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| 1 | Curative effect of heat-sensitive moxibustion on chronic persistent asthma: a multicenter randomized controlled trial显示文摘OBJECTIVE:To compare the curative effects of heat-sensitive moxibustion with conventional drugs on chronic persistent asthma and seek a valuable therapy to replaceWestern Medicine.METHODS:The participants in this multi-center,randomized,and controlled study were randomly divided into two groups:group A(n=144),treated with heat-sensitive moxibustion(50 sessions)and group B(n=144),treated with Seretide(salmeterol50μg/fluticasone 250μg,twice a day).The scores of asthma control test(ACT),forced expiratory volume in 1 second(FEV1),peak expiratory flow(PEF),and attack frequency were measured after 15,30,60,and 90 days of treatment.Patients followed up3 and 6 months after treatment.RESULTS:There was a significant difference(P=0.0002)in the ACT score and lung function between the two groups after 3 months of treatment and(P=0.000 03)during the follow-up visits.In addition,heat-sensitive moxibustion reduced attack frequency in the period from inclusion to the6-month follow-up visit.CONCLUSION:This study shows that heat-sensitive moxibustion may have a comparable curative effect toSeretide(salmeterol/fluticasone)on asthma. | Rixin Chen Mingren Chen Jun Xiong Zhenhai Chi B0 Zhang Ning Tian Zhenhua Xu Tangfa Zhang Wanyao Li Wei Zhang Xiaofeng Rong Zhen Wang Gang Sun Baohe Ge Guoxiong Yu Nanchang Song | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 20 |
| 2 | Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol显示文摘Menopause is associated with dyslipidemia and an increased risk of cardio-cerebrovascular disease.The classic view assumes that the underlying mechanism of dyslipidemia is attributed to an insufficiency of estrogen.In addition to a decrease in estrogen, circulating follicle-stimulating hormone (FSH)levels become elevated at menopause.In this study,we find that blocking FSH reduces serum cholesterol via inhibiting hepatic cholesterol biosynthesis.First,epidemiological results show that the serum FSH levels are positively correlated with the serum total cholesterol levels,even after adjustment by considering the effects of serum estrogen,in addition,the prevalence of hypercholesterolemia is significantly higher in peri-menopausal women than that in premenopausal women.Furthermore,we generated a mouse model of FSH elevation by intraperitoneally injecting exogenous FSH into ovariectomized (OVX)mice,in which a normal level of estrogen (E2)was maintained by exogenous supplementation. Consistently,the results indicate that FSH,independent of estrogen,increases the serum cholesterol level in this mouse model. Moreover,blocking FSH signaling by anti-FSHβ antibody or ablating the FSH receptor (FSHR)gene could effectively prevent hypercholesterolemia induced by FSH injection or high-cholesterol diet feeding.Mechanistically,FSH,via binding to hepatic FSHRs, activates the Gi2α/β-arrestin-2/Akt pathway and subsequently inhibits the binding of FoxO1 with the SREBP-2 promoter,thus preventing FoxO1 from repressing SREBP-2 gene transcription.This effect,in turn,results in the upregulation of SREBP-2,which drives HMGCR nascent transcription and de novo cholesterol biosynthesis,leading to the increase of cholesterol accumulation.This study uncovers that blocking FSH signaling might be a new strategy for treating hypercholesterolemia during menopause, particularly for women in peri-menopause characterized by FSH elevation only. | Yanjing Guo Meng Zhao Tao Bo Shizhan Ma Zhongshang Yuan Wenbin Chen Zhao He Xu Hou Jun Liu Zhenhai Zhang Qiang Zhu Qiangxiu Wang Xiaoyan Lin Zhongli Yang Min Cui Lu Liu Yujie Li Chunxiao Yu Xiaoyi Qi Qian Wang Haiqing Zhang Qingbo Guan Lifang Zhao Shimeng Xuan Huili Yan Yanliang Lin Li Wang Qihang Li Yongfeng Song Ling Gao Jiajun Zhao | 2019 | Cell Research2019，29，2： | 16 |
| 3 | Progress of Apple Rootstock Breeding and Its Use显示文摘Apple rootstock breeding has achieved great progress worldwide.In this review,we first summarize the rootstock breeding targets and utilization in main apple-producing countries.Furthermore,we discuss the focus and important research areas of apple rootstock breeding through five aspects:parent selection and setting of crosses,target genes and marker-assisted breeding,root configuration-guided breeding,apomictic resource utilization,and the application of genetic engineering.Finally,we propose an apple rootstock division plan for China,which has a large potential to provide guidance for apple rootstock breeding and utilization in different apple-producing areas of China. | Yi Wang Wei Li Xuefeng Xu Changpeng Qiu Ting Wu Qinping Wei Fengwang Ma Zhenhai Han | 2019 | Horticultural Plant Journal2019，5，5： | 6 |
| 4 | Determining the optimal time for bortezomib-based induction chemotherapy followed by autologous hematopoietic stem cell transplant in the treatment of multiple myeloma显示文摘In our study, we determined the efficacy of bortezomib-based induction therapy followed by autologous stem cell transplant (ASCT) in newly diagnosed and relapsed/refractory (R/R) multiple myeloma (MM) patients and compared the advantages of early versus late transplant. We used a retrospective analysis to examine 62 patients, including 46 cases of newly diagnosed MM (early transplant group) and 16 cases of relapsed/refractory MM (late transplant group). All of these patients received bortezomib-based induction therapy followed by ASCT. The efficacy and side effects of the treatment regimen were analyzed. Patients' overall survival (OS) and progression-free survival (PFS) times were determined. The ratio of complete remission to near-complete remission (CR/nCR) was 69.5% versus 56.2% (P=0.361), respectively, for the early transplant group versus the late transplant group, respectively, after receiving bortezomib-based induction therapy; the overall response rates of the two group were 91.3% and 81.2%, respectively (P=0.369). After receiving ASCT, the CR/nCR of the two groups increased to 84.8% and 81.3%, respectively. The median time required for neutrophil engraftment of the early transplant group and the late transplant group was 11 and 14.5 days, respectively (P=0.003); the median time required for platelet engraftment was 13 and 21.5 days (P=0.031), respectively. There were no significant differences in the toxic side effects observed during induction therapy and ASCT between the two groups. The OS of the two groups was not statistically different (P=0.058). The PFS of the early transplant group and the late transplant group was 41.6 and 26.5 months, respectively (P=0.008). Multivariate analysis demonstrated that the time of receiving ASCT, the types of M protein, and the International Staging System (ISS) stage were all independent factors that influenced PFS. In conclusion, patients in a suitable condition for ASCT should be recommended to have an early ASCT immediately after diagnosis. | Junru Liu Juan Li Beihui Huang Dong Zheng Mei Chen Zhenhai Zhou Duorong Xu Waiyi Zou | 2013 | Chinese Journal of Cancer Research2013，25，2： | 4 |
| 5 | Performance gain bounds of coherently combining multiple radars in a target-based calibration manner显示文摘To achieve a high signal-to-noise ratio(SNR) while maintaining moderate radar antenna, a target-based calibration manner is available to coherently combine multiple radars. The key to this calibration manner is to estimate coherence parameters(CPs), i.e., time and phase calibration values in transmission and reception estimation, by separating the target returns into monostatic and bistatic echoes. However, CPs estimations exist uncertainties, which will affect the performance gain after multiradar coherent combination. The principle of coherently combining multiple radars is elaborated and the signal probability model for CPs estimation is established. On this basis, CPs Cramer-Rao bound(CRB) is derived in the closed-form, according to which the non-tight and tight upper bounds for multiple radars coherent combination performance gain are derived in the closed-form and via Monte Carlo(MC) simulations, respectively. Simulations validate the correctness of the derived CRB and gain bounds. | LIU Xinghua XU Zhenhai XIAO Shunping | 2019 | Journal of Systems Engineering and Electronics2019，30，2： | 3 |
| 6 | ERF4 affects fruit ripening by acting as a JAZ interactor between ethylene and jasmonic acid hormone signaling pathways显示文摘The regulation of apple(Malus domestica)fruit texture during ripening is complex and a fundamental determinant of its commercial quality.In climacteric fruit,ripening-related processes are regulated by ethylene(ET),and jasmonate(JA)is also involved in the ethylene biosynthesis pathway,mainly through the transcription factor MYC2.However,the molecular genetic mechanism for fruit ripening processes between the JA and ET signaling pathways still needs to be elucidated.In order to explore how JA regulates apple fruit ripening through ERF4,we used’Gala’and’Ralls Janet’fruit at different developmental stages as experimental materials to determine the fruit firmness and related gene expression analysis.Meanwhile,we carried out different hormone treatments on’Gala’fruit at ripening stage.Here,we show that ERF4 is a core JA signaling hub protein JASMONATE ZIM-DOMAIN(JAZ)interactor that affects ethylene signaling pathways.During fruit development,ERF4 represses the expression of ACS1 and ACO1 by interacting with JAZ,as well as with the JA-activated transcription factor MYC2.Ripening is promoted in JAZ-suppressed apples.Thus,ERF4 acts as a molecular link between ethylene and JA hormone signals,and the natural variation of the ERF4Ethylene-responsive binding factor-associated amphiphilic repression(EAR)motif decreases repression of ethylene biosynthesis genes. | Yanan Hu Hualin Sun Zhenyun Han Shuai Wang Ting Wang Qiqi Li Ji Tian Yi Wang Xinzhong Zhang Xuefeng Xu Zhenhai Han Ting Wu | 2022 | Horticultural Plant Journal2022，8，6： | 2 |
| 7 | CrN-Encapsulated Hollow Cr-N-C Capsules Boosting Oxygen Reduction Catalysis in PEMFC显示文摘Understanding the origin of the catalytic activity for the development of efficient catalysts is critical yet challenging.Herein,we report a simple strategy for the synthesis of chromium nitride nanoparticles(CrNNPs)encapsulated into hollow chromium-nitrogen-carbon capsules(CrN@H-Cr-N_(x)-C).The CrN@H-Cr-N_(x)-C demonstrated excellent electrocatalytic activity for the oxygen reduction reaction(ORR)in acidic solutions.When applied as a cathode material in a proton-exchange membrane fuel cell(PEMFC),the CrN@H-Cr-N_(x)-C achieved outstanding initial performance,which is better than that of the PEMFC with H-Cr-N_(x)-C cathode material.The CrN@H-Cr-N_(x)-C cathode also showed good stability over 110 h of operation.These results demonstrated that the coexistence of atomically dispersed CrN_(x) sites and sufficient CrNNPs is essential for excellent PEMFC performances.Density functional theory(DFT)studies further corroborated that CrNNPs can boost the ORR activity of H-Cr-N_(x)-C.This finding opens a new avenue for the fabrication of low-cost,highly active,and durable ORR catalysts for PEMFC and other applications. | Hui Yang Xu Wang Tao Zheng Nelly Cantillo Cuello Gabriel Goenaga Thomas A.Zawodzinski He Tian Joshua T.Wright Robert W.Meulenberg Xiangke Wang Zhenhai Xia Shengqian Ma | 2021 | CCS Chemistry2021，3，5： | 2 |
| 8 | Low impedance nature of 12 acupoints on the limbs,and the unexpected dependence on limb angle显示文摘OBJECTIVE: To better understand the working mechanism of acupuncture, we investigated the skin electrical impedance distribution around acupoints, and the impedance changes at 12 original acupoints bilaterally after bending the limbs.METHODS: We measured the skin electrical impedance in three study subjects in the frequency range of 40 to 10 k Hz using the four-electrode method with a sharp probe and a large reference electrode.A measurement matrix of 7 mm × 7 mm with spacing of 2.0(or 3.0) mm was measured to obtain 2 D impedance mapping of acupoints. The impedance spectra of 12 original acupoints were measured at the 0° position and the 90° position.RESULTS: The electrical impedance of some acupoints, such as Yangchi(TE 4), was 16 times lower than that of the surrounding area, showing a recognizable small central area of low impedance with a diameter of less than 4 mm. In contrast, other acupoints, such as Laogong(PC 8), had an electrical impedance that was not significantly different from that of the surrounding area. When the limb was bent from a straight position(0o) to a vertical position(90o), the electrical impedance of the 12 original acupoints showed varied trends, either increasing or decreasing by a factor of up to ten times, or remaining at the same level.CONCLUSION: Not all acupoints tested show the property of low impedance, which might be related to the varied depth of the openings of superficial collaterals. The unexpected dependence of acupoint impedance on limb angle is a novel discovery, which implies that the channel paths are located in interstitial structures in the limbs. It might be possible to determine an optimized limb position for each particular acupuncture treatment in clinical practice. | Xu Jingjing Yang Fan Han Danhong Wang Zhenhai Hong Yuankai Han Hongbin Xu Shengyong | 2018 | Journal of Traditional Chinese Medicine2018，38，2： | 1 |
| 9 | Hepatitis B virus infection status is an independent risk factor for multiple myeloma patients after autologous hematopoietic stem cell transplantation显示文摘 | Juan Li Junru Liu Beihui Huang Dong Zheng Mei Chen Zhenhai Zhou Duorong Xu Waiyi Zou | 2013 | Tumor Biology2013，，3： | 1 |
| 10 | Cure 90 cases of enfant congenita| heart disease by small right outside incision thoracotomy显示文摘 | Wang Minghai Cao Suwen Xu Zhenhai | 2001 | Chinese thoracic-cardiovascular journal2001，17，1： | 1 |
| 11 | Statistical modeling and analysis of the influence of antenna polarization error on received power显示文摘The problem of statistical modeling of antenna polarization error is studied and the statistical characteristics of antenna's received power are analyzed. A novel Stokes-vector-based method is presented to describe the conception of antenna's polarization purity. Statistical model of antenna's polarization error in polarization domain is then built up. When an antenna with polarization error of uniform distribution is illuminated by an arbitrary polarized incident field, the probability density of antenna's received power is derived analytically. Finally, a group of curves of deviation and standard deviation of received power are plotted numerically. | WANG Xuesong , ZENG Yonghu, CHEN Zhijie , XU Zhenhai and LI Yongzhen( School of Electronic Science and Engineering, National University of Defense Technology, Changsha 410073, China Department of Foundation, National University of Defense Technology, Changsha 410073, China) | 2002 | Progress in Natural Science:Materials International2002，12，4： | 1 |
| 12 | Improvement of ginsenoside Rg1 on hematopoietic function in cyclophosphamideinduced myelosuppression mice显示文摘 | Xu Shangfu Yu Limei Fan Zhenhai | 2012 | Eur J Pharmacol2012，695，13： | 1 |
| 13 | Improvement of ginsenoside Rgl on hematopoietic function in cyclophosphamide-induced myelosuppression mice 显示文摘 | Shangfu Xu Limei Yu Zhenhai Fan | 2012 | Eu- ropean Journal of Pharmacology2012，696，： | 1 |
| 14 | The lose of juvenility elicits adventitious rooting recalcitrance in apple root- stocks显示文摘 | XIAO Zuifei JI Na ZHANG Xinzhong ZHANG Yanzhen WANG Yi WU Ting XU Xuefeng HAN Zhenhai | 2014 | Plant Cell Tissue and Organ Culture (PCTOC)2014，119，1： | 1 |
| 15 | Material patterning on substrates by manipulation of fluidic behavior显示文摘Patterned materials on substrates are of great importance for a wide variety of applications.In solution-based approaches to material patterning;fluidic flow is inevitable.Here we demonstrate not only the importance of fluidic behavior but also the methodology of engineering the flow pattern to guide the material crystallization and assembly.We show by both experiment and simulation that substrate heating;which is generally used to accelerate evaporation,produces irregular complex vortexes.Instead;a top-heating-bottom-cooling(THBC)set-up offers an inverse temperature gradient and results in a single Marangoni vortex,which is desired for ordered nanomaterial patterning near the contact line.We then realize the fabrication of large-scale patterns of iodide perovskite crystals on different substrates under THBC conditions.We further demonstrate that harnessing the flow behavior is a general strategy with great feasibility to pattern various functional materials ranging from inorganic;organic,hybrid to biological categories on different substrates,presenting great potential for practical applications. | Yitan Li Hao Wang Henglu Xu Shiting Wu Xuemei Li Jiapeng Yu Chaoyu Huang Zeyao Zhang Hao Sun Lu Han Meihui Li Anyuan Cao Zhenhai Pan Yan Li | 2019 | National Science Review2019，6，4： | 0 |
| 16 | Genome-wide identification and characterization of the IPT family members in nine Rosaceae species and a functional analysis of MdIPT5b in cold resistance显示文摘Cytokinins are members of a group of phytohormones involved in various growth and developmental processes in plants.Isopentenyl transferase(IPT)is the rate-limiting enzyme in catalyzing the biosynthesis of cytokinins.In this study,to understand the role of IPT family in cold resistance,78 IPT candidates were identified and characterized in nine Rosaceae genomes.The expansion of IPT families in the Rosaceae primarily occurred through segmental duplication rather than tandem duplication.In general,purifying selection controlled the evolution of IPT families in the Rosaceae,with IPT3 and IPT5 homologs as the primary drivers of evolution.Cis-elements,which are involved in the responses to many environmental stresses or phytohormone signals,were identified in the promoters of MdIPT members.This was consistent with the trends of expression of the MdIPT genes in apple(Malus domestica)calli.MdIPT5b was also found to exhibit multiple responses to phytohormones and stress signals.The ectopic expression of MdIPT5b resulted in an increase in cold resistance in transformed apple calli and tomato(Solanum lycopersicum)plantlets.The redox balance was partially stabilized through the accumulation of proline under cold stress.However,the ascorbate–glutathione cycle cannot be stabilized in the cold.All physiological and biochemical assays are preformed in spectrophotometer.These results showed that regulating the expression of IPT genes for moderate cytokinin improvement could enhance the accumulation of proline to stabilize the osmotic and redox balances to improve resistance to cold stress. | Yi Feng Jiahong Lv Mengqun Peng Jie Li Yue Wu Min Gao Xinyi Wu Yi Wang Ting Wu Xinzhong Zhang Xuefeng Xu Zhenhai Han | 2023 | Horticultural Plant Journal2023，9，4： | 0 |
| 17 | IDENTIFICATION OF PARAMETERS IN PARABOLIC EQUATIONS WITH NONLINEARITY显示文摘In this paper, we consider the identification of parameters in parabolic equations with nonlinearity. Some approximation processes for the identification problem are given. Our results improve and generalize the previous results. | Youjun Xu, Maoxin Liao (School of Math. and Physics, University of South China, Hengyang 421001, Hunan) Zhenhai Liu (School of Mathematical Sciences and Computing Technology, Central South University, Changsha 410075) | 2010 | Annals of Differential Equations2010，26，1： | 0 |
| 18 | Niche differentiation shapes the bacterial diversity and composition of apple显示文摘Microorganisms play an important role in plant growth,health and ecological function.It is necessary to explore the microbial community because of the significant ecological and economic value of apples(Malus x domestica).However,the related bacterial communities in different ecological habitats are not clear in the unique scion/rootstock combinations of apples.In this study,the Illumina Miseq platform was used to analyze the bacterial communities in different niches(bulk soil,rhizosphere soil and roots)of two scion/rootstock combinations[Fuji/Malus xiaojinensis Cheng et Jiang(Mx)and Fuji/Malus baccata(L.)Borkh.(Mb)].The relationship between the microbial community,soil properties,and plant characters was explored.The results showed that the diversity of the bacterial community decreased from bulk soil to rhizosphere soil and then to roots.In addition,at the phylum level,Proteobacteria,Actinobacteria and Acitinobacteria were dominant and had notable divergence in different ecological niches.Distinct niches had remarkable effects on the diversity and composition of the bacterial community according to PCoA.The rootstock genotype had an effect on the bacterial composition but no effect on the diversity.pH,soil organic matter(SOM),alkaline hydrolyzable nitrogen(AN)were the main factor affecting the structure of bacterial community in rhizosphere soil,as shown by Pearson analysis.Bacteria taxa in the roots were affected by starch,fructose,sucrose and sorbitol.This study showed the microbial community structure in different ecological niches of different scion/rootstock combinations and provided some evidence for understanding the microbial-plant interaction of apple rootstocks. | Yimei Huang Xiaofen Chai Xiaona Wang Beibei Gao Hui Li Zhenhai Han Xuefeng Xu Xinzhong Zhang Ting Wu Yi Wang | 2023 | Horticultural Plant Journal2023，9，1： | 0 |
| 19 | Characteristics of long-distance mobile mRNAs from shoot to root in grafted plant species显示文摘Thousands of long-distance mobile mRNAs were identified from different grafting systems,based on high-throughput sequencing technology.Moreover,the long-distance delivery of RNAs was proved to involve multiple mechanisms.Here,we analyzed the homology,motif,and tRNA-like structure(TLS)of long-distance mobile mRNAs identified by RNA-seq as well as the RNA-binding protein(RBP)in nine grafting combinations including Arabidopsis thaliana,Vitis vinifera,Cucumis sativus,Citrullus lanatus,Nicotiana benthamiana,Malus domestica,Pyrus spp.,Glycine max and Phaseolus vulgaris.Although several mRNAs were found to be shared in herbaceous,woody,and related species,the vast majority of long-distance mobile mRNAs were species-specific.Four non-specific movement-related motifs were identified,while the TLS was not necessary for mRNA long distance mobility.In addition,we found that RBPs were conserved among herbaceous and woody plants as well as related species.This paper reports a further in-depth analysis of the endogenous mechanisms by which the species-specific transportable m RNAs were selected by bioinformatics,in order to provide insights for future research on long-distance mobile mRNAs. | Mengmeng Fu Zhen Xu Huaying Ma Yifan Hao Ji Tian Yi Wang Xinzhong Zhang Xuefeng Xu Zhenhai Han Ting Wu | 2024 | Horticultural Plant Journal2024，10，1： | 0 |
| 20 | 哺乳动物成熟配子的染色体三维结构及其在早期胚胎发育中的重编程规律显示文摘文章简介染色体高级结构在调控基因表达中发挥非常重要的作用。此前对于哺乳动物胚胎发育过程中染色体三维结构动态变化了解有限。课题组使用优化后的少量细胞Hi-C方法建立小鼠配子和早期胚胎的染色体三维结构图谱。 | Yuwen Ke Yanan Xu Xuepeng Chen Songjie Feng Zhenbo Liu Yaoyu Sun Xuelong Yao Fangzhen Li Wei Zhu Lei Gao Haojie Chen Zhenhai Du Wei Xie Xiaocui Xu 黄行许 刘江 | 2018 | 科学新闻2018，0，4： | 0 |
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