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| 1 | Current perspectives on in vitro maturation and its effects on oocyte genetic and epigenetic profiles显示文摘In vitro maturation(IVM), the maturation in culture of immature oocytes, has been used in clinic for more than 20 years.Although IVM has the specific advantages of low cost and minor side effects over controlled ovarian stimulation, the prevalence of IVM is less than 1% of routine in vitro fertilization and embryo transfer techniques in many reproductive centers. In this review, we searched the MEDLINE database for all full texts and/or abstract articles published in English with content related to oocyte IVM mainly between 2000 and 2016. Many different aspects of the IVM method may influence oocyte potential,including priming, gonadotrophin, growth factors, and culture times. The culture conditions of IVM result in alterations in the oocyte or cumulus cell transcriptome that are not observed under in vivo culture conditions. Additionally, epigenetic modifications, such as DNA methylation or acetylation, are also different between in vitro and in vivo cultured oocytes. In sum,current IVM technique is still not popular and requires more systematic and intensive research to improve its effects and applications. This review will help point our problems, supply evidence or clues for future improving IVM technique, thus assist patients for fertility treatment or preservation as an additional option. | Cuiling Lu Yaoyao Zhang Xiaoying Zheng Xueling Song Rui Yang Jie Yan Huailiang Feng Jie Qiao | 2018 | Science China(Life Sciences)2018，61，6： | 10 |
| 2 | Prioritizing natural-selection signals from the deep-sequencing genomic data suggests multi-variant adaptation in Tibetan highlanders显示文摘Human genetic adaptation to high altitudes(>2500 m)has been extensively studied over the last few years,but few functional adaptive genetic variants have been identified,largely owing to the lack of deep-genome sequencing data available to previous studies.Here,w e build a list of putative adaptive variants,including 63 missense,7 loss-of-function;1,298 evolutionarily conserved variants and 509 expression quantitative traits loci.Notably,the top signal of selection is located in TMEM 247,a transmembrane protein-coding gene.The Tibetan version of TMEM 247 harbors one high-frequency(76.3%)missense variant,rsl 16983452(c.248C>T;p.Ala83Val);with the T allele derived from archaic ancestry and carried by>94%of Tibetans but absent or in low frequencies(<3%)in non-Tibetan populations.The rsl 16983452-T is strongly and positively correlated with altitude and significantly associated with reduced hemoglobin concentration(p=5.78×10^-5),red blood cell count(p=5.72×10^-7)and hematocrit(p=2.57×10^-6).In particular,TMEM247-rs 116983452 shows greater effect size and better predicts the phenotypic outcome than any E P A S1 variants in association with adaptive traits in Tibetans.Modeling the interaction between TM£M247-rsl 16983452 and EPAS1 variants indicates weak but statistically significant epistatic effects.Our results support that multiple variants may jointly deliver the fitness of the Tibetans on the plateau,where a complex model is needed to elucidate the adaptive evolution mechanism. | Lian Deng Chao Zhang Kai Yuan Yang Gao Yuwen Pan Xueling Ge Yaoxi He Yuan Yuan Yan Lu Xiaoxi Zhang Hao Chen Haiyi Lou Xiaoji Wang Dongsheng Lu Jiaojiao Liu Lei Tian Qidi Feng Asifullah Khan Yajun Yang Zi-Bing Jin Jian Yang Fan Lu Jia Qu Longli Kang Bing Su Shuhua Xu | 2019 | National Science Review2019，6，6： | 9 |
| 3 | Direct Effects of Activin A on the Activation of Mouse Macrophage RAW264.7 Cells显示文摘Macrophages play critical roles in innate immune and acquired immune via secreting pro-inflammatory mediators, phagocytosing microorganisms and presenting antigens. Activin A, a member of transforming growth factor β (TGF-β) superfamily, is produced by macrophages and microglia cells. In this study, we reported a direct effect of activin A as a pro-inflammatory factor on mouse macrophage cell line RAW264.7 cells. Our data revealed that activin A could not only increase IL-1β and IL-6 production from RAW264.7 cells, but also promote pinocytic and phagocytic activities of RAW264.7 cells. In addition, activin A obviously up-regulated MHC II expression on the surface of RAW264.7 cells, whereas did not influence MHC I expression. Activin A also enhanced CD80 expression, which is a marker of activated macrophages, but did not influence RAW264.7 cell proliferation. These data suggest that activin A may regulate primary macrophage-mediated innate and acquired immune response via promoting the activation of rest macrophages. | Jingyan Ge Yinan Wang Ye Feng Haiyan Liu Xueling Cui Guixiang Tai Zhonghui Liu | 2009 | Cellular & Molecular Immunology2009，6，2： | 4 |
| 4 | Compressive behavior and rate-controlling mechanisms of ultrafine grained copper over wide temperature and strain rate ranges显示文摘 | Tao Suo Yulong Li Feng Zhao Xueling Fan Weiguo Guo | 2013 | Mechanics of Materials2013，，： | 1 |
| 5 | Detection of HPV Types and Neutralizing Antibodies in Gansu Province, China显示文摘 | Xueling Wu Chuntao Zhang Shuxian Feng | 2009 | Journal of Medical Virdogy2009，，81： | 1 |
| 6 | Genotypic and Phenotypic Characterization of HIV-1 CRF01_AE env Molecular Clones From Infections in China显示文摘 | Jianhui Nie Chuntao Zhang Wei Liu Xueling Wu Feng Li Suting Wang Fuxiong Liang Aijing Song Youchun Wang | 2010 | JAIDS Journal of Acquired Immune Deficiency Syndromes2010，，4： | 1 |
| 7 | Compressive behavior and rate-controlling mechanisms of ultrafine grained copper over wide temperature and strain rate ranges显示文摘 | Tao Suo Yulong Li Feng Zhao Xueling Fan Weiguo Guo | 2013 | Mechanics of Materials2013，，： | 1 |
| 8 | Polyimide Aerogel Fibers with Controllable Porous Microstructure for Super‑Thermal Insulation Under Extreme Environments显示文摘Application of aerogel fibers in thermal insulating garments have sparked a substantial interest.However,achieving a high porosity and low thermal conductivity for aerogel fibers remain challenging,despite the innovative designs of porous struc-ture.Herein,we fabricated lightweight and super-thermal insulating polyimide(PI)aerogel fibers via freeze-spinning by using polyvinyl alcohol(PVA)as a pore regulator.The high affinity of PVA with water enables it to accelerate the ice crystal nucleation,adjust pore formation,and construct a controllable porous structure of PI aerogel fiber.The as-fabricated PI aerogel fiber has a considerable reduced pore size,high porosity(95.6%),improved flexibility and mechanical strength,and can be woven into fabrics.The PI aerogel fabric exhibits low thermal conductivity and excellent thermal insulation in a wide range of temperature(from-196 to 300℃).Furthermore,the PI aerogel fabrics can be easily functionalized to expand their applications,such as in intelligent temperature regulation and photothermal conversion.These results demonstrate that the aerogel fibers/fabric are promising materials for next-generation textile materials for personal thermal management. | Tiantian Xue Chenyu Zhu Xueling Feng Qamar Wali Wei Fan Tianxi Liu | 2022 | Advanced Fiber Materials2022，4，5： | 1 |
| 9 | Upregulation of Adenosine Kinase in Rasmussen Encephalitis显示文摘 | Guoming Luan Qing Gao Yuguang Guan Feng Zhai Jian Zhou Changqing Liu Yin Chen Kun Yao Xueling Qi Tianfu Li | 2013 | Journal of Neuropathology & Experimental Neurology2013，，11： | 1 |
| 10 | Thermally conductive poly(lactic acid)/boron nitride composites via regenerated cellulose assisted Pickering emulsion approach显示文摘Polymer-based thermally conductive composites have attracted tremendous interest in thermal management of electronics.However,it remains challenging to achieve high thermal conductivity partly because the difficulty to obtain favorable distribution and orientation of conductive fillers within the polymer matrix.Herein,networked boron nitride(BN)conductive pathway was realized within the poly(lactic acid)(PLA)matrix,via regenerated cellulose(RC)-assisted assembly of BN on Pickering emulsion interface based on the noncovalent interaction,followed by solvent evaporation and hot-compressing.The strong noncovalent interactions between BN and RC were found critical to enhance the wettability and stability of BN in aqueous media with a lowest mass ratio of 1:40 of RC and BN.The obtained PLA/BN composites feature a thermal conductivity of 1.06 W/(m K)at 28.4 wt%BN loading,representing an enhancement of 430%comparing to neat PLA,and the crystallinity of the composites could increase significantly from11.7%(neat PLA)to 43.7%.This simple,environmentally friendly and effective strategy could be easily extended for effective construction of thermally conductive composites. | Yating Wang Hong Jin Jiajun Shen Bijia Wang Xueling Feng Zhiping Mao Yumei Zhang Xiaofeng Sui | 2022 | Journal of Materials Science & Technology2022，，6： | 1 |
| 11 | Progress in the Development of All-Back-Contacted Silicon Solar Cells显示文摘 | Ngwe Zin Andrew Blakers Evan Franklin Teng Kho Keith McIntosh Johnson Wong Thomas Mueller Armin G. Aberle Yang Yang Xueling Zhang Zhiqiang Feng Qiang Huang | 2012 | Energy Procedia2012，，： | 1 |
| 12 | Polyoxometalate-loaded Nanocellulose Sponge as a Novel Catalyst for the Regioselective Hydroboration of Phenylacetylene显示文摘In this work,an amino-modified cellulose nanofiber sponge was prepared and used as a support for polyoxometalate(POM)catalysts with a high loading efficiency.Fourier transform infrared spectroscopy,thermogravimetric analysis,and energy-dispersive X-ray spectroscopy revealed that an Anderson-type POM,(NH4)4[CuMo6O18(OH)6]·5H2O was successfully immobilized on the sponge based on electrostatic interactions.Morphological analysis indicated that the POM-loaded sponge retained its porous structure and that the POM was homogeneously distributed on the sponge walls.The POM-loaded sponge exhibited excellent mechanical properties by recovering 79.9%of its original thickness following a 60%compression strain.The POM-loaded sponge was found to effectively catalyze the hydroboration of phenylacetylenes,yielding excellent conversion and regioselectivity of up to 96%and 99%,respectively.Its catalytic activity remained unchanged after five reuse cycles.These findings represent a scalable strategy for immobilizing POMs on porous supports. | GuoQing Yang CongCong Zhang BiJia Wang ZhiPing Mao Hong Xu Yi Zhong XueLing Feng XiaoFeng Sui | 2019 | Paper And Biomaterials2019，4，2： | 0 |
| 13 | Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma显示文摘Detailed characterizations of genomic alterations have not identified subtype-specific vulnerabilities in adult gliomas. Mapping gliomas into developmental programs may uncover new vulnerabilities that are not strictly related to genomic alterations. After identifying conserved gene modules co-expressed with EGFR or PDGFRA (EM or PM), we recently proposed an EM/PM classification scheme for adult gliomas in a histological subtype- and grade-independent manner. By using cohorts of bulk samples, paired primary and recurrent samples, multi-region samples from the same glioma, single-cell RNA-seq samples, and clinical samples, we here demonstrate the temporal and spatial stability of the EM and PM subtypes. The EM and PM subtypes, which progress in a subtype-specific mode, are robustly maintained in paired longitudinal samples. Elevated activities of cell proliferation, genomic instability and microenvironment, rather than subtype switching, mark recurrent gliomas. Within individual gliomas, the EM/PM subtype was preserved across regions and single cells. Malignant cells in the EM and PM gliomas were correlated to neural stem cell and oligodendrocyte progenitor cell compartment, respectively. Thus, while genetic makeup may change during progression and/or within different tumor areas, adult gliomas evolve within a neurodevelopmental framework of the EM and PM molecular subtypes. The dysregulated developmental pathways embedded in these molecular subtypes may contain subtype-specific vulnerabilities. | Jing Feng Zheng Zhao Yanfei Wei Zhaoshi Bao Wei Zhang Fan Wu Guanzhang Li Zhiyan Sun Yanli Tan Jiuyi Li Yunqiu Zhang Zejun Duan Xueling Qi Kai Yu Zhengmin Cong Junjie Yang Yaxin Wang Yingyu Sun Fuchou Tang Xiaodong Su Chuan Fang Tao Jiang Xiaolong Fan | 2023 | Frontiers of Medicine2023，17，2： | 0 |
| 14 | Stabilizing semi-transparent perovskite solar cells with a polymer composite hole transport layer显示文摘Semi-transparent perovskite solar cells(ST-PSCs)have broad applications in building integrated photovoltaics.However,the stability of ST-PSCs needs to be improved,especially in n-i-p ST-PSCs since the doped 2,2',7,7'-tetrakis(N,N-di-p-methoxyphenyl-amine)-9,9'-spirobifluorene(Spiro-OMeTAD)is unstable at elevated temperatures and high humidity.In this work,aπ-conjugated polymer poly[(2,6-(4,8-bis(5-(2-ethylhexyl)thiophene-2-yl)-benzo[1,2-b:4,5-b']dithiophene))-alt-(5,5-(1',3'-di-2-thienyl-5',7'-bis(2-ethylhexyl)benzo[1',2'-c:4',5'-c']dithiophene-4,8-dione)](PBDB-T)is selected to form a polymer composite hole transport layer(HTL)with Spiro-OMeTAD.The sulfur atom of the thiophene unit and the carbonyl group of the polymer interact with the undercoordinated Pb2+at the perovskite surface,which stabilizes the perovskite/HTL interface and passivates the interfacial defects.The incorporation of the polymer also increases the glass transition temperature and the moisture resistance of Spiro-OMeTAD.As a result,we obtain ST-PSCs with a champion efficiency of 13.71%and an average visible light transmittance of 36.04%.Therefore,a high light utilization efficiency of 4.94%can be obtained.Moreover,the encapsulated device can maintain 84%of the initial efficiency after 751 h under continuous one-sun illumination(at 30%relative humidity)at the open circuit and the unencapsulated device can maintain 80%of the initial efficiency after maximum power tracking for more than 1250 h under continuous one-sun illumination. | Yongbin Jin Huiping Feng Zheng Fang Liu Yang Kaikai Liu Bingru Deng Jingfu Chen Xueling Chen Yawen Zhong Jinxin Yang Chengbo Tian Liqiang Xie Zhanhua Wei | 2024 | Nano Research2024，17，3： | 0 |
| 15 | Aligned 3D porous polyurethane scaffolds for biological anisotropic tissue regeneration显示文摘A green fabrication process(organic solvent-free)of artificial scaffolds is required in tissue engineering field.In this work,a series of aligned three-dimensional(3D)scaffolds are made from biodegradable waterborne polyurethane(PU)emulsion via directional freeze–drying method to ensure no organic byproducts.After optimizing the concentration of polymer in the emulsion and investigating different freezing temperatures,an aligned PUs scaffold(PU14)generated from 14wt%polymer content and processed at196C was selected based on the desired oriented porous structure(pore size of 32.569.3 lm,porosity of 92%)and balanced mechanical properties both in the horizontal direction(strength of 41.3 kPa,modulus of 72.3 kPa)and in the vertical direction(strength of 45.5 kPa,modulus of 139.3 kPa).The response of L929 cells and the regeneration of muscle tissue demonstrated that such pure material-based aligned 3D scaffold can facilitate the development of orientated cells and anisotropic tissue regeneration both in vitro and in vivo.Thus,these pure material-based scaffolds with ordered architecture have great potentials in tissue engineering for biological anisotropic tissue regeneration,such as muscle,nerve,spinal cord and so on. | Weiwei Lin Wanling Lan Yingke Wu Daiguo Zhao Yanchao Wang Xueling He Jiehua Li Zhen Li Feng Luo Hong Tan Qiang Fu | 2020 | Regenerative Biomaterials2020，7，1： | 0 |
| 16 | A small knottin-like peptide negatively regulates in wheat to stripe rust resistance during early infection of wheat显示文摘Although Blufensins(Bln)have important functions in the response of plants to biotic stress the precise functioning of Bln in wheat remains largely unknown.Here we isolated a Bln gene(TaBln4)from Suwon 11 infected by Puccinia striiformis f.sp.tritici(Pst).Expression of TaBln4 increased in host plants at the early stage of infection with a virulent Pst race(CYR31)but was unchanged in response to infection by an avirulent race(CYR23).Transcription levels of TaBln4 were also regulated by hormone and abiotic stresses.Expression of TaBln4 in tobacco leaves suppressed Bax-induced programmed cell death.Knockdown of TaBln4 by virus-induced gene silencing inhibited colonization of race CYR31 by increasing the accumulation of H2O2 and formation of hypersensitive responses(HR).Transient overexpression of TaBln4 by a transient overexpression system(BSMV-VOX)increased the susceptibility of wheat to CYR31.Results from bimolecular fluorescence complementation and pull-down assays demonstrated that TaBLN4 interacted with calmodulin.Taken together,our results suggest that TaBln4 negatively regulates resistance in wheat to Pst in a reactive oxygen species(ROS)-and HR-dependent manner. | Shuangyuan Guo Min Li Huankun Li Feng Zhang Qiong Zhang Xueling Huang Xing Li Xiaojie Wang Zhensheng Kang Xinmei Zhang | 2023 | The Crop Journal2023，11，2： | 0 |
| 17 | Quantifying Solid Solution Strengthening in Nickel-Based Superalloys via High-Throughput Experiment and Machine Learning显示文摘Solid solution strengthening(SSS)is one of the main contributions to the desired tensile properties of nickel-based superalloys for turbine blades and disks.The value of SSS can be calculated by using Fleischer’s and Labusch’s theories,while the model parameters are incorporated without fitting to experimental data of complex alloys.In thiswork,four diffusionmultiples consisting of multicomponent alloys and pure Niare prepared and characterized.The composition and microhardness of singleγphase regions in samples are used to quantify the SSS.Then,Fleischer’s and Labusch’s theories are examined based on high-throughput experiments,respectively.The fitted solid solution coefficients are obtained based on Labusch’s theory and experimental data,indicating higher accuracy.Furthermore,six machine learning algorithms are established,providing a more accurate prediction compared with traditional physical models and fitted physical models.The results show that the coupling of highthroughput experiments and machine learning has great potential in the field of performance prediction and alloy design. | Zihang Li Zexin Wang Zi Wang Zijun Qin Feng Liu Liming Tan Xiaochao Jin Xueling Fan Lan Huang | 2023 | Computer Modeling in Engineering & Sciences2023，，5： | 0 |
| 18 | Self-assembly of insulated molecular wires of a water-soluble cationic PPV and anionic dendrons显示文摘Insulated molecular wires of poly(phenylenevinylene) (PPV) were prepared by wrapping the conjugated backbones with dendrons through a noncovalent approach. It was found that electrostatic interaction between the quaternary ammonium groups of PPV-1 and the carboxylate moieties in dendrons induced the packing of dendrons along PPV-1 conjugated backbones. Absorption and emission spectroscopic examinations in solution and solid film indicated that the PPV-1 backbones adopted a more planar and isolated conformation in the complexes. Furthermore, interchain interactions in the complexes could be greatly reduced, improving the quantum yield of PPV-1. | FENG XueLing YAO ZhiYi LI Chun SHI Gao Quan | 2009 | Chinese Science Bulletin2009，54，14： | 0 |
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