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| 1 | nterferon alpha (IFNα)-induced TRIM22 interrupts HCV 'eplication by ubiquitinating NS5A显示文摘 | Chen Yang Xinhao Zhao Dakang Sun Leilei Yang Chang Chong Yu Pan Xiumei Chi Yanhang Gao Moli Wang Xiaodong Shi Haibo Sun Juan Lv Yuanda Gao Jin Zhong Junqi Niu Bing Sun | 2016 | Cellular & Molecular Immunology2016，13，1： | 13 |
| 2 | Advanced fabrication for electrospun three-dimensional nanofiber aerogels and scaffolds显示文摘Electrospinning is a versatile strategy for creating nanofiber materials with various structures,which has broad application for a myriad of areas ranging from tissue engineering,energy harvesting,filtration and has become one of the most important academic and technical activities in the field of material science in recent years.In addition to playing a significant role in the construction of two-dimensional(2D)nanomaterials,electrospinning holds great promise as a robust method for producing three-dimensional(3D)aerogels and scaffolds.This article reviews and summarizes the recent advanced methods for fabricating electrospun three-dimensional nanofiber aerogels and scaffolds,including gas foaming,direct electrospinning of 3D nanofibrous scaffold,short nanofibers assembling into 3D aerogels/scaffolds,3D printing,electrospray,origami and cell sheet engineering,centrifugal electrospinning,and other methods.Besides,intriguing formation process,crosslinking pathway,properties,and applications of 3D aerogels and scaffolds are also introduced.Taken together,these aerogels and scaffolds with various excellent features present tremendous potential in various fields. | Yujie Chen Muhammad Shafiq Mingyue Liu Yosry Morsi Xiumei Mo | 2020 | Bioactive Materials2020，5，4： | 12 |
| 3 | Correlation of CD105 and Vascular Endothelial Growth Factor in Laser-induced Choroidal Neovascularization in Rats显示文摘Purpose: Choroidal neovascularization (CNV) plays an important role in pathogenesis of age-related macular degeneration (AMD), ocular histoplasmosis syndrome (OHS) and so on. However, mechanisms of CNV formation are not fully understood. The aim of this study is to investigate the correlation between expressions of CD105 and vascular endothelial growth factor (VEGF) in experimental laser-induced CNV in rats. Methods: CNV model was established by 532 nm laser photocoagulation in Brown-Norway rats. The expression of CD105 and VEGF in CNV was observed by immunohistochemistry at 3, 7, 14, 21, 28 and 56 days after laser photocoagulation. The image analysis was performed with the professional software of Image-Pro Plus. Results: Fluorescein angiography showed fluorescein leakage in CNV from days 7 to 56 after photocoagulation. VEGF expression was mainly observed in vascular endothelial cells, ganglion cells, inner nuclear layers and retinal pigment epithelial cells in normal retina and vascular endothelial cells in normal choroid of the rats. On day 3 after photocoagulation, VEGF began to express in laser-induced lesions. VEGF was strongly expressed in CNV after 7 days (P<0.05) and decreased after 14 days (P>0.05). CD105 was initially presented in CNV at 7 days and obviously expressed at 14 days after photocoagulation (P<0.05). Four weeks later, when angiogenesis tended toward inactive status, expression of CD105 was markedly decreased (P>0.05). There was notablely direct correlation between CD105-positive-microvessel density and positively semiquantitative scoring of VEGF in the CNV(r=0.989, P<0.01). Conclusions: There is direct correlation between the expression of CD105 and VEGF in the laser-induced CNV in rat. It suggests that CD105 and VEGF might participate in the new blood vessel formation and promote the growth of CNV. | Jianfeng Xu Yusheng Wang Xiumei Yang Peng Zhang Lijun Chen | 2006 | 眼科学报2006，22，3： | 8 |
| 4 | An update on the function and regulation of methylerythritol phosphate and mevalonate pathways and their evolutionary dynamics显示文摘Isoprenoids are among the largest and most chemically diverse classes of organic compounds in nature and are involved in the processes of photosynthesis, respiration, growth, development,and plant responses to stress. The basic building block units for isoprenoid synthesis-isopentenyl diphosphate and its isomer dimethylallyl diphosphate-are generated by the mevalonate (MVA) and methylerythritol phosphate(MEP) pathways. Here, we summarize recent advances on the roles of the MEP and MVA pathways in plant growth, development and stress responses, and attempt to define the underlying gene networks that orchestrate the MEP and MVA pathways in response to developmental or environmental cues.Through phylogenomic analysis, we also provide a new perspective on the evolution of the plant isoprenoid pathway. We conclude that the presence of the MVA pathway in plants may be associated with the transition from aquatic to subaerial and terrestrial environments, as lineages for its core components are absent in green algae. The emergence of the MVA pathway has acted as a key evolutionary event in plants that facilitated land colonization and subsequent embryo development, as well as adaptation to new and varied environments. | Xiaojun Pu Xiumei Dong Qing Li Zexi Chen Li Liu | 2021 | Journal of Integrative Plant Biology2021，63，7： | 8 |
| 5 | Free-standing porous carbon electrodes derived from wood for high-performance Li-O2 battery applications显示文摘 | Jingru Luo Xiahui Yao Lei Yang Yang Han Liao Chen Xiumei Geng Vivek Vattipalli Qi Dong Wei Fan Dunwei Wang Hongli Zhu | 2017 | Nano Research2017，10，12： | 7 |
| 6 | Electrospinning nanofiber scaffolds for soft and hard tissue regeneration显示文摘Tissue engineering is an interdisciplinary field that integrates medical,biological,and engineering expertise to restore or regenerate the functionality of healthy tissues and organs.The three fundamental pillars of tissue engineering are scaffolds,cells,and biomolecules.Electrospun nanofibers have been successfully used as scaffolds for a variety of tissue engineering applications because they are biomimetic of the natural,fibrous extracellular matrix(ECM)and contain a three-dimensional(3D)network of interconnected pores.In this review,we provide an overview of the electrospinning process,its principles,and the application of the resultant electrospun nanofibers for tissue engineering.We first briefly introduce the electrospinning process and then cover its principles and standard equipment for biomaterial fabrication.Next,we highlight the most important and recent advances related to the applications of electrospun nanofibers in tissue engineering,including skin,blood vessels,nerves,bone,cartilage,and tendon/ligament applications.Finally,we conclude with current advancements in the fabrication of electrospun nanofiber scaffolds and their biomedical applications in emerging areas. | Xianrui Xie Yujie Chen Xiaoyu Wang Xiaoqing Xu Yihong Shen Atta ur Rehman Khan Ali Aldalbahi Allison E.Fetz Gary L.Bowlin Mohamed El-Newehy Xiumei Mo | 2020 | Journal of Materials Science & Technology2020，59，24： | 5 |
| 7 | Persistent hepatitis C virus infections and hepatopathological manifestations in immune-competent humanized mice显示文摘 | Jizheng Chen Yang Zhao Chao Zhang Hairong Chen Jin Feng Xiumei Chi Yu Pan Jun Du Min Guo Huang Cao Honghe Chen Zilong Wang Rongjuan Pei Qian Wang Lei Pan Junqi Niu Xinwen Chen Hong Tang | 2014 | Cell Research2014，24，9： | 5 |
| 8 | Histological Study on the Digestive System Development of Takifugu rubripes Larvae and Juvenile显示文摘Takifugu 的消化道在早年生活舞台期间磨擦 ripes 与光被学习显微镜学。在孵化的开始,消化道被一个简单、无差别的直试管代表并且不与外表交流,因为嘴和肛门还不是开的。在在孵化以后的 2d,在将成为 intestino 直肠的阀门的肠和直肠之间的收缩是可见的。在内长的喂阶段期间,蛋黄囊被再吞,消化道变得功能、区分。肝和胰在这时候也变得明显。在外长的喂的发作(在孵化以后的 3d ) ,蛋黄囊 resesvesare 不完全弄空,建议混合营养的经期。消化道充分区分进 buccopharynx,食管,胃,肠和直肠。在在孵化以后的 9 d,蛋黄囊储备完全被弄空。从 5to 发生的最显著的事件在孵化以后的 17 d 是 epithelia 类型,灵魂囊的区别,上皮的房间,内脏卷绕旋转, mucosal 褶层增加,和肝和胰的生长的转变。从在孵化以后的 18 ~ 27 d,肠褶层和粘液房间的数字日益增多地增加。从那时起,消化特征的词法变化几乎被完成。在在孵化以后的 27 d,消化系统的形态学和函数类似于成年人的。 | WAN Zhenzhen GAO Tianxiang ZHANG Xiumei CHEN Chao YU Changhong | 2006 | Journal of Ocean University of China2006，5，1： | 5 |
| 9 | The contribution of cultivated land occupation by construction to China's economic growth显示文摘The paper applies Cobb-Douglas Production Function and Solow-Swan Model to constructing the calculation model of the contribution rate of cultivated land occupation by construction (CLOC) to China's economic growth,and analyzes the contribution change of CLOC to China's economic growth qualitatively and quantitatively.The main conclusions are as follows:1) From 1989 to 2007,the contribution rates of capital,labor,and CLOC to China's economic growth were 45.76%,8.47%,and 6.19% respectively.2) From the period 1989-1996 to the period 1997-2007 the contribution rate of CLOC to China's economic growth increased from 5.40% to 5.87%.The degree of contribution was enhanced significantly.3) The contribution of CLOC to China's economic growth had a spatial distribution characteristic that the contribution rate of eastern coastal regions was the highest,that of central regions came second,and that of western regions the lowest.The paper indicates that in order to enhance the contribution of CLOC to China's economic growth,some relevant economic and administrative measures might be taken,and land might be used intensively and economically to increase land economic density.The cost of promoting gross domestic product (GDP) growth might be reduced as much as possible to achieve higher GDP growth and lower land resource consumption. | YANG Ke CHEN Baiming DU Hongliang TANG Xiumei | 2011 | Journal of Geographical Sciences2011，21，5： | 5 |
| 10 | Fargeted elimination of mutant mitochondria DNA in MELAS-iPSCs by mitoTALENs显示文摘 | Yi Yang Han Wu Xiangjin Kang Yanhui Liang Ting Lan Tianjie Li Tao Tan Jiangyun Peng Quanjun Zhang Geng An Yali Liu Qian Yu Zhenglai Ma Ying Lian Boon Seng Soh Qingfeng Chen Ping Liu Yaoyong Chen Xiaofang Sun Rong Li Xiumei Zhen Yang Yu Xiaoping Li Yong Fan | 2018 | Protein & Cell2018，9，3： | 4 |
| 11 | Electrodeposition of calcium phosphate onto polyethylene terephthalate artificial ligament enhances graft-bone integration after anterior cruciate ligament reconstruction显示文摘It is a big challenge to develop a polyethylene terephthalate(PET)artificial ligament with excellent osteogenetic activity to enhance graft-bone integration for ligament reconstruction.Herein,we evaluated the effect of biomineralization(BM)and electrodeposition(ED)method for depositing calcium-phosphate(CaP)on the PET artificial ligament in vitro and in vivo.Scanning electron microscopy and energy-dispersive X-Ray spectrometer mapping analysis revealed that the ED-CaP had more uniform particles and element distribution(Ca,P and O),and thermogravimetric analysis showed there were more CaP on the PET/ED-CaP than the PET/BM-CaP scaffold.Moreover,the hydrophilicity of PET scaffolds was significantly improved after CaP deposition.In vitro study showed that CaP coating via BM or ED method could improve the attachment and proliferation of MC3T3-E1 cells,and ED-CaP coating significantly increased osteogenic differentiation of the cells,in which the Wnt/β-catenin signaling pathway might be involved.In addition,radiological,histological and immunohistochemical results of in vivo study in a rabbit anterior cruciate ligament(ACL)reconstruction model demonstrated that the PET/BM-CaP and PET/ED-CaP scaffolds significantly improved graft-bone integration process compared to the PET scaffold.More importantly,larger areas of new bone ingrowth and the formation of fibrocartilage tissue were observed at 12 weeks in the PET/ED-CaP group,and the biomechanical tests showed increased ultimate failure load and stiffness in PET/ED-CaP group compared to PET/BM-CaP and PET group.Therefore,ED of CaP is an effective strategy for the modification of PET artificial ligament and can enhance graft-bone integration both in vitro and in vivo. | Jiangyu Cai Qianqian Zhang Jiebo Chen Jia Jiang Xiumei Mo Chuanglong He Jinzhong Zhao | 2021 | Bioactive Materials2021，6，3： | 4 |
| 12 | A novel mitochondrial tRNA gene mutation in a chinese family with dilated cardiomyopathy and sensorineural deafness显示文摘Objective: To determine whether a mutation of mitochondrial DNA induces familial dilated cardiomyopathy in Chinese families with cardiomyopathy,and analyzed the correlation between the genotype and phenotype. Methods: Affected members in three Chinese families of the familial dilated cardiomyopathy underwent clinical evaluation and DNA analysis. Polymerase chain reaction and direct DNA sequencing were used to screen for mitochondrial DNA mutation. The type of mtDNA variations and clinical situation were analysed on the patients with mitochondrial DNA mutation. Results: The mitochondrial A3434G mutation was identified in one of the three families,the 3434 th nucleotide A was replaced by G, which led to change of amino acid. No mutations were identified in the clinically unaffected members of the family and all members of the other two families. Conclusion: This study indicates that the mitochondrial A3434G mutation maybe related with familial dilated cardiomyopathy and deafness. | Xianghong Wu Xiumei Xie Guotian Ma Guoju Sun Xiaobin Chen | 2006 | Journal of Nanjing Medical University2006，20，5： | 3 |
| 13 | VcFT-induced mobile florigenic signals in transgenic and transgrafted blueberries显示文摘FLOWERING LOCUS T(FT)can promote early flowering in annual species,but such role has not been well demonstrated in woody species.We produced self and reciprocal grafts involving non-transgenic blueberry(NT)and transgenic blueberry(T)carrying a 35S-driven blueberry FT(VcFT-OX).We demonstrated that the transgenic VcFT-OX rootstock promoted flowering of non-transgenic blueberry scions in the NT(scion):T(rootstock)grafts.We further analyzed RNASeq profiles and six groups of phytohormones in both NT:T and NT:NT plants.We observed content changes of several hormone metabolites,in a descending order,in the transgenic NT:T,non-transgenic NT:T,and non-transgenic NT:NT leaves.By comparing differential expression transcripts(DETs)of these tissues in relative to their control,we found that the non-transgenic NT:T leaves had many DETs shared with the transgenic NT:T leaves,but very few with the transgenic NT:T roots.Interestingly,a number of these shared DETs belong to hormone pathway genes,concurring with the content changes of hormone metabolites in both transgenic and non-transgenic leaves of the NT:T plants.These results suggest that phytohormones induced by VcFT-OX in the transgenic leaves might serve as part of the signals that resulted in early flowering in both transgenic plants and the non-transgenic NT:T scions. | Guo-qing Song Aaron Walworth Tianyi Lin Qiuxia Chen Xiumei Han LIrina Zaharia Gan-yuan Zhong | 2019 | Horticulture Research2019，6，1： | 3 |
| 14 | Determination of Steroid Hormone Residues in Fish Tissues Using Gel Permeation Chromatography and Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry显示文摘A highly sensitive method was developed for the simultaneous determination of 8 steroid hormones in high-fat fish tissues using ultra high performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS).The 8 steroid hormones were extracted from the tissues with diethyl ether.Differing from other common purification methods,the extract solutions were cleaned by gel permeation chromatography(GPC) using ethyl acetate-cyclohexane solution(1:1,v/v) as the mobile phase.The separation of target compounds was carried out by a BEH C18 column and a gradient elution consisting of acetonitrile and 0.2% aqueous formic acid(v/v).The compounds were detected under the multiple reaction monitoring(MRM) mode and quantified with external standard method.This method was validated with respect to linearity,specificity,accuracy and precision.A linearity with correlation coefficient larger than 0.995 was achieved in the range of 0.5 to 50 ng m L^(-1).The average recoveries at the spiked levels of 1.0,5.0,and 10.0 μg kg^(–1) varied between 81.7% and 90.8%,with the relative standard deviations(n=5) ranged from 3.50% to 10.0%.The limit of quantification(LOQ) for 8 steroid hormones ranged from 0.2 to 1.5 μg kg^(-1).It was concluded that this method can be successfully applied for the determination of 8 steroid hormones in complicated matrices including high-fat fish tissues. | LI Peipei YAN Zhongyong SUN Xiumei CHEN Si CHEN Yin ZHANG Xiaojun | 2018 | Journal of Ocean University of China2018，17，5： | 3 |
| 15 | Changes in Vegetation and Assessment of Meteorological Conditions in Ecologically Fragile Karst Areas显示文摘Meteorological conditions have an important impact on changes of vegetation in ecologically fragile karst areas.This study aims to explore a method for quantitative evaluation of these meteorological conditions. We analyzed the changing trend of vegetation during 2000–2018 and the correlations between vegetation changes and various meteorological factors in karst rocky areas of Guangxi Zhuang Autonomous Region, China. Key meteorological factors in vegetation areas with varying degrees of improvement were selected and evaluated at seasonal timescale. A quantitative evaluation model of comprehensive influences of meteorological factors on vegetation was built by using the partial least-square regression(PLS). About 91.45% of the vegetation tended to be improved, while only the rest 8.55% showed a trend of degradation from 2000 to 2018. Areas with evident vegetation improvement were mainly distributed in the middle and northeast, and those with obvious vegetation degradation were scattered. Meteorological factors affecting vegetation were significantly different among the four seasons. Overall, high air humidity, small temperature difference in spring and autumn, and low daily minimum temperature and air pressure were favorable conditions. Low temperature in winter as well as high temperature in summer and autumn were unfavorable conditions. The Climate Vegetation Index(CVI) model was established by PLS using the maximum, minimum, and average temperatures;vapor pressure;rainfall;and air pressure as key meteorological factors. The Enhanced Vegetation Index(EVI) was well fitted by the CVI model, with the average coefficient of determination(r2) and root mean square error(RMSE) of 0.856 and 0.042, respectively. Finally, an assessment model of comprehensive meteorological conditions was built based on the interannual differences in CVI. The meteorological conditions in the study area in 2014 were successfully evaluated by combining the model and selected seasonal key meteorological factors. | Yanli CHEN Weihua MO Yonglin HUANG Jianfei MO Xiaohan HUANG Xiumei WEN | 2021 | Journal of Meteorological Research2021，35，1： | 3 |
| 16 | Decoupling Relationship Between Cultivated Land Occupation by Construction and Economic Growth in China During 1998-2007显示文摘With the rapid development of economy,the conversion of cultivated land into nonagricultural land occurs more frequently and makes cultivated land sparser.This article based on the decoupling theory takes the situations of cultivated land occupation by construction and economic growth in China from 1998 to 2007 as an example to evaluate and analyze the decoupling.The conclusions are drawn as follows.First,the article applies IU curve and gross method.The decoupling status by gross method,in contrast to that by IU curve,can express the pressure from cultivated land occupation better and is similar to the decoupling status based on the model of decoupling in this article.Second,in most provinces of China,the relationship between the cultivated land occupation by construction and economic growth has transformed from expansive negative decoupling to strong decoupling.In general,the transformation was firstly from economically advanced eastern municipalities under the central government directly,then to economically advanced eastern coastal provinces,and lastly to central,western and northeastern regions.Third,the decoupling status was relative to contemporaneous policies and laws on cultivated land protection and regional development planning.Their effect is obvious and positive. | Yang Ke Chen Baiming Tang Xiumei | 2010 | Chinese Journal of Population,Resources and Environment2010，8，1： | 3 |
| 17 | Design, Synthesis and Biological Evaluation of Isothiazole Based 1,2,4-Trizaole Derivatives显示文摘 | Lai Chen Qifan Wu Zhijin Fan Hongpeng Li Jiwei Li Wenhao Hu Xiumei Liu Nataliya P Belskaya Tatiana Glukhareva Bin Zhao | 2018 | Chinese Journal of Chemistry2018，36，8： | 2 |
| 18 | A Taxonomic Re-Assessment of the Novispathodus waageni Group and Its Role in Defining the Base of the Olenekian (Lower Triassic)显示文摘Lower Triassic conodont biostratigraphy has been well studied around the world in the past decades, but the Induan-Olenekian boundary(IOB) remains undecided. The Novispathodus waageni group has been taxonomically re-assessed based on abundant new materials from the Jianshi and Chaohu sections, South China. New study shows that Nv. waageni typically possesses:(1) an approximately equi-dimentional P1 blade element,(2) an accurate upper profile with denticle height descending in both directions,(3) a denticulated posterior edge(lower denticles posterior of the highest denticle), and(4) a round basal cavity outline. Of the three proposed subspecies of the waageni species, both Nv. waageni waageni(Sweet, 1970) and Nv. w. eowaageni(Zhao and Orchard, 2005) are valid, and the former differs clearly from Nv. w. eowaageni in having(1) a slightly higher length/height ratio(holotype=1.30 : 1.23),(2) a thicker blade, sometimes with medial thickening,(3) fewer(broader) denticles per unit length,(4) generally recurved denticles, not straight and upright,(5) highest denticles closer to posterior,(6) common differentiation of a posterior cusp, and(7) more sinuous basal profile, with increased posterior upturning. A third subspecies illustrated as Nv. waageni n. subsp. A sensu Goudemand, 2014 is not conspecific with older individuals of Nv. w. eowaageni, and also cannot be assigned to the Nv. waageni group. Abundant new materials demonstrate a clear ontogenic process for Nv. w. eowaageni, indicating that Nv. w. eowaageni occurring in the Induan-Olenekian boundary(IOB) succession is rather stable. Small, earlier individuals(i.e., those from Bed 225 in Jianshi) are referred to as Nv. w. eowaageni Morphotype A, and are thought to have likely evolved from Ns. dieneri Morphotype 3, and to be the precursor of mature elements of Nv. w. eowaageni. The first appearance datum of Nv. w. eowaageni therefore is an ideal mark defining the IOB. | Zhengyi Lyu Michael J Orchard Zhong-Qiang Chen Laishi Zhao Lei Zhang Xiumei Zhang | 2018 | Journal of Earth Science2018，29，4： | 2 |
| 19 | Association of assisted reproductive technology, germline de novo mutations and congenital heart defects in a prospective birth cohort study显示文摘Emerging evidence suggests that children conceived through assisted reproductive technology(ART)have a higher risk of congenital heart defects(CHDs)even when there is no family history.De novo mutation(DNM)is a well-known cause of sporadic congenital diseases;however,whether ART procedures increase the number of germline DNM(gDNM)has not yet been well studied.Here,we performed whole-genome sequencing of 1137 individuals from 160 families conceived through ART and 205 families conceived spontaneously.Children conceived via ART carried 4.59 more gDNMs than children conceived spontaneously,including 332 paternal and 1.26 maternal DNMs,after correcting for parental age at conception,cigarette smoking,alcohol drinking,and exercise behaviors.Paternal DNMs in offspring conceived via ART are characterized by C>T substitutions at CpG sites,which potentially affect protein-coding genes and are significantly associated with the increased risk of CHD.In addition,the accumulation of non-coding functional mutations was independently associated with CHD and 87.9% of the mutations were originated from the father.Among ART offspring,infertility of the father was associated with elevated paternal DNMs;usage of both recombinant and urinary follicle-stimulating hormone and high-dosage human chorionic gonadotropin trigger was associated with an increase of maternal DNMs.In sum,the increased gDNMs in offspring conceived by ART were primarily originated from fathers,indicating that ART itself may not be a major reason for the accumulation of gDNMs.Our findings emphasize the importance of evaluating the germline status of the fathers in families with the use of ART. | Cheng Wang Hong Lv Xiufeng Ling Hong Li Feiyang Diao Juncheng Dai Jiangbo Du Ting Chen Qi Xi Yang Zhao Kun Zhou Bo Xu Xiumei Han Xiaoyu Liu Meijuan Peng Congcong Chen Shiyao Tao Lei Huang Cong Liu Mingyang Wen Yangqian Jiang Tao Jiang Chuncheng Lu Wei Wu Di Wu Minjian Chen Yuan Lin Xuejiang Guo Ran Huo Jiayin Liu Hongxia Ma Guangfu Jin Yankai Xia Jiahao Sha Hongbing Shen Zhibin Hu | 2021 | Cell Research2021，31，8： | 2 |
| 20 | Ferroxidase-like activity of Au nanorod/Pt nanodot structures and implications for cellular oxidative stress显示文摘铂 nanoparticles (NP ) 被报导模仿各种各样的抗氧化剂酶并且可以因此由减少反应的氧生产积极生物效果种类(ROS ) 层次。在这张手稿,我们报导磅 NP 由在金 nanorods (Au@Pt NDR ) 上扔铂 nanodots ferroxidase 作为酶模仿。Au@Pt NDR 显示出 pH 依赖的象 ferroxidase 一样活动并且在中立 pH 价值举办更高的活动。有人的房间线(肺腺癌 A549 和正常支气管的上皮的房间线 HBE ) 的 Cytotoxicity 结果证明 Au@Pt NDR 经由 endocytosis 和 translocate 被收起进房间进 endosome/lysosome。Au@Pt NDR 在比 0.15 n 低的 NDR 粒子集中有好 biocompatibility。然而,面对 H 2 O 2, lysosomelocated NDR 展出象 peroxidase 一样活动因此增加 cytotoxicity。面对 Fe 2+, , NDR 的象 ferroxidase 一样活动由消费 H 2 O 2 。当在生物系统采用 Au@Pt NDR 时,彻底的考虑应该被给这行为。 | Jianbo Liu Xiumei Jiang Liming Wang Zhijian Hu Tao Wen Wenqi Liu Junjie Yin Chunying Chen Xiaochun Wu | 2015 | Nano Research2015，8，12： | 2 |
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