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| 1 | White Matter Deficits Underlying the Impaired Consciousness Level in Patients with Disorders of Consciousness显示文摘In this study, we aimed to(1) identify white matter(WM) deficits underlying the consciousness level in patients with disorders of consciousness(DOCs) using diffusion tensor imaging(DTI), and(2) evaluate the relationship between DTI metrics and clinical measures of the consciousness level in DOC patients. With a cohort of 8 comatose, 8 unresponsive wakefulness syndrome/vegetative state, and 14 minimally conscious state patients and 25 patient controls, we performed group comparisons of the DTI metrics in 48 core WM regions of interest(ROIs), and examined the clinical relevance using correlation analysis. We identified multiple abnormal WM ROIs in DOC patients compared with normal controls, and the DTI metrics in these ROIs were significantly correlated with clinical measures of the consciousness level. Therefore, our findings suggested that multiple WM tracts are involved in the impaired consciousness levels in DOC patients and demonstrated the clinical relevance of DTI for DOC patients. | Xuehai Wu Jiaying Zhang Zaixu Cui Weijun Tang Chunhong Shao Jin Hu Jianhong Zhu Yao Zhao Lu Lu Gang Chen Georg Northoff Gaolang Gong Ying Mao Yong He | 2018 | Neuroscience Bulletin2018，34，4： | 8 |
| 2 | Research into comprehensive gas extraction technology of single coal seams with low permeability in the Jiaozuo coal mining area显示文摘For a low permeability single coal seam prone to gas outbursts,pre-drainage of gas is difficult and inefficient,seriously restricting the safety and efficiency of production.Radical measures of increasing gas extraction efficiency are pressure relief and infrared antirefiection.We have analyzed the effect of mining conditions and the regularity of mine pressure distribution in front of the working face of a major coal mine of the Jiaozuo Industrial(Group) Co.as our test area,studied the width of the depressurization zone in slice mining and analyzed gas efficiency and fast drainage in the advanced stress relaxation zone.On that basis,we further investigated and practiced the exploitation technology of shallow drilling,fan drilling and grid shape drilling at the working face.Practice and our results show that the stress relaxation zone is the ideal region for quick and efflcient extraction of gas.By means of an integrated extraction technology,the amount of gas emitted into the zone was greatly reduced,while the risk of dangerous outbursts of coal and gas was lowered markedly.This exploration provides a new way to control for gas in working faces of coal mines with low permeability and risk of gas outbursts of single coal seams in the Jiaozuo mining area. | Fu Jiangwei Fu Xuehai Hu Xiao Chen Li Ou Jianchun | 2011 | Mining Science and Technology2011，21，4： | 5 |
| 3 | Microglia-Derived NLRP3 Activation Mediates the Pressor Effect of Prorenin in the Rostral Ventrolateral Medulla of Stress-Induced Hypertensive Rats显示文摘Increased microglial activation and neuroinflammation within autonomic brain regions such as the rostral ventrolateral medulla(RVLM)have been implicated in stress-induced hypertension(SIH).Prorenin,a member of the brain renin-angiotensin system(RAS),can directly activate microglia.The present study aimed to investigate the effects of prorenin on microglial activation in the RVLM of SIH rats.Rats were subjected to intermittent electric foot-shocks plus noise,this stress was administered for 2 h twice daily for 15 consecutive days,and mean arterial pressure(MAP)and renal sympathetic nerve activity(RSNA)were monitored.The results showed that MAP and RSNA were augmented,and this paralleled increased pro-inflammatory phenotype(M1)switching.Prorenin and its receptor(PRR)expression and the NLR family pyrin domain containing 3(NLRP3)activation were increased in RVLM of SIH rats.In addition,PLX5622(a microglial depletion agent),MCC950(a NLRP3 inhibitor),and/or PRO20(a(Pro)renin receptor antagonist)had antihypertensive effects in the rats.The NLRP3 expression in the RVLM was decreased in SIH rats treated with PLX5622.Mito-tracker staining showed translocation of NLRP3 from mitochondria to the cytoplasm in proreninstimulated microglia.Prorenin increased the ROS-triggering M1 phenotype-switching and NLRP3 activation,while MCC950 decreased the M1 polarization.In conclusion,upregulated prorenin in the RVLM may be involved in the pathogenesis of SIH,mediated by activation of the microglia-derived NLRP3 inflammasome.The link between prorenin and NLRP3 in microglia provides insights for the treatment of stress-related hypertension. | Li Hu Shutian Zhang Kokwin Ooi Xuehai Wu Jiaxiang Wu Jian Cai Yinggang Sun Jijiang Wang Danian Zhu Fuxue Chen Chunmei Xia | 2020 | Neuroscience Bulletin2020，36，5： | 3 |
| 4 | Validation and modification of the AJCC 8th TNM staging system for pancreatic ductal adenocarcinoma in a Chinese cohort:A nationwide pancreas data center analysis显示文摘Objective:To validate the 8 th edition of the American Joint Committee on Cancer(AJCC)staging system for pancreatic ductal adenocarcinoma(PDAC)in a Chinese cohort of radically resected patients and to develop a refined staging system for PDAC.Methods:Data were collected from the China Pancreas Data Center(CPDC)for patients with resected PDAC in 2016 and 2017,and cancer-specific survival(CSS)was evaluated using the Kaplan-Meier method and log-rank test.Univariate and multivariate analyses based on Cox regression were performed to identify prognostic factors.The recursive partitioning analysis(RPA),Kaplan-Meier method,and log-rank test were performed on the training dataset to generate a proposed modification for the 8 th TNM staging system utilizing the preoperative carbohydrate antigen(CA)19-9 level.Validation was performed for both staging systems in the validation cohort.Results:A total of 1,676 PDAC patients were retrieved,and the median CSS was significantly different between the 8 th TNM groupings,with no significant difference in survival between stage IB and IIA.The analysis of T and N stages demonstrated a better prognostic value in the N category.Multivariate analysis showed that the preoperative serum CA19-9 level was the strongest prognostic indicator among all the independent risk factors.All patients with CA19-9>500 U/mL had similar survival,and we proposed a new staging system by combining IB and IIA and stratifying all patients with high CA19-9 into stage III.The modified staging system had a better performance for predicting CSS than the 8 th AJCC staging scheme.Conclusions:The 8 th AJCC staging system for PDAC is suitable for a Chinese cohort of resected patients,and the N category has a better prognostic value than the T category.Our modified staging system has superior accuracy in predicting survival than the 8 th AJCC TNM staging system. | Hao Hu Chang Qu Bingjun Tang Weikang Liu Yongsu Ma Yiran Chen Xuehai Xie Yan Zhuang Hongqiao Gao Xiaodong Tian Yinmo Yang | 2021 | Chinese Journal of Cancer Research2021，33，4： | 3 |
| 5 | Evaluation of the Occurrence Possibility of SNP in Brassica napus with Sliding Window Features by Using RBF Networks显示文摘We extract some physical and chemical features re-lated to the occurrence of single nucleotide polymorphism (SNP) from three groups of sliding windows around SNP site,and then make the predictions about accuracy by using radial basis function (RBF) networks. The result of the forward sliding windows sug-gests that the accuracies and Matthews correlation coefficient (MCC values) ascend with the increasing of length of sliding windows. The accuracies range from 73.27 % to 80.69 %,and MCC values range from 0.465 to 0.614. The backward sliding windows and the sliding windows with fixed length three are de-signed to find the crucial sites related to SNP. The results imply that the occurrence possibility of SNP relies heavily on the above physical and chemical features of sites which are at a distance around 20 bases from the SNP site. Compared with the support vector machine (SVM),our RBF network approach has achieved more satisfactory results. | HU Xuehai LI Ruiyuan 2ENG Jinling XIONG Huijuan XIA Jingbo LI Zhi | 2011 | Wuhan University Journal of Natural Sciences2011，16，1： | 2 |
| 6 | Shear-Flow Induced Secondary Circulation in Parallel Underwater Topographic Corrugation and Its Application to Satellite Image Interpretation显示文摘This study aims to figure out satellite imaging mechanisms for submerged sand ridges in the shallow water region in the case of the flow parallel to the topography corrugation.Solving the disturbance governing equations of the shear-flow yields the analytical solutions of the secondary circulation.The solutions indicate that a flow with a parabolic horizontal velocity shear and a sinusoidal vertical velocity shear will induce a pair of vortexes with opposite signs distributed symmetrically on the two sides of central line of a rectangular canal.In the case of the presence of surface Ekman layer with the direction of Ekman current opposite to(coincident with) the mean flow,the two vortexes converge(diverge) at the central line of canal in the upper layer and form a surface current convergent(divergent) zone along the central line of the canal.In the case of the absence of surface Ekman layer,there is no convergent(divergent) zone formed over the sea surface.The theoretical results are applied to interpretations of three convergent cases,one divergent case and statistics of 27 cases of satellite observations in the submerged sand ridge region of the Liaodong Shoal in the Bohai Sea.We found that the long,finger-like,bright patterns on SAR images are corresponding to the locations of the canals(or tidal channels) formed by two adjacent sand ridges rather than the sand ridges themselves. | ZHENG Quanan ZHAO Qing YUAN Yeli LIU Xian HU Jianyu LIU Xuehai YIN Liping YE Xiaomin | 2012 | Journal of Ocean University of China2012，11，4： | 2 |
| 7 | Residual-based a posteriori error estimates for symmetric conforming mixed finite elements for linear elasticity problems显示文摘A posteriori error estimators for the symmetric mixed finite element methods for linear elasticity problems with Dirichlet and mixed boundary conditions are proposed. Reliability and efficiency of the estimators are proved. Numerical examples are presented to verify the theoretical results. | Long Chen Jun Hu Xuehai Huang Hongying Man | 2018 | Science China Mathematics2018，61，6： | 0 |
| 8 | iCREPCP:A deep learning-based web server for identifying base-resolution cis-regulatory elements within plant core promoters显示文摘Dear Editor,A central question of plant biology is how to specify the temporal and spatial patterns as well as the quantitative levels of gene expression,which are significantly associated with important agronomic traits.There has been a growing consensus in the past decade that the two key factors determining gene expression level are cis-regulatory modules(CRMs)and trans-acting factors(TAFs)(Schmitz et al.,2022).Common CRMs include gene-proximal promoters and distal enhancers,which are both considered to be complex assemblies of cis-regulatory elements(CREs).It is the binding or interaction between CREs and TAFs(often transcription factors[TFs])in a ubiquitous or cell-specific manner that determines in which cell,at what time,and at what level a gene is expressed.Therefore,the identification of plant CRMs or critical CREs will not only help us understand transcriptional regulatory mechanisms in plants but also serve as an essential prerequisite for plant breeding 4.0—breeding by genome editing(Gao,2021). | Kaixuan Deng Qizhe Zhang Yuxin Hong Jianbing Yan Xuehai Hu | 2023 | Plant Communications2023，4，1： | 0 |
| 9 | 本刊英文版2018年61卷第6期摘要显示文摘Residual-based a posteriori error estimates for symmetric conforming mixed finite elements for linear elasticity problems Long Chen,Jun Hu,Xuehai Huang&Hongying Man Abstract A posteriori error estimators for the symmetric mixed finite element methods for linear elasticity problems with Dirichlet and mixed boundary conditions are proposed.Reliability and efficiency of the | Long Chen Jun Hu Xuehai Huang Hongying Man | 2018 | 中国科学:数学2018，48，6： | 0 |
| 10 | A Study of Rules-Based OPS5 Parallel Firing显示文摘Based on the introduction of the PS, this paper analyzes the correlation of parallel firing rules. Then it presents an algorithm to support OPS5 parallel firing during the act phase and a new parallel reasoning model for OPS5. At last, it gives an evaluation on the model in the aspects of time complexity, running efficiency, etc. | Zhang Xuehai Li Mingshu Hu Mingzeng (Dpartment of Computer Science) | 1990 | 哈尔滨工业大学学报1990，22，3： | 0 |
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