0.05).CONCLUSION p1l6, Bcl-2, and COX-2 but not p53 gene may play a role in the early genesis/ progression of gastric carcinoma and are associated with H. pylori infection. p53 gene is relatively late event in gastric tumorigenesis and mainly relates to its progression. There is more cellular-biological behavior of malignant tumor in gastric mucosal lesions with H. pylori infection. Aberrant Bcl-2 protein expression appears to be preferentially associated with the intestinal type cancer. COX-2 seems to be related to tumor staging and lymph node metastasis. | Heng Jun Gao Lian Zhen Yu Jian Feng Bai Yan Shen Peng Gu Sun Han Lin Zhao Kun Miu Xiu Zhen Lü Xiao Yong Zhang Zhi Quan Zhao | 2000 | World Journal of Gastroenterology2000，6，6： | 52 |
| 2 | Expression of insulin-like growth factor Ⅱ and its receptor in liver cells of chronic liver diseases显示文摘ExpressionofinsulinlikegrowthfactorⅡanditsreceptorinlivercelsofchronicliverdiseasesYANGDongHua1,XIUChong1,YANGBo1,GUJianR... | YANG Dong Hua 1, XIU Chong 1, YANG Bo 1, GU Jian Ren 2, QIAN Lian Fang 2 and QU Shu Ming 2 | 1997 | World Journal of Gastroenterology1997，3，2： | 21 |
| 3 | Traditional Chinese medicine integrated with chemotherapy for stage Ⅳ non-surgical gastric cancer: a retrospective clinical analysis显示文摘OBJECTIVE: Traditional Chinese medicine(TCM) is regarded as an important treatment for gastric cancer patients, especially for those in advanced stage. To evaluate the effects of TCM treatment on gastric cancer patients, the authors performed a retrospective study to report the result of the integrated treatment of TCM with chemotherapy for stage IV non-surgical gastric cancer.METHODS: In this study, 182 patients with stage IV and non-surgical gastric cancer were retrospectively analyzed to evaluate the effects of TCM integrated with chemotherapy. Among the 182 cases, 88 cases received integrated therapy consisting of TCM and chemotherapy, while 94 cases received chemotherapy alone. The overall survival and Karnofsky performance status(KPS) score were measured as the main outcome.RESULTS: The median overall survival of the integrated therapy group and chemotherapy group were 16.9 and 10.5 months, respectively. The 1-, 3-and 5-year survival rates of integrated therapy group vs. chemotherapy group were 70% vs. 32%, 18% vs. 4%, and 11% vs. 0%, respectively. There was a significant difference between the two groups(χ2 = 42.244, P < 0.001). After six-month treatment, KPS scores of the integrated therapy group and the chemotherapy group were 75.00 ± 14.78 and 60.64 ± 21.39, respectively(P < 0.001). The Cox regression analysis showed that TCM treatment is a protective factor for patients' overall survival. CONCLUSION: This study demonstrated that TCM integrated with chemotherapy may prolong overall survival and improve survival rate and life quality of patients with stage IV non-surgical gastric cancer. | xuan liu li-juan xiu jian-peng jiao jing zhao ying zhao ye lu jun shi yong-jin li min ye yu-fang gu xiao-wei wang jing-yu xu ci-an zhang yong-ying liu yun luo xiao-qiang yue | 2017 | Journal of Integrative Medicine2017，15，6： | 18 |
| 4 | Leakage Prediction Method for Contacting Mechanical Seals with Parallel Faces显示文摘Since the beginning of the 20th century, many researches on the sealing characteristic of mechanical seals were carried out broadly and in depth by various methods and some leakage models were built. But due to the lack of the way to characterize the main factors of influence on the leakage, most of the early researches were based on the assumptions that the seal faces topography and the frictional conditions were invariant. In the early built models, the effect of the surface topography change of the seal face on the leakage rate was neglected. Based on the fractal theory, the contact of end faces of the rotary and stationary rings was simplified to be the contact of a rough surface and an ideal rigid smooth surface, and the contact interface’s cavity size-distribution function as well as the fractal characteristic of the cavity profile curve was discussed. By analyzing the influence of abrasion on the seal face topography and the leakage channel, the time-correlation leakage prediction model of mechanical seals based on the fractal theory was established and the method for predicting the leakage rate of mechanical seals with parallel plane was proposed. The values of the leakage rate predicted theoretically are similar to the measured values of the leakage rate in the model test and in situ test. The experimental results indicate that the leakage rate of mechanical seals is a transient value. The surface topography of the end faces of the seal rings and its change during the frictional wear of mechanical seals can be accurately characterized by the fractal parameters. Under the work conditions of changeless frictional mechanism, the fractal parameters measured or calculated based on the accelerated testing equation can be used to predict the leakage rate of mechanical seal in service. The proposed research provides the basis for determining the leakage state and predicting working life of mechanical seal. | SUN Jianjun WEI Long FENG Xiu GU Boqin | 2010 | Chinese Journal of Mechanical Engineering2010，23，1： | 16 |
| 5 | Ginsenoside-Rg_6, a Novel Triterpenoid Saponin from the Stem-Leaves of Panax ginseng C. A. Mey.显示文摘A novel dammarane-type triterpene oligoglycoside, named ginsenoside-Rg6 3, was isolated from the stem-leaves of Panax ginseng C. A. Mey., together with two known ones, 20(S)-ginsenoside-Rg2 1 and 20(R)-ginsenoside-Rg2 2. On the basis of chemical and physicochemical evidence , the structure of ginsenoside-Rg6 have been elucidated as 6-O-(-L-rhamnosyl-(1?2)-(-D-glucopyranosyl-dammarane-(E)-20(22), 24-diene-3(, 6(, 12(-triol. | Xiu Wei YANG, Long Yun LI, Jian Ming TIAN, Zhi Wei ZHANG, Jin Mei YE, Wei Fang Gu (National Research Laboratory of Natural & Biomimetic Drugs, Peking University, Beijing 100083) (Academy of Chinese Traditional Medicine and Materia Medica of Jilin Provinc | 2000 | Chinese Chemical Letters2000，11，10： | 12 |
| 6 | LASER LIFT-OFF OF GaN THIN FILMS FROM SAPPHIRE SUBSTRATES显示文摘Gallium Nitride film was successfully separated from sapphire substrate by laser radiation. The absorption of the 248nm radiation by the GaN at the interface results in rapid thermal decomposition of the interfacial layer, yielding metallic Ga and N2 gas. The substrate can be easily removed by heating above the Ga melting point (29℃). X-ray diffraction, atomic force microscopy and Photoluminescence of CaN before and after lift-off process have been performed, which demonstrated that the separation and transfer process do not alter the structural quality of the GaN films. And further discussions on the threshold energy and crack-free strategies of laser lift-off process have also been presented. | J. Xu, R. Zhang, Y.P. Wang, X.Q. Xiu, S.L. Gu, B. Shen, Y. Shi, Z.G. Liu and Y.D. Zheng (Department of Physics and National Laboratory of Solid State Microstructures, Nanjing University, Nanjing 210093, China) | 2001 | Acta Metallurgica Sinica(English Letters)2001，14，6： | 10 |
| 7 | Association between Plasma Metal Levels and Diabetes Risk: a Case-control Study in China显示文摘Objective Many metals, some of which have been classified as environmental endocrine disruptors, are used extensively in everyday consumer products and are ubiquitous in our living environment. In the present study, we aimed to explore the associations between the prevalence risk of type 2 diabetes and plasma levels of 20 trace elements as well as those of heavy metals in a Han Chinese population. Methods We conducted a case-control study to investigate the associations between plasma concentrations of 20 metals and diabetes in Jiangsu province. A total of 122 newly diagnosed cases of type 2 diabetes and 429 matched controls were recruited from community physical examinations in Suzhou City of Jiangsu Province. Plasma metal levels were measured by inductively-coupled plasma mass spectrometry. Results After adjusting for confounders, plasma vanadium, chromium, manganese, copper, zinc, arsenic, selenium, strontium, palladium, cadmium, cesium, and barium were associated with diabetes risk(P < 0.05). The adjusted OR increased with increasing concentration of vanadium, manganese, copper, zinc, and cesium. Conclusion Many metals, including manganese, copper, zinc, arsenic, selenium, and cadmium in plasma, are associated with the morbidity of diabetes. Monitoring of environmental metal levels and further studies are urgently needed. | LI Xiu Ting YU Peng Fei GAO Yan GUO Wen Hui WANG Jun LIU Xin GU Ai Hua JI Gui Xiang DONG Qiu WANG Bo Shen CAO Ying ZHU Bao Li XIAO Hang | 2017 | Biomedical and Environmental Sciences2017，30，7： | 8 |
| 8 | Influence of IFNα-2b and BCG on the release of TNF and IL-1 by Kupffer cells in rats with hepatoma显示文摘INTRODUCTIONKupffer cells are residential macrophages in the liver ,which play a critical role in the maintenance of normal liver function and in immunal surveilance of hepatocellular carcinoma (HCC) and other cancers[1].The biological immune modulants have cancers[2].In our previous studies ,the combined use of biological immune modulants showed better dffects . | Xian Yong Bai~1 Xiu Hong Jia~2 Ling Zhong Cheng~3 Yun Di Gu~3 ~1Department of Histology and Embryology,Binzhou Medical College,Binzhou 256603,Shandong Province,China ~2Departrnent of Pediatrics,Binzhou Medical College,Binzhou 256603,Shandong Province,China ~3Department of Histology and Embryology,Shanghai Medical University,Shanghai 200032,ChinaDr.Xian Yong Bai graduated from the Shanghai Medical University as a postgraduate in 1995,Professor of Histology and Embryology,specialized in hepatic tumor immunology,having 36 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 7 |
| 9 | Genetic aberration in primary hepatocellular carcinoma:correlation between p53 gene mutation and loss-of-heterozygosity on chromosome 16q21-q23 and 9p21-p23显示文摘To elucidate the molecular pathology underlying the development of hepatocellular carcinoma (HCC), we used 41 highly polymorphic microsatellite markers to examine 55 HCC and corresponding non-tumor liver tissues on chromosome 9, 16 and 17. Loss-of-heterozygosity (LOH) is observed with high frequency on chromosomal region 17p13 (36/55, 65%), 9p21-p23 (28/55, 51%), 16q21-q23 (27/55, 49%) in tumors. Meanwhile, microsatellite instability is rarely found in these microsatellite loci. Direct sequencing was performed to detect the tentative mutation of tumor suppressor genes in these regions: p53, MTS1/p16, and CDH1/E-cadherin. Within exon 5-9 of p53 gene, 14 out of 55 HCC specimens (24%) have somatic mutations, and nucleotide deletion of this gene is reported in HCC for the first time. Mutation in MTS1/pl6 is found only in one tumor case. We do not find mutations in CDH1/E-cadherin. Furthermore, a statistically significant correlation is present between p53 gene mutation and loss of chromosome region 16q21q23 and 9p21-p23, which indicates that synergism between p53 inactivation and deletion of 16q21-q23 and 9p21-p23 may play a role in the pathogenesis of HCC. Genetic aberration in hepatocellular | WANG GANG CHANG HUI HUANG YAN ZHAO LING CAI YING WANG SHI JIN XIU ZHENG WEN JIANG SHUANG YANG XIN TAI ZHAO WEI HUANG JIAN REN GU | 2000 | Cell Research2000，10，4： | 7 |
| 10 | Effect of β3-adrenergic agonists on alveolar fluid clearance in hypoxic rat lungs显示文摘背景最近的研究建议 _2 肾上腺素能的收缩筋在生理、病理学的条件下面增加牙槽的液体清理(声频抗流圈) 。_3 肾上腺素能的收缩筋是否也在病理学的条件下面增加声频抗流圈,是未知的。这研究的目的是调查 _3 的效果肾上腺素能的声频抗流圈后面的 hypoxic 肺损害和机制 involved.Methods Hypoxic 老鼠上的收缩筋暴露于 10% 氧。BRL-37344 (_3 肾上腺素能的收缩筋) 或 CGP-12177 (选择 _3 肾上腺素能的收缩筋) 与受体对手,钠隧道 blockers,或 Na^+/K^+-ATPase blockers 独自一个或联合被酒直到暴露于 10% 氧 48 个小时的老鼠的牙槽的空间。全部的肺水内容(TLW ) 和声频抗流圈是声频抗流圈没改变开始的 24 个小时了,但是然后在 48 小时的暴露以后减少到 10% 氧的 measured.Results。BRL-37344 或 CGP-12177 的灌注显著地在正常和 hypoxic 老鼠增加了声频抗流圈。CGP-12177 的刺激声频抗流圈的效果被 37% 和 49% 分别地与 amiloride (Na^+ 隧道 blocker ) 和 ouabain (一个 Na^+/K^+-ATPase 禁止者) 降低。用番红花作原料而制成的植物盐基显著地禁止了 CGP-12177.Conclusions 的效果这些调查结果建议那(3-adrenergic 收缩筋能在老鼠在 hypoxic 肺损害期间增加声频抗流圈并且加速肺的浮肿的改善。 | LI Nai-jing LI Wei HE Ping GU Xiu LI Sheng-qi | 2010 | Chinese Medical Journal2010，，8： | 6 |
| 11 | Anatomical characteristics of patients with symptomatic severe aortic stenosis in China显示文摘With accumulating evidence of transcatheter aortic valve replacement(TAVR)worldwide,it is gradually realized that patients being treated are different across different coun-tries,including but not limited to their age,habitus,disease etiology,aortic valve morphology,and sizes of structures.[1]In China,the average age of TAVR patients is around 5 years younger than industrialized countries,[2]making Chinese patients a good predictive sample of what the industrialized countries might see in TAVR screening in the near future due to the expansion of this technique to younger patients,but anatomical features appreciated from multi-slice computed tomography(MSCT)in the Chinese patient population have not been well demonstrated. | Tian-Yuan Xiong Yi-Ming Li Yi-Jun Yao Yu-Heng Jia Kai Xu Zhen-Fei Fang Jun Jin Guo-Sheng Fu Yi-Ning Yang Lei Jiang Wei-Dong Li Yan-Qing Wu Yan-Song Guo Ran Guo Yun-Dai Chen Yi Li Yi-Bing Shao Yi Zhang Bo-Sen Yang Yi-Ke Zhang Jing-Jing He Kai-Yu Jia Sheng-Hu He Fa-Xin Ren Jian-Cheng Xiu Xing-Hua Gu Liang-Long Chen Ke Han Yuan Feng Mao Chen | 2021 | Chinese Medical Journal2021，，22： | 5 |
| 12 | Some observational results of sea storm current显示文摘 | Xiu Richen, Liu Aiju, Ye Hesong, Gu Yuhe, Xu Lanying (1. First Institute of Oceanography, State Oceanic Administration, Qingdao 266061, China 2. Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China) | 2001 | Acta Oceanologica Sinica2001，20，2： | 4 |
| 13 | Towards a global One Health index: a potential assessment tool for One Health performance显示文摘Background:A One Health approach has been increasingly mainstreamed by the international community, as it provides for holistic thinking in recognizing the close links and inter-dependence of the health of humans, animals and the environment. However, the dearth of real-world evidence has hampered application of a One Health approach in shaping policies and practice. This study proposes the development of a potential evaluation tool for One Health performance, in order to contribute to the scientific measurement of One Health approach and the identification of gaps where One Health capacity building is most urgently needed.Methods:We describe five steps towards a global One Health index (GOHI), including (i) framework formulation;(ii) indicator selection;(iii) database building;(iv) weight determination;and (v) GOHI scores calculation. A cell-like framework for GOHI is proposed, which comprises an external drivers index (EDI), an intrinsic drivers index (IDI) and a core drivers index (CDI). We construct the indicator scheme for GOHI based on this framework after multiple rounds of panel discussions with our expert advisory committee. A fuzzy analytical hierarchy process is adopted to determine the weights for each of the indicators.Results:The weighted indicator scheme of GOHI comprises three first-level indicators, 13 second-level indicators, and 57 third-level indicators. According to the pilot analysis based on the data from more than 200 countries/territories the GOHI scores overall are far from ideal (the highest score of 65.0 out of a maximum score of 100), and we found considerable variations among different countries/territories (31.8–65.0). The results from the pilot analysis are consistent with the results from a literature review, which suggests that a GOHI as a potential tool for the assessment of One Health performance might be feasible.Conclusions:GOHI—subject to rigorous validation—would represent the world’s first evaluation tool that constructs the conceptual framework from a holistic perspective of One Health. Future application of GOHI might promote a common understanding of a strong One Health approach and provide reference for promoting effective measures to strengthen One Health capacity building. With further adaptations under various scenarios, GOHI, along with its technical protocols and databases, will be updated regularly to address current technical limitations, and capture new knowledge. | Xiao-Xi Zhang Jing-Shu Liu Le-Fei Han Shang Xia Shi-Zhu Li Odel YLi Kokouvi Kassegne Min Li Kun Yin Qin-Qin Hu Le-Shan Xiu Yong-Zhang Zhu Liang-Yu Huang Xiang-Cheng Wang Yi Zhang Han-Qing Zhao Jing-Xian Yin Tian-Ge Jiang Qin Li Si-Wei Fei Si-Yu Gu Fu-Min Chen Nan Zhou Zi-Le Cheng Yi Xie Hui-Min Li Jin Chen Zhao-Yu Guo Jia-Xin Feng Lin Ai Jing-Bo Xue Qian Ye Liz Grant Jun-Xia Song Geoff Simm Jürg Utzinger Xiao-Kui Guo Xiao-Nong Zhou | 2022 | Infectious Diseases of Poverty2022，11，3： | 3 |
| 14 | Effect of Phenylephrine on Alveolar Fluid Clearance in Ventilator-induced Lung Injury显示文摘Objective To investigate the effect of phenylephrine(an α-adrenergic agonist) on alveolar fluid clearance(AFC) in ventilator-induced lung injury and the possible mechanism involved.Methods A total of 170 male Wistar rats were randomly allocated into 17 groups(n=10) using random number tables.Short-term(40 minutes) mechanical ventilation with high tidal volume(HVT) was performed to induce lung injury,impair active Na + transport and lung liquid clearance in the rats.Unventilated rats served as controls.To demonstrate the effect of phenylephrine on AFC,phenylephrine at different concentrations(1×10-5,1×10-6,1×10-7,1×10-8,and 1×10-9 mol/L) was injected into the alveolar space of the HVT ventilated rats.To identify the influence of adrenergic antagonists,Na + channel,and microtubular system on the effect of phenylephrine,phenylephrine at 1×10-5 mol/L combined with prazosin(an α 1-adrenergic antagonist,1×10-4 mol/L),yohimbine(an α 2-adrenergic antagonist,1×10-4 mol/L),atenolol(a β 1 adrenergic antagonist,1×10-5 mol/L),ICI-118551(an β 2-adrenergic antagonist,1×10-5 mol/L),amiloride(a Na + channel blocker,5×10-4 mol/L),ouabain(a Na + /K +-ATPase blocker,5×10-4 mol/L),colchicine(a microtubular disrupting agent,0.25 mg/100 g body weight),or β-lumicolchicine(an isomer of colchicine,0.25 mg/100 g body weight) were perfused into the alveolar space of the rats ventilated with HVT for 40 minutes.AFC and total lung water content were measured.Results Basal AFC in control rats was(17.47±2.56)%/hour,which decreased to(9.64± 1.32)%/hour in HVT ventilated rats(P=0.003).The perfusion of phenylephrine at 1×10-8,1×10-7,1×10-6,and 1×10-5 mol/L significantly increased the AFC in HVT ventilated rats(all P<0.05).This effect of phenylephrine on AFC was suppressed by prazosin,atenolol,and ICI-118551 in HVT ventilated rats by 53%,31%,and 37%,respectively(all P<0.05).The AFC-stimulating effect of phenylephrine was lowered by 33% and 42% with amiloride and ouabain,respectively(both P<0.05).Colchicine significantly inhibited the effect of phenylephrine(P=0.031).Conclusion Phenylephrine could increase the AFC in HVT-ventilated rats and accelerate the absorption of pulmonary edema. | Nai-jing Li Xiu Gu Wei Li Yan Li Sheng-qi Li Ping He | 2013 | Chinese Medical Sciences Journal2013，28，1： | 3 |
| 15 | Development of Orthographic Awareness, Morphological Awareness and Rapid Automatized Naming of Elementary-level Students in China: A Longitudinal Analysis from Grades 1 to 4显示文摘 | Xiu LUO Rui KONG Ling-fei LIU Jia WANG Huai-ting GU Fang HOU Ran-ran SONG | 2018 | Current Medical Science2018，38，2： | 2 |
| 16 | Towards carbon neutrality:A study on China's long-term low-carbon transition pathways and strategies显示文摘As the world's biggest carbon dioxide(CO_(2))emitter and the largest developing country,China faces daunting challenges to peak its emissions before 2030 and achieve carbon neutrality within 40 years.This study fully considered the carbon-neutrality goal and the temperature rise constraints required by the Paris Agreement,by developing six long-term development scenarios,and conducting a quantitative evaluation on the carbon emissions pathways,energy transformation,technology,policy and investment demand for each scenario.This study combined both bottom-up and top-down methodologies,including simulations and analyses of energy consumption of end-use and power sectors(bottom-up),as well as scenario analysis,investment demand and technology evaluation at the macro level(top-down).This study demonstrates that achieving carbon neutrality before 2060 translates to significant efforts and overwhelming challenges for China.To comply with the target,a high rate of an average annual reduction of CO_(2) emissions by 9.3%from 2030 to 2050 is a necessity,which requires a huge investment demand.For example,in the 1.5℃ scenario,an investment in energy infrastructure alone equivalent to 2.6%of that year's GDP will be necessary.The technological pathway towards carbon neutrality will rely highly on both conventional emission reduction technologies and breakthrough technologies.China needs to balance a long-term development strategy of lower greenhouse gas emissions that meets both the Paris Agreement and the long-term goals for domestic economic and social development,with a phased implementation for both its five-year and long-term plans. | Jiankun He Zheng Li Xiliang Zhang Hailin Wang Wenjuan Dong Ershun Du Shiyan Chang Xunmin Ou Siyue Guo Zhiyu Tian Alun Gu Fei Teng Bin Hu Xiu Yang Siyuan Chen Mingtao Yao Zhiyi Yuan Li Zhou Xiaofan Zhao Ying Li Danwei Zhang | 2022 | Environmental Science and Ecotechnology2022，，1： | 2 |
| 17 | Annual Periodic Increases in Serum Carcinoembryonic Antigen Concurrent with Ground-Glass Opacity in the Lung: Report of a Case显示文摘 | Tsutomu Sakuma Yumiko Iwata Yoshimichi Ueda Xiu Gu Makoto Sugita Motoyasu Sagawa | 2005 | Surgery Today2005，，10： | 1 |
| 18 | The rs2227481 C>T Polymorphism in the IL22 Gene Promoter Significantly Reduces the Risk of Liver,Lung,and Gastric Cancer in a Han Chinese Population显示文摘Cancer is a serious threat to public health and the economy worldwide.Statistical data from the World Health Organization(WHO)in 2018 have demonstrated that lung cancer is the most commonly diagnosed cancer(11.6%of the total cases)and the leading cause of cancer death(18.4%of the total cancer deaths),closely followed bygastric cancer(5.7%and 8.2%),and liver cancer(4.7%and 8.2%). | CHAI Long Long XIAO Ying Xuan MENG Ling Han WANG Huan FENG Xian Hong GU Xiu Li LI Qi Chang XIONG Qian Tao CHEN Bi Feng | 2021 | Biomedical and Environmental Sciences2021，34，7： | 1 |
| 19 | Expression of RET proto-oncogene and GDNF deficit in Hirschsprung's disease显示文摘 | Zhan J Xiu Y Gu J | 1999 | J Pediatr Surg1999，34，11： | 1 |
| 20 | Functions of Mulberry in the Development of Ecological Animal Husbandry and Development Ideas显示文摘Ecological animal husbandry is an animal husbandry industry system integrating ecological benefit,economic benefit and social benefit.Breeding cycle is one of the main patterns of ecological animal husbandry development,but breeding cycle does not form a relatively closed cycle of endogenous resources.In recent years,forage value and ecological value of mulberry have made some progresses in different research areas and angles,but the thought and practice of both forage and ecological value of mulberry has not been systematically interpreted and researched.Based on the short board of animal husbandry development and the advantage of mulberry,animal husbandry and mulberry were complemented and fused,and relatively closed planting and raising ecological recycling pattern with mulberry as the axis was raised.Phased scientific research and production test data were obtained,and the problems and development suggestions were put forward in the following aspects: selection of mulberry varieties with both forage and ecological value,cost control of mulberry with both forage and ecological value,quality and safety control system of forage mulberry,orientation of feeding value of forage mulberry. | Zeng Xiu Wang Jieping Zhou Chan Lv Jinfeng Wang Haiyan Gu Shanlin Xiong Dingkui | 2017 | Animal Husbandry and Feed Science2017，9，6： | 1 |
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