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| 1 | Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes显示文摘 | Xiao-Lei Shi Yimeng Gao YupengYan HuchengMa Lulu Sun Pengyu Huang Xuan Ni Ludi Zhang Xin Zhao Haozhen Ren Dan Hu Yan Zhou Feng Tian Yuan Ji Xin Cheng Guoyu Pan Yi-Tao Ding LijianHui | 2016 | Cell Research2016，26，2： | 31 |
| 2 | Timosaponin A3 induces hepatotoxicity in rats through inducing oxidative stress and down-regulating bile acid transporters显示文摘 | Zhi-tao WU Xin-ming QI Jing-jing SHENG Lei-lei MA Xuan NI Jin REN Cheng-gang HUANG Guo-yu PAN | 2014 | Acta Pharmacologica Sinica2014，35，9： | 13 |
| 3 | Optimization of Protein Extraction and Decoloration Conditions for Tea Residues显示文摘To optimize alkaline method for extracting proteins from tea residue(TR), the effect of extraction conditions on tea protein extraction rate(TPER) was investigated. Single factor experiment showed the extraction temperature 80 °C, extraction time 100 min, p H value 13 and liquid–solid ratio 40:1 as the optimal extraction conditions. The orthogonal test revealed that the maximum TPER reached 29.71% under the following optimal combination of conditions: extraction temperature 70 °C, extraction time 60 min, p H 12 and liquid–solid ratio 50:1. For optimizing the purification of tea residue proteins, isoelectric point precipitation(p I), ammonium sulfate precipitation(a S) and isoelectric point plus ammonium sulfate precipitation(i PAS) were compared. The result showed that the highest protein precipitation rate(PPR) was 89.70% which was generated by using i PAS. Furthermore, powdered activated carbon was chosen as the most suitable decolorant for the extracted proteins. | CUI Qiaoyun NI Xinghong ZENG Liang TU Zheng LI Jin SUN Kang CHEN Xuan LI Xinghui | 2017 | Horticultural Plant Journal2017，3，4： | 8 |
| 4 | A preliminary study of variations of the Changjiang Diluted Water between August of 1999 and 2006显示文摘A large area hypoxia has been already reported respectively by two interdisciplinary surveys off the Changjiang Estuary since summer of 1999 and 2006.The hypoxic zone shows distinct year-to-year variations.Observed oceanographic data are first analysized and reveal a big difference for the Changjiang Diluted Water(CDW) between these two periods.These great changes are related to the tremendous reduction of the freshwater discharge and variations of wind fields between these two years.It is also found that the monthly mean intrusion of Kuroshio and its branches has increased in the northern East China Sea(ECS),but decreased in the southern ECS in August of 2006 as compared with 1999 on the base of general circulation models.Then,the Regional Ocean Modelling Systems is applied to the East China Sea to evaluate the contributions and relative importance of impacts from the river discharge,wind forcing and open boundary data.Our simulations reproduce the phenomena that more fresh water extends northeastward in 2006 and forms a negative SSS anomaly to the northeast of the river mouth as compared with 1999,which is consistent with observations.The five group numerical tests suggest that the wind forcing dominates the CDW variations followed by the Kuroshio and its branches.The study implies important roles played by hydrodynamic processes on the variability of hypoxic zone in the study areas. | ZHOU Feng XUAN Jiliang NI Xiaobo HUANG Daji | 2009 | Acta Oceanologica Sinica2009，28，6： | 8 |
| 5 | Electrical conductivity of hydrous silicate melts and aqueous fluids: Measurement and applications显示文摘The combination of magnetotelluric survey and laboratory measurements of electrical conductivity is a powerful approach for exploring the conditions of Earth's deep interior. Electrical conductivity of hydrous silicate melts and aqueous fluids is sensitive to composition, temperature, and pressure, making it useful for understanding partial melting and fluid activity at great depths. This study presents a review on the experimental studies of electrical conductivity of silicate melts and aqueous fluids, and introduces some important applications of experimental results. For silicate melts, electrical conductivity increases with increasing temperature but decreases with pressure. With a similar Na^+ concentration, along the calc-alkaline series electrical conductivity generally increases from basaltic to rhyolitic melt, accompanied by a decreasing activation enthalpy. Electrical conductivity of silicate melts is strongly enhanced with the incorporation of water due to promoted cation mobility. For aqueous fluids, research is focused on dilute electrolyte solutions. Electrical conductivity typically first increases and then decreases with increasing temperature, and increases with pressure before approaching a plateau value. The dissociation constant of electrolyte can be derived from conductivity data. To develop generally applicable quantitative models of electrical conductivity of melt/fluid addressing the dependences on temperature, pressure, and composition, it requires more electrical conductivity measurements of representative systems to be implemented in an extensive P-T range using up-to-date methods. | GUO Xuan CHEN Qi NI HuaiWei | 2016 | Science China Earth Sciences2016，59，5： | 6 |
| 6 | Underwater vs conventional endoscopic mucosal resection in treatment of colorectal polyps:A meta-analysis显示文摘BACKGROUND Underwater endoscopic mucosal resection(UEMR)of colorectal lesions is emerging as an alternative method to conventional endoscopic mucosal resection(EMR);however,it is still controversial whether there is a difference in the effectiveness between UEMR and EMR.AIM To evaluate the effectiveness and safety of UEMR in the treatment of colorectal polyps.METHODS Clinical studies comparing the effectiveness or safety of UEMR in the treatment of colorectal polyps were searched in medical databases,including Pub Med,Embase,Cochrane Library,CNKI,and Wanfang Data,monographs,theses,and papers presented at conferences.Statistical analyses were performed using Revman 5.3 software.RESULTS Seven non-randomized controlled trials and one randomized controlled trial met the inclusion criteria.In total,1382 patients(1511 polyps)were included in the study,including 722 who received UEMR and 789 who received EMR.In the UEMR and EMR groups,the en bloc resection rates were 85.87%and 73.89%,respectively,with a relative risk(RR)value of 1.14(95%confidence interval[CI]:1.01-1.30;P<0.05).In the sub-group analysis,the en bloc resection rate showed no statistically significant difference between the EMR and UEMR groups for polyps less than 20 mm in diameter.However,a statistically significant difference was found between the EMR and UEMR groups for polyps equal to or greater than 20 mm in diameter.The post-endoscopic resection recurrence rates at 3-6 mo of the UEMR and EMR groups were 3.26%and 15.17%,respectively,with an RR value of 0.27(95%CI:0.09-0.83;P<0.05).The post-endoscopic resection recurrence rates of UEMR and EMR at 12 mo were 6.25%and 14.40%,respectively,with an RR value of 0.43(95%CI:0.20-0.92;P<0.05).Additionally,the incidence of adverse events was 8.17%and 6.21%,respectively,with an RR value of 1.07(95%CI:0.50-2.30;P>0.05).CONCLUSION UEMR is an effective technique for colorectal polyps and appears to have some advantages over EMR,particularly with regard to some treatment outcomes. | Dong-Qiong Ni Yu-Ping Lu Xi-Qiao Liu Li-Ying Gao Xuan Huang | 2020 | World Journal of Clinical Cases2020，8，20： | 6 |
| 7 | Water and partial melting of Earth's mantle显示文摘Water plays a crucial role in the melting of Earth's mantle. Mantle magmatisms mostly occur at plate boundaries(including subduction zones and mid-ocean ridges) and in some intraplate regions with thermal anomaly. At oceanic subduction zones, water released by the subducted slab may induce melting of the overlying mantle wedge or even the slab itself, giving rise to arc magmatism, or may evolve into a supercritical fluid. The physicochemical conditions for the formation of slab melt and supercritical fluid are still under debate. At mid-ocean ridges and intraplate hot zones, water and CO_2 cause melting of the upwelling mantle to occur at greater depths and in greater extents. Low degree melting of the mantle may occur at boundaries between Earth's internal spheres, including the lithosphere-asthenosphere boundary(LAB), the upper mantletransition zone boundary, and the transition zone-lower mantle boundary, usually attributed to contrasting water storage capacity across the boundary. The origin for the stimulating effect of water on melting lies in that water as an incompatible component has a strong tendency to be enriched in the melt(i.e., with a mineral-melt partition coefficient much smaller than unity), thereby lowering the Gibbs free energy of the melt. The partitioning of water between melt and mantle minerals such as olivine, pyroxenes and garnet has been investigated extensively, but the effects of hydration on the density and transport properties of silicate melts require further assessments by experimental and computational approaches. | NI HuaiWei ZHANG Li GUO Xuan | 2016 | Science China Earth Sciences2016，59，4： | 4 |
| 8 | MAPKs and acetyl-CoA are associated with Curvularia lunata pathogenicity and toxin production in maize显示文摘Mitogen-activated protein kinase(MAPK) cascades play an important role in extracellular signal transduction and are involved in the pathogenicity of fungal pathogens to host plants.In Curvularia lunata,the roles of two MAPK genes,Clk1 and Clm1,have already been studied.Clk1 is involved in conidia formation and pathogenicity,and Clm1 is closely related to pathogen cell wall formation and pathogenicity to maize leaves.In this study,a third C.lunata MAPK gene,Clh1,which is homologous to hog1,was successfully cloned.We found that a Clh1 deletion mutant had lower intracellular glycerol accumulation than the wild-type stain and was unable to grow normally under osmotic stress conditions.Furthermore,the deletion mutants of three C.lunata MAPK genes(Clk1,Clm1 and Clh1) had lower levels of acetyl-Co A,which is an important intermediate product in the synthesis of melanin and furan toxin,and down-regulated expression of pathogenicity-associated genes.Furthermore,pathogenicity and the ability to produce toxin were restored after adding acetyl-Co A to the culture medium,suggesting that acetyl-Co A is closely involved in the pathogen MAPK signaling pathway. | NI Xuan GAO Jin-xin YU Chuan-jin WANG Meng SUN Jia-nan LI Ya-qian CHEN Jie | 2018 | Journal of Integrative Agriculture2018，17，1： | 3 |
| 9 | Inhibition of hepatic cytochrome P450 enzymes and sodium/bile acid cotransporter exacerbates leflunomide-induced hepatotoxicity显示文摘目的: Leflunomide 是作为修改疾病的治疗风湿药剂药出售的一个抑制免疫力的代理人。但是它引起严重副作用,包括的致命的肝炎和肝失败。在我们调查了的这研究,肝的新陈代谢的贡献和到 leflunomide 的 leflunomide 和它的主要代谢物 teriflunomide 的运输在 vitro 并且在 vivo.Methods 导致了 hepatotoxicity : leflunomide 和 teriflunomide 的新陈代谢和毒性在 vitro 在主要老鼠 hepatocytes 被评估。肝的细胞色素 P450 reductase 0 (HRN ) 老鼠被用来在 vivo 检验介绍的 PK 和 leflunomide 的 hepatotoxicity。钠 / 胆汁酸 cotransporter (NTCP ) 的表达式和函数在老鼠和人的 hepatocytes 和 NTCP-transfected HEK293 房间被估计。在男 Sprague-Dawley ( SD )老鼠以后是管理 teriflunomide ( 1,6 , 12 mg· ; kg −1·d−1, ig )为 4 个星期,他们的血样品是 analyzed.Results : A nonspecific CYP 禁止者 aminobenzotriazole ( ABT , 1 mmol/L )减少在从 409~216 μ 的老鼠 hepatocytes 的 leflunomide 的 IC 50价值; mol/L 另外一个 nonspecific CYP 禁止者 proadifen ( SKF , 30 μ ; mol/L )增加了 leflunomide 的细胞的累积到3.68褶层在口头的 dosing (15 mg/kg ) 以后,血浆暴露(leflunomide 的 AUC 0-t) 与野类型老鼠相比在 HRN 老鼠增加了到 3 褶层。leflunomide 的管理(25 mg·为 7 d 的 kg −1·d−1) 显著地在 HRN 老鼠增加了浆液中高音和著名计算机生产厂商层次;当剂量被增加到 50 mg· 时; kg −1·d−1, 所有 HRN 老鼠在 d 上死了 6。Teriflunomide 显著地减少了在人的 hepatocytes 的 NTCP 的表示,以及在老鼠 hepatocytes 和 NTCP-transfected HEK293 房间的 NTCP 的功能。teriflunomide 的四星期的管理显著地在雌老鼠,然而并非在男 rats.Conclusion 增加了浆液总数 bilirubin 和直接 bilirubin 层次: 而主要代谢物 teriflunomide 压制 NTCP 的表达式和函数,肝的 CYP 在 leflunomide 的 detoxification 过程起一个关键作用,导致潜在的 cholestasis。 | Lei-lei MA Zhi-tao WU Le WANG Xue-feng ZHANG Jing WANG Chen CHEN Xuan NI Yun-fei LIN Yi-yi CAO Yang LUAN Guo-yu PAN | 2016 | Acta Pharmacologica Sinica2016，37，3： | 3 |
| 10 | The Influence of Diabetes, Hypertension, and Hyperlipidemia on the Onset of Age-Related Macular Degeneration in North China: The Kailuan Eye Study显示文摘Objective To analyze the prevalence of dry and wet age-related macular degeneration(AMD)in patients with diabetes,hypertension and hyperlipidemia,and to analyze the risk factors for AMD.Methods A population-based cross-sectional epidemiologic study was conducted involving 14,440 individuals.We assessed the prevalence of dry and wet AMD in diabetic and non-diabetic subjects and analyzed the risk factors for AMD.Results The prevalence of wet AMD in diabetic and non-diabetic patients was 0.3%and 0.5%,respectively,and the prevalence of dry AMD was 17%and 16.4%,respectively.The prevalence of wet AMD in healthy,hypertensive,hyperlipidemic,and hypertensive/hyperlipidemic populations was 0.5%,0.3%,0.2%,and 0.7%,respectively.The prevalence of dry AMD in healthy,hypertensive,hyperlipidemic,and hypertensive/hyperlipidemic populations was 16.6%,16.2%,15.2%,and 17.2%,respectively.Age,sex,body mass index,and use of hypoglycemic drugs or lowering blood pressure drugs were corrected in the risk factor analysis of AMD.Diabetes,diabetes/hypertension,diabetes/hyperlipidemia,and diabetes/hypertension/hyperlipidemia were analyzed.None of the factors analyzed in the current study increased the risk for the onset of AMD.Conclusion There was no significant difference in the prevalence of wet and dry AMD among diabetic and non-diabetic subjects.Similarly,there was no significant difference in the prevalence of wet and dry AMD among subjects with hypertension and hyperlipidemia.Diabetes co-existing with hypertension and hyperlipidemia were not shown to be risk factors for the onset of dry AMD. | ZHANG Yong Peng WANG Ya Xing ZHOU Jin Qiong WANG Qian YAN Yan Ni YANG Xuan YANG Jing Yan ZHOU Wen Jia WANG Ping SHEN Chang YANG Ming LUAN Ya Nan WANG Jin Yuan WU Shou Ling CHEN Shuo Hua WANG Hai Wei FANG Li Jian WAN Qian Qian ZHU Jing Yuan NIE Zi Han CHEN Yu Ning XIE Ying JONAS JB WEI Wen Bin | 2022 | Biomedical and Environmental Sciences2022，35，7： | 2 |
| 11 | Sod gene of Curvularia lunata is associated with the virulence in maize leaf显示文摘Curvularia leaf spot,caused mainly by Curvularia lunata,is a widespread plant disease in China. In the recent years,directional host selection by the pathogen,which likely results in the virulence differentiation in pathogens,is widely reported. Among the hallmarks potentially associated to pathogen variation in virulence,superoxide dismutase gene Sod has been found to be closely related to the enhancement of virulence. In the present study,the full-length of Sod was obtained via Blastn alignment against Gen Bank and the whole genome of C. lunata. In order to understand the role of Sod in the virulence variation in C. lunata,targeted gene disruption was performed to construct Sod mutants. The cell wall degrading enzyme(CWDE)activities and toxin production of ΔSod were not distinctly different from wild-type strain CX-3 and its complon. However,at an early stage of infection,ΔSod virulence appeared to be lower than CX-3 and the complon,while at a later stage,its virulence gradually returned to the level of CX-3 and the complon. Furthermore,the melanin production of ΔSod was significantly reduced compared to CX-3 and the complon,suggesting that Sod gene influences the virulence by regulating melanin production at an early stage of infection but is not essential for pathogenicity. However,the disruption of Sod did not significantly affect the transcriptional expression of the melanin biosynthesis-associated genes,brn1 and scd. Therefore,we infer that Sod in C. lunata are involved,to some extent,with the virulence in maize leaf,but still needs further studies to have a clear understanding of its mechanism. | GAO Shi-gang NI Xuan LI Ying-ying FU Ke-he YU Chuan-jin GAO Jin-xin WANG Meng LI Ya-qian CHEN Jie | 2017 | Journal of Integrative Agriculture2017，16，4： | 2 |
| 12 | Electropolymerization of cobalt porphyrins and corroles for the oxygen evolution reaction显示文摘Developing large-scale electrocatalysts using molecular complexes for the oxygen evolution reaction(OER)is of great importance. Herein, four cobalt porphyrins and corroles are deposited on electrode substrates using a simple and fast electropolymerization method. Our results showed that Co-1-P@CC, formed by electropolymerizing Co tetrakis(p-N-pyrrolylphenyl)porphyrin(Co-1-P) on carbon cloth(CC), is the most active OER catalyst in the examined Co porphyrins and corroles in alkaline aqueous solutions by displaying an onset overpotential of 380 m V. Long-term electrolysis tests confirmed the stability of these electropolymerized films by functioning as OER electrocatalysts. | Qingxin Zhang Yabo Wang Yanzhi Wang Shujiao Yang Xuan Wu Bin Lv Ni Wang Yimei Gao Xiaoran Xu Haitao Lei Rui Cao | 2021 | Chinese Chemical Letters2021，32，12： | 2 |
| 13 | Comparative genomics of Helicobacter pylori显示文摘Genomic sequences have been determined for a number of strains of Helicobacter pylori (H pylori) and related bacteria. With the development of microarray analysis and the wide use of subtractive hybridization techniques, comparative studies have been carried out with respect to the interstrain differences between H pylori and inter-species differences in the genome of related bacteria. It was found that the core genome of H pylori constitutes 1111 genes that are determinants of the species properties. A great pool of auxillary genes are mainly from the categories of cag pathogenicity islands, outer membrane proteins, restriction-modification system and hypothetical proteins of unknown function. Persistence of H pylori in the human stomach leads to the diversification of the genome. Comparative genomics suggest that a host jump has occurs from humans to felines. Candidate genes specific for the development of the gastric diseases were identified. With the aid of proteomics, population genetics and other molecular methods, future comparative genomic studies would dramatically promote our understanding of the evolution, pathogenesis and microbiology of H pylori. | Quan-Jiang Dong Qing Wang Ying-Nin Xin Ni Li Shi-Ying Xuan | 2009 | World Journal of Gastroenterology2009，15，32： | 2 |
| 14 | Packaging and testing of multi-wavelength DFB laser array using REC technology 显示文摘 | Ni Yi Kong Xuan Gu Xiaofeng | 2014 | Optics Communications2014，312，： | 1 |
| 15 | Destination of organic pollutants during electrochemical oxidation of biologically-pretreated dye wastewater using boron-doped diamond anode显示文摘 | Xiuping Zhu Jinren Ni Junjun Wei Xuan Xing Hongna Li | 2011 | Journal of Hazardous Materials2011，，1： | 1 |
| 16 | Anti-viral memory T cell responses in the absence of IgG production in a COVID-19 convalescent individual显示文摘Cellular and humoral immunity are both important in host defense against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Although defects in SARS-CoV-2-specific T cell immunity have been found in patients with severe lung pathology,it is still largely unclear whether virus-specific T cells are sufficient for host protection.Here,we found that in a previously characterized cohort of convalescent subjects,one individual,though lacking detectable anti-viral neutralizing IgG antibodies,showed virus-specific T cell responses,both in CD4^(+)and CD8^(+)T cells.SARS-CoV-2-specific T cells in this and other individuals are maintained for up to 10 months.This study thus further supports a critical role of T cells in host defense against SARS-CoV-2,offering new insights into the design and evaluation of COVID-19 vaccines. | Ling Ni Fang Ye Qin Qiao Yu Feng Yazheng Yang Hui Zhao Li-Nan Zhang Meng-Li Cheng Gengzhen Zhu Xiaoli Li Xuan Zhong Ruifeng Li Cheng-Feng Qin Fang Chen Chen Dong | 2022 | National Science Open2022，1，1： | 1 |
| 17 | The genome of the cucumber显示文摘 | HUANG S LI R ZHANG Z LI L GU X FAN W LUCAS W J WANG X XIE B NI P REN Y ZHU H LI J LIN K JIN W FEI Z LI G STAUB J KILIAN A VAN DER VOSSEN EA WUY GUO J HE J JIA Z REN Y TIAN G LU Y RUAN J QIANW WANG M HUANG Q LI B XUAN Z CAO J ASAN WUZ ZHANG J CAI Q BAI Y ZHAO B HAN Y LI Y LI X WANG S SHI Q LIU S CHO WK KIM JY XU Y HELLER-USZYNSKA K MIAO H CHENG Z ZHANG S WU J YANG Y KANG H LI M LIANG H REN X SHI Z WEN M JIAN M YANG H ZHANG G YANG Z CHEN R LIU S LI J MA L LIU H ZHOU Y ZHAO J FANG X LI G FANG L LI Y LIUD ZHENG H ZHANG Y QIN N LI Z YANG G YANG S BOLUND L KRISTIANSEN K ZHENG H LI S ZHANG X YANG H WANG J SUN R ZHANG B JIANG S WANG J DUY LI S | 2009 | Cucumis Sativus L NatureGenetics2009，41，： | 1 |
| 18 | Thesequence and de novo assembly of the giant panda genome显示文摘 | LI R FAN W TIAN G ZHU H HE L CAI J HUANG Q CAIQ LI B BAI Y ZHANG Z ZHANG Y WANG W LI J WEI F LI H JIAN M LI J ZHANG Z NIELSEN R LI D GU W YANG Z XUAN Z RYDER OA LEUNG FC ZHOU Y CAO J SUN X FU Y FANG X GUO X WANG B HOU R SHEN F MU B NI P LIN R QIAN W WANG G YU C NIE W WANGJ WU Z LIANG H MIN J WU Q CHENG S RUAN J WANGM SHI Z WEN M LIU B REN X ZHENG H DONG D COOKK SHAN G ZHANG H KOSIOL C XIE X LU Z ZHENG H LI Y STEINER CC LAM TT LIN S ZHANG Q LI G TIAN J GONG T LIU H ZHANG D FANG L YE C ZHANG J HU W XU A REN Y ZHANG G BRUFORD MW LI Q MA L GUOY AN N HU Y ZHENG Y SHI Y LI Z LIU Q CHEN Y ZHAO J QU N ZHAO S TIAN F WANG X WANG H XU L LIU X VINAR T WANG Y LAM TW YIU SM LIU S ZHANGH LI D HUANG Y WANG X YANG G JIANG Z WANG J QIN N LI L LI J BOLUND L KRISTIANSEN K WONG GK OLSON M ZHANG X LI S YANG H WANG J WANG J | 2010 | Na-ture2010，463，： | 1 |
| 19 | The genome of the cucumber,Cucumis sativus L显示文摘 | Huang S W Li R Q Zhang Z H Li L Gu X F Fan W Lucas W J Wang X W Xie B Y Ni P X Ren Y Zhu H M Li J Lin K Jin W W Fei Z J Li G C Staub J B Kilian A van der Vossen E A G Wu Y Guo J He J Jia Z Q Ren Y Tian G Lu Y Ruan J Qian W Wang M W Huang Q F Li B Xuan Z L | | 0，，12： | 1 |
| 20 | Reconstruction of volumetric ultrasound panorama based on improved 3D SIFT显示文摘 | Dong Ni Yim Pan Chui Yingge Qu Xuan Yang Jing Qin Tien-Tsin Wong Simon S.H. Ho Pheng Ann Heng | 2009 | Computerized Medical Imaging and Graphics2009，，7： | 1 |
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